BRPI1010704A2 - proteínas de fusão actriib truncadas - Google Patents

proteínas de fusão actriib truncadas

Info

Publication number
BRPI1010704A2
BRPI1010704A2 BRPI1010704-5A BRPI1010704A BRPI1010704A2 BR PI1010704 A2 BRPI1010704 A2 BR PI1010704A2 BR PI1010704 A BRPI1010704 A BR PI1010704A BR PI1010704 A2 BRPI1010704 A2 BR PI1010704A2
Authority
BR
Brazil
Prior art keywords
fusion proteins
actriib fusion
truncated actriib
fat
tissue
Prior art date
Application number
BRPI1010704-5A
Other languages
English (en)
Inventor
Seehra Jasbir
Kumar Ravindra
Original Assignee
Acceleron Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc. filed Critical Acceleron Pharma Inc.
Publication of BRPI1010704A2 publication Critical patent/BRPI1010704A2/pt
Publication of BRPI1010704B1 publication Critical patent/BRPI1010704B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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Abstract

proteínas de fusão actriib truncadas em certos aspectos, a presente invenção fornece composições e métodos para modular (promover ou inibir) o crescimento de um tecido, tal como um osso, cartilagem, músculo, gordura, gordura marrom e/ou tecido neuronal e para o tratamento de distúrbios metabólicos, tais como diabetes e obesidade, bem como distúrbios associados com qualquer um dos tecidos já mencionados.
BRPI1010704-5A 2009-06-12 2010-06-08 Polipeptídeo recombinante, proteína de fusão recombinante, preparação farmacêutica e uso da mesma BRPI1010704B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26842009P 2009-06-12 2009-06-12
US61/268.420 2009-06-12
US61/268,420 2009-06-12
US28054309P 2009-11-03 2009-11-03
US61/280,543 2009-11-03
US61/280.543 2009-11-03
PCT/US2010/037787 WO2010151426A1 (en) 2009-06-12 2010-06-08 Truncated actriib-fc fusion proteins

Publications (2)

Publication Number Publication Date
BRPI1010704A2 true BRPI1010704A2 (pt) 2019-04-09
BRPI1010704B1 BRPI1010704B1 (pt) 2021-12-14

Family

ID=43306633

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122021017187-4A BR122021017187B1 (pt) 2009-06-12 2010-06-08 Ácido nucléico e polipeptídeo recombinante, preparação farmacêutica compreendendo o dito polipeptídeo e usos terapêuticos da mesma
BRPI1010704-5A BRPI1010704B1 (pt) 2009-06-12 2010-06-08 Polipeptídeo recombinante, proteína de fusão recombinante, preparação farmacêutica e uso da mesma

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122021017187-4A BR122021017187B1 (pt) 2009-06-12 2010-06-08 Ácido nucléico e polipeptídeo recombinante, preparação farmacêutica compreendendo o dito polipeptídeo e usos terapêuticos da mesma

Country Status (15)

Country Link
US (6) US8293881B2 (pt)
EP (3) EP3290439B1 (pt)
JP (5) JP2012529294A (pt)
KR (5) KR20180026795A (pt)
CN (3) CN102656187A (pt)
AU (5) AU2010263182B2 (pt)
BR (2) BR122021017187B1 (pt)
CA (1) CA2765108C (pt)
CO (1) CO6491031A2 (pt)
CY (1) CY1123580T1 (pt)
ES (1) ES2836534T3 (pt)
HK (2) HK1213013A1 (pt)
IL (3) IL216861A (pt)
MX (3) MX351286B (pt)
WO (1) WO2010151426A1 (pt)

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AU2009244308A1 (en) * 2008-05-06 2009-11-12 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
CN102131822A (zh) * 2008-06-26 2011-07-20 阿塞勒隆制药公司 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
TWI626945B (zh) 2008-08-14 2018-06-21 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
AU2010204985A1 (en) 2009-01-13 2011-08-04 Acceleron Pharma Inc. Methods for increasing adiponectin
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EP3290439B1 (en) 2009-06-12 2020-09-02 Acceleron Pharma Inc. Truncated actriib-fc fusion proteins
JP6211767B2 (ja) * 2009-09-09 2017-10-11 アクセルロン ファーマ， インコーポレイテッド ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用
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CN102770458A (zh) 2009-12-02 2012-11-07 阿塞勒隆制药公司 用于增加Fc融合蛋白的血清半寿期的组合物和方法
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US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
MA40008A (fr) 2014-06-13 2021-05-05 Acceleron Pharma Inc Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
TWI730949B (zh) 2014-12-03 2021-06-21 美商西建公司 活化素-ａｃｔｒｉｉ拮抗劑及治療貧血之用途
BR112017021510A2 (pt) 2015-04-06 2018-07-03 Acceleron Pharma Inc heteromultímeros do receptor tipo i e tipo ii da superfamília tgf-beta e sua utilização
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