BRPI1014277A2 - método para melhorar o perfil de dissolução de um material biologicamente ativo - Google Patents

método para melhorar o perfil de dissolução de um material biologicamente ativo

Info

Publication number
BRPI1014277A2
BRPI1014277A2 BRPI1014277A BRPI1014277A BRPI1014277A2 BR PI1014277 A2 BRPI1014277 A2 BR PI1014277A2 BR PI1014277 A BRPI1014277 A BR PI1014277A BR PI1014277 A BRPI1014277 A BR PI1014277A BR PI1014277 A2 BRPI1014277 A2 BR PI1014277A2
Authority
BR
Brazil
Prior art keywords
improving
active material
biologically active
dissolution profile
dissolution
Prior art date
Application number
BRPI1014277A
Other languages
English (en)
Inventor
Aaron Dodd
Adrian Russell
Felix Meiser
Matt Callahan
Marck Norret
William H Bosch
Original Assignee
Iceutica Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009901741A external-priority patent/AU2009901741A0/en
Application filed by Iceutica Pty Ltd filed Critical Iceutica Pty Ltd
Publication of BRPI1014277A2 publication Critical patent/BRPI1014277A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12Powders or granules
    • A01N25/14Powders or granules wettable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/4211,3-Oxazoles, e.g. pemoline, trimethadione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Dentistry (AREA)
  • Toxicology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Disintegrating Or Milling (AREA)
BRPI1014277A 2009-04-24 2010-04-23 método para melhorar o perfil de dissolução de um material biologicamente ativo BRPI1014277A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17230109P 2009-04-24 2009-04-24
AU2009901741A AU2009901741A0 (en) 2009-04-24 Method for Improving the Dissolution Profile of a Biologically Active Material
PCT/AU2010/000465 WO2010121321A1 (en) 2009-04-24 2010-04-23 Method for improving the dissolution profile of a biologically active material

Publications (1)

Publication Number Publication Date
BRPI1014277A2 true BRPI1014277A2 (pt) 2016-10-18

Family

ID=43010604

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014277A BRPI1014277A2 (pt) 2009-04-24 2010-04-23 método para melhorar o perfil de dissolução de um material biologicamente ativo

Country Status (21)

Country Link
US (6) US20120165323A1 (pt)
EP (1) EP2421516A4 (pt)
JP (3) JP5898613B2 (pt)
KR (3) KR20120047207A (pt)
CN (3) CN102438600A (pt)
AP (2) AP2015008965A0 (pt)
AU (2) AU2010239160B2 (pt)
BR (1) BRPI1014277A2 (pt)
CA (1) CA2759104C (pt)
CO (1) CO6470804A2 (pt)
EA (1) EA201171280A1 (pt)
IL (1) IL215871B (pt)
MA (1) MA33293B1 (pt)
MX (1) MX360545B (pt)
MY (1) MY163538A (pt)
NZ (1) NZ595972A (pt)
PH (1) PH12015501781A1 (pt)
SG (1) SG175308A1 (pt)
UA (1) UA110772C2 (pt)
WO (1) WO2010121321A1 (pt)
ZA (1) ZA201108647B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007264418B2 (en) 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
MX360019B (es) * 2009-04-24 2018-10-15 Iceutica Pty Ltd Una formulación novedosa de metaxalona.
SG10201607849TA (en) * 2009-04-24 2016-11-29 Iceutica Pty Ltd Production of encapsulated nanoparticles at commercial scale
CN102438594A (zh) 2009-04-24 2012-05-02 伊休蒂卡有限公司 吲哚美辛的新剂型
EA201171284A1 (ru) * 2009-04-24 2012-05-30 Айсьютика Пти Лтд. Новая технология изготовления напроксена
AP3138A (en) * 2009-04-24 2015-02-28 Iceutica Pty Ltd Production of encapsulated nanoparticles at high volume fractions
JP5898613B2 (ja) * 2009-04-24 2016-04-06 イシューティカ ピーティーワイ リミテッド 生物学的活性物質の溶解プロファイルを改善するための方法
US10369108B2 (en) * 2013-03-15 2019-08-06 Mylan Laboratories, Inc. Hot melt granulation formulations of poorly water-soluble active agents
US20150157646A1 (en) 2013-09-27 2015-06-11 Iceutica Inc. Abiraterone Steroid Formulation
CN104644556B (zh) * 2013-11-22 2018-05-22 沈阳药科大学 盐酸依福地平固体粉末及其制备方法
AU2015200340B2 (en) * 2014-02-05 2019-01-24 Upl Limited Combinations
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
US11175268B2 (en) 2014-06-09 2021-11-16 Biometry Inc. Mini point of care gas chromatographic test strip and method to measure analytes
CN106537128B (zh) 2014-06-09 2021-06-18 生物统计股份有限公司 用于测量分析物的低成本测试条和方法
EP3310344A1 (en) * 2015-06-19 2018-04-25 Biotie Therapies, Inc. Controlled-release tozadenant formulations
ES2881435T3 (es) * 2015-10-23 2021-11-29 Basf Se Soluciones sólidas de sustancias odorantes y aromatizantes con polímeros de vinilactama
CN105385739B (zh) * 2015-12-09 2017-09-29 梁尚文 -种从金边蚂蟥中制取蛋白肽的方法
CN114859028A (zh) 2016-07-19 2022-08-05 生物统计股份有限公司 使用批量可校准测试条测量分析物的方法和系统
CN107853670A (zh) * 2017-10-30 2018-03-30 潍坊友容实业有限公司 一种盐地碱蓬生物盐提取方法
CN108379238B (zh) * 2018-01-17 2020-07-14 南昌大学 一种储存物理稳定性好的环孢素固体脂质纳米粒及其制备方法
KR102843054B1 (ko) 2018-05-11 2025-08-05 난징 델로바 바이오테크 컴퍼니 리미티드 멜록시캄 조성물, 제제 및 이의 제조 방법 및 응용
AU2019332696A1 (en) * 2018-08-31 2021-03-18 Kemin Industries, Inc. Technology for water dispersible phospholipids and lysophospholipids
JP2022504250A (ja) * 2018-10-05 2022-01-13 アンパサンド バイオファーマシューティカルズ インコーポレイテッド ケトンの経皮投与のための製剤および方法
US11197830B2 (en) * 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen
CN113133970A (zh) * 2020-01-17 2021-07-20 美国琛蓝营养制品股份有限公司 一种姜黄素复合物及其制备方法和检测方法
US20230173073A1 (en) * 2020-06-25 2023-06-08 Omya International Ag Co-ground active(s) comprising product comprising surface-reacted calcium carbonate
TR202017034A2 (tr) * 2020-10-26 2021-09-21 Hacettepe Ueniversitesi Rektoerluek Kuru öğütme yöntemi̇ i̇le hazirlanan ve çözünme hizi arttirilmiş selekoksi̇b i̇çeren farmasöti̇k kompozi̇syonlar
CN114306253B (zh) * 2021-11-16 2023-08-22 扬子江药业集团广州海瑞药业有限公司 格列美脲片剂及其制备方法
JP7745851B2 (ja) * 2021-12-24 2025-09-30 日本乳化剤株式会社 精製イオン液体の製造方法、セルロース溶解液および再生セルロース繊維の製造方法、ならびに繊維組成物および有機繊維コード
CN113996161B (zh) * 2021-12-30 2022-04-19 河北鑫鹏新材料科技有限公司 一种硫转移剂及其制备方法和应用
CN114732009B (zh) * 2022-06-13 2022-08-23 山东百农思达生物科技有限公司 一种含有吡唑醚菌酯和烯酰吗啉的水分散粒剂的制备方法
CN116196273B (zh) * 2023-03-31 2025-04-29 江苏慧聚药业股份有限公司 一种美洛昔康注射液及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2642486B2 (ja) * 1989-08-04 1997-08-20 田辺製薬株式会社 難溶性薬物の超微粒子化法
AU660852B2 (en) * 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
JP4117811B2 (ja) * 1997-04-22 2008-07-16 日本化薬株式会社 フルタミド製剤及びその製法
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
JP4969761B2 (ja) * 2000-08-31 2012-07-04 オバン・エナジー・リミテッド 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法
JP2004099442A (ja) * 2002-09-04 2004-04-02 Nisshin Pharma Inc 難溶性薬物含有製剤およびその製造方法
EP1830824B1 (en) * 2004-12-31 2016-01-13 Iceutica Pty Ltd. Nanoparticle composition and methods for synthesis thereof
DK1973527T3 (da) * 2005-12-15 2010-02-01 Acusphere Inc Fremgangsmåder til fremstilling af partikelbaserede farmaceutiske formulationer til parenteral indgivelse
CA2631493A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
AU2007264418B2 (en) * 2006-06-30 2012-05-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
NZ705763A (en) * 2006-06-30 2016-10-28 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
JP5898613B2 (ja) * 2009-04-24 2016-04-06 イシューティカ ピーティーワイ リミテッド 生物学的活性物質の溶解プロファイルを改善するための方法
CN102438594A (zh) * 2009-04-24 2012-05-02 伊休蒂卡有限公司 吲哚美辛的新剂型
KR101580656B1 (ko) * 2009-04-24 2015-12-30 아이슈티카 피티와이 리미티드 디클로페낙의 신규 제형

Also Published As

Publication number Publication date
CO6470804A2 (es) 2012-06-29
KR20160098535A (ko) 2016-08-18
MY163538A (en) 2017-09-15
IL215871B (en) 2019-07-31
US20130277468A1 (en) 2013-10-24
MX360545B (es) 2018-10-26
KR101679522B1 (ko) 2016-11-24
JP6619386B2 (ja) 2019-12-11
CN102438600A (zh) 2012-05-02
JP2015199736A (ja) 2015-11-12
NZ595972A (en) 2014-01-31
SG175308A1 (en) 2011-11-28
WO2010121321A1 (en) 2010-10-28
MA33293B1 (fr) 2012-05-02
CA2759104A1 (en) 2010-10-28
JP2012524717A (ja) 2012-10-18
JP2017222643A (ja) 2017-12-21
MX2011011217A (es) 2012-02-08
US20250049720A1 (en) 2025-02-13
CN103830243A (zh) 2014-06-04
AP2015008965A0 (en) 2016-01-31
EP2421516A1 (en) 2012-02-29
KR20120047207A (ko) 2012-05-11
AU2015243003A1 (en) 2017-05-04
AP3629A (en) 2016-03-08
UA110772C2 (uk) 2016-02-25
EP2421516A4 (en) 2012-11-07
ZA201108647B (en) 2013-01-30
US20120165323A1 (en) 2012-06-28
CA2759104C (en) 2019-01-29
US20180169018A1 (en) 2018-06-21
US20200375903A1 (en) 2020-12-03
AU2010239160B2 (en) 2014-10-02
PH12015501781A1 (en) 2016-10-03
AP2011005994A0 (en) 2011-12-31
JP5898613B2 (ja) 2016-04-06
IL215871A0 (en) 2012-01-31
EA201171280A1 (ru) 2012-09-28
US20210401753A1 (en) 2021-12-30
KR101873500B1 (ko) 2018-08-02
KR20150013948A (ko) 2015-02-05
CN104825396A (zh) 2015-08-12
AU2010239160A1 (en) 2011-11-10

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