BRPI0923176A8 - sal de hemifumarato de ácido 1-[4-[1-(4-ciclo-hexil-3 trifluorometilbenzilóxi-imino)-etil]-2etil-benzil]-azetidina-3-carboxílio. - Google Patents

sal de hemifumarato de ácido 1-[4-[1-(4-ciclo-hexil-3 trifluorometilbenzilóxi-imino)-etil]-2etil-benzil]-azetidina-3-carboxílio.

Info

Publication number: BRPI0923176A8
Authority: BR; Brazil
Prior art keywords: ethyl; trifluoromethylbenzyloxy; azetidine; imino; cyclohexyl
Prior art date: 2008-12-18

Application number

BRPI0923176A

Other languages

English (en)

Inventor

Vogel Caspar

Riegert Christian

Ciszewski Lech

De La Cruz Marilyn

Mutz Michael

H Karpinki Piotr

Schneeberger Ricardo

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-18

Filing date

2009-12-16

Publication date

2017-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923176(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-12-16 Application filed by Novartis Ag filed Critical Novartis Ag

2016-02-16 Publication of BRPI0923176A2 publication Critical patent/BRPI0923176A2/pt

2017-09-12 Publication of BRPI0923176A8 publication Critical patent/BRPI0923176A8/pt

2020-12-01 Publication of BRPI0923176B1 publication Critical patent/BRPI0923176B1/pt

2021-05-25 Publication of BRPI0923176B8 publication Critical patent/BRPI0923176B8/pt

Links

KIHYPELVXPAIDH-UHFFFAOYSA-N 1-[[4-[n-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-c-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid Chemical compound CCC1=CC(C(C)=NOCC=2C=C(C(C3CCCCC3)=CC=2)C(F)(F)F)=CC=C1CN1CC(C(O)=O)C1 KIHYPELVXPAIDH-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0923176A 2008-12-18 2009-12-16 forma cristalina do sal de hemifumarato de ácido 1-(4-{1-[(e)- 4-ciclo-hexil-3-trifluormetil-benzilóxi-imino]-etil}-2- etil-benzil)-azetidina-3-carboxílico e composição farmaceutica BRPI0923176B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20305308P	2008-12-18	2008-12-18
US61/203,053		2008-12-18
PCT/US2009/068143 WO2010080409A1 (en)	2008-12-18	2009-12-16	Hemifumarate salt of 1- [4- [1- ( 4 -cyclohexyl-3 -trifluoromethyl-benzyloxyimino ) -ethyl] -2 -ethyl-benzyl] -a zetidine-3-carboxylic acid

Publications (4)

Publication Number	Publication Date
BRPI0923176A2 BRPI0923176A2 (pt)	2016-02-16
BRPI0923176A8 true BRPI0923176A8 (pt)	2017-09-12
BRPI0923176B1 BRPI0923176B1 (pt)	2020-12-01
BRPI0923176B8 BRPI0923176B8 (pt)	2021-05-25

Family

ID=42236293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0923176A BRPI0923176B8 (pt)	2008-12-18	2009-12-16	forma cristalina do sal de hemifumarato de ácido 1-(4-{1-[(e)- 4-ciclo-hexil-3-trifluormetil-benzilóxi-imino]-etil}-2- etil-benzil)-azetidina-3-carboxílico e composição farmaceutica

Country Status (35)

Country	Link
US (7)	US20120115840A1 (pt)
EP (2)	EP2676953B1 (pt)
JP (1)	JP5627597B2 (pt)
KR (5)	KR101885052B1 (pt)
CN (2)	CN102256943A (pt)
AR (3)	AR074694A1 (pt)
AU (1)	AU2009335924B2 (pt)
BR (1)	BRPI0923176B8 (pt)
CA (2)	CA2951479A1 (pt)
CL (1)	CL2011001490A1 (pt)
CO (1)	CO6390104A2 (pt)
CY (2)	CY1114662T1 (pt)
DK (2)	DK2379497T3 (pt)
EC (1)	ECSP11011210A (pt)
ES (2)	ES2631203T3 (pt)
HR (2)	HRP20131106T1 (pt)
HU (1)	HUE034819T2 (pt)
IL (3)	IL294514A (pt)
JO (1)	JO2894B1 (pt)
LT (1)	LT2676953T (pt)
MA (1)	MA32961B1 (pt)
MX (1)	MX2011006609A (pt)
MY (1)	MY152669A (pt)
NZ (1)	NZ593061A (pt)
PE (2)	PE20120336A1 (pt)
PL (2)	PL2676953T3 (pt)
PT (2)	PT2676953T (pt)
RS (2)	RS56110B1 (pt)
RU (1)	RU2518114C3 (pt)
SG (1)	SG171785A1 (pt)
SI (2)	SI2676953T1 (pt)
TW (2)	TWI591055B (pt)
UY (1)	UY32330A (pt)
WO (1)	WO2010080409A1 (pt)
ZA (1)	ZA201103709B (pt)

