BRPI1013822A2 - Método para síntese de um trissacarídeo. - Google Patents

Método para síntese de um trissacarídeo.

Info

Publication number
BRPI1013822A2
BRPI1013822A2 BRPI1013822-6A BRPI1013822A BRPI1013822A2 BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2 BR PI1013822 A BRPI1013822 A BR PI1013822A BR PI1013822 A2 BRPI1013822 A2 BR PI1013822A2
Authority
BR
Brazil
Prior art keywords
trisaccharide
synthesis
Prior art date
Application number
BRPI1013822-6A
Other languages
English (en)
Inventor
Gyula Dékany
Istvan Bajza
Julien Boutet
Ignacio Figueroa Pérez
Markus Hederos
Ferenc Horvath
Piroska Kovács-Pénzes
Lars Kröger
Johan Olsson
Christoph Röhrig
Andreas Schroven
Ioannis Vrasidas
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom As filed Critical Glycom As
Publication of BRPI1013822A2 publication Critical patent/BRPI1013822A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI1013822-6A 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo. BRPI1013822A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900469 2009-04-07
PCT/EP2010/054608 WO2010115935A1 (en) 2009-04-07 2010-04-07 Synthesis of 2 ' -o-fucosyllactose

Publications (1)

Publication Number Publication Date
BRPI1013822A2 true BRPI1013822A2 (pt) 2015-08-25

Family

ID=42173049

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013822-6A BRPI1013822A2 (pt) 2009-04-07 2010-04-07 Método para síntese de um trissacarídeo.

Country Status (13)

