CA1066701A - Method for the preparation of piperazine derivatives - Google Patents
Method for the preparation of piperazine derivativesInfo
- Publication number
- CA1066701A CA1066701A CA191,286A CA191286A CA1066701A CA 1066701 A CA1066701 A CA 1066701A CA 191286 A CA191286 A CA 191286A CA 1066701 A CA1066701 A CA 1066701A
- Authority
- CA
- Canada
- Prior art keywords
- group
- compound
- formula
- ethyl
- piperazinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3845373A JPS5546400B2 (de) | 1973-04-03 | 1973-04-03 | |
| JP5654473A JPS565753B2 (de) | 1973-05-21 | 1973-05-21 | |
| JP6446473A JPS565755B2 (de) | 1973-06-07 | 1973-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1066701A true CA1066701A (en) | 1979-11-20 |
Family
ID=27289838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA191,286A Expired CA1066701A (en) | 1973-04-03 | 1974-01-30 | Method for the preparation of piperazine derivatives |
Country Status (11)
| Country | Link |
|---|---|
| AR (2) | AR204003A1 (de) |
| AT (1) | AT340931B (de) |
| CA (1) | CA1066701A (de) |
| CH (1) | CH593281A5 (de) |
| ES (1) | ES424851A1 (de) |
| FI (1) | FI56011C (de) |
| IE (1) | IE39102B1 (de) |
| NL (1) | NL186087C (de) |
| NO (1) | NO142221C (de) |
| PH (2) | PH10529A (de) |
| SE (1) | SE416051B (de) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031120A1 (de) * | 1979-12-21 | 1981-07-01 | Unibios S.p.A. | Verfahren zur Herstellung von 2-substituierten 6-Alkoxycarbonyl-8-äthyl-5-oxo-5,8-dihydro-pyrido(2,3-d)-pyrimidinen und deren Säuren |
| US8680108B2 (en) | 2009-12-18 | 2014-03-25 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| US8940752B2 (en) | 2009-06-29 | 2015-01-27 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| US9199982B2 (en) | 2011-09-02 | 2015-12-01 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US9527848B2 (en) | 2010-12-20 | 2016-12-27 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US9944646B2 (en) | 2012-04-02 | 2018-04-17 | Incyte Holdings Corporation | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US10336759B2 (en) | 2015-02-27 | 2019-07-02 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
| US12226418B2 (en) | 2018-06-01 | 2025-02-18 | Incyte Corporation | Dosing regimen for the treatment of PI3K related disorders |
-
1974
- 1974-01-01 AR AR253060A patent/AR204003A1/es active
- 1974-01-30 CA CA191,286A patent/CA1066701A/en not_active Expired
- 1974-02-01 SE SE7401361A patent/SE416051B/xx not_active IP Right Cessation
- 1974-02-04 FI FI298/74A patent/FI56011C/fi active
- 1974-02-04 NL NLAANVRAGE7401509,A patent/NL186087C/xx not_active IP Right Cessation
- 1974-02-04 NO NO740349A patent/NO142221C/no unknown
- 1974-02-14 CH CH205474A patent/CH593281A5/de not_active IP Right Cessation
- 1974-03-25 IE IE00650/74A patent/IE39102B1/xx unknown
- 1974-04-02 ES ES424851A patent/ES424851A1/es not_active Expired
- 1974-04-03 PH PH15698A patent/PH10529A/en unknown
- 1974-04-03 AT AT277774A patent/AT340931B/de not_active IP Right Cessation
-
1975
- 1975-01-01 AR AR258571A patent/AR204660A1/es active
- 1975-09-05 PH PH17546A patent/PH10984A/en unknown
Cited By (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031120A1 (de) * | 1979-12-21 | 1981-07-01 | Unibios S.p.A. | Verfahren zur Herstellung von 2-substituierten 6-Alkoxycarbonyl-8-äthyl-5-oxo-5,8-dihydro-pyrido(2,3-d)-pyrimidinen und deren Säuren |
| US9975907B2 (en) | 2009-06-29 | 2018-05-22 | Incyte Holdings Corporation | Pyrimidinones as PI3K inhibitors |
| US8940752B2 (en) | 2009-06-29 | 2015-01-27 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| US10829502B2 (en) | 2009-06-29 | 2020-11-10 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| US11401280B2 (en) | 2009-06-29 | 2022-08-02 | Incyte Holdings Corporation | Pyrimidinones as PI3K inhibitors |
| US10428087B2 (en) | 2009-06-29 | 2019-10-01 | Incyte Corporation | Pyrimidinones as PI3K inhibitors |
| US8680108B2 (en) | 2009-12-18 | 2014-03-25 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| US9527848B2 (en) | 2010-12-20 | 2016-12-27 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| US9815839B2 (en) | 2010-12-20 | 2017-11-14 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| US9730939B2 (en) | 2011-09-02 | 2017-08-15 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US11819505B2 (en) | 2011-09-02 | 2023-11-21 | Incyte Corporation | Heterocyclylamines as PI3K inhibitors |
| US11433071B2 (en) | 2011-09-02 | 2022-09-06 | Incyte Corporation | Heterocyclylamines as PI3K inhibitors |
| US12201636B2 (en) | 2011-09-02 | 2025-01-21 | Incyte Corporation | Heterocyclylamines as PI3K inhibitors |
| US10092570B2 (en) | 2011-09-02 | 2018-10-09 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US9707233B2 (en) | 2011-09-02 | 2017-07-18 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US9199982B2 (en) | 2011-09-02 | 2015-12-01 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US10646492B2 (en) | 2011-09-02 | 2020-05-12 | Incyte Corporation | Heterocyclylamines as PI3K inhibitors |
| US10376513B2 (en) | 2011-09-02 | 2019-08-13 | Incyte Holdings Corporation | Heterocyclylamines as PI3K inhibitors |
| US10259818B2 (en) | 2012-04-02 | 2019-04-16 | Incyte Corporation | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors |
| US9944646B2 (en) | 2012-04-02 | 2018-04-17 | Incyte Holdings Corporation | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors |
| US10479803B2 (en) | 2014-06-11 | 2019-11-19 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US11130767B2 (en) | 2014-06-11 | 2021-09-28 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US11999751B2 (en) | 2014-06-11 | 2024-06-04 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| US10336759B2 (en) | 2015-02-27 | 2019-07-02 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
| US11084822B2 (en) | 2015-02-27 | 2021-08-10 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
| US12024522B2 (en) | 2015-02-27 | 2024-07-02 | Incyte Corporation | Salts and processes of preparing a PI3K inhibitor |
| US10125150B2 (en) | 2015-05-11 | 2018-11-13 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US12226418B2 (en) | 2018-06-01 | 2025-02-18 | Incyte Corporation | Dosing regimen for the treatment of PI3K related disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA277774A (de) | 1977-05-15 |
| PH10529A (en) | 1977-05-30 |
| IE39102L (en) | 1974-10-03 |
| NL7401509A (de) | 1974-10-07 |
| PH10984A (en) | 1977-10-18 |
| CH593281A5 (en) | 1977-11-30 |
| AR204003A1 (es) | 1975-11-12 |
| IE39102B1 (en) | 1978-08-02 |
| NO740349L (no) | 1974-10-04 |
| NO142221B (no) | 1980-04-08 |
| NL186087C (nl) | 1990-09-17 |
| AR204660A1 (es) | 1976-02-20 |
| SE416051B (sv) | 1980-11-24 |
| FI56011B (fi) | 1979-07-31 |
| NO142221C (no) | 1980-07-16 |
| AT340931B (de) | 1978-01-10 |
| NL186087B (nl) | 1990-04-17 |
| FI56011C (fi) | 1979-11-12 |
| ES424851A1 (es) | 1976-06-01 |
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