CA1098830A - Traduction non-disponible - Google Patents

Traduction non-disponible

Info

Publication number: CA1098830A
Authority: CA; Canada
Prior art keywords: composition; fluoride; earth metal; alkaline earth; acid
Prior art date: 1977-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA298,783A

Other languages

English (en)

Inventor

Satish K. Wason

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

JM Huber Corp

Original Assignee

JM Huber Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-20

Filing date

1978-03-13

Publication date

1981-04-07

1978-03-13 Application filed by JM Huber Corp filed Critical JM Huber Corp

1981-04-07 Application granted granted Critical

1981-04-07 Publication of CA1098830A publication Critical patent/CA1098830A/fr

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 130
239000003082 abrasive agent Substances 0.000 title claims abstract description 81
229910052784 alkaline earth metal Inorganic materials 0.000 title claims description 16
229910021486 amorphous silicon dioxide Inorganic materials 0.000 title claims 7
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title abstract description 130
239000000551 dentifrice Substances 0.000 title description 8
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 221
239000000606 toothpaste Substances 0.000 claims abstract description 153
229940034610 toothpaste Drugs 0.000 claims abstract description 110
239000000377 silicon dioxide Substances 0.000 claims abstract description 100
235000012239 silicon dioxide Nutrition 0.000 claims abstract description 57
238000000034 method Methods 0.000 claims abstract description 37
229910001420 alkaline earth metal ion Inorganic materials 0.000 claims abstract description 24
239000011575 calcium Substances 0.000 claims abstract description 18
238000006243 chemical reaction Methods 0.000 claims abstract description 18
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 17
229910052791 calcium Inorganic materials 0.000 claims abstract description 17
238000002360 preparation method Methods 0.000 claims abstract description 12
239000000243 solution Substances 0.000 claims description 51
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
229910001868 water Inorganic materials 0.000 claims description 50
239000003795 chemical substances by application Substances 0.000 claims description 41
239000002002 slurry Substances 0.000 claims description 37
239000000463 material Substances 0.000 claims description 30
239000002253 acid Substances 0.000 claims description 28
239000000047 product Substances 0.000 claims description 28
-1 alkaline earth metal salt Chemical class 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 21
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 20
238000007792 addition Methods 0.000 claims description 19
229910052910 alkali metal silicate Inorganic materials 0.000 claims description 19
230000035515 penetration Effects 0.000 claims description 18
229910019142 PO4 Inorganic materials 0.000 claims description 17
239000004115 Sodium Silicate Substances 0.000 claims description 16
235000001465 calcium Nutrition 0.000 claims description 16
239000013505 freshwater Substances 0.000 claims description 16
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 16
NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical group [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 16
229910052911 sodium silicate Inorganic materials 0.000 claims description 16
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 15
210000004268 dentin Anatomy 0.000 claims description 14
239000003906 humectant Substances 0.000 claims description 14
229910052500 inorganic mineral Inorganic materials 0.000 claims description 14
235000010755 mineral Nutrition 0.000 claims description 14
239000011707 mineral Substances 0.000 claims description 14
150000001342 alkaline earth metals Chemical class 0.000 claims description 13
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 12
239000011230 binding agent Substances 0.000 claims description 12
239000010452 phosphate Substances 0.000 claims description 12
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 11
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 11
229910001424 calcium ion Inorganic materials 0.000 claims description 11
239000000796 flavoring agent Substances 0.000 claims description 10
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 8
238000005299 abrasion Methods 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 8
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 8
239000000920 calcium hydroxide Substances 0.000 claims description 8
229910001861 calcium hydroxide Inorganic materials 0.000 claims description 8
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 7
238000013019 agitation Methods 0.000 claims description 7
230000002272 anti-calculus Effects 0.000 claims description 7
125000004432 carbon atom Chemical group C* 0.000 claims description 7
239000003921 oil Substances 0.000 claims description 7
239000011775 sodium fluoride Substances 0.000 claims description 7
235000013024 sodium fluoride Nutrition 0.000 claims description 7
239000000600 sorbitol Substances 0.000 claims description 7
235000010356 sorbitol Nutrition 0.000 claims description 7
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
229910052681 coesite Inorganic materials 0.000 claims description 6
229910052906 cristobalite Inorganic materials 0.000 claims description 6
239000011737 fluorine Substances 0.000 claims description 6
229910052731 fluorine Inorganic materials 0.000 claims description 6
235000011187 glycerol Nutrition 0.000 claims description 6
230000002285 radioactive effect Effects 0.000 claims description 6
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 6
229910052682 stishovite Inorganic materials 0.000 claims description 6
229910052905 tridymite Inorganic materials 0.000 claims description 6
238000010521 absorption reaction Methods 0.000 claims description 5
230000002882 anti-plaque Effects 0.000 claims description 5
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 4
238000001914 filtration Methods 0.000 claims description 4
235000013355 food flavoring agent Nutrition 0.000 claims description 4
235000003599 food sweetener Nutrition 0.000 claims description 4
125000005341 metaphosphate group Chemical group 0.000 claims description 4
229960002799 stannous fluoride Drugs 0.000 claims description 4
239000003765 sweetening agent Substances 0.000 claims description 4
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical class [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 4
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 3
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 3
150000008051 alkyl sulfates Chemical class 0.000 claims description 3
239000000292 calcium oxide Substances 0.000 claims description 3
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
239000000679 carrageenan Substances 0.000 claims description 3
235000010418 carrageenan Nutrition 0.000 claims description 3
229920001525 carrageenan Polymers 0.000 claims description 3
229940113118 carrageenan Drugs 0.000 claims description 3
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 3
229910017604 nitric acid Inorganic materials 0.000 claims description 3
239000002245 particle Substances 0.000 claims description 3
238000001556 precipitation Methods 0.000 claims description 3
229910052712 strontium Inorganic materials 0.000 claims description 3
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 3
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical group [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
229910052783 alkali metal Inorganic materials 0.000 claims description 2
150000001340 alkali metals Chemical group 0.000 claims description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 2
150000004287 bisbiguanides Chemical class 0.000 claims description 2
239000001110 calcium chloride Substances 0.000 claims description 2
229910001628 calcium chloride Inorganic materials 0.000 claims description 2
235000015165 citric acid Nutrition 0.000 claims description 2
KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 claims description 2
150000004665 fatty acids Chemical group 0.000 claims description 2
239000001630 malic acid Substances 0.000 claims description 2
235000011090 malic acid Nutrition 0.000 claims description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims description 2
239000011975 tartaric acid Substances 0.000 claims description 2
235000002906 tartaric acid Nutrition 0.000 claims description 2
239000000811 xylitol Substances 0.000 claims description 2
235000010447 xylitol Nutrition 0.000 claims description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
229960002675 xylitol Drugs 0.000 claims description 2
229960001866 silicon dioxide Drugs 0.000 claims 5
229960005069 calcium Drugs 0.000 claims 4
ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims 4
229940032330 sulfuric acid Drugs 0.000 claims 3
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
230000001747 exhibiting effect Effects 0.000 claims 2
229910052749 magnesium Inorganic materials 0.000 claims 2
239000011777 magnesium Substances 0.000 claims 2
239000012265 solid product Substances 0.000 claims 2
238000005406 washing Methods 0.000 claims 2
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims 1
229910001634 calcium fluoride Inorganic materials 0.000 claims 1
238000001035 drying Methods 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
235000019960 monoglycerides of fatty acid Nutrition 0.000 claims 1
239000001509 sodium citrate Substances 0.000 claims 1
238000001694 spray drying Methods 0.000 claims 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims 1
229940038773 trisodium citrate Drugs 0.000 claims 1
235000019263 trisodium citrate Nutrition 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 abstract description 11
150000004673 fluoride salts Chemical class 0.000 abstract description 2
230000003993 interaction Effects 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 1
125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 abstract 1
229940091249 fluoride supplement Drugs 0.000 description 126
239000011734 sodium Substances 0.000 description 28
150000003013 phosphoric acid derivatives Chemical class 0.000 description 22
229910052708 sodium Inorganic materials 0.000 description 22
238000004140 cleaning Methods 0.000 description 19
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 17
150000002500 ions Chemical class 0.000 description 16
238000012360 testing method Methods 0.000 description 15
210000003298 dental enamel Anatomy 0.000 description 14
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 12
235000021317 phosphate Nutrition 0.000 description 12
239000012429 reaction media Substances 0.000 description 10
238000003860 storage Methods 0.000 description 10
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 8
230000008569 process Effects 0.000 description 8
239000006228 supernatant Substances 0.000 description 8
KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 7
239000012153 distilled water Substances 0.000 description 7
239000006072 paste Substances 0.000 description 7
239000011591 potassium Substances 0.000 description 7
229910052700 potassium Inorganic materials 0.000 description 7
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000008901 benefit Effects 0.000 description 6
238000011156 evaluation Methods 0.000 description 6
235000019634 flavors Nutrition 0.000 description 6
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 6
229910052938 sodium sulfate Inorganic materials 0.000 description 6
235000011152 sodium sulphate Nutrition 0.000 description 6
235000019832 sodium triphosphate Nutrition 0.000 description 6
229960002920 sorbitol Drugs 0.000 description 6
125000000129 anionic group Chemical group 0.000 description 5
235000011116 calcium hydroxide Nutrition 0.000 description 5
239000006227 byproduct Substances 0.000 description 4
239000012065 filter cake Substances 0.000 description 4
210000000214 mouth Anatomy 0.000 description 4
235000011007 phosphoric acid Nutrition 0.000 description 4
125000005372 silanol group Chemical group 0.000 description 4
235000013162 Cocos nucifera Nutrition 0.000 description 3
244000060011 Cocos nucifera Species 0.000 description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
229920000388 Polyphosphate Polymers 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000009286 beneficial effect Effects 0.000 description 3
