BRPI1011394A2 - 23método para avaliação de responsividade de linforma de células b ao tratamento com anticorpos anti-cd40 - Google Patents
23método para avaliação de responsividade de linforma de células b ao tratamento com anticorpos anti-cd40Info
- Publication number
- BRPI1011394A2 BRPI1011394A2 BRPI1011394A BRPI1011394A BRPI1011394A2 BR PI1011394 A2 BRPI1011394 A2 BR PI1011394A2 BR PI1011394 A BRPI1011394 A BR PI1011394A BR PI1011394 A BRPI1011394 A BR PI1011394A BR PI1011394 A2 BRPI1011394 A2 BR PI1011394A2
- Authority
- BR
- Brazil
- Prior art keywords
- linforma
- responsiveness
- assessing
- cell
- antibody treatment
- Prior art date
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title 1
- 230000004043 responsiveness Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17061509P | 2009-04-18 | 2009-04-18 | |
| PCT/US2010/031528 WO2010121231A1 (en) | 2009-04-18 | 2010-04-17 | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1011394A2 true BRPI1011394A2 (pt) | 2016-03-15 |
| BRPI1011394A8 BRPI1011394A8 (pt) | 2018-06-26 |
Family
ID=42358184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011394A BRPI1011394A8 (pt) | 2009-04-18 | 2010-04-17 | método para avaliação de responsividade de linforma de células b ao tratamento com anticorpos anti-cd40 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9617600B2 (pt) |
| EP (1) | EP2419531B1 (pt) |
| JP (1) | JP5836929B2 (pt) |
| KR (1) | KR101787768B1 (pt) |
| CN (1) | CN102459639A (pt) |
| AU (1) | AU2010236168B2 (pt) |
| BR (1) | BRPI1011394A8 (pt) |
| CA (1) | CA2758523C (pt) |
| ES (1) | ES2605228T3 (pt) |
| IL (1) | IL215707A (pt) |
| MX (1) | MX2011010938A (pt) |
| WO (1) | WO2010121231A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101910414B (zh) | 2007-11-07 | 2016-01-13 | 健泰科生物技术公司 | 用于评估b细胞淋巴瘤对抗cd40抗体治疗的响应性的方法和组合物 |
| WO2012149356A2 (en) | 2011-04-29 | 2012-11-01 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
| ES2634254T3 (es) | 2011-09-12 | 2017-09-27 | Atrys Health, SA | Métodos para el pronóstico del linfoma difuso de linfocitos B grandes |
| PT2882441T (pt) | 2012-08-09 | 2020-06-29 | Celgene Corp | Tratamento de doenças associadas à imunidade e inflamatórias |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| CN104918957B (zh) | 2012-10-30 | 2018-11-16 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| ES2969532T3 (es) | 2014-05-19 | 2024-05-21 | Celgene Corp | 3-(4-((4-(Morfolinometil-bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona para el tratamiento de lupus eritematoso sistémico |
| CA2999179A1 (en) | 2015-09-25 | 2017-03-30 | Celgene Corporation | Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| US20240002941A1 (en) * | 2020-12-02 | 2024-01-04 | Albert Einstein College Of Medicine | Method for predicting patient response to cd40-targeted therapies |
| CN117092336A (zh) * | 2023-06-16 | 2023-11-21 | 中国医学科学院北京协和医院 | 血浆n4bp1、creb1、ubap2、deaf1自身抗体标志物在弥漫大b细胞淋巴瘤预后预测中的应用 |
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| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
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| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5182368A (en) | 1986-06-13 | 1993-01-26 | Ledbetter Jeffrey A | Ligands and methods for augmenting B-cell proliferation |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
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| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| US5874082A (en) | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
| NZ278740A (en) | 1993-12-23 | 1998-05-27 | Immunex Corp | Treating disease characterised by neoplastic cells expressing cd40 using a cd40 binding protein |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
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| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
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| PL1889065T3 (pl) | 2005-05-18 | 2013-12-31 | Novartis Ag | Metody diagnostyki i leczenia chorób posiadających składnik autoimmunologiczny i/lub zapalny |
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| BRPI0619586A2 (pt) | 2005-12-09 | 2018-08-28 | Seattle Genetics Inc | método para o tratamento ou prevenção de um distúrbio associado com cd40 |
| US7527774B2 (en) | 2005-12-22 | 2009-05-05 | Basf Catalysts Llc | Inlet metallic foam support coupled to precious metal catalyst for application on 4 stroke platforms |
| EP1987161A4 (en) * | 2006-01-20 | 2009-06-24 | Univ Mcgill | METHOD FOR IDENTIFYING CD40-SENSITIVE CELLS |
| RU2473555C2 (ru) | 2006-12-19 | 2013-01-27 | ДжинГоу, Инк. | Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных |
| CN101910414B (zh) * | 2007-11-07 | 2016-01-13 | 健泰科生物技术公司 | 用于评估b细胞淋巴瘤对抗cd40抗体治疗的响应性的方法和组合物 |
-
2010
- 2010-04-17 CA CA2758523A patent/CA2758523C/en active Active
- 2010-04-17 JP JP2012505990A patent/JP5836929B2/ja active Active
- 2010-04-17 AU AU2010236168A patent/AU2010236168B2/en not_active Ceased
- 2010-04-17 WO PCT/US2010/031528 patent/WO2010121231A1/en not_active Ceased
- 2010-04-17 ES ES10715067.4T patent/ES2605228T3/es active Active
- 2010-04-17 KR KR1020117027354A patent/KR101787768B1/ko active Active
- 2010-04-17 MX MX2011010938A patent/MX2011010938A/es active IP Right Grant
- 2010-04-17 US US13/264,973 patent/US9617600B2/en active Active
- 2010-04-17 EP EP10715067.4A patent/EP2419531B1/en active Active
- 2010-04-17 CN CN201080027267XA patent/CN102459639A/zh active Pending
- 2010-04-17 BR BRPI1011394A patent/BRPI1011394A8/pt active Search and Examination
-
2011
- 2011-10-11 IL IL215707A patent/IL215707A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1011394A8 (pt) | 2018-06-26 |
| IL215707A (en) | 2016-08-31 |
| JP5836929B2 (ja) | 2015-12-24 |
| WO2010121231A1 (en) | 2010-10-21 |
| AU2010236168B2 (en) | 2015-08-13 |
| IL215707A0 (en) | 2012-01-31 |
| MX2011010938A (es) | 2012-01-12 |
| US9617600B2 (en) | 2017-04-11 |
| EP2419531B1 (en) | 2016-09-07 |
| KR101787768B1 (ko) | 2017-10-18 |
| EP2419531A1 (en) | 2012-02-22 |
| KR20120013992A (ko) | 2012-02-15 |
| JP2012523838A (ja) | 2012-10-11 |
| CN102459639A (zh) | 2012-05-16 |
| CA2758523C (en) | 2019-03-12 |
| US20120123695A1 (en) | 2012-05-17 |
| AU2010236168A1 (en) | 2011-11-10 |
| ES2605228T3 (es) | 2017-03-13 |
| CA2758523A1 (en) | 2010-10-21 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |