BRPI1014390A2 - composto de sal de amônio quaternário, composição medicinal, e, agente preventivo ou terapêutico - Google Patents

composto de sal de amônio quaternário, composição medicinal, e, agente preventivo ou terapêutico

Info

Publication number
BRPI1014390A2
BRPI1014390A2 BRPI1014390A BRPI1014390A BRPI1014390A2 BR PI1014390 A2 BRPI1014390 A2 BR PI1014390A2 BR PI1014390 A BRPI1014390 A BR PI1014390A BR PI1014390 A BRPI1014390 A BR PI1014390A BR PI1014390 A2 BRPI1014390 A2 BR PI1014390A2
Authority
BR
Brazil
Prior art keywords
preventative
therapeutic agent
quaternary ammonium
ammonium salt
salt compound
Prior art date
Application number
BRPI1014390A
Other languages
English (en)
Inventor
Etsuko Mitsuyama
Hiroyuki Sugiyama
Johji Nomura
Junji Igarashi
Kei Segawa
Satoshi Yamamura
Takayuki Hara
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of BRPI1014390A2 publication Critical patent/BRPI1014390A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1014390A 2009-04-30 2010-04-27 composto de sal de amônio quaternário, composição medicinal, e, agente preventivo ou terapêutico BRPI1014390A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009110760 2009-04-30
PCT/JP2010/057422 WO2010126025A1 (ja) 2009-04-30 2010-04-27 四級アンモニウム塩化合物

Publications (1)

Publication Number Publication Date
BRPI1014390A2 true BRPI1014390A2 (pt) 2016-04-05

Family

ID=43032170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014390A BRPI1014390A2 (pt) 2009-04-30 2010-04-27 composto de sal de amônio quaternário, composição medicinal, e, agente preventivo ou terapêutico

Country Status (17)

Country Link
US (1) US9072734B2 (pt)
EP (1) EP2426121A4 (pt)
JP (1) JP5379224B2 (pt)
KR (1) KR20120061061A (pt)
CN (1) CN102459231B (pt)
AR (1) AR078121A1 (pt)
AU (1) AU2010242646A1 (pt)
BR (1) BRPI1014390A2 (pt)
CA (1) CA2760630A1 (pt)
IL (1) IL216015A0 (pt)
MX (1) MX2011011446A (pt)
MY (1) MY155212A (pt)
NZ (1) NZ595810A (pt)
SG (1) SG177468A1 (pt)
TW (1) TWI486343B (pt)
WO (1) WO2010126025A1 (pt)
ZA (1) ZA201108372B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20110083U1 (it) 2010-05-13 2011-11-14 De La Cruz Jose Antonio Freire Piastra per la costruzione di carrelli per aeroplani
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
ME02297B (me) * 2011-06-10 2016-02-20 Chiesi Farm Spa Jedinjenja koja imaju aktivnost antagonista muskarinskih receptora i agonist beta2 adrenergičnog receptora
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
BR112015012730B1 (pt) * 2012-12-06 2022-07-05 Chiesi Farmaceutici S.P.A. Composto, composição farmaceutica, dispositivo, uso de um composto e combinação
MA38260B1 (fr) 2012-12-18 2018-04-30 Almirall Sa Nouveaux dérivés de cyclohexyl et quinuclidinyl carbamate ayant une activité d'agoniste adrénergique beta2 et une activité d'antagoniste muscarinique m3
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有maba化合物和皮質類固醇之組合
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽
KR20160148589A (ko) * 2014-04-25 2016-12-26 바이엘 크롭사이언스 악티엔게젤샤프트 루테늄 촉매반응에 의한 아닐리드로부터 비페닐아민의 제조방법
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物
CN104557589A (zh) * 2014-12-24 2015-04-29 天津大学 N-(1,1’-二芳基)取代的酰胺类衍生物的制备方法
CN107108502A (zh) * 2015-05-14 2017-08-29 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的联苯衍生物及其在医药上的用途
CN107108562B (zh) * 2015-05-14 2020-07-10 四川海思科制药有限公司 具有β2受体激动及M受体拮抗活性的含氮杂螺环衍生物及其在医药上的用途
RU2722720C1 (ru) * 2016-12-14 2020-06-03 Бейджинг Шоубай Фармасьютикэл Ко., Лтд. Класс бифункциональных соединений со структурой соли четвертичного аммония
CN108854841B (zh) * 2018-06-25 2020-09-29 长治学院 一种连接基含酯基的吡咯烷类手性Gemini表面活性剂及其制备方法
US11841822B2 (en) 2019-04-27 2023-12-12 Cambricon Technologies Corporation Limited Fractal calculating device and method, integrated circuit and board card
WO2020220935A1 (zh) 2019-04-27 2020-11-05 中科寒武纪科技股份有限公司 运算装置
CN111217746B (zh) * 2020-03-10 2021-09-24 佛山市隆信医药科技有限公司 一种盐酸丙卡特罗的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3240784A (en) * 1966-03-15 Esters of quaternary z-hydroxy methyl piperidinium compounds
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
WO2004007426A1 (en) 2002-07-17 2004-01-22 Chiang Long Y Fullerene compounds
CN101239971B (zh) * 2003-02-14 2011-07-20 施万制药 联苯衍生物
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
JP4767842B2 (ja) 2003-04-01 2011-09-07 セラヴァンス, インコーポレーテッド β2アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物
CA2638788A1 (en) 2003-04-25 2004-11-11 Kos Life Sciences, Inc. Formation of strong superporous hydrogels
DE602004021921D1 (de) 2003-05-28 2009-08-20 Theravance Inc Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
EP1656370B1 (en) * 2003-06-03 2012-08-15 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
PE20050231A1 (es) * 2003-06-24 2005-05-20 Novartis Ag Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3
TW200534855A (en) 2004-01-13 2005-11-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
WO2007107828A2 (en) 2006-03-20 2007-09-27 Pfizer Limited Amine derivatives
GB0702413D0 (en) 2007-02-07 2007-03-21 Argenta Discovery Ltd New chemical compounds
PL2242759T3 (pl) 2008-02-06 2013-06-28 Astrazeneca Ab Związki

Also Published As

Publication number Publication date
MY155212A (en) 2015-09-30
CN102459231A (zh) 2012-05-16
TWI486343B (zh) 2015-06-01
US20120046467A1 (en) 2012-02-23
IL216015A0 (en) 2012-01-31
AR078121A1 (es) 2011-10-19
WO2010126025A1 (ja) 2010-11-04
JP5379224B2 (ja) 2013-12-25
TW201103909A (en) 2011-02-01
ZA201108372B (en) 2012-07-25
EP2426121A1 (en) 2012-03-07
CA2760630A1 (en) 2010-11-04
KR20120061061A (ko) 2012-06-12
AU2010242646A1 (en) 2011-11-03
JPWO2010126025A1 (ja) 2012-11-01
NZ595810A (en) 2013-05-31
SG177468A1 (en) 2012-02-28
US9072734B2 (en) 2015-07-07
HK1166790A1 (en) 2012-11-09
CN102459231B (zh) 2015-04-22
MX2011011446A (es) 2011-11-18
EP2426121A4 (en) 2012-10-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]