BRPI0921632A8 - Processo para preparar nebivolol - Google Patents

Processo para preparar nebivolol

Info

Publication number
BRPI0921632A8
BRPI0921632A8 BRPI0921632A BRPI0921632A BRPI0921632A8 BR PI0921632 A8 BRPI0921632 A8 BR PI0921632A8 BR PI0921632 A BRPI0921632 A BR PI0921632A BR PI0921632 A BRPI0921632 A BR PI0921632A BR PI0921632 A8 BRPI0921632 A8 BR PI0921632A8
Authority
BR
Brazil
Prior art keywords
preparing nebivolol
nebivolol
preparing
debenzylation
purity
Prior art date
Application number
BRPI0921632A
Other languages
English (en)
Inventor
Maragni Paolo
Michieletto Ivan
Volpicelli Raffaella
Soriato Giorgio
Foletto Johnny
Cotarca Livius
Verzini Massimo
Original Assignee
Zach System Spa
Fis Fabbrica Italiana Sintetici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa, Fis Fabbrica Italiana Sintetici Spa filed Critical Zach System Spa
Publication of BRPI0921632A2 publication Critical patent/BRPI0921632A2/pt
Publication of BRPI0921632A8 publication Critical patent/BRPI0921632A8/pt
Publication of BRPI0921632B1 publication Critical patent/BRPI0921632B1/pt
Publication of BRPI0921632B8 publication Critical patent/BRPI0921632B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCESSO PARA PREPARAR NEBIVOLOL. A presente invenção se refere a um processo para preparação de nebivolol e, mais particularmente, a um método aperfeiçoado de desbenzilação de um composto de fórmula (II), útil para preparar nebivolol dotado de elevado grau de pureza.
BRPI0921632A 2008-10-31 2009-10-28 processo para preparar nebivolol BRPI0921632B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2008A001924 2008-10-31
ITMI2008A001924A IT1392067B1 (it) 2008-10-31 2008-10-31 Processo di preparazione di nebivololo
PCT/EP2009/064230 WO2010049455A1 (en) 2008-10-31 2009-10-28 Process for preparing nebivolol

Publications (4)

Publication Number Publication Date
BRPI0921632A2 BRPI0921632A2 (pt) 2015-08-18
BRPI0921632A8 true BRPI0921632A8 (pt) 2017-07-11
BRPI0921632B1 BRPI0921632B1 (pt) 2021-03-23
BRPI0921632B8 BRPI0921632B8 (pt) 2021-05-25

Family

ID=40849284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921632A BRPI0921632B8 (pt) 2008-10-31 2009-10-28 processo para preparar nebivolol

Country Status (17)

Country Link
US (1) US8927742B2 (pt)
EP (1) EP2346845B1 (pt)
JP (1) JP5560279B2 (pt)
CN (1) CN102186835B (pt)
AU (1) AU2009309680B2 (pt)
BR (1) BRPI0921632B8 (pt)
CA (1) CA2737340C (pt)
DK (1) DK2346845T3 (pt)
ES (1) ES2540092T3 (pt)
HR (1) HRP20150554T1 (pt)
HU (1) HUE025673T2 (pt)
IL (1) IL211497A (pt)
IT (1) IT1392067B1 (pt)
PL (1) PL2346845T3 (pt)
PT (1) PT2346845E (pt)
SI (1) SI2346845T1 (pt)
WO (1) WO2010049455A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2700973T3 (es) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
CN117567422A (zh) * 2023-11-24 2024-02-20 江苏威奇达药业有限公司 一种连续流反应合成盐酸奈必洛尔的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) * 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
HU227236B1 (en) * 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
CN101862322A (zh) * 2004-07-30 2010-10-20 托伦特药物有限公司 奈必洛尔及其药学可接受盐、制备方法以及奈必洛尔的药物组合物
ES2341250T3 (es) * 2004-08-11 2010-06-17 Hetero Drugs Limited Procedimiento novedoso de preparacion de intermediarios de nebivolol.
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
JP5259612B2 (ja) * 2006-11-27 2013-08-07 ザック システム エス．ピー．エー． ネビボロールの調製法

Also Published As

Publication number Publication date
ITMI20081924A1 (it) 2010-05-01
DK2346845T3 (en) 2015-06-08
IT1392067B1 (it) 2012-02-09
EP2346845A1 (en) 2011-07-27
IL211497A0 (en) 2011-05-31
AU2009309680A1 (en) 2010-05-06
IL211497A (en) 2014-12-31
PT2346845E (pt) 2015-07-30
HUE025673T2 (en) 2016-04-28
PL2346845T3 (pl) 2015-08-31
CN102186835B (zh) 2016-01-13
EP2346845B1 (en) 2015-03-25
WO2010049455A1 (en) 2010-05-06
BRPI0921632A2 (pt) 2015-08-18
CA2737340A1 (en) 2010-05-06
US8927742B2 (en) 2015-01-06
JP2012506894A (ja) 2012-03-22
US20110207948A1 (en) 2011-08-25
AU2009309680B2 (en) 2015-08-06
CN102186835A (zh) 2011-09-14
BRPI0921632B1 (pt) 2021-03-23
SI2346845T1 (sl) 2015-10-30
JP5560279B2 (ja) 2014-07-23
BRPI0921632B8 (pt) 2021-05-25
CA2737340C (en) 2016-09-06
HRP20150554T1 (hr) 2015-07-03
ES2540092T3 (es) 2015-07-08

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/10/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF