BRPI0906444A8 - compostos de 4-piridinona e seu uso para câncer - Google Patents

compostos de 4-piridinona e seu uso para câncer Download PDF

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Publication number
BRPI0906444A8
BRPI0906444A8 BRPI0906444A BRPI0906444A BRPI0906444A8 BR PI0906444 A8 BRPI0906444 A8 BR PI0906444A8 BR PI0906444 A BRPI0906444 A BR PI0906444A BR PI0906444 A BRPI0906444 A BR PI0906444A BR PI0906444 A8 BRPI0906444 A8 BR PI0906444A8
Authority
BR
Brazil
Prior art keywords
compounds
cancer
pyridinone compounds
formula
pharmaceutical compositions
Prior art date
Application number
BRPI0906444A
Other languages
English (en)
Inventor
M Borzilleri Robert
Cai Zhen-Wei
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BRPI0906444A2 publication Critical patent/BRPI0906444A2/pt
Publication of BRPI0906444A8 publication Critical patent/BRPI0906444A8/pt
Publication of BRPI0906444B1 publication Critical patent/BRPI0906444B1/pt
Publication of BRPI0906444B8 publication Critical patent/BRPI0906444B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos de 4-piridinona, composições farmacêuticas contendo ditos compostos e uso desses compostos a presente invenção refere-se a compostos de fórmula (1) e sais dos mesmos. também, refere-se a métodos para usar os compostos no tratamento de doenças proliferativas, tal como câncer, e composições farmacêuticas compreendendo ao menos um composto de fórmula (1) ou um sal farmaceuticamente aceitável.
BRPI0906444A 2008-01-23 2009-01-22 compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos BRPI0906444B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2284808P 2008-01-23 2008-01-23
US61/022,848 2008-01-23
PCT/US2009/031649 WO2009094417A1 (en) 2008-01-23 2009-01-22 4-pyridinone compounds and their use for cancer

Publications (4)

Publication Number Publication Date
BRPI0906444A2 BRPI0906444A2 (pt) 2015-07-14
BRPI0906444A8 true BRPI0906444A8 (pt) 2020-02-27
BRPI0906444B1 BRPI0906444B1 (pt) 2021-03-16
BRPI0906444B8 BRPI0906444B8 (pt) 2021-05-25

Family

ID=40637826

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906444A BRPI0906444B8 (pt) 2008-01-23 2009-01-22 compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos

Country Status (21)

Country Link
US (2) US8124768B2 (pt)
EP (1) EP2235002B1 (pt)
JP (1) JP5314050B2 (pt)
KR (1) KR101596527B1 (pt)
CN (1) CN101977906B (pt)
AU (1) AU2009206440B2 (pt)
BR (1) BRPI0906444B8 (pt)
CA (1) CA2713111C (pt)
CO (1) CO6230986A2 (pt)
CY (1) CY1114140T1 (pt)
DK (1) DK2235002T3 (pt)
EA (1) EA017736B1 (pt)
ES (1) ES2398335T3 (pt)
HR (1) HRP20130040T1 (pt)
IL (1) IL207212A (pt)
NZ (1) NZ586630A (pt)
PL (1) PL2235002T3 (pt)
PT (1) PT2235002E (pt)
SI (1) SI2235002T1 (pt)
WO (1) WO2009094417A1 (pt)
ZA (1) ZA201005248B (pt)