239000001768 carboxy methyl cellulose Substances 0.000 description 3
125000002091 cationic group Chemical group 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000012937 correction Methods 0.000 description 3
230000000875 corresponding effect Effects 0.000 description 3
208000002925 dental caries Diseases 0.000 description 3
210000001315 dental pellicle Anatomy 0.000 description 3
235000011180 diphosphates Nutrition 0.000 description 3
235000019820 disodium diphosphate Nutrition 0.000 description 3
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
229910000397 disodium phosphate Inorganic materials 0.000 description 3
235000019800 disodium phosphate Nutrition 0.000 description 3
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 3
229940038485 disodium pyrophosphate Drugs 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
238000010348 incorporation Methods 0.000 description 3
229910052914 metal silicate Inorganic materials 0.000 description 3
229910000402 monopotassium phosphate Inorganic materials 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
239000011574 phosphorus Substances 0.000 description 3
229910052698 phosphorus Inorganic materials 0.000 description 3
239000001205 polyphosphate Substances 0.000 description 3
235000011176 polyphosphates Nutrition 0.000 description 3
NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 3
229910000162 sodium phosphate Inorganic materials 0.000 description 3
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 3
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 3
229910000404 tripotassium phosphate Inorganic materials 0.000 description 3
235000019798 tripotassium phosphate Nutrition 0.000 description 3
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
RMSOEGBYNWXXBG-UHFFFAOYSA-N 1-chloronaphthalen-2-ol Chemical compound C1=CC=CC2=C(Cl)C(O)=CC=C21 RMSOEGBYNWXXBG-UHFFFAOYSA-N 0.000 description 2
DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
235000008733 Citrus aurantifolia Nutrition 0.000 description 2
241001237728 Precis Species 0.000 description 2
235000011941 Tilia x europaea Nutrition 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
125000001931 aliphatic group Chemical group 0.000 description 2
239000003513 alkali Substances 0.000 description 2
229910052936 alkali metal sulfate Inorganic materials 0.000 description 2
150000003863 ammonium salts Chemical class 0.000 description 2
230000000170 anti-cariogenic effect Effects 0.000 description 2
125000004429 atom Chemical group 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
230000001680 brushing effect Effects 0.000 description 2
239000003638 chemical reducing agent Substances 0.000 description 2
239000003086 colorant Substances 0.000 description 2
238000005260 corrosion Methods 0.000 description 2
230000007797 corrosion Effects 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
230000005484 gravity Effects 0.000 description 2
230000006872 improvement Effects 0.000 description 2
239000012535 impurity Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
239000004571 lime Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
229910021645 metal ion Inorganic materials 0.000 description 2
235000019799 monosodium phosphate Nutrition 0.000 description 2
239000000049 pigment Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
235000007686 potassium Nutrition 0.000 description 2
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 2
229940048084 pyrophosphate Drugs 0.000 description 2
125000001453 quaternary ammonium group Chemical group 0.000 description 2
230000036647 reaction Effects 0.000 description 2
239000012066 reaction slurry Substances 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
235000019204 saccharin Nutrition 0.000 description 2
229940081974 saccharin Drugs 0.000 description 2
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
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GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 2
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DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
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OMRRUNXAWXNVFW-UHFFFAOYSA-N fluoridochlorine Chemical compound ClF OMRRUNXAWXNVFW-UHFFFAOYSA-N 0.000 description 1
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ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
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238000011086 high cleaning Methods 0.000 description 1
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150000004677 hydrates Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
150000001261 hydroxy acids Chemical class 0.000 description 1
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239000007791 liquid phase Substances 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
238000003760 magnetic stirring Methods 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
229940094996 pepsodent Drugs 0.000 description 1
229940086255 perform Drugs 0.000 description 1
UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
150000003018 phosphorus compounds Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
239000011698 potassium fluoride Substances 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
239000010453 quartz Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000005855 radiation Effects 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
239000000700 radioactive tracer Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
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239000011833 salt mixture Substances 0.000 description 1
239000000523 sample Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
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229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
101150115956 slc25a26 gene Proteins 0.000 description 1
239000000344 soap Substances 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000013595 supernatant sample Substances 0.000 description 1
239000000271 synthetic detergent Substances 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
229940116269 uric acid Drugs 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
239000001052 yellow pigment Substances 0.000 description 1
BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Birds (AREA)
Epidemiology (AREA)
Cosmetics (AREA)
Dental Preparations (AREA)

