CA1056381A - 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES - Google Patents

5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Info

Publication number
CA1056381A
CA1056381A CA223,250A CA223250A CA1056381A CA 1056381 A CA1056381 A CA 1056381A CA 223250 A CA223250 A CA 223250A CA 1056381 A CA1056381 A CA 1056381A
Authority
CA
Canada
Prior art keywords
fluoro
process according
hydrogen
chloro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA223,250A
Other languages
English (en)
Other versions
CA223250S (en
Inventor
Jacob J. Plattner
James R. Tretter
Charles A. Harbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Priority to CA314,650A priority Critical patent/CA1067497A/fr
Application granted granted Critical
Publication of CA1056381A publication Critical patent/CA1056381A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA223,250A 1974-04-01 1975-03-27 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES Expired CA1056381A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA314,650A CA1067497A (fr) 1974-04-01 1978-10-27 LES 5-PHENYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45664074A 1974-04-01 1974-04-01

Publications (1)

Publication Number Publication Date
CA1056381A true CA1056381A (fr) 1979-06-12

Family

ID=23813560

Family Applications (1)

Application Number Title Priority Date Filing Date
CA223,250A Expired CA1056381A (fr) 1974-04-01 1975-03-27 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Country Status (6)

Country Link
JP (3) JPS5874682A (fr)
BE (1) BE827451A (fr)
CA (1) CA1056381A (fr)
GB (1) GB1476087A (fr)
IE (1) IE41352B1 (fr)
ZA (1) ZA751990B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004063818A (ja) 2002-07-30 2004-02-26 Oki Electric Ind Co Ltd フレキシブルチューブを利用した半導体装置の製造方法
RU2591194C2 (ru) 2010-04-22 2016-07-10 Интра-Селлулар Терапиз, Инк. Органические соединения
JP2015514135A (ja) 2012-04-14 2015-05-18 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規組成物および方法
DK2968320T3 (da) 2013-03-15 2021-02-01 Intra Cellular Therapies Inc Organiske forbindelser
CA3148303C (fr) 2013-12-03 2024-02-27 Intra-Cellular Therapies, Inc. Composes de gamma-carboline fusionnes heterocycliques pour l'utilisation dans le traitement des troubles bipolaires
CA2944755A1 (fr) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Composes organiques
CA2944512C (fr) 2014-04-04 2018-04-24 Intra-Cellular Therapies, Inc. Carbolines gamma fusionnees heterocycliques destinees au traitement de troubles du systeme nerveux central
PT3407888T (pt) 2016-01-26 2021-03-19 Intra Cellular Therapies Inc Compostos de piridopirroloquinoxalina, suas composições e utilizações
SI3407889T1 (sl) 2016-03-25 2021-09-30 Intra-Cellular Therapies, Inc. Organske spojine in njihova uporaba v zdravljenju ali preprečevanju motenj centralnega živčnega sistema
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018126143A1 (fr) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
WO2018126140A1 (fr) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
IL304026B2 (en) 2017-03-24 2024-11-01 Intra Cellular Therapies Inc A pharmaceutical preparation containing 1-(4-fluoro-phenyl)-4-((Sa10,Rb6)-3-D2-2,2-methyl-2, 3, a10, 10, 9, b6- hexahydro-H7, H1- Pyrido[3',4',:4,5]pyrrolo[3,2,1-de]quioxalin-8-yl)-butan-1-one and its uses
JP7223742B2 (ja) 2017-07-26 2023-02-16 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US11427587B2 (en) 2017-07-26 2022-08-30 Intra-Cellular Therapies, Inc. Organic compounds
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
IL277504B1 (en) 2018-03-23 2026-02-01 Intra Cellular Therapies Inc Deuterium-converted ((sa10,rb6)-8-(3-(4-fluorophenoxy)propyl 6b, 7, 8, 9, 10, 10a-hexahydro-1h-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-82(h3)-one compounds, pharmaceutical composition containing them and their uses
WO2019237037A1 (fr) 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Nouvelles méthodes
DK3609891T3 (da) 2018-06-11 2026-02-23 Intra Cellular Therapies Inc Syntese af substituerede heterocykliske fusionerede gamma-carboliner
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
AU2019328528B2 (en) 2018-08-31 2025-01-23 Intra-Cellular Therapies, Inc. Novel methods
MX2021002321A (es) 2018-08-31 2021-04-28 Intra Cellular Therapies Inc Nuevos metodos.
EP3898580A4 (fr) 2018-12-17 2022-08-10 Intra-Cellular Therapies, Inc. Synthèse de gamma-carbolines fusionnées à hétérocycles substitués
ES3047409T3 (en) 2018-12-17 2025-12-03 Intra Cellular Therapies Inc Substituted heterocycle fused gamma-carbolines synthesis
WO2020132474A1 (fr) 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Composé organique
CN114072150A (zh) 2019-07-07 2022-02-18 细胞内治疗公司 新方法
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
CN116425670A (zh) * 2022-07-15 2023-07-14 英矽智能科技(上海)有限公司 作为tead抑制剂的新型杂环化合物

Also Published As

Publication number Publication date
JPS5874682A (ja) 1983-05-06
IE41352L (en) 1975-10-01
JPS5874681A (ja) 1983-05-06
GB1476087A (en) 1977-06-10
JPS5915911B2 (ja) 1984-04-12
BE827451A (fr) 1975-10-01
IE41352B1 (en) 1979-12-19
ZA751990B (en) 1976-02-25
JPS5874683A (ja) 1983-05-06

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