MA32961B1 - Sel hemifumarate d'acide 1-[4-[1(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl -benzyl]-azetidine-3-carboxylique - Google Patents

Sel hemifumarate d'acide 1-[4-[1(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl -benzyl]-azetidine-3-carboxylique

Info

Publication number
MA32961B1
MA32961B1 MA34008A MA34008A MA32961B1 MA 32961 B1 MA32961 B1 MA 32961B1 MA 34008 A MA34008 A MA 34008A MA 34008 A MA34008 A MA 34008A MA 32961 B1 MA32961 B1 MA 32961B1
Authority
MA
Morocco
Prior art keywords
hemifumarate
ethyl
benzyloxyimino
azetidin
salmon
Prior art date
Application number
MA34008A
Other languages
Arabic (ar)
English (en)
Inventor
Lech Ciszewski
La Cruz Marilyn De
Piotr H Karpinski
Michael Mutz
Christian Riegert
Caspar Vogel
Ricardo Schneeberger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32961(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA32961B1 publication Critical patent/MA32961B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention porte sur un sel hémifumarate d'acide 1-(4-{1-[(E)-4-cyclohexyl-3-trifluorométhyl-benzyloxyimino]-éthyl}-2-éthyl-benzyl)-azétidine-3-carboxylique (Composé I), sur des compositions pharmaceutiques comprenant ce sel, sur des procédés de formation de ce sel et sur son utilisation dans un traitement médical. De plus, la présente invention porte également sur de nouvelles formes polymorphes de la forme sel hémifumarate du Composé I, ainsi que sur des compositions pharmaceutiques comprenant ces formes polymorphes, sur des procédés permettant de les obtenir et sur leur utilisation dans un traitement médical.
MA34008A 2008-12-18 2009-12-16 Sel hemifumarate d'acide 1-[4-[1(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl -benzyl]-azetidine-3-carboxylique MA32961B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20305308P 2008-12-18 2008-12-18
PCT/US2009/068143 WO2010080409A1 (fr) 2008-12-18 2009-12-16 Sel hémifumarate d'acide 1-[4-[1-(4-cyclohexyl-3-trifluorométhyl-benzyloxyimino]-éthyl]-2-éthyl-benzyl]-azétidine-3-carboxylique

Publications (1)

Publication Number Publication Date
MA32961B1 true MA32961B1 (fr) 2012-01-02

Family

ID=42236293

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34008A MA32961B1 (fr) 2008-12-18 2009-12-16 Sel hemifumarate d'acide 1-[4-[1(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl -benzyl]-azetidine-3-carboxylique

Country Status (35)

Country Link
US (7) US20120115840A1 (fr)
EP (2) EP2676953B1 (fr)
JP (1) JP5627597B2 (fr)
KR (5) KR20160064245A (fr)
CN (2) CN102256943A (fr)
AR (3) AR074694A1 (fr)
AU (1) AU2009335924B2 (fr)
BR (1) BRPI0923176B8 (fr)
CA (2) CA2951479A1 (fr)
CL (1) CL2011001490A1 (fr)
CO (1) CO6390104A2 (fr)
CY (2) CY1114662T1 (fr)
DK (2) DK2676953T3 (fr)
EC (1) ECSP11011210A (fr)
ES (2) ES2436197T3 (fr)
HR (2) HRP20131106T1 (fr)
HU (1) HUE034819T2 (fr)
IL (3) IL294514A (fr)
JO (1) JO2894B1 (fr)
LT (1) LT2676953T (fr)
MA (1) MA32961B1 (fr)
MX (1) MX2011006609A (fr)
MY (1) MY152669A (fr)
NZ (1) NZ593061A (fr)
PE (2) PE20142374A1 (fr)
PL (2) PL2379497T3 (fr)
PT (2) PT2379497E (fr)
RS (2) RS56110B1 (fr)
RU (1) RU2518114C3 (fr)
SG (1) SG171785A1 (fr)
SI (2) SI2379497T1 (fr)
TW (2) TWI500603B (fr)
UY (1) UY32330A (fr)
WO (1) WO2010080409A1 (fr)
ZA (1) ZA201103709B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6111202B2 (ja) * 2011-01-07 2017-04-05 ノバルティス アーゲー 免疫抑制製剤
WO2012095853A1 (fr) 2011-01-10 2012-07-19 Novartis Pharma Ag Formulations à libération modifiée comprenant des modulateurs des récepteurs sip
ES2865451T3 (es) 2014-04-10 2021-10-15 Novartis Ag Formulación inmunosupresora
EP3129020A1 (fr) * 2014-04-10 2017-02-15 Novartis AG Régime posologique de modulateur s1p à libération immédiate
WO2016135644A1 (fr) 2015-02-26 2016-09-01 Novartis Ag Traitement de maladie auto-immune chez un patient recevant en outre un bêtabloquant
US20190047951A1 (en) 2016-01-04 2019-02-14 Auspex Pharmaceuticals, Inc. Azetidine modulators of the sphingosine 1-phosphate receptor
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
US11958805B2 (en) * 2017-03-09 2024-04-16 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
CA3074043A1 (fr) * 2017-09-27 2019-04-04 Novartis Ag Formulation parenterale comprenant du sitomod
WO2019064184A1 (fr) * 2017-09-27 2019-04-04 Dr. Reddy's Laboratories Limited Procédé de préparation de siponimod, de ses sels et de formes à l'état solide associées
EP3687531A1 (fr) * 2017-09-29 2020-08-05 Novartis AG Schéma posologique de siponimod
CA3073910A1 (fr) * 2017-09-29 2019-04-04 Novartis Ag Schema posologique de siponimod
WO2019144094A1 (fr) 2018-01-22 2019-07-25 Teva Pharmaceuticals International Gmbh Acide fumarique siponimod cristallin et polymorphes de celui-ci
CN110776450B (zh) * 2018-07-27 2022-09-27 广东东阳光药业有限公司 一种辛波莫德晶型及其制备方法
KR20200072795A (ko) 2018-12-13 2020-06-23 고려대학교 산학협력단 옥시이미노메틸벤젠 유도체를 유효성분으로 포함하는 일주기 연관성 질환의 예방 또는 치료용 약학적 조성물
CN111484434A (zh) * 2019-01-29 2020-08-04 东莞市东阳光仿制药研发有限公司 一种辛波莫德晶型及其制备方法
WO2020161632A1 (fr) * 2019-02-07 2020-08-13 Dr. Reddy’S Laboratories Limited Formes solides cristallines de siponimod
WO2020174408A1 (fr) * 2019-02-27 2020-09-03 Dr. Reddy's Laboratories Limited Formes à l'état solide de siponimod
KR20210134065A (ko) * 2019-03-28 2021-11-08 주식회사 퍼스트바이오테라퓨틱스 벤조티아졸 화합물의 약제학적 염, 다형체 및 이들의 제조 방법
WO2020234423A1 (fr) 2019-05-21 2020-11-26 Synthon B.V. Sel d'acide maléique et d'acide fumarique siponimod
JP7749552B2 (ja) 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Ｃｘｃｒ７アンタゴニストのｓ１ｐ１受容体調節剤との合剤
GB202002560D0 (en) * 2020-02-24 2020-04-08 Johnson Matthey Plc Crystalline forms of voxelotor, and processes for the preparation thereof
US20230212115A1 (en) * 2020-05-29 2023-07-06 Cipla Limited Methods for the preparation of sphingosine 1-phosphate receptor modulators and solid forme thereof
CN116456977A (zh) * 2020-09-25 2023-07-18 斯索恩有限公司 西尼莫德盐和共晶
WO2022064007A1 (fr) 2020-09-25 2022-03-31 Synthon B.V. Sels et co-cristaux de siponimod
CN112402610A (zh) * 2020-11-20 2021-02-26 睿阜隆(杭州)生物医药有限公司 1-磷酸鞘氨醇受体调节剂在制备治疗糖尿病的药物中的新用途
WO2022127863A1 (fr) * 2020-12-16 2022-06-23 苏州晶云药物科技股份有限公司 Formes cristallines de sel hémifumarate d'un composé d'acide carboxylique et procédé de préparation associé
CA3202656A1 (fr) 2021-03-26 2022-09-29 Olon S.P.A. Nouveau compose cristallin d'hemifumarate de siponimod
EP4212156A1 (fr) 2022-01-13 2023-07-19 Abivax Combinaison de 8-chloro-n-(4-(trifluorométhoxy)phényl)quinolin-2-amine et de ses dérivés avec un modulateur de récepteur de s1p

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86632A0 (en) 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
ATE124217T1 (de) * 1991-06-04 1995-07-15 Fujisawa Pharmaceutical Co Vorbeugende/therapeutische zusammensetzung für die pleuropneumonie des schweins.
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
TW225528B (fr) 1992-04-03 1994-06-21 Ciba Geigy Ag
AU687727B2 (en) 1992-10-28 1998-03-05 Genentech Inc. Vascular endothelial cell growth factor antagonists
DE69430575T2 (de) * 1993-06-08 2002-10-02 Hisamitsu Pharmaceutical Co., Inc. Iontophoretisches system
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
SI9620103A (sl) 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
KR20000005224A (ko) * 1996-04-04 2000-01-25 가와무라 요시부미 페닐알킬카르복실산 유도체_
EA001595B1 (ru) 1996-04-12 2001-06-25 Варнер-Ламберт Компани Необратимые ингибиторы тирозинкиназ
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
CA2258548C (fr) 1996-06-24 2005-07-26 Pfizer Inc. Derives tricycliques substitues par phenylamino, destines au traitement des maladies hyperproliferatives
AU735648B2 (en) 1996-07-12 2001-07-12 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
DE19638745C2 (de) 1996-09-11 2001-05-10 Schering Ag Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR)
EP0954315A2 (fr) 1996-09-13 1999-11-10 Sugen, Inc. Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs
EP0837063A1 (fr) 1996-10-17 1998-04-22 Pfizer Inc. Dérivés de 4-aminoquinazoline
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
TW557297B (en) 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
PT1107964E (pt) 1998-08-11 2010-06-11 Novartis Ag Derivados de isoquinolina com actividade inibidora da angiogénese
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
DK1140173T4 (da) 1998-12-22 2013-06-10 Genentech Inc Vaskulære endothelcellevækstfaktorantagonister og anvendelser deraf
CN1660840A (zh) 1999-03-30 2005-08-31 诺瓦提斯公司 治疗炎性疾病的酞嗪衍生物
EP1309556B1 (fr) * 2000-12-29 2004-11-24 Pfizer Limited Fumarate d'amlodipine
US20030119060A1 (en) * 2001-08-10 2003-06-26 Desrosiers Peter J. Apparatuses and methods for creating and testing pre-formulations and systems for same
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
IL164155A0 (en) * 2002-03-20 2005-12-18 Teva Pharma Crystalline forms of quetiapine hemifumarate
US6900206B2 (en) * 2002-06-20 2005-05-31 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
WO2004110330A1 (fr) 2003-06-13 2004-12-23 Stephen Dichiera Support de lit reglable et lit
AR051444A1 (es) * 2004-09-24 2007-01-17 Centocor Inc Proteinas derivadas de inmunoglobulina especifica de il-23p40, composiciones, epitopos, metodos y usos
KR20070085465A (ko) * 2004-11-29 2007-08-27 노파르티스 아게 Ｓ１ｐ 수용체 효능제의 투여 용법
AU2006278596A1 (en) * 2005-08-04 2007-02-15 Novartis Ag Salts of vildagliptin
GT200600350A (es) * 2005-08-09 2007-03-28 Formulaciones líquidas
US20060223820A1 (en) * 2006-03-21 2006-10-05 Chemagis Ltd. Crystalline aripiprazole salts and processes for preparation and purification thereof
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
PE20081157A1 (es) * 2006-11-07 2008-09-26 Novartis Ag Forma cristalina de hemifumarato de alisquireno

Also Published As

Publication number Publication date
PE20120336A1 (es) 2012-04-30
EP2379497B1 (fr) 2013-08-21
PE20142374A1 (es) 2015-01-30
BRPI0923176B8 (pt) 2021-05-25
US20210323915A1 (en) 2021-10-21
CO6390104A2 (es) 2012-02-29
AU2009335924B2 (en) 2012-11-08
HRP20170916T1 (hr) 2017-09-22
DK2676953T3 (en) 2017-07-03
EP2676953B1 (fr) 2017-03-22
RU2011129222A (ru) 2013-01-27
CN104803902A (zh) 2015-07-29
AU2009335924A1 (en) 2011-06-30
CA2951479A1 (fr) 2010-07-15
KR20160064245A (ko) 2016-06-07
KR20180006492A (ko) 2018-01-17
IL253845B (en) 2022-08-01
ZA201103709B (en) 2012-01-25
AR112227A2 (es) 2019-10-02
CA2747437A1 (fr) 2010-07-15
KR101885052B1 (ko) 2018-08-02
CY1114662T1 (el) 2016-10-05
PT2379497E (pt) 2013-11-29
SI2676953T1 (sl) 2017-07-31
CL2011001490A1 (es) 2012-01-13
CY1119037T1 (el) 2018-01-10
KR20110096584A (ko) 2011-08-30
SI2379497T1 (sl) 2013-12-31
HUE034819T2 (en) 2018-02-28
IL294514A (en) 2022-09-01
IL253845A0 (en) 2017-09-28
US20180118678A1 (en) 2018-05-03
HRP20131106T1 (hr) 2013-12-20
RU2518114C3 (ru) 2021-11-24
JO2894B1 (en) 2015-09-15
BRPI0923176A2 (pt) 2016-02-16
UY32330A (es) 2010-07-30
ES2436197T3 (es) 2013-12-27
BRPI0923176B1 (pt) 2020-12-01
US20240239743A1 (en) 2024-07-18
RS56110B1 (sr) 2017-10-31
PL2379497T3 (pl) 2014-01-31
SG171785A1 (en) 2011-07-28
TW201035048A (en) 2010-10-01
LT2676953T (lt) 2017-06-26
AR074694A1 (es) 2011-02-02
KR20160129915A (ko) 2016-11-09
ECSP11011210A (es) 2011-08-31
HK1159631A1 (en) 2012-08-03
JP5627597B2 (ja) 2014-11-19
EP2676953A1 (fr) 2013-12-25
JP2012512881A (ja) 2012-06-07
RS53041B (sr) 2014-04-30
CN102256943A (zh) 2011-11-23
MY152669A (en) 2014-10-31
EP2379497A1 (fr) 2011-10-26
KR20170062554A (ko) 2017-06-07
TWI591055B (zh) 2017-07-11
DK2379497T3 (da) 2013-11-25
US20220402870A1 (en) 2022-12-22
RU2518114C2 (ru) 2014-06-10
IL213071A0 (en) 2011-07-31
WO2010080409A1 (fr) 2010-07-15
US20150175536A1 (en) 2015-06-25
MX2011006609A (es) 2011-06-30
NZ593061A (en) 2013-08-30
US20230357142A9 (en) 2023-11-09
US20120115840A1 (en) 2012-05-10
PT2676953T (pt) 2017-06-29
AR121635A2 (es) 2022-06-22
US20140005162A1 (en) 2014-01-02
PL2676953T3 (pl) 2017-09-29
TWI500603B (zh) 2015-09-21
CA2747437C (fr) 2018-08-21
TW201509909A (zh) 2015-03-16
ES2631203T3 (es) 2017-08-29
BRPI0923176A8 (pt) 2017-09-12