CA298,783A 1977-12-20 1978-03-13 Traduction non-disponible Expired CA1098830A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86238477A	1977-12-20	1977-12-20
US862,384		1977-12-20

Publications (1)

Publication Number	Publication Date
CA1098830A true CA1098830A (fr)	1981-04-07

Family

ID=25338376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA298,783A Expired CA1098830A (fr)	1977-12-20	1978-03-13	Traduction non-disponible

Country Status (22)

Country	Link
JP (2)	JPS5486636A (fr)
AT (1)	AT366907B (fr)
AU (1)	AU514449B2 (fr)
BE (1)	BE864872A (fr)
BR (1)	BR7801523A (fr)
CA (1)	CA1098830A (fr)
CH (1)	CH640135A5 (fr)
DE (2)	DE2811097A1 (fr)
DK (1)	DK158561C (fr)
ES (1)	ES467854A1 (fr)
FI (1)	FI71226C (fr)
FR (1)	FR2412307A1 (fr)
GB (1)	GB1598233A (fr)
GR (1)	GR68943B (fr)
IE (1)	IE46578B1 (fr)
IT (1)	IT1105167B (fr)
LU (1)	LU79230A1 (fr)
NL (1)	NL191202C (fr)
NO (2)	NO149031C (fr)
PH (3)	PH17943A (fr)
SE (2)	SE436738B (fr)
ZA (1)	ZA781413B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN112456505A (zh) *	2020-12-16	2021-03-09	广州市飞雪材料科技有限公司	一种高密度高分散牙膏用二氧化硅摩擦剂的制备方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4314990A (en) *	1979-10-15	1982-02-09	The Procter & Gamble Company	Toothpaste compositions
GB2074859B (en) *	1980-04-25	1984-10-17	Colgate Palmolive Co	Opaque dental creams
JPS5818315A (ja) *	1981-07-27	1983-02-02	Sunstar Inc	口腔適用組成物
PH22221A (en) *	1982-06-22	1988-06-28	Procter & Gamble	Oral compositions
KR100449132B1 (ko) *	1995-06-30	2004-11-16	크로스필드 리미티드	비결정질실리카및경구용조성물
US5871715A (en) *	1997-02-28	1999-02-16	Gillette Canada Inc.	Stannous fluoride gel with improved stand-up
JP4694794B2 (ja) *	2004-04-28	2011-06-08	花王株式会社	歯磨剤
JP5103067B2 (ja) *	2007-06-25	2012-12-19	花王株式会社	歯磨剤
JP5435848B2 (ja) *	2007-08-24	2014-03-05	花王株式会社	歯磨剤組成物
WO2010134904A1 (fr)	2009-05-18	2010-11-25	Colgate-Palmolive Company	Compositions orales contenant des composés polyguanidinium et procédés de fabrication et d'utilisation de celles-ci
TWI499430B (zh)	2009-12-17	2015-09-11	美國棕欖公司	抗侵蝕的牙膏組成物
JP5727517B2 (ja)	2010-01-29	2015-06-03	コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−ＰａｌｍｏｌｉｖｅＣｏｍｐａｎｙ	敏感なエナメル質のケアのための口腔ケア製品
TWI483740B (zh) *	2011-09-23	2015-05-11	Sancastle Worldwide Corp	預防或治療牙本質相關症狀或疾病之組成物及方法
US9901755B2 (en)	2011-09-23	2018-02-27	Sancastle Worldwide Corporation	Composition for preventing or treating dentin-associated symptoms or diseases, and method using the same
CA3045015C (fr) *	2016-12-19	2021-11-09	The Procter & Gamble Company	Compositions de dentifrice contenant des particules de silice compatibles avec l'etain bivalent

