BRPI0916560A2 - análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. - Google Patents

análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente.

Info

Publication number: BRPI0916560A2
Authority: BR; Brazil
Prior art keywords: patient; treatment; nucleic acid; host cell; expression vector
Prior art date: 2008-07-31

Application number

BRPI0916560A

Other languages

English (en)

Inventor

Michael Weiss

Original Assignee

Univ Case Western Reserve

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-31

Filing date

2009-07-31

Publication date

2015-11-10

2009-07-31 Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve

2015-11-10 Publication of BRPI0916560A2 publication Critical patent/BRPI0916560A2/pt

Links

239000013604 expression vector Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
239000004026 insulin derivative Substances 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0916560A 2008-07-31 2009-07-31 análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. BRPI0916560A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8521208P	2008-07-31	2008-07-31
PCT/US2009/052477 WO2010014946A2 (en)	2008-07-31	2009-07-31	Halogen-stabilized insulin

Publications (1)

Publication Number	Publication Date
BRPI0916560A2 true BRPI0916560A2 (pt)	2015-11-10

Family

ID=41610982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916560A BRPI0916560A2 (pt)	2008-07-31	2009-07-31	análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente.

Country Status (13)

Country	Link
EP (2)	EP2318432B1 (pt)
JP (2)	JP5780958B2 (pt)
KR (1)	KR20110061552A (pt)
CN (1)	CN102171245B (pt)
AU (1)	AU2009276346B2 (pt)
BR (1)	BRPI0916560A2 (pt)
CA (1)	CA2732439A1 (pt)
ES (1)	ES2552636T3 (pt)
MX (1)	MX2011001181A (pt)
MY (1)	MY158627A (pt)
NZ (1)	NZ590792A (pt)
RU (1)	RU2555557C2 (pt)
WO (1)	WO2010014946A2 (pt)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8343914B2 (en)	2006-01-06	2013-01-01	Case Western Reserve University	Fibrillation resistant proteins
EP2074140B8 (en)	2006-10-04	2015-10-28	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
WO2009129250A2 (en)	2008-04-14	2009-10-22	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
EP2318432B1 (en) *	2008-07-31	2015-09-02	Case Western Reserve University	Halogen-stabilized insulin
US9200053B2 (en)	2008-07-31	2015-12-01	Case Western Reserve University	Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko)	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
AU2008365557A1 (en)	2008-12-15	2011-07-21	Zealand Pharma A/S	Glucagon analogues
US8642540B2 (en)	2008-12-15	2014-02-04	Zealand Pharma A/S	Glucagon analogues
MA32970B1 (fr)	2008-12-15	2012-01-02	Zealand Pharma As	Analogues du glucagon
ES2502218T3 (es)	2008-12-15	2014-10-03	Zealand Pharma A/S	Análogos de glucagón
JP6054742B2 (ja)	2009-07-13	2016-12-27	ジーランドファーマアクティーゼルスカブ	アシル化グルカゴン類似体
US8399407B2 (en)	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
RU2012123642A (ru) *	2009-12-11	2014-01-20	Кейз Вестерн Ризев Юнивесити	Аналоги инсулина, содержащие хлорированные аминокислоты
AR081975A1 (es)	2010-06-23	2012-10-31	Zealand Pharma As	Analogos de glucagon
CA2802897A1 (en)	2010-06-24	2011-12-29	Zealand Pharma A/S	Glucagon analogues
EA201390796A1 (ru)	2011-01-20	2014-07-30	Зилэнд Фарма А/С	Применение ацилированного аналога глюкагона
US10995129B2 (en) *	2011-07-13	2021-05-04	Case Western Reserve University	Non-standard insulin analogues
WO2013010048A2 (en)	2011-07-13	2013-01-17	Case Western Reserve University	Non-standard insulin analogues
EP2771026A4 (en) *	2011-10-27	2015-08-05	Univ Case Western Reserve	ULTRA-CONCENTRATED AND FAST-ACTING INSULIN ANALOG FORMULATIONS
CN104168911A (zh) *	2012-01-20	2014-11-26	卡斯西部储备大学	谷氨酸-稳定的胰岛素类似物
CA2872314C (en)	2012-05-03	2021-08-31	Zealand Pharma A/S	Gip-glp-1 dual agonist compounds and methods
NZ704043A (en)	2012-07-23	2017-07-28	Zealand Pharma As	Glucagon analogues
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
EP2948166B1 (en) *	2013-01-22	2020-12-09	Case Western Reserve University	N-terminal truncated insulin analogues
JP2016516728A (ja) *	2013-03-15	2016-06-09	ケースウェスタンリザーブユニバーシティＣａｓｅＷｅｓｔｅｒｎＲｅｓｅｒｖｅＵｎｉｖｅｒｓｉｔｙ	第２部位インスリン類似体
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
AR098065A1 (es)	2013-10-17	2016-04-27	Zealand Pharma As	Análogos de glucagón acilados
AU2014345570B2 (en)	2013-11-06	2019-01-24	Zealand Pharma A/S	Glucagon-GLP-1-GIP triple agonist compounds
CA2929459C (en)	2013-11-06	2022-05-03	Zealand Pharma A/S	Gip-glp-1 dual agonist compounds and methods
CA2936563A1 (en) *	2014-01-13	2015-07-16	Thermalin Diabetes, Llc	Rapid action insulin formulations and pharmaceutical delivery systems
AU2015328222B9 (en)	2014-10-06	2020-12-24	Case Western Reserve University	Biphasic single-chain insulin analogues
EP3212218B1 (en)	2014-10-29	2021-06-30	Zealand Pharma A/S	Gip agonist compounds and methods
JP2018505874A (ja) *	2015-01-20	2018-03-01	ケースウェスタンリザーブユニバーシティＣａｓｅＷｅｓｔｅｒｎＲｅｓｅｒｖｅＵｎｉｖｅｒｓｉｔｙ	選択的シグナリング特性及びより低い分裂促進性を有するインスリンアナログ
PL3283507T3 (pl)	2015-04-16	2020-05-18	Zealand Pharma A/S	Acylowany analog glukagonu
HK1255634A1 (zh)	2015-12-23	2019-08-23	Case Western Reserve University	超稳胰岛素类似物在聚合物熔体中的包囊
JP7143275B2 (ja)	2016-07-22	2022-09-28	ザユニバーシティオブユタリサーチファウンデイション	インスリンアナログ
WO2018042352A1 (en) *	2016-08-31	2018-03-08	Taro Pharmaceutical Industries	Fenoldopam topical formulations for treating skin disorders
NZ781774A (en)	2019-03-08	2023-03-31	Taro Pharma Ind	Stable topical compositions of fenoldopam
EP4326311A1 (en) *	2021-04-22	2024-02-28	The United States of America, as represented by the Secretary, Department of Health and Human Services	Human insulin c-alpha-peptides and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990001038A1 (en)	1988-07-20	1990-02-08	Nordisk Gentofte A/S	Human insulin analogs and preparations containing them
US5474978A (en)	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
UA72427C2 (en) *	1996-06-20	2005-03-15	Novo Nordisk As	Water-soluble insulin preparation containing mannite, method for manufacturing composition containing soluble insulin or crystalline insulin
DE19825447A1 (de) *	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
US7316999B2 (en) *	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
AU2002346490A1 (en)	2001-12-20	2003-07-09	Eli Lilly And Company	Insulin molecule having protracted time action
US8343914B2 (en)	2006-01-06	2013-01-01	Case Western Reserve University	Fibrillation resistant proteins
EP2074140B8 (en)	2006-10-04	2015-10-28	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
EP2318432B1 (en) *	2008-07-31	2015-09-02	Case Western Reserve University	Halogen-stabilized insulin

