BRPI0916560A2 - análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. - Google Patents

análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente.

Info

Publication number: BRPI0916560A2
Authority: BR; Brazil
Prior art keywords: patient; treatment; nucleic acid; host cell; expression vector
Prior art date: 2008-07-31

Application number

BRPI0916560A

Other languages

English (en)

Inventor

Michael Weiss

Original Assignee

Univ Case Western Reserve

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-31

Filing date

2009-07-31

Publication date

2015-11-10

2009-07-31 Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve

2015-11-10 Publication of BRPI0916560A2 publication Critical patent/BRPI0916560A2/pt

Links

239000013604 expression vector Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
239000004026 insulin derivative Substances 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Hematology (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0916560A 2008-07-31 2009-07-31 análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente. BRPI0916560A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8521208P	2008-07-31	2008-07-31
PCT/US2009/052477 WO2010014946A2 (en)	2008-07-31	2009-07-31	Halogen-stabilized insulin

Publications (1)

Publication Number	Publication Date
BRPI0916560A2 true BRPI0916560A2 (pt)	2015-11-10

Family

ID=41610982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916560A BRPI0916560A2 (pt)	2008-07-31	2009-07-31	análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente.

Country Status (13)

Country	Link
EP (2)	EP2318432B1 (pt)
JP (2)	JP5780958B2 (pt)
KR (1)	KR20110061552A (pt)
CN (1)	CN102171245B (pt)
AU (1)	AU2009276346B2 (pt)
BR (1)	BRPI0916560A2 (pt)
CA (1)	CA2732439A1 (pt)
ES (1)	ES2552636T3 (pt)
MX (1)	MX2011001181A (pt)
MY (1)	MY158627A (pt)
NZ (1)	NZ590792A (pt)
RU (1)	RU2555557C2 (pt)
WO (1)	WO2010014946A2 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007081824A2 (en)	2006-01-06	2007-07-19	Case Western Reserve University	Fibrillation resistant proteins
WO2008043033A2 (en)	2006-10-04	2008-04-10	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
US8993516B2 (en)	2008-04-14	2015-03-31	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
MX2011001181A (es) *	2008-07-31	2011-04-05	Univ Case Western Reserve	Insulina estabilizada con halogeno.
KR20120129875A (ko)	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en)	2008-07-31	2015-12-01	Case Western Reserve University	Insulin analogues containing penta-fluoro-Phenylalanine at position B24
JP5635531B2 (ja)	2008-12-15	2014-12-03	ジーランドファーマアクティーゼルスカブ	グルカゴン類似体
EP2370462B1 (en)	2008-12-15	2014-07-16	Zealand Pharma A/S	Glucagon analogues
ES2477880T3 (es)	2008-12-15	2014-07-18	Zealand Pharma A/S	Análogos del glucagón
CN102282167B (zh)	2008-12-15	2014-08-13	西兰制药公司	胰高血糖素类似物
AU2010272944B2 (en)	2009-07-13	2015-11-19	Zealand Pharma A/S	Acylated glucagon analogues
US8399407B2 (en)	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
AU2010327949A1 (en) *	2009-12-11	2012-06-28	Case Western Reserve University	Insulin analogues with chlorinated amino acids
UY33462A (es)	2010-06-23	2012-01-31	Zealand Pharma As	Analogos de glucagon
US9169310B2 (en)	2010-06-24	2015-10-27	Zealand Pharma A/S	Glucagon analogues
KR20140043709A (ko)	2011-01-20	2014-04-10	질랜드 파마 에이/에스	아실화 글루카곤 유사체와 인슐린 유사체의 조합
US9487572B2 (en)	2011-07-13	2016-11-08	Case Western Reserve University	Non-standard insulin analogues
US10995129B2 (en) *	2011-07-13	2021-05-04	Case Western Reserve University	Non-standard insulin analogues
KR20150021011A (ko) *	2011-10-27	2015-02-27	케이스 웨스턴 리저브 유니버시티	초고도 농축된, 속효성 인슐린 유사체 제형
EP2804621A4 (en) *	2012-01-20	2015-11-18	Univ Case Western Reserve	GLUTAMINE-SAFE STABILIZED INSULIN ANALOG
IN2014MN02304A (pt)	2012-05-03	2015-08-07	Zealand Pharma As
IN2015DN00544A (pt)	2012-07-23	2015-06-26	Zealand Pharma As
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
US9725493B2 (en) *	2013-01-22	2017-08-08	Case Western Reserve University	N-terminal truncated insulin analogues
BR112015023672A2 (pt) *	2013-03-15	2017-07-18	Univ Case Western Reserve	análogo de insulina, orto-fluoro, sequência de dna codificando a cadeia a de análogo de insulina, sequência de dna codificando a cadeia b de análogo de insulina e uso de um análogo de insulina.
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
