BRPI1012198A2 - sais de dissacarina, ácido difumárico, ácido di-1-hidróxi-2-naftoico e ácido mono-benzoico de 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il)metil) fenil) acetato de 4-(dimetilamino)butila - Google Patents

sais de dissacarina, ácido difumárico, ácido di-1-hidróxi-2-naftoico e ácido mono-benzoico de 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il)metil) fenil) acetato de 4-(dimetilamino)butila

Info

Publication number
BRPI1012198A2
BRPI1012198A2 BRPI1012198A BRPI1012198A BRPI1012198A2 BR PI1012198 A2 BRPI1012198 A2 BR PI1012198A2 BR PI1012198 A BRPI1012198 A BR PI1012198A BR PI1012198 A BRPI1012198 A BR PI1012198A BR PI1012198 A2 BRPI1012198 A2 BR PI1012198A2
Authority
BR
Brazil
Prior art keywords
acid
methyl
disaccharine
difumaic
pentylamino
Prior art date
Application number
BRPI1012198A
Other languages
English (en)
Inventor
Austen Pimm
Dainippon Sumitomo Pharma Co Ltd
Nicholas James Bennett
Stephen Thom
Thomas Mcinally
Yoshiaki Isobe
Original Assignee
Astrazenec Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazenec Ab filed Critical Astrazenec Ab
Publication of BRPI1012198A2 publication Critical patent/BRPI1012198A2/pt
Publication of BRPI1012198A8 publication Critical patent/BRPI1012198A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI1012198A 2009-05-21 2010-05-20 sais de dissacarina, ácido difumárico, ácido di-1-hidróxi-2-naftoico e ácido mono-benzoico de 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il)metil) fenil) acetato de 4-(dimetilamino)butila BRPI1012198A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0908772.7A GB0908772D0 (en) 2009-05-21 2009-05-21 New salts 756
PCT/GB2010/050822 WO2010133882A1 (en) 2009-05-21 2010-05-20 Disaccharin, difumaric acid, di-l-hydroxy-2-naphthoic acid and mono-benzoic acid salts of 4- (dimethylamin0)butyl 2- (4- ( (2-amino-4-methyl-6- (pentylamino) pyrimidin- 5 -yl) methyl) phenyl)acetate

Publications (2)

Publication Number Publication Date
BRPI1012198A2 true BRPI1012198A2 (pt) 2016-04-05
BRPI1012198A8 BRPI1012198A8 (pt) 2016-10-04

Family

ID=40862774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012198A BRPI1012198A8 (pt) 2009-05-21 2010-05-20 sais de dissacarina, ácido difumárico, ácido di-1-hidróxi-2-naftoico e ácido mono-benzoico de 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il)metil) fenil) acetato de 4-(dimetilamino)butila

Country Status (30)

Country Link
US (1) US8476288B2 (pt)
EP (1) EP2435412B1 (pt)
JP (1) JP5717727B2 (pt)
KR (1) KR101709363B1 (pt)
CN (1) CN102596917B (pt)
AR (1) AR076597A1 (pt)
AU (1) AU2010250920B2 (pt)
BR (1) BRPI1012198A8 (pt)
CA (1) CA2760765A1 (pt)
CL (1) CL2011002941A1 (pt)
CO (1) CO6440532A2 (pt)
CR (1) CR20110611A (pt)
CU (1) CU24053B1 (pt)
DO (1) DOP2011000360A (pt)
EA (1) EA021854B1 (pt)
EC (1) ECSP11011469A (pt)
ES (1) ES2566912T3 (pt)
GB (1) GB0908772D0 (pt)
HN (1) HN2011003072A (pt)
IL (1) IL216280A0 (pt)
MX (1) MX2011012344A (pt)
NI (1) NI201100205A (pt)
NZ (1) NZ596118A (pt)
PE (1) PE20120989A1 (pt)
SA (1) SA110310402B1 (pt)
SG (1) SG175322A1 (pt)
TW (1) TW201100389A (pt)
UY (1) UY32649A (pt)
WO (1) WO2010133882A1 (pt)
ZA (1) ZA201109383B (pt)

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TWI733652B (zh) 2014-07-11 2021-07-21 美商基利科學股份有限公司 用於治療ＨＩＶ之ｔｏｌｌ樣受體調節劑
JP2017526730A (ja) 2014-09-16 2017-09-14 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体モジュレーターの固体形態
KR20190084991A (ko) 2016-11-28 2019-07-17 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피라졸로-헤테로아릴 유도체, 이의 제조 방법 및 의학적 용도
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JP2021526520A (ja) 2018-05-25 2021-10-07 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Ｊｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．， Ｌｔｄ． ピラゾロヘテロアリール誘導体の塩酸塩の結晶形および調製方法
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AU2010250920A1 (en) 2011-11-17
HK1168850A1 (zh) 2013-01-11
GB0908772D0 (en) 2009-07-01
ECSP11011469A (es) 2011-12-30
CN102596917B (zh) 2015-01-21
TW201100389A (en) 2011-01-01
CO6440532A2 (es) 2012-05-15
NI201100205A (es) 2012-08-01
CL2011002941A1 (es) 2012-04-13
EA201190296A1 (ru) 2012-06-29
UY32649A (es) 2010-12-31
EP2435412B1 (en) 2016-01-27
CR20110611A (es) 2012-01-09
JP5717727B2 (ja) 2015-05-13
KR20120016635A (ko) 2012-02-24
CA2760765A1 (en) 2010-11-25
CU24053B1 (es) 2014-12-26
BRPI1012198A8 (pt) 2016-10-04
DOP2011000360A (es) 2011-12-15
EA021854B1 (ru) 2015-09-30
AR076597A1 (es) 2011-06-22
JP2012527442A (ja) 2012-11-08
ES2566912T3 (es) 2016-04-18
SG175322A1 (en) 2011-12-29
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US8476288B2 (en) 2013-07-02
KR101709363B1 (ko) 2017-02-22
CN102596917A (zh) 2012-07-18
US20100298364A1 (en) 2010-11-25
ZA201109383B (en) 2013-05-29
PE20120989A1 (es) 2012-08-26
WO2010133882A1 (en) 2010-11-25
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NZ596118A (en) 2013-07-26

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