BRPI0921632A2 - Processo para preparar nebivolol - Google Patents
Processo para preparar nebivololInfo
- Publication number
- BRPI0921632A2 BRPI0921632A2 BRPI0921632-4A BRPI0921632A BRPI0921632A2 BR PI0921632 A2 BRPI0921632 A2 BR PI0921632A2 BR PI0921632 A BRPI0921632 A BR PI0921632A BR PI0921632 A2 BRPI0921632 A2 BR PI0921632A2
- Authority
- BR
- Brazil
- Prior art keywords
- nebivolol
- prepare
- prepare nebivolol
- Prior art date
Links
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title 1
- 229960000619 nebivolol Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2008A001924A IT1392067B1 (it) | 2008-10-31 | 2008-10-31 | Processo di preparazione di nebivololo |
| ITMI2008A001924 | 2008-10-31 | ||
| PCT/EP2009/064230 WO2010049455A1 (en) | 2008-10-31 | 2009-10-28 | Process for preparing nebivolol |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0921632A2 true BRPI0921632A2 (pt) | 2015-08-18 |
| BRPI0921632A8 BRPI0921632A8 (pt) | 2017-07-11 |
| BRPI0921632B1 BRPI0921632B1 (pt) | 2021-03-23 |
| BRPI0921632B8 BRPI0921632B8 (pt) | 2021-05-25 |
Family
ID=40849284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921632A BRPI0921632B8 (pt) | 2008-10-31 | 2009-10-28 | processo para preparar nebivolol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8927742B2 (pt) |
| EP (1) | EP2346845B1 (pt) |
| JP (1) | JP5560279B2 (pt) |
| CN (1) | CN102186835B (pt) |
| AU (1) | AU2009309680B2 (pt) |
| BR (1) | BRPI0921632B8 (pt) |
| CA (1) | CA2737340C (pt) |
| DK (1) | DK2346845T3 (pt) |
| ES (1) | ES2540092T3 (pt) |
| HR (1) | HRP20150554T1 (pt) |
| HU (1) | HUE025673T2 (pt) |
| IL (1) | IL211497A (pt) |
| IT (1) | IT1392067B1 (pt) |
| PL (1) | PL2346845T3 (pt) |
| PT (1) | PT2346845E (pt) |
| SI (1) | SI2346845T1 (pt) |
| WO (1) | WO2010049455A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2700973T3 (es) | 2014-02-14 | 2019-02-20 | Corden Pharma Int Gmbh | Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol |
| EP2907810A1 (en) * | 2014-02-14 | 2015-08-19 | Corden Pharma International GmbH | A new method for producing nebivolol hydrochloride of high purity |
| DE102014107132A1 (de) | 2014-05-20 | 2015-11-26 | Corden Pharma International Gmbh | Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind |
| CN117567422A (zh) * | 2023-11-24 | 2024-02-20 | 江苏威奇达药业有限公司 | 一种连续流反应合成盐酸奈必洛尔的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337429C (en) * | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| HU227236B1 (en) * | 2002-11-06 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol |
| MX2007000911A (es) * | 2004-07-30 | 2007-04-12 | Torrent Pharmaceuticals Ltd | Nevibolol y sus sales farmaceuticamente aceptables, proceso para su preparacion y composiciones farmaceuticas de nevibolol. |
| ATE465157T1 (de) * | 2004-08-11 | 2010-05-15 | Hetero Drugs Ltd | Neues verfahren zur herstellung von nebivololzwischenprodukten |
| EP1803716B1 (en) * | 2005-12-28 | 2012-07-25 | Acino Pharma AG | A process for preparation of racemic nebivolol |
| JP5259612B2 (ja) * | 2006-11-27 | 2013-08-07 | ザック システム エス．ピー．エー． | ネビボロールの調製法 |
-
2008
- 2008-10-31 IT ITMI2008A001924A patent/IT1392067B1/it active
-
2009
- 2009-10-28 PL PL09751854T patent/PL2346845T3/pl unknown
- 2009-10-28 AU AU2009309680A patent/AU2009309680B2/en active Active
- 2009-10-28 CN CN200980140649.0A patent/CN102186835B/zh active Active
- 2009-10-28 DK DK09751854.2T patent/DK2346845T3/en active
- 2009-10-28 EP EP09751854.2A patent/EP2346845B1/en active Active
- 2009-10-28 CA CA2737340A patent/CA2737340C/en active Active
- 2009-10-28 WO PCT/EP2009/064230 patent/WO2010049455A1/en not_active Ceased
- 2009-10-28 BR BRPI0921632A patent/BRPI0921632B8/pt active IP Right Grant
- 2009-10-28 HR HRP20150554TT patent/HRP20150554T1/hr unknown
- 2009-10-28 HU HUE09751854A patent/HUE025673T2/en unknown
- 2009-10-28 ES ES09751854.2T patent/ES2540092T3/es active Active
- 2009-10-28 US US13/126,800 patent/US8927742B2/en active Active
- 2009-10-28 PT PT97518542T patent/PT2346845E/pt unknown
- 2009-10-28 SI SI200931205T patent/SI2346845T1/sl unknown
- 2009-10-28 JP JP2011533712A patent/JP5560279B2/ja active Active
-
2011
- 2011-03-01 IL IL211497A patent/IL211497A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20150554T1 (hr) | 2015-07-03 |
| IT1392067B1 (it) | 2012-02-09 |
| ITMI20081924A1 (it) | 2010-05-01 |
| CN102186835B (zh) | 2016-01-13 |
| BRPI0921632B8 (pt) | 2021-05-25 |
| EP2346845B1 (en) | 2015-03-25 |
| JP2012506894A (ja) | 2012-03-22 |
| HUE025673T2 (en) | 2016-04-28 |
| AU2009309680B2 (en) | 2015-08-06 |
| AU2009309680A1 (en) | 2010-05-06 |
| PL2346845T3 (pl) | 2015-08-31 |
| JP5560279B2 (ja) | 2014-07-23 |
| IL211497A0 (en) | 2011-05-31 |
| DK2346845T3 (en) | 2015-06-08 |
| ES2540092T3 (es) | 2015-07-08 |
| CA2737340A1 (en) | 2010-05-06 |
| BRPI0921632A8 (pt) | 2017-07-11 |
| SI2346845T1 (sl) | 2015-10-30 |
| BRPI0921632B1 (pt) | 2021-03-23 |
| EP2346845A1 (en) | 2011-07-27 |
| PT2346845E (pt) | 2015-07-30 |
| CN102186835A (zh) | 2011-09-14 |
| US8927742B2 (en) | 2015-01-06 |
| US20110207948A1 (en) | 2011-08-25 |
| CA2737340C (en) | 2016-09-06 |
| IL211497A (en) | 2014-12-31 |
| WO2010049455A1 (en) | 2010-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |