BRPI1013822A2 - Método para síntese de um trissacarídeo. - Google Patents

Método para síntese de um trissacarídeo.

Info

Publication number
BRPI1013822A2
BRPI1013822A2 BRPI1013822-6A BRPI1013822A BRPI1013822A2 BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2 BR PI1013822 A BRPI1013822 A BR PI1013822A BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2
Authority
BR
Brazil
Prior art keywords
trisaccharide
synthesis
Prior art date
Application number
BRPI1013822-6A
Other languages
English (en)
Inventor
Gyula Dékany
Istvan Bajza
Julien Boutet
Ignacio Figueroa Pérez
Markus Hederos
Ferenc Horvath
Piroska Kovács-Pénzes
Lars Kröger
Johan Olsson
Christoph Röhrig
Andreas Schroven
Ioannis Vrasidas
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom As filed Critical Glycom As
Publication of BRPI1013822A2 publication Critical patent/BRPI1013822A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI1013822-6A 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo. BRPI1013822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900469 2009-04-07
PCT/EP2010/054608 WO2010115935A1 (en) 2009-04-07 2010-04-07 Synthesis of 2 ' -o-fucosyllactose

Publications (1)

Publication Number Publication Date
BRPI1013822A2 true BRPI1013822A2 (pt) 2015-08-25

Family

ID=42173049

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013822-6A BRPI1013822A2 (pt) 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo.

Country Status (13)

Country Link
US (2) US9012625B2 (pt)
EP (2) EP2417143B1 (pt)
JP (1) JP2012522827A (pt)
KR (1) KR20120022875A (pt)
CN (2) CN102459294A (pt)
AU (1) AU2010233770A1 (pt)
BR (1) BRPI1013822A2 (pt)
CA (1) CA2758097A1 (pt)
IL (1) IL215270A0 (pt)
MX (1) MX2011010214A (pt)
RU (1) RU2011144838A (pt)
WO (2) WO2010115935A1 (pt)
ZA (1) ZA201107336B (pt)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2798675A1 (en) * 2010-06-01 2011-12-08 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
US9102966B2 (en) * 2010-07-16 2015-08-11 Glycom A/S Synthesis of sialooligosaccharide derivatives
CA2822490C (en) 2010-12-31 2020-03-31 Abbott Laboratories Nutritional compositions comprising human milk oligosaccharides and nucleotides and uses thereof for treating and/or preventing enteric viral infection
MY166945A (en) 2010-12-31 2018-07-25 Abbott Lab Nutritional formulations including human milk oligosaccharides and long chain polyunsaturated polyunsaturated fatty acids and uses thereof
CN107019701B (zh) 2010-12-31 2020-07-28 雅培制药有限公司 使用人乳低聚糖来降低婴儿、幼儿或儿童的坏死性小肠结肠炎的发病率的方法
MY191538A (en) 2010-12-31 2022-06-30 Abbott Lab Human milk oligosaccharides to promote growth of beneficial bacteria
ES2804258T3 (es) 2010-12-31 2021-02-05 Abbott Lab Procedimientos para reducir la incidencia de estrés oxidativo usando oligosacáridos de leche humana, vitamina C y agentes antiinflamatorios
US8802650B2 (en) 2010-12-31 2014-08-12 Abbott Laboratories Methods of using human milk oligosaccharides for improving airway respiratory health
ES2667393T3 (es) 2010-12-31 2018-05-10 Abbott Laboratories Oligosacáridos de leche humana para modular inflamación
CN103429604A (zh) * 2011-02-21 2013-12-04 格礼卡姆股份公司 寡糖前体的混合物的组合物的催化氢解及其用途
AU2012232727A1 (en) * 2011-03-18 2013-09-26 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
US20140323705A1 (en) * 2011-05-13 2014-10-30 Markus Hederos Manufacture of lacto-n-tetraose
EP2522232A1 (en) 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
CA2846603A1 (en) 2011-08-29 2013-03-07 Abbott Laboratories Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
CN103958537A (zh) * 2011-09-30 2014-07-30 格礼卡姆股份公司 Hmo核心结构的合成
WO2013057049A1 (en) * 2011-10-18 2013-04-25 Nestec S.A. Composition for use in brain growth and/or cognitive and/or psychomotor development
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
EP2861609A4 (en) 2012-06-14 2015-11-04 Glycom As IMPROVING STABILITY AND PURITY AND INCREASING THE BIOAVAILABILITY OF HUMAN MILK OLIGOSACCHARIDES OR PRECURSORS OR MIXTURES THEREOF
ITFI20120143A1 (it) 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
EP2708147B1 (en) * 2012-09-14 2020-03-11 Abbott Laboratories Methods for increasing brain functionality using 2-fucosyl-lactose
ES2572831T3 (es) 2012-09-14 2016-06-02 Abbott Laboratories Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
US9834574B2 (en) 2012-11-13 2017-12-05 Glycom A/S Crystalline 3-O-fucosyllactose
US20160113952A1 (en) 2013-05-22 2016-04-28 Glycom As Synthetic Mixture of Oligosaccharides for Treating a Microbiota of a Mammal
CN103408609B (zh) * 2013-09-02 2016-01-13 济南尚博生物科技有限公司 一种制备1-S-2,3,4-三-O-苄基-l-硫代吡喃岩藻糖苷的方法
US9902984B2 (en) 2013-09-06 2018-02-27 Glycom A/S Fermentative production of oligosaccharides
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
ES2701163T3 (es) 2014-01-20 2019-02-21 Jennewein Biotechnologie Gmbh Procedimiento para la purificación eficiente de oligosacáridos de la leche humana (HMO) neutros a partir de la fermentación microbiana
CN104098615A (zh) * 2014-06-09 2014-10-15 华中科技大学 一种以氢氧根离子型的碱为催化剂进行脱酰基化的方法
DK3191498T3 (da) 2014-09-12 2020-12-21 Basf Se Fremgangsmåde til fremstilling af 2'-o-fucosyllactose
WO2016063262A1 (en) 2014-10-24 2016-04-28 Glycom A/S MIXTURES OF HMOs
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
PL3212198T3 (pl) 2014-10-29 2021-08-23 Glycom A/S Syntetyczna kompozycja i sposób promowania gojenia się błony śluzowej
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
WO2016066175A1 (en) 2014-10-29 2016-05-06 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
EP3227309B1 (en) 2014-12-05 2025-09-24 Glycom A/S Crystalline difucosyllactose
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
CN107106584A (zh) 2014-12-08 2017-08-29 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
ES2960750T3 (es) 2015-03-05 2024-03-06 Glycom As Oligosacáridos de la leche humana para el tratamiento de infecciones agudas del aparato respiratorio
PL3277287T3 (pl) 2015-03-31 2024-04-22 Glycom A/S Mieszaniny oligosacharydów mleka ludzkiego zawierające 3'-O-sialilolaktozę
PL3307752T3 (pl) 2015-06-09 2021-11-02 Glycom A/S Mieszaniny trójskładnikowe 6’-sl, lnnt i lst c
RU2634707C2 (ru) * 2015-07-23 2017-11-03 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Способ избирательного удаления О-ацетильных защитных групп в присутствии О-бензоильных
US10751354B2 (en) 2015-09-14 2020-08-25 Glycom A/S Synthetic composition for microbiota modulation
