BRPI0916532A2 - nitratos de isosorbida tendo atividade vasodilatadora - Google Patents

nitratos de isosorbida tendo atividade vasodilatadora

Info

Publication number: BRPI0916532A2
Authority: BR; Brazil
Prior art keywords: vasodilatory activity; isosorbide nitrates; isosorbide; nitrates; vasodilatory
Prior art date: 2008-07-22

Application number

BRPI0916532A

Other languages

English (en)

Inventor

Francisco Pubill Coy

José Repollés Moliner

Juan Carlos Del Castillo Nieto

Lydia Cabeza Llorente

Marisabel Mourelle Mancini

Original Assignee

Lacer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-22

Filing date

2009-07-21

Publication date

2015-11-10

2009-07-21 Application filed by Lacer Sa filed Critical Lacer Sa

2015-11-10 Publication of BRPI0916532A2 publication Critical patent/BRPI0916532A2/pt

Links

229960002479 isosorbide Drugs 0.000 title 1
-1 isosorbide nitrates Chemical class 0.000 title 1
230000000304 vasodilatating effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0916532A 2008-07-22 2009-07-21 nitratos de isosorbida tendo atividade vasodilatadora BRPI0916532A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08380221A EP2149576A1 (en)	2008-07-22	2008-07-22	Isosorbide Nitrates having vasodilating activity
US12/334,986 US8211939B2 (en)	2008-07-22	2008-12-15	Isosorbide nitrates
PCT/EP2009/059387 WO2010010101A1 (en)	2008-07-22	2009-07-21	Isosorbide nitrates having vasodilating activity

Publications (1)

Publication Number	Publication Date
BRPI0916532A2 true BRPI0916532A2 (pt)	2015-11-10

Family

ID=39800661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916532A BRPI0916532A2 (pt)	2008-07-22	2009-07-21	nitratos de isosorbida tendo atividade vasodilatadora

Country Status (15)

Country	Link
US (2)	US8211939B2 (pt)
EP (2)	EP2149576A1 (pt)
JP (1)	JP2011528691A (pt)
KR (1)	KR20110039562A (pt)
CN (1)	CN102124010B (pt)
AR (1)	AR072591A1 (pt)
AT (1)	ATE507230T1 (pt)
AU (1)	AU2009273233B2 (pt)
BR (1)	BRPI0916532A2 (pt)
CA (1)	CA2731574A1 (pt)
DE (1)	DE602008006545D1 (pt)
ES (2)	ES2365688T3 (pt)
MX (1)	MX2011000808A (pt)
UY (1)	UY32001A (pt)
WO (1)	WO2010010101A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2149576A1 (en) *	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity
CA2902009A1 (en) *	2013-03-05	2014-09-12	Archer Daniels Midland Company	Isohexide monotriflates and process for synthesis thereof
US10691097B2 (en)	2014-05-09	2020-06-23	The Boeing Company	Path repeatable machining for full sized determinant assembly
US10501471B1 (en) *	2018-11-04	2019-12-10	John F. Schmedtje, Jr.	Compounds useful for treating cardiovascular diseases
US10913748B2 (en) *	2018-11-04	2021-02-09	Coeurative, Inc.	Compounds useful for treating cardiovascular diseases
CN113683623B (zh) *	2021-09-09	2022-08-12	中国人民解放军空军军医大学	一种no供体化合物及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3028289C2 (de) *	1980-07-25	1986-11-27	Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe	2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
JP2628756B2 (ja)	1988-09-15	1997-07-09	シュバルツファルマアクチェンゲゼルシャフト	新規有機ニトレート及びそれらの製造方法
US4891373A (en)	1988-11-23	1990-01-02	Pfizer Inc.	Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
NL9001955A (nl)	1990-09-05	1992-04-01	Cedona Pharm Bv	Nieuwe thiazolidinederivaten.
FR2680173A1 (fr)	1991-08-07	1993-02-12	Hoechst Lab	Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
DK0656881T3 (da)	1992-07-30	1999-06-23	Cal Int Ltd	Ester og kombinationer af et organisk nitrat og et salicylat
ES2142773B1 (es) *	1998-10-07	2001-01-01	Lacer Sa	Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
ES2258365B1 (es)	2003-10-03	2007-12-01	Lacer, S.A.	Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) *	2006-12-28	2008-07-09	Lacer, S.A.	Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
EP2149576A1 (en) *	2008-07-22	2010-02-03	Lacer, S.A.	Isosorbide Nitrates having vasodilating activity

2008
- 2008-07-22 EP EP08380221A patent/EP2149576A1/en not_active Withdrawn
- 2008-11-14 AT AT08380318T patent/ATE507230T1/de not_active IP Right Cessation
- 2008-11-14 DE DE602008006545T patent/DE602008006545D1/de active Active
- 2008-11-14 ES ES08380318T patent/ES2365688T3/es active Active
- 2008-11-17 ES ES200803270A patent/ES2341075B1/es not_active Expired - Fee Related
- 2008-12-15 US US12/334,986 patent/US8211939B2/en not_active Expired - Fee Related
2009
- 2009-07-21 BR BRPI0916532A patent/BRPI0916532A2/pt not_active IP Right Cessation
- 2009-07-21 EP EP09800052A patent/EP2324033B1/en not_active Not-in-force
- 2009-07-21 CA CA2731574A patent/CA2731574A1/en not_active Abandoned
- 2009-07-21 CN CN2009801321115A patent/CN102124010B/zh not_active Expired - Fee Related
- 2009-07-21 JP JP2011519153A patent/JP2011528691A/ja active Pending
- 2009-07-21 AU AU2009273233A patent/AU2009273233B2/en not_active Ceased
- 2009-07-21 WO PCT/EP2009/059387 patent/WO2010010101A1/en not_active Ceased
- 2009-07-21 MX MX2011000808A patent/MX2011000808A/es active IP Right Grant
- 2009-07-21 UY UY0001032001A patent/UY32001A/es not_active Application Discontinuation
- 2009-07-21 KR KR1020117003953A patent/KR20110039562A/ko not_active Ceased
- 2009-07-22 AR ARP090102783A patent/AR072591A1/es unknown
2012
- 2012-04-05 US US13/439,894 patent/US20120189616A1/en not_active Abandoned

Also Published As

Publication number	Publication date
UY32001A (es)	2010-02-26
WO2010010101A1 (en)	2010-01-28
AU2009273233A1 (en)	2010-01-28
US20120189616A1 (en)	2012-07-26
EP2149576A1 (en)	2010-02-03
AR072591A1 (es)	2010-09-08
ES2365688T3 (es)	2011-10-10
WO2010010101A8 (en)	2011-03-10
ATE507230T1 (de)	2011-05-15
ES2341075B1 (es)	2011-03-01
MX2011000808A (es)	2011-05-30
CN102124010B (zh)	2013-12-18
AU2009273233B2 (en)	2013-03-28
CN102124010A (zh)	2011-07-13
US20100022638A1 (en)	2010-01-28
US8211939B2 (en)	2012-07-03
EP2324033A1 (en)	2011-05-25
ES2341075A1 (es)	2010-06-14
KR20110039562A (ko)	2011-04-19
DE602008006545D1 (de)	2011-06-09
CA2731574A1 (en)	2010-01-28
JP2011528691A (ja)	2011-11-24
EP2324033B1 (en)	2012-08-22

Legal Events

Date	Code	Title	Description
2016-06-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2016-09-27	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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