Country Link
US (2) US8927698B2 (pt)
EP (2) EP2417144B1 (pt)
JP (1) JP2012522827A (pt)
KR (1) KR20120022875A (pt)
CN (2) CN102459294A (pt)
AU (1) AU2010233770A1 (pt)
BR (1) BRPI1013822A2 (pt)
CA (1) CA2758097A1 (pt)
IL (1) IL215270A0 (pt)
MX (1) MX2011010214A (pt)
RU (1) RU2011144838A (pt)
WO (2) WO2010115934A1 (pt)
ZA (1) ZA201107336B (pt)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
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WO2011150939A1 (en) 2010-06-01 2011-12-08 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
AU2011278236A1 (en) * 2010-07-16 2013-02-07 Glycom A/S Derivatization of oligosaccharides
DK2658399T4 (da) 2010-12-31 2024-03-25 Abbott Lab Ernæringssammensætninger omfattende humane mælkeoligosaccharider til anvendelse i behandling og/eller forebyggelse af enterisk rotavirus-infektion
MY191538A (en) 2010-12-31 2022-06-30 Abbott Lab Human milk oligosaccharides to promote growth of beneficial bacteria
BR112013016606A2 (pt) 2010-12-31 2016-09-27 Abbott Lab processos para redução de incidência de tensão oxidante usando oligossacarídeos de leite humano, vitamina c e agentes antiflamatórios
CA2822219C (en) 2010-12-31 2020-12-29 Abbott Laboratories Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides
MY196432A (en) 2010-12-31 2023-04-10 Abbott Lab Methods Of Using Human Milk Oligosaccharides For Improving Airway Respiratory Health
BR112013016903A2 (pt) 2010-12-31 2019-09-24 Abbott Lab oligossacarídeos de leite humano para modular inflamação
BR112013016587A2 (pt) 2010-12-31 2016-09-27 Abbott Lab formulações nutricionais incluindo oligossacarídeos de leite humano e antioxidantes e usos das mesmas
WO2012113404A1 (en) * 2011-02-21 2012-08-30 Glycom A/S Novel glycosyl phosphites
CN103443113A (zh) * 2011-03-18 2013-12-11 格力康公司 新型含岩藻糖的糖类衍生物的合成
EP2522232A1 (en) * 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
WO2012155916A1 (en) * 2011-05-13 2012-11-22 Glycom A/S Manufacture of lacto-n-tetraose
HK1199607A1 (en) 2011-08-29 2015-07-10 Abbott Laboratories Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract
EP2760875A4 (en) * 2011-09-30 2015-08-26 Glycom As SYNTHESIS OF HMO NUCLEAR STRUCTURES
ES2601891T3 (es) 2011-10-18 2017-02-16 Nestec S.A. Composición para su uso en crecimiento cerebral y/o desarrollo cognitivo y/o psicomotor
WO2013091660A1 (en) * 2011-12-23 2013-06-27 Glycom A/S A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof
DE202013012829U1 (de) 2012-06-14 2020-03-04 Glycom A/S Verbesserung der Stabilität und Reinheit sowie Erhöhung der Bioverfügbarkeit von menschlichen Milch-Oligosacchariden oder Vorläufern oder Mischungen davon
ITFI20120143A1 (it) 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
ES2572831T3 (es) 2012-09-14 2016-06-02 Abbott Laboratories Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
DK2708147T3 (da) * 2012-09-14 2020-05-18 Abbott Lab Fremgangsmåder til forøgelse af hjernefunktionalitet under anvendelse af 2-fucosyl-lactose
EP2943500B1 (en) * 2012-11-13 2017-11-08 Glycom A/S Crystalline 3-o-fucosyllactose
DK2999358T3 (en) 2013-05-22 2021-10-11 Glycom As Synthetic mixture of oligosaccharides for the treating a microbiota of a mammal
CN103408609B (zh) * 2013-09-02 2016-01-13 济南尚博生物科技有限公司 一种制备1-S-2,3,4-三-O-苄基-l-硫代吡喃岩藻糖苷的方法
DK3041946T4 (en) 2013-09-06 2025-11-03 Glycom As Fermentative production of oligosaccharides
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
EP2896628B1 (en) * 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
CN104098615A (zh) * 2014-06-09 2014-10-15 华中科技大学 一种以氢氧根离子型的碱为催化剂进行脱酰基化的方法
CN106795193B (zh) 2014-09-12 2021-02-26 巴斯夫欧洲公司 制备2′-o-岩藻糖基乳糖的方法
PL3209673T5 (pl) 2014-10-24 2023-10-23 Glycom A/S Mieszaniny hmo
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
EP3212197A4 (en) 2014-10-29 2018-07-11 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
EP3212198B1 (en) 2014-10-29 2020-12-23 Glycom A/S Synthetic composition and method for promoting mucosal healing
US10500221B2 (en) 2014-12-05 2019-12-10 Glycom A/S Crystalline difucosyllactose
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
EP3229812A4 (en) 2014-12-08 2018-10-03 Glycom A/S Synthetic composition for treating metabolic disorders
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
CN107405354A (zh) 2015-03-05 2017-11-28 格礼卡姆股份公司 治疗急性呼吸道感染的组合物和方法
WO2016157108A1 (en) 2015-03-31 2016-10-06 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
CN107614511B (zh) 2015-06-09 2020-10-23 格礼卡姆股份公司 6’-SL、LNnT和LST c的三元混合物
RU2634707C2 (ru) * 2015-07-23 2017-11-03 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Способ избирательного удаления О-ацетильных защитных групп в присутствии О-бензоильных
ES2886951T3 (es) 2015-09-14 2021-12-21 Glycom As Composición para su uso en la modulación de la microbiota
US10780103B2 (en) 2015-10-28 2020-09-22 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
PL3368046T3 (pl) 2015-10-28 2022-11-28 Glycom A/S Syntetyczna kompozycja i sposób modulowania funkcji mózgu i zachowania
EP3377071B1 (en) 2015-11-17 2024-01-10 Glycom A/S Human milk oligosaccharides for treating antibiotic associated complications
EP3389668A4 (en) 2015-12-15 2019-08-21 Glycom A/S MIXTURE OF HMOS
MX2018009515A (es) * 2016-02-03 2018-09-05 Basf Se Proceso para producir 2'-o-fucosil lactosa.
WO2017144062A1 (en) 2016-02-24 2017-08-31 Glycom A/S Synthetic composition for microbiota modulation
JP2019509285A (ja) * 2016-03-09 2019-04-04 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ２’−ｏ−フコシルラクトースの製造方法
KR101731263B1 (ko) 2016-04-25 2017-05-02 서울대학교 산학협력단 코리네박테리움 글루타미쿰을 이용한 2'-푸코실락토오스의 생산방법
ES2924137T3 (es) 2016-05-05 2022-10-04 Glycom As Composición que comprende HMOS para uso en el tratamiento de la hipersensibilidad y/o dolor visceral mediados por mastocitos
DK3452050T3 (da) 2016-05-05 2023-02-20 Glycom As Composition comprising hmos for the treatment of noninfectious diarrhoea
CN105924480B (zh) * 2016-05-10 2018-09-25 浙江大学 含岩藻糖三糖硫酸酯及其制备方法和应用
US11224605B2 (en) 2016-05-19 2022-01-18 Glycom A/S Synthetic composition
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
WO2018157900A1 (en) 2017-03-01 2018-09-07 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
US11524019B2 (en) 2017-08-21 2022-12-13 Glycom A/S Synthetic composition for reducing allergy symptoms
EP3450443A1 (en) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CN111356461A (zh) 2017-10-04 2020-06-30 加利福尼亚大学董事会 免疫调节性低聚糖
CN111526879A (zh) 2017-11-02 2020-08-11 格礼卡姆股份公司 用于减少或预防疲劳和/或改善注意力或专注力的一种或多种hmo
EP3716984B1 (en) 2017-11-30 2024-03-20 Glycom A/S Mixture of hmos for treating wheat sensitivity
US11602545B2 (en) 2017-12-05 2023-03-14 Glycom A/S Human milk oligosaccharides for treating migraine
WO2019123316A1 (en) 2017-12-22 2019-06-27 Glycom A/S Composition comprising hmos for preventing or reducing nociception
CN108084234A (zh) * 2018-01-23 2018-05-29 佛山科学技术学院 双重随机糖基化合成三糖的方法
US11554131B2 (en) 2018-05-31 2023-01-17 Glycom A/S Mixture of HMOs for treating autoimmune diseases
AU2019362595B2 (en) 2018-10-18 2024-12-19 Basf Se Crystalline form II of 2'-O-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
EP3741770A1 (en) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
EP4065128A4 (en) 2019-11-29 2023-12-20 Glycom A/S MIXTURE OF HMOS TO IMPROVE THE MICROBIOTA OF PREGNANT WOMEN
CN115279778B (zh) 2020-03-12 2025-06-24 格礼卡姆股份公司 2’-fl的结晶
CN111588726A (zh) * 2020-04-28 2020-08-28 南开大学 2′-岩藻糖基乳糖调节宿主肠道菌群及增强肠屏障的应用
EP4255444A4 (en) 2020-12-04 2024-10-16 Glycom A/S Human milk oligosaccharides for use in supporting maturation or improvement of sleeping patterns
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
WO2023099297A1 (en) * 2021-12-02 2023-06-08 Dsm Ip Assets B.V. Synthesis of hmo butyrate
WO2024013393A1 (en) 2022-07-15 2024-01-18 Dsm Ip Assets B.V. Combination of bifidobacterium and fucosylated hmo for use in increasing nmn or nad+
EP4619409A1 (en) * 2022-11-15 2025-09-24 Ecole Polytechnique Federale De Lausanne (Epfl) Method for preparing an at least partially acetal-protected sugar
WO2025196273A1 (en) 2024-03-22 2025-09-25 Dsm Ip Assets B.V. Combination of mixtures of hmos with mfgm and their use
WO2025196272A1 (en) 2024-03-22 2025-09-25 Dsm Ip Assets B.V. Combination of mixtures of hmos with mfgm and their use
WO2025219496A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. Nutritional composition comprising bifidobacterium longum ssp. infantis r0033 and human milk oligosaccharides
WO2025219497A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. Combination comprising bifidobacterium bifidum ha-132 and human milk oligosaccharides
WO2025219495A1 (en) 2024-04-19 2025-10-23 Dsm Ip Assets B.V. A nutritional composition comprising bifidobacterium bifidum r0071 and human milk oligosaccharides

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CN1072677C (zh) * 1998-07-17 2001-10-10 中国科学院生态环境研究中心 二糖及三糖原酸酯及其合成方法
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Also Published As

Publication number Publication date
WO2010115934A1 (en) 2010-10-14
AU2010233770A1 (en) 2011-10-27
EP2417144A1 (en) 2012-02-15
EP2417143A1 (en) 2012-02-15
ZA201107336B (en) 2014-03-26
US9012625B2 (en) 2015-04-21
EP2417143B1 (en) 2016-12-21
US20130131334A1 (en) 2013-05-23
EP2417144B1 (en) 2017-08-23
IL215270A0 (en) 2011-11-30
JP2012522827A (ja) 2012-09-27
RU2011144838A (ru) 2013-05-20
CN102459295A (zh) 2012-05-16
KR20120022875A (ko) 2012-03-12
CA2758097A1 (en) 2010-10-14
CN102459294A (zh) 2012-05-16
MX2011010214A (es) 2012-01-20
US20120116065A1 (en) 2012-05-10
WO2010115935A1 (en) 2010-10-14
US8927698B2 (en) 2015-01-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.11 NA RPI 2333 DE 22/09/2015