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AU2009303602B2 (en) 2008-10-14 2012-06-14 Sunshine Lake Pharma Co., Ltd. Compounds and methods of use
EP2408300B1 (en) 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Amino ester derivatives, salts thereof and methods of use
EP2563773A1 (en) 2010-04-29 2013-03-06 Deciphera Pharmaceuticals, LLC Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
RU2477723C2 (ru) 2011-06-16 2013-03-20 Общество С Ограниченной Ответственностью "Фьюжн Фарма" Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
SG11201404505PA (en) 2012-01-31 2014-10-30 Daiichi Sankyo Co Ltd Pyridone derivative
EP2879677B1 (en) 2012-07-28 2017-06-14 Calitor Sciences, LLC Substituted pyrazolone compounds and methods of use
US8975282B2 (en) 2012-07-28 2015-03-10 Sunshine Lake Pharma Co., Ltd. Substituted pyrazolone compounds and methods of use
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) * 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
TWI723572B (zh) 2014-07-07 2021-04-01 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
CN105153026B (zh) * 2015-08-21 2018-02-02 江西科技师范大学 含联芳基酰胺结构的索拉非尼衍生物及其制备方法和应用
AU2020205035A1 (en) * 2019-01-03 2021-07-22 Array Biopharma Inc. Quinoline compounds as inhibitors of TAM and MET kinases
US20240293386A1 (en) * 2021-06-22 2024-09-05 Lg Chem, Ltd. Novel compound as protein kinase inhibitor
TW202315628A (zh) * 2021-06-24 2023-04-16 南韓商Ｌｇ化學股份有限公司 作為ｒｏｎ抑制劑之新穎吡啶衍生物化合物
WO2024067783A1 (zh) * 2022-09-28 2024-04-04 上海济煜医药科技有限公司 含磷类化合物及其制备方法和医药应用
CN117180289A (zh) * 2023-10-25 2023-12-08 南京医科大学 麦他替尼胺丁三醇联合pd-l1抗体在制备治疗黑色素瘤药物中的应用

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DE69622183D1 (de) 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
WO1999065867A1 (en) * 1998-06-17 1999-12-23 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
CA2374995C (en) * 1999-07-20 2010-12-07 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
US6355660B1 (en) * 1999-07-20 2002-03-12 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
EE200200119A (et) 1999-09-21 2003-04-15 Astrazeneca Ab Kinasoliini derivaadid ja nende kasutamine ravimitena
US6498151B2 (en) * 2000-03-22 2002-12-24 Merck Frosst Canada & Co. Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
FR2812633A1 (fr) * 2000-08-04 2002-02-08 Aventis Cropscience Sa Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides
SE0102384D0 (sv) * 2001-07-03 2001-07-03 Pharmacia Ab New compounds
WO2003045921A1 (en) * 2001-11-28 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic amide compounds as apolipoprotein b inhibitors
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2005263787A (ja) * 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
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Also Published As

Publication number Publication date
WO2009094417A1 (en) 2009-07-30
CA2713111C (en) 2015-06-30
AU2009206440B2 (en) 2013-08-15
US20120114643A1 (en) 2012-05-10
US20110034416A1 (en) 2011-02-10
PT2235002E (pt) 2013-01-30
CO6230986A2 (es) 2010-12-20
US8258118B2 (en) 2012-09-04
JP2011510087A (ja) 2011-03-31
BRPI0906444B8 (pt) 2021-05-25
CN101977906B (zh) 2014-11-05
CA2713111A1 (en) 2009-07-30
NZ586630A (en) 2011-12-22
PL2235002T3 (pl) 2013-04-30
ZA201005248B (en) 2011-09-28
US8124768B2 (en) 2012-02-28
ES2398335T3 (es) 2013-03-15
EP2235002B1 (en) 2012-11-21
DK2235002T3 (da) 2013-03-11
BRPI0906444A2 (pt) 2015-07-14
HRP20130040T1 (hr) 2013-02-28
CY1114140T1 (el) 2016-07-27
KR20100103636A (ko) 2010-09-27
IL207212A (en) 2015-01-29
CN101977906A (zh) 2011-02-16
HK1143157A1 (en) 2010-12-24
EA017736B1 (ru) 2013-02-28
EP2235002A1 (en) 2010-10-06
IL207212A0 (en) 2010-12-30
SI2235002T1 (sl) 2013-06-28
KR101596527B1 (ko) 2016-02-22
JP5314050B2 (ja) 2013-10-16
EA201001196A1 (ru) 2011-02-28
BRPI0906444B1 (pt) 2021-03-16
AU2009206440A1 (en) 2009-07-30

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/01/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF