BRPI1004934A2 - processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico - Google Patents

processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico

Info

Publication number
BRPI1004934A2
BRPI1004934A2 BRPI1004934A BRPI1004934A BRPI1004934A2 BR PI1004934 A2 BRPI1004934 A2 BR PI1004934A2 BR PI1004934 A BRPI1004934 A BR PI1004934A BR PI1004934 A BRPI1004934 A BR PI1004934A BR PI1004934 A2 BRPI1004934 A2 BR PI1004934A2
Authority
BR
Brazil
Prior art keywords
diarypyrimidine
nucleoside
synthesis
reverse transcriptase
transcriptase inhibitor
Prior art date
Application number
BRPI1004934A
Other languages
English (en)
Inventor
Gurjar Mukund Keshav
Joshi Shashikant Gangaram
Kamble Mangesh Gorakhanath
Maikap Golakchandra Sudarshan
Mehta Samit Satish
Pardeshi Devising Rameshsing
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Publication of BRPI1004934A2 publication Critical patent/BRPI1004934A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
BRPI1004934A 2009-06-22 2010-06-18 processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico BRPI1004934A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1479MU2009 2009-06-22
PCT/IN2010/000422 WO2010150279A2 (en) 2009-06-22 2010-06-18 Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor

Publications (1)

Publication Number Publication Date
BRPI1004934A2 true BRPI1004934A2 (pt) 2016-11-29

Family

ID=43386984

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1004934A BRPI1004934A2 (pt) 2009-06-22 2010-06-18 processo para a síntese de inibidor não nucleosídico de transcriptase reversa diarilpirimidínico

Country Status (12)

Country Link
US (1) US20110196156A1 (pt)
EP (1) EP2342186B1 (pt)
JP (1) JP5406934B2 (pt)
AP (1) AP2858A (pt)
BR (1) BRPI1004934A2 (pt)
CO (1) CO6430461A2 (pt)
ES (1) ES2527103T3 (pt)
IL (1) IL214862A (pt)
RU (1) RU2556986C2 (pt)
UA (1) UA106972C2 (pt)
WO (1) WO2010150279A2 (pt)
ZA (1) ZA201108690B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017079A1 (en) 2009-07-27 2011-02-10 Teva Pharmaceutical Industries Ltd. Process for the preparation and purification of etravirine and intermediates thereof
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
WO2012147104A1 (en) 2011-04-26 2012-11-01 Mylan Laboratories Ltd Novel process for the preparation of etravirine
WO2012170647A1 (en) * 2011-06-09 2012-12-13 Assia Chemical Industriew Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
US20130123498A1 (en) 2011-10-19 2013-05-16 Maja Sepelj MAJER Process for the preparation of etravirine and intermediates in the synthesis thereof
WO2013159286A1 (zh) * 2012-04-24 2013-10-31 上海迪赛诺药业有限公司 依曲韦林及其中间体的制备方法
CN103373965B (zh) * 2012-04-24 2016-04-27 上海迪赛诺药业有限公司 依曲韦林及其中间体的制备方法
CN102675220B (zh) * 2012-05-28 2014-03-19 南京药石药物研发有限公司 一种制备依曲韦林的方法及其中间体
CN104447573B (zh) * 2014-11-27 2016-11-09 山东大学 一种依曲韦林的制备方法
RU2728555C1 (ru) * 2019-12-24 2020-07-30 Общество с ограниченной ответственностью "Балтфарма" Способ получения этравирина
CN111675661B (zh) * 2020-06-28 2021-08-24 山东大学 一种含有反式双键的二芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU762523C (en) 1998-11-10 2004-02-12 Janssen Pharmaceutica N.V. HIV replication inhibiting pyrimidines
ATE316781T1 (de) * 1999-09-24 2006-02-15 Janssen Pharmaceutica Nv Antivirale feste dispersionen
BRPI0607214B8 (pt) * 2005-01-27 2021-05-25 Janssen R & D Ireland derivados de 2-(4-cianofenilamino)pirimidina inibidores de hiv, composição farmacêutica que os compreende e seus processos de preparação
RU2398768C2 (ru) * 2005-02-18 2010-09-10 Тиботек Фармасьютикалз Лтд. Ингибирующие вич производные 2-(4-цианофениламино)-пиримидин-оксида
RU2401261C2 (ru) * 2005-03-04 2010-10-10 Тиботек Фармасьютикалз Лтд. Ингибирующие вич 2-(4-цианофенил)-6-гидроксиламинопиримидины
CN101495461A (zh) * 2006-07-24 2009-07-29 吉里德科学公司 新的hiv逆转录酶抑制剂
WO2009005690A2 (en) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Antiviral compounds
WO2010131118A2 (en) * 2009-05-12 2010-11-18 Pliva Hrvatska D.O.O. Polymorphs of etravirine and processes for preparation thereof

Also Published As

Publication number Publication date
RU2556986C2 (ru) 2015-07-20
UA106972C2 (uk) 2014-11-10
WO2010150279A2 (en) 2010-12-29
EP2342186B1 (en) 2014-09-17
RU2011129982A (ru) 2013-01-27
JP5406934B2 (ja) 2014-02-05
IL214862A0 (en) 2011-11-30
AP2858A (en) 2014-02-28
CO6430461A2 (es) 2012-04-30
ZA201108690B (en) 2013-01-30
ES2527103T3 (es) 2015-01-20
JP2012509314A (ja) 2012-04-19
AP2011005715A0 (en) 2011-06-30
IL214862A (en) 2015-07-30
EP2342186A4 (en) 2012-03-21
US20110196156A1 (en) 2011-08-11
WO2010150279A3 (en) 2011-02-24
EP2342186A2 (en) 2011-07-13

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL

B350 Update of information on the portal [chapter 15.35 patent gazette]