CA1050427A - Preparation pharmaceutique contenant de la sapogenine, principe actif de l'hellebore - Google Patents

Preparation pharmaceutique contenant de la sapogenine, principe actif de l'hellebore

Info

Publication number: CA1050427A
Authority: CA; Canada
Prior art keywords: roots; rhizomes; principal; helleborus; sapogenin
Prior art date: 1974-04-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA224,029A

Other languages

English (en)

Other versions

CA224029S (en

Inventor

Otto Isaac

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Evonik Operations GmbH

Original Assignee

Deutsche Gold und Silber Scheideanstalt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-08

Filing date

1975-04-08

Publication date

1979-03-13

1974-04-08 Priority claimed from DE2416978A external-priority patent/DE2416978A1/de

1974-04-08 Priority claimed from DE2416979A external-priority patent/DE2416979C3/de

1975-04-08 Application filed by Deutsche Gold und Silber Scheideanstalt filed Critical Deutsche Gold und Silber Scheideanstalt

1979-03-13 Application granted granted Critical

1979-03-13 Publication of CA1050427A publication Critical patent/CA1050427A/fr

Status Expired legal-status Critical Current

Links

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239000003651 drinking water Substances 0.000 description 1
235000020188 drinking water Nutrition 0.000 description 1
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239000000469 ethanolic extract Substances 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
125000005912 ethyl carbonate group Chemical class 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
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239000007888 film coating Substances 0.000 description 1
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235000004515 gallic acid Nutrition 0.000 description 1
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239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229940116364 hard fat Drugs 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N iso-butyl alcohol Natural products CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 1
229940035429 isobutyl alcohol Drugs 0.000 description 1
SXQFCVDSOLSHOQ-UHFFFAOYSA-N lactamide Chemical class CC(O)C(N)=O SXQFCVDSOLSHOQ-UHFFFAOYSA-N 0.000 description 1
150000003893 lactate salts Chemical class 0.000 description 1
235000019421 lipase Nutrition 0.000 description 1
230000002879 macerating effect Effects 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000010933 magnesium salts of fatty acid Nutrition 0.000 description 1
239000001778 magnesium salts of fatty acids Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 1
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000002156 mixing Methods 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
235000014593 oils and fats Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
208000011906 peptic ulcer disease Diseases 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
229960003424 phenylacetic acid Drugs 0.000 description 1
229960004838 phosphoric acid Drugs 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
HBDHXDBPCVDGQN-FPLPWBNLSA-N propan-2-yl (z)-tetradec-9-enoate Chemical compound CCCC\C=C/CCCCCCCC(=O)OC(C)C HBDHXDBPCVDGQN-FPLPWBNLSA-N 0.000 description 1
239000012264 purified product Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
150000004671 saturated fatty acids Chemical class 0.000 description 1
230000028043 self proteolysis Effects 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000004296 sodium metabisulphite Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000000891 standard diet Nutrition 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000001117 sulphuric acid Substances 0.000 description 1
235000011149 sulphuric acid Nutrition 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
229910052905 tridymite Inorganic materials 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1
150000003738 xylenes Chemical class 0.000 description 1

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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA224,029A 1974-04-08 1975-04-08 Preparation pharmaceutique contenant de la sapogenine, principe actif de l'hellebore Expired CA1050427A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2416978A DE2416978A1 (de)	1974-04-08	1974-04-08	Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff
DE2416979A DE2416979C3 (de)	1974-04-08	1974-04-08	Verfahren zur Gewinnung des in den Wurzeln und Rhizomen von Helleborus-Arten enthaltenen Hauptsapogenins

Publications (1)

Publication Number	Publication Date
CA1050427A true CA1050427A (fr)	1979-03-13

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CA224,029A Expired CA1050427A (fr)	1974-04-08	1975-04-08	Preparation pharmaceutique contenant de la sapogenine, principe actif de l'hellebore

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Cited By (1)

* Cited by examiner, † Cited by third party
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CN121445860A (zh) *	2025-12-22	2026-02-03	北京工科生科技有限公司	一种水溶性免疫复合佐剂、疫苗及其制备方法

1975
- 1975-04-08 CA CA224,029A patent/CA1050427A/fr not_active Expired

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN121445860A (zh) *	2025-12-22	2026-02-03	北京工科生科技有限公司	一种水溶性免疫复合佐剂、疫苗及其制备方法

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CA1050427A - Preparation pharmaceutique contenant de la sapogenine, principe actif de l'hellebore - Google Patents

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Applications Claiming Priority (2)

Publications (1)

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ID=25766942

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Country Status (1)

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