2009
- 2009-07-31 EP EP09803678.3A patent/EP2318432B1/en not_active Not-in-force
- 2009-07-31 CA CA2732439A patent/CA2732439A1/en not_active Abandoned
- 2009-07-31 KR KR1020117003855A patent/KR20110061552A/ko not_active Ceased
- 2009-07-31 NZ NZ590792A patent/NZ590792A/xx not_active IP Right Cessation
- 2009-07-31 WO PCT/US2009/052477 patent/WO2010014946A2/en not_active Ceased
- 2009-07-31 AU AU2009276346A patent/AU2009276346B2/en not_active Ceased
- 2009-07-31 JP JP2011521365A patent/JP5780958B2/ja not_active Expired - Fee Related
- 2009-07-31 BR BRPI0916560A patent/BRPI0916560A2/pt not_active IP Right Cessation
- 2009-07-31 ES ES09803678.3T patent/ES2552636T3/es active Active
- 2009-07-31 MY MYPI2011000433A patent/MY158627A/en unknown
- 2009-07-31 RU RU2011106744/10A patent/RU2555557C2/ru not_active IP Right Cessation
- 2009-07-31 CN CN200980139607.5A patent/CN102171245B/zh not_active Expired - Fee Related
- 2009-07-31 EP EP15183054.4A patent/EP2982687A1/en not_active Withdrawn
- 2009-07-31 MX MX2011001181A patent/MX2011001181A/es active IP Right Grant
2015
- 2015-05-07 JP JP2015094752A patent/JP2015180647A/ja active Pending

Also Published As

Publication number	Publication date
MY158627A (en)	2016-10-31
RU2555557C2 (ru)	2015-07-10
CN102171245A (zh)	2011-08-31
AU2009276346A1 (en)	2010-02-04
EP2982687A1 (en)	2016-02-10
RU2011106744A (ru)	2012-09-10
WO2010014946A2 (en)	2010-02-04
EP2318432A2 (en)	2011-05-11
EP2318432B1 (en)	2015-09-02
JP2015180647A (ja)	2015-10-15
NZ590792A (en)	2012-12-21
EP2318432A4 (en)	2012-02-29
CN102171245B (zh)	2015-03-25
AU2009276346B2 (en)	2014-07-03
JP5780958B2 (ja)	2015-09-16
MX2011001181A (es)	2011-04-05
ES2552636T3 (es)	2015-12-01
JP2011529692A (ja)	2011-12-15
WO2010014946A3 (en)	2010-05-20
HK1161275A1 (en)	2012-08-24
CA2732439A1 (en)	2010-02-04
KR20110061552A (ko)	2011-06-09

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application fees: dismissal - article 86 of industrial property law	Free format text: REFERENTE A 7A ANUIDADE.
2017-01-10	B08K	Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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