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US3893840A (en) *	1972-09-06	1975-07-08	Huber Corp J M	Amorphous precipitated siliceous pigments and methods for their production
US3928541A (en) *	1972-09-05	1975-12-23	Huber Corp J M	Amorphous precipitated siliceous pigments for cosmetic or dentrifrice use and methods for their production
US3988162A (en) *	1972-09-06	1976-10-26	J. M. Huber Corporation	Amorphous precipitated silica products and method for their production
JPS50899A (fr) *	1973-04-28	1975-01-07
AU505536B2 (en)	1975-03-12	1979-11-22	J.M. Huber Corp.	Methods for production and use of siliceous products

1978
- 1978-03-09 GR GR55662A patent/GR68943B/el unknown
- 1978-03-10 ZA ZA00781413A patent/ZA781413B/xx unknown
- 1978-03-13 CA CA298,783A patent/CA1098830A/fr not_active Expired
- 1978-03-13 NO NO780865A patent/NO149031C/no unknown
- 1978-03-14 IE IE524/78A patent/IE46578B1/en not_active IP Right Cessation
- 1978-03-14 ES ES467854A patent/ES467854A1/es not_active Expired
- 1978-03-14 BR BR7801523A patent/BR7801523A/pt unknown
- 1978-03-14 GB GB9954/78A patent/GB1598233A/en not_active Expired
- 1978-03-14 AU AU34100/78A patent/AU514449B2/en not_active Expired
- 1978-03-14 LU LU79230A patent/LU79230A1/fr unknown
- 1978-03-14 DE DE19782811097 patent/DE2811097A1/de active Granted
- 1978-03-14 DE DE2858216A patent/DE2858216C2/de not_active Expired
- 1978-03-14 BE BE185917A patent/BE864872A/fr not_active IP Right Cessation
- 1978-03-14 FI FI780807A patent/FI71226C/fi not_active IP Right Cessation
- 1978-03-14 DK DK114178A patent/DK158561C/da not_active IP Right Cessation
- 1978-03-14 FR FR7807344A patent/FR2412307A1/fr active Granted
- 1978-03-14 IT IT48426/78A patent/IT1105167B/it active
- 1978-03-14 SE SE7802901A patent/SE436738B/sv not_active IP Right Cessation
- 1978-03-14 CH CH277978A patent/CH640135A5/de not_active IP Right Cessation
- 1978-03-15 AT AT0185578A patent/AT366907B/de not_active IP Right Cessation
- 1978-03-15 PH PH20883A patent/PH17943A/en unknown
- 1978-03-15 NL NL7802800A patent/NL191202C/xx not_active IP Right Cessation
- 1978-03-15 JP JP3047578A patent/JPS5486636A/ja active Granted
1979
- 1979-02-15 NO NO790502A patent/NO148358C/no unknown
1981
- 1981-12-17 SE SE8107583A patent/SE445293B/sv not_active IP Right Cessation
1983
- 1983-01-10 PH PH28371A patent/PH20181A/en unknown
- 1983-03-30 PH PH28725A patent/PH18150A/en unknown
1985
- 1985-03-11 JP JP60048102A patent/JPS60214725A/ja active Granted

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN112456505A (zh) *	2020-12-16	2021-03-09	广州市飞雪材料科技有限公司	一种高密度高分散牙膏用二氧化硅摩擦剂的制备方法
CN112456505B (zh) *	2020-12-16	2021-07-09	广州市飞雪材料科技有限公司	一种高密度高分散牙膏用二氧化硅摩擦剂的制备方法