PL3057984T3 (pl)	2013-10-17	2018-12-31	Zealand Pharma A/S	Acylowane analogi glukagonu
WO2015067715A2 (en)	2013-11-06	2015-05-14	Zealand Pharma A/S	Gip-glp-1 dual agonist compounds and methods
CN105829339B (zh)	2013-11-06	2021-03-12	西兰制药公司	胰高血糖素-glp-1-gip三重激动剂化合物
KR102351111B1 (ko) *	2014-01-13	2022-01-14	써멀린 다이어비티즈, 엘엘씨	초속효성 인슐린 제형 및 약제학적 전달 시스템
BR112017004544A2 (pt)	2014-10-06	2018-01-23	Univ Case Western Reserve	insulina de cadeia simples, composição farmacêutica e método para tratar diabetes mellitus
KR102620911B1 (ko)	2014-10-29	2024-01-05	질랜드 파마 에이/에스	Gip 효능제 화합물 및 방법
KR20170106373A (ko) *	2015-01-20	2017-09-20	케이스 웨스턴 리저브 유니버시티	선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
DK3283507T3 (da)	2015-04-16	2020-01-02	Zealand Pharma As	Acyleret glucagonanalog
EP3393498A4 (en) *	2015-12-23	2019-08-07	Case Western Reserve University	SECULATION OF ULTRASTABILEN INSULIN ANALOGUE WITH POLYMER MELTS
BR112019000991A2 (pt)	2016-07-22	2019-07-02	University Of Utah Research Foundation	análogo da insulina, composição farmacêutica, método para tratar e/ou prevenir uma afeção relacionada com insulina, método para decrescer níveis de glicose no sangue, uso do análogo da insulina, método de replanejamento ou modificação de um polipeptídeo que é conhecido por se ligar a um receptor da insulina, polipeptídeo, molécula isolada, método para identificar um composto que se liga ao receptor de insulina, método de base computacional para identificar um composto que imita a atividade da insulina, composto identificado usando um método, cristal do polipeptídeo, estrutura do polipeptídeo, uso da estrutura, uso do modelo estrutural, peptídeo, método para aumentar a ativação do receptor da insulina em um sujeito, método para diminuir o açúcar no sangue em um sujeito, método para tratar diabetes tipo 1 em um sujeito e proteína terapêutica
CA3035308A1 (en) *	2016-08-31	2018-03-08	Taro Pharmaceutical Industries, Ltd.	Fenoldopam topical formulations for treating skin disorders
US11446237B2 (en)	2019-03-08	2022-09-20	Taro Pharmaceutical Industries Ltd.	Stable topical compositions of fenoldopam
WO2022226197A1 (en) *	2021-04-22	2022-10-27	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Human insulin c-alpha-peptides and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03506023A (ja)	1988-07-20	1991-12-26	ノボ　ノルデイスク　アクツイエセルスカプ	ポリペプチド
US5474978A (en)	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
UA72427C2 (en) *	1996-06-20	2005-03-15	Novo Nordisk As	Water-soluble insulin preparation containing mannite, method for manufacturing composition containing soluble insulin or crystalline insulin
DE19825447A1 (de) *	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
US7316999B2 (en) *	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
CZ2004710A3 (cs) *	2001-12-20	2005-02-16	Eli Lilly And Company	Inzulínová sloučenina s protrahovaným účinkem
WO2007081824A2 (en)	2006-01-06	2007-07-19	Case Western Reserve University	Fibrillation resistant proteins
WO2008043033A2 (en)	2006-10-04	2008-04-10	Case Western Reserve University	Fibrillation-resistant insulin and insulin analogues
MX2011001181A (es) *	2008-07-31	2011-04-05	Univ Case Western Reserve	Insulina estabilizada con halogeno.

2009
- 2009-07-31 MX MX2011001181A patent/MX2011001181A/es active IP Right Grant
- 2009-07-31 BR BRPI0916560A patent/BRPI0916560A2/pt not_active IP Right Cessation
- 2009-07-31 WO PCT/US2009/052477 patent/WO2010014946A2/en not_active Ceased
- 2009-07-31 CA CA2732439A patent/CA2732439A1/en not_active Abandoned
- 2009-07-31 JP JP2011521365A patent/JP5780958B2/ja not_active Expired - Fee Related
- 2009-07-31 AU AU2009276346A patent/AU2009276346B2/en not_active Ceased
- 2009-07-31 KR KR1020117003855A patent/KR20110061552A/ko not_active Ceased
- 2009-07-31 CN CN200980139607.5A patent/CN102171245B/zh not_active Expired - Fee Related
- 2009-07-31 EP EP09803678.3A patent/EP2318432B1/en not_active Not-in-force
- 2009-07-31 ES ES09803678.3T patent/ES2552636T3/es active Active
- 2009-07-31 MY MYPI2011000433A patent/MY158627A/en unknown
- 2009-07-31 RU RU2011106744/10A patent/RU2555557C2/ru not_active IP Right Cessation
- 2009-07-31 EP EP15183054.4A patent/EP2982687A1/en not_active Withdrawn
- 2009-07-31 NZ NZ590792A patent/NZ590792A/xx not_active IP Right Cessation
2015
- 2015-05-07 JP JP2015094752A patent/JP2015180647A/ja active Pending

