PE20110941A1 - 2-[(5-cloro-2-{[3-metil-1-(1-metiletil)-1h-pirazol-5-il]amino}-4-piridinil)amino]-n-(metiloxi)benzamida como inhibidor fak - Google Patents
2-[(5-cloro-2-{[3-metil-1-(1-metiletil)-1h-pirazol-5-il]amino}-4-piridinil)amino]-n-(metiloxi)benzamida como inhibidor fakInfo
- Publication number
- PE20110941A1 PE20110941A1 PE2011000920A PE2011000920A PE20110941A1 PE 20110941 A1 PE20110941 A1 PE 20110941A1 PE 2011000920 A PE2011000920 A PE 2011000920A PE 2011000920 A PE2011000920 A PE 2011000920A PE 20110941 A1 PE20110941 A1 PE 20110941A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- methyl
- chloro
- alkyl
- pyridinyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLILAMINOPIRIDINAS DE FORMULA (I) DONDE R1 ES HALO, CF3, ALQUILO(C1-C6), CN, ENTRE OTROS; R2 ES F, Cl, METILO, METOXI, ENTRE OTROS; R3 ES H, CICLOALQUILO(C3-C6), ALCOXI(C1-C6), ENTRE OTROS; R11 ES ALQUILO(C1-C6), CF3, ENTRE OTROS; R12 ES H, ALQUILO(C1-C6), F, NITRO, ENTRE OTROS; R13 ES H, F, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; p ES DE 0 A 3; Q ES -C(O)-, -S(O)- O -SO2-; Z ES N O CR5, EN DONDE R5 ES H O ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: 2-[5-CLORO-2-(2-METIL-5-FENIL-2H-PIRAZOL-3-ILAMINO)-PIRIDIN-4-ILAMINO]-N-METIL-BENZAMIDA; 2-({5-CLORO-2-[(1-METIL-1H-PIRAZOL-5-IL)AMINO]-4-PIRIDINIL}AMINO)-N-METILBENZAMIDA; 2-[(5-CLORO-2-{[3-METIL-1-(1-METILETIL)-1H-PIRAZOL-5-IL]AMINO}-4-PIRIDINIL)AMINO]-N-METILBENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA DE ADHESION FOCAL (FAK) SIENDO UTILES EN EL TRATAMIENTO DE SARCOMA ASTROCITICO, LINFOMA, LEUCEMIA LINFOCITICA CRONICA, PSORIASIS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10856808P | 2008-10-27 | 2008-10-27 | |
| US17851709P | 2009-05-15 | 2009-05-15 | |
| US24243209P | 2009-09-15 | 2009-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110941A1 true PE20110941A1 (es) | 2012-02-08 |
Family
ID=42132177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000920A PE20110941A1 (es) | 2008-10-27 | 2009-10-27 | 2-[(5-cloro-2-{[3-metil-1-(1-metiletil)-1h-pirazol-5-il]amino}-4-piridinil)amino]-n-(metiloxi)benzamida como inhibidor fak |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US20100113475A1 (es) |
| EP (1) | EP2421537B1 (es) |
| JP (1) | JP5642689B2 (es) |
| KR (1) | KR101512217B1 (es) |
| CN (1) | CN102264371B (es) |
| AR (1) | AR073993A1 (es) |
| AU (1) | AU2009320144B2 (es) |
| BR (1) | BRPI0920053B8 (es) |
| CA (1) | CA2741760C (es) |
| CL (1) | CL2011000933A1 (es) |
| CO (1) | CO6361929A2 (es) |
| CR (1) | CR20110264A (es) |
| CY (1) | CY1116399T1 (es) |
| DK (1) | DK2421537T3 (es) |
| DO (1) | DOP2011000113A (es) |
| EA (1) | EA021927B1 (es) |
| ES (1) | ES2539835T3 (es) |
| HR (1) | HRP20150531T1 (es) |
| IL (1) | IL212444A (es) |
| JO (1) | JO3067B1 (es) |
| MA (1) | MA32727B1 (es) |
| MX (1) | MX2011004369A (es) |
| MY (1) | MY161890A (es) |
| NZ (1) | NZ592477A (es) |
| PE (1) | PE20110941A1 (es) |
| PL (1) | PL2421537T3 (es) |
| PT (1) | PT2421537E (es) |
| RS (1) | RS54045B1 (es) |
| SG (1) | SG195608A1 (es) |
| SI (1) | SI2421537T1 (es) |
| SM (1) | SMT201500157B (es) |
| TW (1) | TWI454467B (es) |
| UY (1) | UY32200A (es) |
| WO (1) | WO2010062578A1 (es) |
| ZA (1) | ZA201102892B (es) |
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| US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| AU2012209100A1 (en) * | 2011-01-26 | 2013-08-01 | Board Of Regents The University Of Texas System | Combinations |
| WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| DK2675794T3 (da) | 2011-02-17 | 2019-05-06 | Cancer Therapeutics Crc Pty Ltd | Selektive fak-inhibitorer |
| CA2840211A1 (en) * | 2011-06-28 | 2013-01-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of administration and treatment |
| US10106834B2 (en) | 2013-10-09 | 2018-10-23 | The General Hospital Corporation | Methods of diagnosing and treating B cell acute lymphoblastic leukemia |
| EA201890161A1 (ru) | 2015-06-29 | 2018-06-29 | Верастэм, Инк. | Терапевтические композиции, комбинации и способы применения |
| CN108948019B (zh) * | 2017-05-18 | 2022-07-08 | 广东东阳光药业有限公司 | 黏着斑激酶抑制剂及其用途 |
| WO2019117813A1 (en) * | 2017-12-15 | 2019-06-20 | National University Of Singapore | Focal adhesion kinase targeted therapeutics for the treatment of glaucoma and fibrosis |
| AU2019236402A1 (en) | 2018-03-12 | 2020-10-01 | Assistance Publique-Hôpitaux De Paris (Aphp) | Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers |
| CN108912095B (zh) * | 2018-08-09 | 2019-08-20 | 广州安岩仁医药科技有限公司 | 苯并咪唑类化合物及其制备方法和应用 |
| CA3109617A1 (en) | 2018-09-27 | 2020-04-02 | Dana-Farber Cancer Institute, Inc. | Degradation of fak or fak and alk by conjugation of fak and alk inhibitors with e3 ligase ligands and methods of use |
| CN111377871B (zh) * | 2018-12-27 | 2021-03-19 | 海创药业股份有限公司 | 一种fak抑制剂及其联合用药物 |
| JP2022525186A (ja) | 2019-03-15 | 2022-05-11 | ザ ジェネラル ホスピタル コーポレイション | Ｔｅａｄ転写因子新規小分子阻害剤 |
| CN113387947B (zh) * | 2021-07-12 | 2022-07-01 | 中国科学院成都生物研究所 | 调节雌激素受体合成活性的吡唑并吡啶衍生物 |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| CN119499253A (zh) * | 2024-11-15 | 2025-02-25 | 贵州医科大学 | 一种化合物在抑制Aurora和JAK激酶家族活性及在几种肿瘤治疗方面的应用 |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US166139A (en) * | 1875-07-27 | Improvement in dental pluggers | ||
| DE69928411D1 (de) * | 1998-09-08 | 2005-12-22 | Agouron Pharma | Modifikationen des vegf-rezeptor-2 proteins und verfahren zu seiner verwendung |
| US7102009B2 (en) * | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| ATE542801T1 (de) * | 2003-08-15 | 2012-02-15 | Novartis Ag | Zur behandlung von neoplastischen krankheiten, entzündlichen erkrankungen und erkrankungen des immunsystems geeignete 2,4-pyrimidindiamine |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| GB0419160D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| EP1746096A1 (en) * | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer |
| EP2134689B1 (en) * | 2007-03-16 | 2014-04-23 | The Scripps Research Institute | Inhibitors of focal adhesion kinase |
| WO2009105498A1 (en) * | 2008-02-19 | 2009-08-27 | Smithkline Beecham Corporation | Anilinopyridines as inhibitors of fak |
| CN102124000B (zh) * | 2008-06-17 | 2014-09-17 | 阿斯利康(瑞典)有限公司 | 吡啶化合物 |
-
2009
- 2009-10-25 JO JOP/2009/0395A patent/JO3067B1/ar active
- 2009-10-26 UY UY32200A patent/UY32200A/es not_active Application Discontinuation
- 2009-10-26 TW TW98136145A patent/TWI454467B/zh not_active IP Right Cessation
- 2009-10-27 ES ES09829580.1T patent/ES2539835T3/es active Active
- 2009-10-27 DK DK09829580.1T patent/DK2421537T3/da active
- 2009-10-27 SG SG2013079579A patent/SG195608A1/en unknown
- 2009-10-27 PT PT98295801T patent/PT2421537E/pt unknown
- 2009-10-27 WO PCT/US2009/062163 patent/WO2010062578A1/en not_active Ceased
- 2009-10-27 CN CN2009801526261A patent/CN102264371B/zh active Active
- 2009-10-27 EP EP20090829580 patent/EP2421537B1/en active Active
- 2009-10-27 MY MYPI2011001828A patent/MY161890A/en unknown
- 2009-10-27 EA EA201170617A patent/EA021927B1/ru not_active IP Right Cessation
- 2009-10-27 US US12/606,390 patent/US20100113475A1/en not_active Abandoned
- 2009-10-27 RS RS20150365A patent/RS54045B1/sr unknown
- 2009-10-27 NZ NZ59247709A patent/NZ592477A/xx not_active IP Right Cessation
- 2009-10-27 BR BRPI0920053A patent/BRPI0920053B8/pt active IP Right Grant
- 2009-10-27 US US13/126,064 patent/US20110207743A1/en not_active Abandoned
- 2009-10-27 AR ARP090104137A patent/AR073993A1/es not_active Application Discontinuation
- 2009-10-27 JP JP2011533421A patent/JP5642689B2/ja not_active Expired - Fee Related
- 2009-10-27 HR HRP20150531TT patent/HRP20150531T1/hr unknown
- 2009-10-27 PE PE2011000920A patent/PE20110941A1/es not_active Application Discontinuation
- 2009-10-27 CA CA2741760A patent/CA2741760C/en active Active
- 2009-10-27 PL PL09829580T patent/PL2421537T3/pl unknown
- 2009-10-27 AU AU2009320144A patent/AU2009320144B2/en not_active Ceased
- 2009-10-27 MX MX2011004369A patent/MX2011004369A/es active IP Right Grant
- 2009-10-27 SI SI200931192T patent/SI2421537T1/sl unknown
- 2009-10-27 KR KR1020117011999A patent/KR101512217B1/ko not_active Expired - Fee Related
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2011
- 2011-04-17 IL IL212444A patent/IL212444A/en not_active IP Right Cessation
- 2011-04-18 ZA ZA2011/02892A patent/ZA201102892B/en unknown
- 2011-04-22 MA MA33791A patent/MA32727B1/fr unknown
- 2011-04-26 CL CL2011000933A patent/CL2011000933A1/es unknown
- 2011-04-27 DO DO2011000113A patent/DOP2011000113A/es unknown
- 2011-04-29 US US13/097,271 patent/US20110269774A1/en not_active Abandoned
- 2011-05-11 CO CO11058067A patent/CO6361929A2/es active IP Right Grant
- 2011-05-17 CR CR20110264A patent/CR20110264A/es unknown
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2013
- 2013-10-07 US US14/047,688 patent/US9012479B2/en active Active
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2015
- 2015-03-30 US US14/672,477 patent/US20150265589A1/en not_active Abandoned
- 2015-05-22 CY CY20151100462T patent/CY1116399T1/el unknown
- 2015-07-03 SM SM201500157T patent/SMT201500157B/xx unknown
- 2015-10-20 US US14/887,763 patent/US9446034B2/en active Active
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