BRPI0916355B8 - Vetor recombinante compreendendo um polinucleotídeo isolado, e, método para produzir um precursor de piripiropeno a - Google Patents

Vetor recombinante compreendendo um polinucleotídeo isolado, e, método para produzir um precursor de piripiropeno a

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Publication number
BRPI0916355B8
BRPI0916355B8 BRPI0916355A BRPI0916355A BRPI0916355B8 BR PI0916355 B8 BRPI0916355 B8 BR PI0916355B8 BR PI0916355 A BRPI0916355 A BR PI0916355A BR PI0916355 A BRPI0916355 A BR PI0916355A BR PI0916355 B8 BRPI0916355 B8 BR PI0916355B8
Authority
BR
Brazil
Prior art keywords
pyripyropene
recombinant vector
producing
polynucleotide
precursor
Prior art date
Application number
BRPI0916355A
Other languages
English (en)
Inventor
Anzai Hiroyuki
Yamamoto Kentaro
Tsuchida Mariko
Oyama Kazuhiko
Mitomi Masaaki
Original Assignee
Meiji Seika Kaisha
Meiji Seika Pharma Co Ltd
Mmag Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Meiji Seika Pharma Co Ltd, Mmag Co Ltd filed Critical Meiji Seika Kaisha
Publication of BRPI0916355A2 publication Critical patent/BRPI0916355A2/pt
Publication of BRPI0916355B1 publication Critical patent/BRPI0916355B1/pt
Publication of BRPI0916355B8 publication Critical patent/BRPI0916355B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

polinucleotídeo isolado, vetor recombinante, transformante, e, método para produzir um precursor de piripiropeno a são revelados um polinucleotídeo inédito isolado compreendendo uma sequência de nucleotídeos que codifica pelo menos um polipeptídeo envolvido na biossíntese de piripiropeno a, um vetor recombinante compreendendo o polinucleotídeo e uni transformante compreendendo o polinucleotídeo. pela presente invenção, são fornecidos um gene biossintético de piripiropeno a usado para a produção de um análogo de piripiropeno inédito, melhoria da produtividade de uma bactéria produtora de piripiropeno a, produção de um agente inseticida para microrganismos, criação de uma planta resistente a pestes de insetos ou similares.
BRPI0916355A 2008-07-24 2009-07-24 Vetor recombinante compreendendo um polinucleotídeo isolado, e, método para produzir um precursor de piripiropeno a BRPI0916355B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2008190862 2008-07-24
JP2008-190862 2008-07-24
JP2008270294 2008-10-20
JP2008-270294 2008-10-20
JP2009-020591 2009-01-30
JP2009020591 2009-01-30
PCT/JP2009/063293 WO2010010955A1 (ja) 2008-07-24 2009-07-24 ピリピロペンa生合成遺伝子

Publications (3)

Publication Number Publication Date
BRPI0916355A2 BRPI0916355A2 (pt) 2020-08-18
BRPI0916355B1 BRPI0916355B1 (pt) 2021-11-09
BRPI0916355B8 true BRPI0916355B8 (pt) 2022-12-13

Family

ID=41570415

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916355A BRPI0916355B8 (pt) 2008-07-24 2009-07-24 Vetor recombinante compreendendo um polinucleotídeo isolado, e, método para produzir um precursor de piripiropeno a

Country Status (17)

Country Link
US (2) US8557550B2 (pt)
EP (1) EP2319923B1 (pt)
JP (2) JP4642922B2 (pt)
KR (1) KR101690802B1 (pt)
CN (1) CN102144030B (pt)
AU (1) AU2009274832B2 (pt)
BR (1) BRPI0916355B8 (pt)
CA (1) CA2731760C (pt)
DK (1) DK2319923T3 (pt)
ES (1) ES2453665T3 (pt)
IL (1) IL210795A (pt)
MX (1) MX2011000023A (pt)
NZ (1) NZ590795A (pt)
PL (1) PL2319923T3 (pt)
RU (1) RU2540017C2 (pt)
WO (1) WO2010010955A1 (pt)
ZA (1) ZA201100709B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2319923T3 (en) * 2008-07-24 2014-02-24 Meiji Seika Pharma Co Ltd A PYRIPYROPEN biosynthetic genes
CA2788058C (en) * 2010-01-26 2018-04-17 Meiji Seika Pharma Co., Ltd. Method for producing pyripyropene
CA2787829A1 (en) * 2010-01-26 2011-08-04 Meiji Seika Pharma Co., Ltd. Method for producing pyripyropene derivatives by the enzymatic method
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MX355432B (es) 2010-09-14 2018-04-18 Basf Se Composiciones que contienen un insecticida de piripiropeno y una base.
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
RU2648950C2 (ru) * 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
WO2013073689A1 (ja) * 2011-11-17 2013-05-23 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ピリピロペン生合成遺伝子発現植物体
ES2566910T3 (es) 2012-03-12 2016-04-18 Basf Se Formulación de concentrado líquido que contiene un insecticida de piripiropeno II
ES2566911T3 (es) 2012-03-12 2016-04-18 Basf Se Formulación de concentrado líquido que contiene un insecticida de piripiropeno I
EP2825043B1 (en) 2012-03-12 2018-09-05 Basf Se Method for producing an aqueous suspension concentrate formulation of a pyripyropene insecticide
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WO2015196128A2 (en) 2014-06-19 2015-12-23 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
US10407683B2 (en) 2014-07-16 2019-09-10 Modernatx, Inc. Circular polynucleotides
PL3350333T3 (pl) 2015-09-17 2022-03-07 Modernatx, Inc. Polinukleotydy zawierające region stabilizujący ogon
WO2017049286A1 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a morpholino linker
US10148618B2 (en) 2016-06-07 2018-12-04 Abb Schweiz Ag Network isolation
WO2017223176A1 (en) 2016-06-24 2017-12-28 Modernatx, Inc. Methods and apparatus for filtration
KR102098018B1 (ko) 2017-12-22 2020-04-07 주식회사 포스코 압력탱크

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Also Published As

Publication number Publication date
PL2319923T3 (pl) 2014-05-30
EP2319923A4 (en) 2011-12-28
EP2319923B1 (en) 2013-12-25
AU2009274832A1 (en) 2010-01-28
JPWO2010010955A1 (ja) 2012-01-05
DK2319923T3 (en) 2014-02-24
KR101690802B1 (ko) 2016-12-28
BRPI0916355B1 (pt) 2021-11-09
US8557550B2 (en) 2013-10-15
CN102144030B (zh) 2016-05-04
JP2010193878A (ja) 2010-09-09
ES2453665T3 (es) 2014-04-08
RU2011106496A (ru) 2012-08-27
CA2731760C (en) 2019-09-24
RU2540017C2 (ru) 2015-01-27
EP2319923A1 (en) 2011-05-11
ZA201100709B (en) 2012-05-01
IL210795A0 (en) 2011-04-28
WO2010010955A1 (ja) 2010-01-28
AU2009274832B2 (en) 2015-07-16
US20140142289A1 (en) 2014-05-22
MX2011000023A (es) 2011-03-30
CN102144030A (zh) 2011-08-03
NZ590795A (en) 2012-11-30
BRPI0916355A2 (pt) 2020-08-18
IL210795A (en) 2014-12-31
CA2731760A1 (en) 2010-01-28
JP4642922B2 (ja) 2011-03-02
US20120015410A1 (en) 2012-01-19
US9315785B2 (en) 2016-04-19
KR20110038678A (ko) 2011-04-14

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