Also Published As

Publication number	Publication date
NO148358B (no)	1983-06-20
NO148358C (no)	1983-09-28
PH20181A (en)	1986-10-16
JPS615448B2 (fr)	1986-02-18
ZA781413B (en)	1979-10-31
JPS637523B2 (fr)	1988-02-17
FI71226C (fi)	1986-12-19
FR2412307A1 (fr)	1979-07-20
IE46578B1 (en)	1983-07-27
BR7801523A (pt)	1979-07-10
AU514449B2 (en)	1981-02-12
ES467854A1 (es)	1979-09-01
DE2811097A1 (de)	1979-06-28
SE445293B (sv)	1986-06-16
AU3410078A (en)	1979-09-20
SE8107583L (sv)	1981-12-17
DE2811097C2 (fr)	1989-01-05
SE436738B (sv)	1985-01-21
NL7802800A (nl)	1979-06-22
FI780807A7 (fi)	1979-06-21
FR2412307B1 (fr)	1983-01-07
NL191202B (nl)	1994-10-17
CH640135A5 (en)	1983-12-30
DK158561B (da)	1990-06-11
FI71226B (fi)	1986-09-09
GB1598233A (en)	1981-09-16
GR68943B (fr)	1982-03-29
DK158561C (da)	1990-11-05
NO149031B (no)	1983-10-24
ATA185578A (de)	1981-10-15
AT366907B (de)	1982-05-25
LU79230A1 (fr)	1978-10-17
JPS60214725A (ja)	1985-10-28
IT1105167B (it)	1985-10-28
NO780865L (no)	1979-06-21
DK114178A (da)	1979-06-21
IT7848426A0 (it)	1978-03-14
SE7802901L (sv)	1979-06-21
NO149031C (no)	1984-02-01
IE780524L (en)	1979-06-20
PH17943A (en)	1985-02-11
JPS5486636A (en)	1979-07-10
BE864872A (fr)	1978-09-14
PH18150A (en)	1985-04-03
NL191202C (nl)	1995-03-16
NO790502L (no)	1979-06-21
DE2858216C2 (fr)	1987-10-15

Legal Events

Date	Code	Title	Description
1998-04-07	MKEX	Expiry

Publication	Publication Date	Title
US4420312A (en)	1983-12-13	Method for production of high fluoride compatibility dentifrice abrasives and compositions
US4421527A (en)	1983-12-20	High fluoride compatibility dentifrice abrasives and compositions
US4340583A (en)	1982-07-20	High fluoride compatibility dentifrice abrasives and compositions
CA1145677A (fr)	1983-05-03	Tampon de phosphate dans de la pate dentifrice a haute teneur en humectant
US5279815A (en)	1994-01-18	Dentifrice abrasive compositions
US4272509A (en)	1981-06-09	Precipitated silicon dioxide cleaning agent and dentifrice composition
IE46578B1 (en)	1983-07-27	Dentrifrice abrasives and compositions
WO2008082756A2 (fr)	2008-07-10	Dentifrices comprenant des silices biogènes et au moins un phosphate de calcium
GB1587175A (en)	1981-04-01	Therapeutic dentifirices in unlined container and method
EP0772431B1 (fr)	2003-08-27	Composition pour l'hygiene bucco-dentaire
EP1973522A2 (fr)	2008-10-01	Dentifrices comprenant des matières à base de silice biogénique
US4280822A (en)	1981-07-28	Method for production of abrasive composition for use in toothpaste
JPH11511178A (ja)	1999-09-28	シリカ及び炭酸カルシウムを基とし且つ弗素と適合性である研磨剤又は添加剤を含む歯磨剤組成物
US6645471B2 (en)	2003-11-11	Composite abrasive material for oral compositions, and methods of making and using same
WO2008082757A1 (fr)	2008-07-10	Dentifrices comprenant des silices biogéniques et du carbonate de calcium
RU2292869C2 (ru)	2007-02-10	Композиция средства для чистки зубов, содержащая тальк
WO1990005113A1 (fr)	1990-05-17	Compositions abrasives de dioxyde de silicium precipite presentant un haut degre de compatibilite avec les agents fluores anti-plaque et therapeutiques, pour des applications aux produits dentifrices, produits dentifrices les contenant, et procede de fabrication de ces compositions
US20070154413A1 (en)	2007-07-05	Dentifrices comprising biogenic silica materials
WO2007078630A1 (fr)	2007-07-12	Dentifrices comprenant des matières à base de silice biogénique
JPH0655662B2 (ja)	1994-07-27	口腔用組成物
KR810001123B1 (ko)	1981-09-20	융화성고 불화물을 갖는 치약조성물
DK166257B (da)	1993-03-29	Fluorholdig tandpasta
CN121604948A (zh)	2026-03-03	过氧化物相容的二氧化硅
JPS6234722B2 (fr)	1987-07-28
CA1102563A (fr)	1981-06-09	Traduction non-disponible