CA1056381A - 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES - Google Patents
5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINESInfo
- Publication number
- CA1056381A CA1056381A CA223,250A CA223250A CA1056381A CA 1056381 A CA1056381 A CA 1056381A CA 223250 A CA223250 A CA 223250A CA 1056381 A CA1056381 A CA 1056381A
- Authority
- CA
- Canada
- Prior art keywords
- fluoro
- process according
- hydrogen
- chloro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA314,650A CA1067497A (fr) | 1974-04-01 | 1978-10-27 | LES 5-PHENYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45664074A | 1974-04-01 | 1974-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1056381A true CA1056381A (fr) | 1979-06-12 |
Family
ID=23813560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA223,250A Expired CA1056381A (fr) | 1974-04-01 | 1975-03-27 | 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES |
Country Status (6)
| Country | Link |
|---|---|
| JP (3) | JPS5874683A (fr) |
| BE (1) | BE827451A (fr) |
| CA (1) | CA1056381A (fr) |
| GB (1) | GB1476087A (fr) |
| IE (1) | IE41352B1 (fr) |
| ZA (1) | ZA751990B (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004063818A (ja) | 2002-07-30 | 2004-02-26 | Oki Electric Ind Co Ltd | フレキシブルチューブを利用した半導体装置の製造方法 |
| EP2560676B8 (fr) | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Composés organiques |
| WO2013155504A1 (fr) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Nouveaux procédés |
| HUE053159T2 (hu) | 2013-03-15 | 2021-06-28 | Intra Cellular Therapies Inc | Szerves vegyületek |
| IL305990B2 (en) | 2013-12-03 | 2025-12-01 | Intra Cellular Therapies Inc | Long-acting injectable composition comprising polymeric microspheres of heterocycle fused gamma-carboline compounds or a pharmaceutical composition for sustained or delayed release comprising the compounds and their use in the treatment of bipolar disorder i and/or bipolar ii disorder |
| MX365969B (es) | 2014-04-04 | 2019-06-21 | Intra Cellular Therapies Inc | Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio. |
| RU2016143091A (ru) | 2014-04-04 | 2018-05-08 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| CN108883111B (zh) | 2016-01-26 | 2021-10-08 | 细胞内治疗公司 | 有机化合物 |
| PL3407889T3 (pl) | 2016-03-25 | 2021-11-22 | Intra-Cellular Therapies, Inc. | Związki organiczne i ich zastosowanie w leczeniu lub zapobieganiu zaburzeniom ośrodkowego układu nerwowego |
| EP3436083A4 (fr) | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| US11331316B2 (en) | 2016-10-12 | 2022-05-17 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| US10906906B2 (en) | 2016-12-29 | 2021-02-02 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| IL268970B2 (en) | 2017-03-24 | 2023-12-01 | Intra Cellular Therapies Inc | Oral transmucosal formulations of substituted heterocycle fused gamma carbolines |
| JP7224333B2 (ja) | 2017-07-26 | 2023-02-17 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| JP7223742B2 (ja) | 2017-07-26 | 2023-02-16 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2019178484A1 (fr) | 2018-03-16 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Nouveaux procédés |
| AU2019240226B2 (en) | 2018-03-23 | 2024-11-28 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2019237037A1 (fr) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
| CA3106447A1 (fr) | 2018-06-11 | 2019-12-19 | Intra-Cellular Therapies, Inc. | Synthese de gamma-carbolines fusionnees a heterocycles substitues |
| EP3843729A4 (fr) | 2018-08-29 | 2022-06-01 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| CA3108558A1 (fr) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Nouvelles methodes |
| CN112584837A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
| IL283963B2 (en) | 2018-12-17 | 2025-01-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| EP3898580A4 (fr) | 2018-12-17 | 2022-08-10 | Intra-Cellular Therapies, Inc. | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
| US12195463B2 (en) | 2018-12-21 | 2025-01-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP7673040B2 (ja) | 2019-07-07 | 2025-05-08 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| CN116425670A (zh) * | 2022-07-15 | 2023-07-14 | 英矽智能科技(上海)有限公司 | 作为tead抑制剂的新型杂环化合物 |
-
1975
- 1975-03-19 IE IE589/75A patent/IE41352B1/xx unknown
- 1975-03-26 GB GB1277375A patent/GB1476087A/en not_active Expired
- 1975-03-27 CA CA223,250A patent/CA1056381A/fr not_active Expired
- 1975-04-01 BE BE1006567A patent/BE827451A/fr not_active IP Right Cessation
- 1975-04-01 ZA ZA00751990A patent/ZA751990B/xx unknown
-
1982
- 1982-09-14 JP JP57160719A patent/JPS5874683A/ja active Pending
- 1982-09-14 JP JP57160718A patent/JPS5874682A/ja active Pending
- 1982-09-14 JP JP57160717A patent/JPS5915911B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1476087A (en) | 1977-06-10 |
| JPS5874681A (ja) | 1983-05-06 |
| JPS5915911B2 (ja) | 1984-04-12 |
| IE41352L (en) | 1975-10-01 |
| JPS5874682A (ja) | 1983-05-06 |
| ZA751990B (en) | 1976-02-25 |
| BE827451A (fr) | 1975-10-01 |
| JPS5874683A (ja) | 1983-05-06 |
| IE41352B1 (en) | 1979-12-19 |
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