CA1056381A - 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES - Google Patents

5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Info

Publication number
CA1056381A
CA1056381A CA223,250A CA223250A CA1056381A CA 1056381 A CA1056381 A CA 1056381A CA 223250 A CA223250 A CA 223250A CA 1056381 A CA1056381 A CA 1056381A
Authority
CA
Canada
Prior art keywords
fluoro
process according
hydrogen
chloro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA223,250A
Other languages
English (en)
Other versions
CA223250S (en
Inventor
Jacob J. Plattner
James R. Tretter
Charles A. Harbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Priority to CA314,650A priority Critical patent/CA1067497A/fr
Application granted granted Critical
Publication of CA1056381A publication Critical patent/CA1056381A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA223,250A 1974-04-01 1975-03-27 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES Expired CA1056381A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA314,650A CA1067497A (fr) 1974-04-01 1978-10-27 LES 5-PHENYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45664074A 1974-04-01 1974-04-01

Publications (1)

Publication Number Publication Date
CA1056381A true CA1056381A (fr) 1979-06-12

Family

ID=23813560

Family Applications (1)

Application Number Title Priority Date Filing Date
CA223,250A Expired CA1056381A (fr) 1974-04-01 1975-03-27 5-ARYL-1,2,3,4-TETRAHYDRO-.gamma.-CARBOLINES

Country Status (6)

Country Link
JP (3) JPS5874683A (fr)
BE (1) BE827451A (fr)
CA (1) CA1056381A (fr)
GB (1) GB1476087A (fr)
IE (1) IE41352B1 (fr)
ZA (1) ZA751990B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004063818A (ja) 2002-07-30 2004-02-26 Oki Electric Ind Co Ltd フレキシブルチューブを利用した半導体装置の製造方法
CA2796756A1 (fr) 2010-04-22 2011-10-27 Intra-Cellular Therapies, Inc. Pyrido(3',4':4,5)pyrrolo(1,2,3-de)quinoxalines substituees destinees au traitement de troubles du systeme nerveux central
KR20140146192A (ko) 2012-04-14 2014-12-24 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
KR102373288B1 (ko) 2013-12-03 2022-03-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
CA2944755A1 (fr) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Composes organiques
PL3838274T3 (pl) 2016-01-26 2024-04-02 Intra-Cellular Therapies, Inc. Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN
DK3407889T3 (da) 2016-03-25 2021-08-09 Intra Cellular Therapies Inc Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
EP3525763B1 (fr) 2016-10-12 2025-03-05 Intra-Cellular Therapies, Inc. Dispersions solides amorphes
EP3562484B1 (fr) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Dérivés de pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline utiles dans les traitements de troubles du snc
WO2018126140A1 (fr) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
EP3658144B1 (fr) 2017-07-26 2022-01-26 Intra-Cellular Therapies, Inc. Composés pyridopyrroloquinoxalines, leurs compositions et utilisations en thérapie
WO2019023062A1 (fr) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Composés organiques
WO2019178484A1 (fr) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Nouveaux procédés
CN112040940A (zh) 2018-03-23 2020-12-04 细胞内治疗公司 有机化合物
EP3801527B1 (fr) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Gamma-carbolines fusionnées pour le traitement aigu de l'anxiété ou de la dépression
CA3240552A1 (fr) 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Synthese de gamma-carbolines fusionnees a heterocycles substitues
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
WO2020047408A1 (fr) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Nouvelles méthodes
BR112021003655A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
IL315005B2 (en) 2018-12-17 2026-04-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
JP7520013B2 (ja) 2018-12-17 2024-07-22 イントラ－セルラー・セラピーズ・インコーポレイテッド 置換複素環縮合γ－カルボリンの合成
US12195463B2 (en) 2018-12-21 2025-01-14 Intra-Cellular Therapies, Inc. Organic compounds
WO2021007245A1 (fr) 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Nouveaux procédés
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
CN116425670A (zh) * 2022-07-15 2023-07-14 英矽智能科技(上海)有限公司 作为tead抑制剂的新型杂环化合物

Also Published As

Publication number Publication date
IE41352L (en) 1975-10-01
IE41352B1 (en) 1979-12-19
JPS5874682A (ja) 1983-05-06
JPS5874681A (ja) 1983-05-06
JPS5915911B2 (ja) 1984-04-12
BE827451A (fr) 1975-10-01
GB1476087A (en) 1977-06-10
ZA751990B (en) 1976-02-25
JPS5874683A (ja) 1983-05-06

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