US10835545B2 (en) 2015-10-28 2020-11-17 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
US10780103B2 (en) 2015-10-28 2020-09-22 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
PL3377071T3 (pl) 2015-11-17 2024-06-24 Glycom A/S Oligosacharydy mleka ludzkiego do leczenia powikłań związanych z antybiotykami
EP3389404B1 (en) 2015-12-15 2019-10-02 Société des Produits Nestlé S.A. Mixture of hmos
CN108602845A (zh) * 2016-02-03 2018-09-28 巴斯夫欧洲公司 生产2’-o-岩藻糖基乳糖的方法
WO2017144062A1 (en) 2016-02-24 2017-08-31 Glycom A/S Synthetic composition for microbiota modulation
WO2017153452A1 (en) 2016-03-09 2017-09-14 Basf Se Method for preparing 2'-o-fucosyllactose
KR101731263B1 (ko) 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
PL3452050T3 (pl) 2016-05-05 2023-06-12 Glycom A/S Kompozycja zawierająca hmo do leczenia biegunki niezakaźnej
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
CN105924480B (zh) * 2016-05-10 2018-09-25 浙江大学 含岩藻糖三糖硫酸酯及其制备方法和应用
WO2017198276A1 (en) 2016-05-19 2017-11-23 Glycom A/S Synthetic composition
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
US11278558B2 (en) 2017-03-01 2022-03-22 Glycom A/S Synthetic composition for microbiota modulation
US11291677B2 (en) 2017-05-09 2022-04-05 Glycom A/S Synthetic composition for microbiota modulation
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
EP3630123A4 (en) 2017-05-24 2020-10-28 Glycom A/S SYNTHETIC COMPOSITION CONSISTING OF ONE OR MORE HUMAN MILK OLIGOSACCHARIDES (HMOS)
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CA3076920A1 (en) 2017-10-04 2019-04-11 The Regents Of The University Of California Immunomodulatory oligosaccharides
CN111526879A (zh) 2017-11-02 2020-08-11 格礼卡姆股份公司 用于减少或预防疲劳和/或改善注意力或专注力的一种或多种hmo
JP7327724B2 (ja) 2017-11-30 2023-08-16 グリコム・アクティーゼルスカブ 小麦過敏症を処置するためのｈｍｏの混合物
WO2019111115A2 (en) 2017-12-05 2019-06-13 Glycom A/S Human milk oligosaccharides for treating migraine
CN111683666A (zh) 2017-12-22 2020-09-18 格礼卡姆股份公司 预防或减少伤害感受的包含hmo的组合物
CN108084234A (zh) * 2018-01-23 2018-05-29 佛山科学技术学院 双重随机糖基化合成三糖的方法
EP3801558A4 (en) 2018-05-31 2022-03-09 Glycom A/S HMOS BLEND FOR THE TREATMENT OF AUTOIMMUNE DISEASES
EP3867258A1 (en) 2018-10-18 2021-08-25 Basf Se Method for obtaining crystalline 2'-fucosyllactose
US12233079B2 (en) 2018-12-19 2025-02-25 Glycom A/S Composition and method for treating humans using low-fodmap diets
EP3741770A1 (en) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
JP7833397B2 (ja) 2019-11-29 2026-03-19 グリコム・アクティーゼルスカブ 妊婦の細菌叢を改善するためのｈｍｏの混合物
KR20220154158A (ko) 2020-03-12 2022-11-21 글리콤 에이/에스 2'-fl의 결정화
CN111588726A (zh) * 2020-04-28 2020-08-28 南开大学 2′-岩藻糖基乳糖调节宿主肠道菌群及增强肠屏障的应用
WO2022118269A1 (en) 2020-12-04 2022-06-09 Glycom A/S Human milk oligosaccharides for use in supporting maturation or improvement of sleeping patterns
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
WO2023099297A1 (en) * 2021-12-02 2023-06-08 Dsm Ip Assets B.V. Synthesis of hmo butyrate
KR20250036879A (ko) 2022-07-15 2025-03-14 디에스엠 아이피 어셋츠 비.브이. Nmn 또는 nad+의 증가에 사용하기 위한 비피도박테리움 및 푸코실화된 hmo의 조합물
CN120187736A (zh) * 2022-11-15 2025-06-20 洛桑联邦理工学院 制备至少部分缩醛保护的糖的方法
WO2025196273A1 (en) 2024-03-22 2025-09-25 Dsm Ip Assets B.V. Combination of mixtures of hmos with mfgm and their use
WO2025196272A1 (en) 2024-03-22 2025-09-25 Dsm Ip Assets B.V. Combination of mixtures of hmos with mfgm and their use
WO2025219496A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. Nutritional composition comprising bifidobacterium longum ssp. infantis r0033 and human milk oligosaccharides
WO2025219497A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. Combination comprising bifidobacterium bifidum ha-132 and human milk oligosaccharides
WO2025219495A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. A nutritional composition comprising bifidobacterium bifidum r0071 and human milk oligosaccharides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438124A (en) 1991-07-16 1995-08-01 Health Research, Inc. Glycosylating reagent for the synthesis of linear and other α-L-fucosyl oligosaccharides
CN1072677C (zh) * 1998-07-17 2001-10-10 中国科学院生态环境研究中心 二糖及三糖原酸酯及其合成方法
IT1392456B1 (it) 2008-12-18 2012-03-09 Inalco Spa Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati.

Also Published As

Publication number Publication date
EP2417143A1 (en) 2012-02-15
CN102459294A (zh) 2012-05-16
US9012625B2 (en) 2015-04-21
US20130131334A1 (en) 2013-05-23
US20120116065A1 (en) 2012-05-10
EP2417143B1 (en) 2016-12-21
KR20120022875A (ko) 2012-03-12
RU2011144838A (ru) 2013-05-20
CN102459295A (zh) 2012-05-16
ZA201107336B (en) 2014-03-26
EP2417144B1 (en) 2017-08-23
EP2417144A1 (en) 2012-02-15
MX2011010214A (es) 2012-01-20
AU2010233770A1 (en) 2011-10-27
US8927698B2 (en) 2015-01-06
IL215270A0 (en) 2011-11-30
CA2758097A1 (en) 2010-10-14
JP2012522827A (ja) 2012-09-27
WO2010115934A1 (en) 2010-10-14
WO2010115935A1 (en) 2010-10-14

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.11 NA RPI 2333 DE 22/09/2015