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US11958805B2 (en) *	2017-03-09	2024-04-16	Novartis Ag	Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11629124B2 (en)	2017-03-09	2023-04-18	Novartis Ag	Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11434200B2 (en)	2017-03-09	2022-09-06	Novartis Ag	Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
BR112020006223A2 (pt)	2017-09-27	2020-12-01	Dr. Reddy's Laboratories Limited	processo para a preparação de siponimode, seus sais e formas em estado sólido dos mesmos
ES3024636T3 (en) *	2017-09-27	2025-06-04	Novartis Ag	Parenteral formulation comprising siponimod
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CN116456977A (zh) *	2020-09-25	2023-07-18	斯索恩有限公司	西尼莫德盐和共晶
EP4217341A1 (en)	2020-09-25	2023-08-02	Synthon B.V.	Siponimod salts and cocrystals
CN112402610A (zh) *	2020-11-20	2021-02-26	睿阜隆(杭州)生物医药有限公司	1-磷酸鞘氨醇受体调节剂在制备治疗糖尿病的药物中的新用途
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2009
- 2009-12-16 HR HRP20131106AT patent/HRP20131106T1/hr unknown
- 2009-12-16 CN CN2009801512748A patent/CN102256943A/zh active Pending
- 2009-12-16 PL PL13177190T patent/PL2676953T3/pl unknown
- 2009-12-16 MA MA34008A patent/MA32961B1/fr unknown
- 2009-12-16 ES ES13177190.9T patent/ES2631203T3/es active Active
- 2009-12-16 IL IL294514A patent/IL294514A/en unknown
- 2009-12-16 HU HUE13177190A patent/HUE034819T2/en unknown
- 2009-12-16 CN CN201510102280.1A patent/CN104803902A/zh active Pending
- 2009-12-16 KR KR1020187000381A patent/KR101885052B1/ko not_active Expired - Fee Related
- 2009-12-16 ES ES09793413T patent/ES2436197T3/es active Active
- 2009-12-16 KR KR1020117016548A patent/KR20110096584A/ko not_active Ceased
- 2009-12-16 WO PCT/US2009/068143 patent/WO2010080409A1/en not_active Ceased
- 2009-12-16 DK DK09793413.7T patent/DK2379497T3/da active
- 2009-12-16 MY MYPI20112413 patent/MY152669A/en unknown
- 2009-12-16 RS RS20170599A patent/RS56110B1/sr unknown
- 2009-12-16 JP JP2011542351A patent/JP5627597B2/ja active Active
- 2009-12-16 PE PE2011001226A patent/PE20120336A1/es not_active Application Discontinuation
- 2009-12-16 KR KR1020167013818A patent/KR20160064245A/ko not_active Ceased
- 2009-12-16 PE PE2014001111A patent/PE20142374A1/es not_active Application Discontinuation
- 2009-12-16 UY UY0001032330A patent/UY32330A/es not_active Application Discontinuation
- 2009-12-16 PT PT131771909T patent/PT2676953T/pt unknown
- 2009-12-16 US US13/140,478 patent/US20120115840A1/en not_active Abandoned
- 2009-12-16 IL IL253845A patent/IL253845B/en unknown
- 2009-12-16 KR KR1020177014691A patent/KR20170062554A/ko not_active Ceased
- 2009-12-16 RS RS20130510A patent/RS53041B/sr unknown
- 2009-12-16 CA CA2951479A patent/CA2951479A1/en not_active Abandoned
- 2009-12-16 PT PT97934137T patent/PT2379497E/pt unknown
- 2009-12-16 SG SG2011036886A patent/SG171785A1/en unknown
- 2009-12-16 AR ARP090104917A patent/AR074694A1/es not_active Application Discontinuation
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Also Published As

Publication number	Publication date
SI2676953T1 (sl)	2017-07-31
MA32961B1 (fr)	2012-01-02
PE20120336A1 (es)	2012-04-30
WO2010080409A1 (en)	2010-07-15
KR20110096584A (ko)	2011-08-30
EP2379497B1 (en)	2013-08-21
HK1159631A1 (en)	2012-08-03
CY1119037T1 (el)	2018-01-10
AU2009335924A1 (en)	2011-06-30
RU2518114C3 (ru)	2021-11-24
PT2676953T (pt)	2017-06-29
US20210323915A1 (en)	2021-10-21
ECSP11011210A (es)	2011-08-31
PL2379497T3 (pl)	2014-01-31
EP2379497A1 (en)	2011-10-26
CA2747437C (en)	2018-08-21
ES2436197T3 (es)	2013-12-27
US20240239743A1 (en)	2024-07-18
CA2951479A1 (en)	2010-07-15
AR112227A2 (es)	2019-10-02
CA2747437A1 (en)	2010-07-15
KR101885052B1 (ko)	2018-08-02
TW201509909A (zh)	2015-03-16
JO2894B1 (en)	2015-09-15
US20150175536A1 (en)	2015-06-25
BRPI0923176B8 (pt)	2021-05-25
HUE034819T2 (en)	2018-02-28
RS53041B (sr)	2014-04-30
RU2011129222A (ru)	2013-01-27
PE20142374A1 (es)	2015-01-30
TW201035048A (en)	2010-10-01
US20120115840A1 (en)	2012-05-10
EP2676953B1 (en)	2017-03-22
CN104803902A (zh)	2015-07-29
US20220402870A1 (en)	2022-12-22
AU2009335924B2 (en)	2012-11-08
IL253845B (en)	2022-08-01
AR121635A2 (es)	2022-06-22
RS56110B1 (sr)	2017-10-31
CL2011001490A1 (es)	2012-01-13
RU2518114C2 (ru)	2014-06-10
LT2676953T (lt)	2017-06-26
NZ593061A (en)	2013-08-30
TWI591055B (zh)	2017-07-11
CN102256943A (zh)	2011-11-23
BRPI0923176B1 (pt)	2020-12-01
UY32330A (es)	2010-07-30
MX2011006609A (es)	2011-06-30
SG171785A1 (en)	2011-07-28
KR20180006492A (ko)	2018-01-17
KR20160129915A (ko)	2016-11-09
IL294514A (en)	2022-09-01
PT2379497E (pt)	2013-11-29
MY152669A (en)	2014-10-31
US20140005162A1 (en)	2014-01-02
DK2379497T3 (da)	2013-11-25
BRPI0923176A2 (pt)	2016-02-16
PL2676953T3 (pl)	2017-09-29
TWI500603B (zh)	2015-09-21
DK2676953T3 (en)	2017-07-03
SI2379497T1 (sl)	2013-12-31
ZA201103709B (en)	2012-01-25
KR20170062554A (ko)	2017-06-07
IL213071A0 (en)	2011-07-31
AR074694A1 (es)	2011-02-02
KR20160064245A (ko)	2016-06-07
CO6390104A2 (es)	2012-02-29
JP5627597B2 (ja)	2014-11-19
HRP20131106T1 (hr)	2013-12-20
EP2676953A1 (en)	2013-12-25
JP2012512881A (ja)	2012-06-07
CY1114662T1 (el)	2016-10-05
IL253845A0 (en)	2017-09-28
ES2631203T3 (es)	2017-08-29
US20180118678A1 (en)	2018-05-03
US20230357142A9 (en)	2023-11-09
HRP20170916T1 (hr)	2017-09-22

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Date	Code	Title	Description
2018-04-17	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2020-03-10	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-03-17	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-08-04	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2020-11-17	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2020-12-01	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/12/2020, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/12/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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