Similar Documents

Publication Publication Date Title
MA32961B1 (fr) Sel hemifumarate d'acide 1-[4-[1(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl]-2-ethyl -benzyl]-azetidine-3-carboxylique
BRPI0922457A2 (pt) forma polimórfica de ácido 1-(4-{1-[(e)-4-ciclo-hexil-3-trifluormetil-benziloxi-imino]-etil)-2-etil-benzil)-azetidino-3-carboxílico"
EA201170151A1 (ru) Пиперидиниловые агонисты gpcr
EP2235857A4 (fr) Signalisation de la présence de trames d'extension
EP2580165A4 (fr) Retrait de composés physiologiquement actifs d'eaux usées
EP2097111A4 (fr) Hétérodimères d'acide glutamique
MA32797B1 (fr) Formes cristallines de la (r)-5[3-chloro-4-(2,3-dihydroxy-propoxy)-benz-[z]-ylidène]-2-([z]-propylimino)-3-o-tolyl- thiazolidin-4-one
UY31986A (es) Derivados n- sustituídos de la 2-metil-propionamida;{1-[5-sustiuido-4-sustituido-tiazol-2-il-carbamoil]-1-metil-etil} amidas de ácidos carboxílicos sustituidos, derivados farmacéuticamente aceptables de los mismos, composiciones y aplicaciones.
EP2195946A4 (fr) Correction d'erreurs pour une allocation des ressources permanentes
EA200901563A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA200970161A1 (ru) Производные 1-(-d-гликопиранозил)-3-(4-циклопропилфенилметил)-4-галогеноиндола и их применение в качестве ингибиторов sglt
DE602007008851D1 (de) Ektionsmittel
ATE478849T1 (de) 4-anilinochinolin-3-carbonsäureamide als csf-1r- kinaseinhibitoren
ATE522624T1 (de) Identifizierung von krankheitserregern
CY1109911T1 (el) Πυρρολοβενζοδιαζεπινες
DE112007001307A5 (de) Mikrobiologische Herstellung von 3-Hydroxyisobuttersäure
LTC1912640I2 (lt) HDAC inhibitoriaus panobinostato panaudojimas mielomos gydymui
EP2112219A4 (fr) Nouvelles bacteries d'acide lactique
EA201171211A1 (ru) Производные оксадиазола
SI1771441T1 (sl) Novi amidi karboksilnih kislin kot inhibitorji faktorja XA
EA200900946A1 (ru) Новый способ синтеза агомелатина
EA200970871A1 (ru) Новое терапевтическое применение 4-[2-(4-метилфенилсульфанил)фенил]пиперидина
MX2011009148A (es) Sal de sodio de acido 5-ciclopropil-2-{[2-2,6-difluorofenil) pirimidin-5-il]amino}benzoico como inhibidor de dhodh.
NO20080265L (no) 2-(1H-indolylsulfanyl)-arylaminderivater
EA201001882A1 (ru) Гидроксизамещенные тиенопиримидиноны как антагонисты рецептора-i меланинконцентрирующего гормона