Also Published As

Publication number	Publication date
KR20110061552A (ko)	2011-06-09
NZ590792A (en)	2012-12-21
CA2732439A1 (en)	2010-02-04
EP2318432A2 (en)	2011-05-11
EP2318432A4 (en)	2012-02-29
JP5780958B2 (ja)	2015-09-16
WO2010014946A3 (en)	2010-05-20
CN102171245A (zh)	2011-08-31
ES2552636T3 (es)	2015-12-01
RU2555557C2 (ru)	2015-07-10
AU2009276346A1 (en)	2010-02-04
AU2009276346B2 (en)	2014-07-03
RU2011106744A (ru)	2012-09-10
WO2010014946A2 (en)	2010-02-04
EP2318432B1 (en)	2015-09-02
JP2011529692A (ja)	2011-12-15
JP2015180647A (ja)	2015-10-15
EP2982687A1 (en)	2016-02-10
CN102171245B (zh)	2015-03-25
MX2011001181A (es)	2011-04-05
HK1161275A1 (en)	2012-08-24
MY158627A (en)	2016-10-31

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application fees: dismissal - article 86 of industrial property law	Free format text: REFERENTE A 7A ANUIDADE.
2017-01-10	B08K	Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0916560A2 (pt)	2015-11-10	análogo de insulina, ácido nucléico, vetor de expressão, célula hospedeira e método de tratamento de um paciente.
BRPI0911571A2 (pt)	2018-04-03	método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira
LT3287525T (lt)	2020-02-10	Rnr preparatai, apimantys išgrynintą modifikuotą rnr, skirti ląstelių reprogramavimui
BRPI1012642A2 (pt)	2016-04-05	formulação de insulina e método para o tratamento de um indivíduo diabético.
BR112012024287A2 (pt)	2017-03-01	anticorpo, composição farmacêutica, método, ácido nucleico, vetor de expressão e célula hospedeira
BRPI0920026A2 (pt)	2015-12-15	método de tratamento de infecção pulmonar, composição farmacêutica e respectivos usos.
BRPI1014760A2 (pt)	2017-07-18	preparacao compreendendo insulina, nicotinamida e um aminoacido
BRPI1007996A2 (pt)	2016-03-01	fluido de tratamento, e, método
WO2012046084A3 (en)	2012-09-27	Short rna molecules
IL207558A0 (en)	2010-12-30	Pharmaceutical solutions, process of prepartion and therapeutic uses
IT1391555B1 (it)	2012-01-11	Apparato trattamento extracorporeo sangue
IL230076A0 (en)	2014-01-30	Certain chemical entities, compositions and methods
AP2010005462A0 (en)	2010-12-31	Harmful organism control composition, and method for control of harmful organisms.
EP2509032A4 (en)	2014-02-26	ACTIVE ELECTRONIC LABEL, APPLICATION SYSTEM AND METHOD THEREFOR
DK2376015T3 (da)	2019-08-19	Pneumopedisk-ortodontisk instrument, system og fremgangsmåde.
EP2768429A4 (en)	2015-04-08	ACTIVE CONTROLLABLE STENT, STENTIMPLANT, HEADLOCK, AND CONTROL PROCESS THEREFOR
IL244941A (en)	2017-12-31	Insulin preparations containing methionine
LT2451482T (lt)	2019-07-25	Kombinuota terapija, skirta diabeto gydymui
BR112012027545A2 (pt)	2017-03-14	composto de fórmula i, composição farmacêutica, uso da composição farmacêutica, uso de um composto e método de modulação do nível de glicose no sangue em um indivíduo
EP2482645A4 (en)	2017-10-18	Method, device and fluid for treatment of a heart after harvesting
EP2241621A4 (en)	2011-02-02	MODIFIED GLUCOSE-DEHYDROGENASE GENE
IL192333A0 (en)	2011-08-01	Photobioreactor, system and method for the cultivation of microalgae
PL3133396T3 (pl)	2019-03-29	Sposób leczenia z zastosowaniem leków wychwytujących amoniak
WO2011115809A3 (en)	2012-01-19	High energy radiation insensitive analyte sensors
BRPI0920246A2 (pt)	2017-06-27	método de preparação de alfa-beta peptídios biologicamente ativos.