CA1011333A - (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation - Google Patents

(4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation

Info

Publication number
CA1011333A
CA1011333A CA194,513A CA194513A CA1011333A CA 1011333 A CA1011333 A CA 1011333A CA 194513 A CA194513 A CA 194513A CA 1011333 A CA1011333 A CA 1011333A
Authority
CA
Canada
Prior art keywords
benzodiazepines
triazolo
dihydro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA194,513A
Other languages
English (en)
Other versions
CA194513S (en
Inventor
Etienne Szarvasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7308510A external-priority patent/FR2220257A1/fr
Priority claimed from FR7335522A external-priority patent/FR2246273A2/fr
Priority claimed from FR7341583A external-priority patent/FR2252102A2/fr
Application filed by LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA Liyonnaise Industrielle Pharmaceutique
Application granted granted Critical
Publication of CA1011333A publication Critical patent/CA1011333A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA194,513A 1973-03-09 1974-03-08 (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation Expired CA1011333A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7308510A FR2220257A1 (en) 1973-03-09 1973-03-09 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7335522A FR2246273A2 (en) 1973-10-04 1973-10-04 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects
FR7341583A FR2252102A2 (en) 1973-11-22 1973-11-22 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects

Publications (1)

Publication Number Publication Date
CA1011333A true CA1011333A (en) 1977-05-31

Family

ID=27250074

Family Applications (1)

Application Number Title Priority Date Filing Date
CA194,513A Expired CA1011333A (en) 1973-03-09 1974-03-08 (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation

Country Status (13)

Country Link
US (1) US4110337A (de)
JP (1) JPS49125395A (de)
CA (1) CA1011333A (de)
CH (1) CH589084A5 (de)
DD (1) DD110497A5 (de)
DE (1) DE2409308C3 (de)
DK (1) DK139099B (de)
ES (1) ES424067A1 (de)
GB (1) GB1409693A (de)
IE (1) IE38931B1 (de)
IL (1) IL44338A (de)
NL (1) NL7403247A (de)
NO (1) NO139048C (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076823A (en) * 1977-08-18 1978-02-28 E. R. Squibb & Sons, Inc. Triazolo-2,4-benzodiazepines
ES2139595T3 (es) * 1991-04-23 2000-02-16 Toray Industries Derivados triazolicos triciclicos, fabricacion de los mismos y su utilizacion.
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
FR2769309B1 (fr) 1997-10-08 2001-06-15 Oreal Composition de teinture d'oxydation des fibres keratiniques comprenant un derive d'aminoacide en tant que base d'oxydation et nouveaux derives d'aminoacides
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP5127096B2 (ja) 1999-04-30 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用
US7144880B2 (en) 1999-04-30 2006-12-05 Regents Of The University Of Michigan Compositions relating to novel compounds and targets thereof
US7276348B2 (en) * 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US20050113460A1 (en) * 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP2008528448A (ja) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
JP2008545757A (ja) 2005-06-01 2008-12-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 溶媒和されていないベンゾジアゼピン組成物および方法
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
EP1948191B1 (de) 2005-11-01 2013-01-16 The Regents of the University of Michigan Neuartige 1,4-benzodiazepin-2,5-dione mit therapeutischen eigenschaften
DE102005061840A1 (de) 2005-12-23 2007-06-28 Merck Patent Gmbh Triazolderivate
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2418206A3 (de) 2006-06-09 2012-06-27 The Regents of the University of Michigan Benzodiazepin-derivate zur behandlung von autoimmunerkrankungen
KR101164718B1 (ko) 2007-03-09 2012-07-11 더 리젠츠 오브 더 유니버시티 오브 미시간 신규 화합물 및 이의 표적에 관한 조성물 및 방법
MX2010002732A (es) 2007-09-14 2010-06-02 Univ Michigan Inhibidores de f1f0-atpasa y metodos relacionados.
CN101918375A (zh) 2007-11-06 2010-12-15 密歇根大学董事会 在皮肤病症的治疗中有用的苯并二氮杂*酮化合物
US8497307B2 (en) 2008-09-11 2013-07-30 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
EP2470020A4 (de) 2009-09-18 2013-03-13 Univ Michigan Benzodiazepinonverbindungen und behandlungsverfahren damit
WO2011062765A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
JP5856064B2 (ja) 2009-11-17 2016-02-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
PL3157928T3 (pl) 2014-06-20 2019-07-31 Constellation Pharmaceuticals, Inc. Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681343A (en) * 1971-05-11 1972-08-01 Upjohn Co 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines

Also Published As

Publication number Publication date
AU6627674A (en) 1975-09-11
DE2409308A1 (de) 1974-09-19
IE38931L (en) 1974-09-09
JPS49125395A (de) 1974-11-30
DK139099C (de) 1979-05-28
ES424067A1 (es) 1976-06-01
NL7403247A (de) 1974-09-11
US4110337A (en) 1978-08-29
IL44338A0 (en) 1974-06-30
IE38931B1 (en) 1978-07-05
DE2409308C3 (de) 1978-05-18
CH589084A5 (de) 1977-06-30
NO139048B (no) 1978-09-18
NO740833L (no) 1974-09-10
DE2409308B2 (de) 1977-09-22
GB1409693A (en) 1975-10-15
DK139099B (da) 1978-12-18
NO139048C (no) 1979-01-03
DD110497A5 (de) 1974-12-20
IL44338A (en) 1977-01-31

Similar Documents

Publication Publication Date Title
CA1011333A (en) (4h)-5,6-dihydro-(4,3-a)-s-triazolo-1,5-benzodiazepines and their process of preparation
IL45289A0 (en) Preparation of benzodiazepines
CA1010866A (en) Preparation of quinazolines
CS189872B1 (en) Derivatives of pyrido/1,2a/pyrimidine and process for preparing thereof
CA1034125A (en) Pyrimido benzodiazepines
CA1028705A (en) Preparation of 2-aryl-as-triazine-3,5(2h,4h)-diones
AU476794B2 (en) Method for the preparation of phthalazino [2,3-b] phthalazine-5 (14h), 12(7h)-dione
IE38686L (en) 3-hydrazonomethyl rifamycin
ZA742961B (en) 7-(substituted phenylglycinamido)-3-substituted-3-cephem-4-carboxylic acid derivatives and preparation thereof
AU3800472A (en) PROCESS FORTHE PREPARATION OF 10, 11 DIHYDRODIBENZO [b, i] AZEPINONES
IL44304A0 (en) Pyrido(3,4-e)-as-triazine derivatives and their preparation
GR60851B (en) Preparation process of pyrrolo(2,1-b)(3)benzozazepines
CA1033730A (en) Preparation of benzodiazepine derivatives
SU576933A3 (ru) Способ получени фталазино (2,3-в) фталазин-5(14н), 12(7н)-диона
AU484413B2 (en) Process forthe preparation of 2, 4, 6 trimethyephenol
CA1011337A (en) Piperazine derivatives and their process of preparation
CA1033740A (en) Preparation of 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-derivatives
IL45343A0 (en) Process for the preparation of benzo-diazepine derivatives
AU476528B2 (en) Novel benzodiazepines and their preparation
CH612435A5 (en) Process for the preparation of 1-aminomethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine compounds
IL44305A0 (en) Pyrido(3,4-e)-as-triazine derivatives and their preparation
CA1001621A (en) Production of benzodiazepines
AU483190B2 (en) Triazolo [4,3-a] [1,4] benzodiazepines
AU480183B2 (en) Preparation of block polymers
AU487602B2 (en) 2-substituted-1,2,4-thiadiazolo-(2,3-a)- benzimidazoles and process for their preparation