CA1212665B - PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE - Google Patents

PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE

Info

Publication number
CA1212665B
CA1212665B CA000499579A CA499579A CA1212665B CA 1212665 B CA1212665 B CA 1212665B CA 000499579 A CA000499579 A CA 000499579A CA 499579 A CA499579 A CA 499579A CA 1212665 B CA1212665 B CA 1212665B
Authority
CA
Canada
Prior art keywords
formula
resultant compound
compound
resultant
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000499579A
Other languages
English (en)
Inventor
Giovanni Franceschi
Maurizio Foglio
Federico Arcamone
Cosimo Scarafile
Aurora Sanfilippo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of CA1212665B publication Critical patent/CA1212665B/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CA000499579A 1979-02-24 1986-01-14 PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE Expired CA1212665B (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7906634 1979-02-24
GB7906634 1979-02-24
GB7932591 1979-09-20
GB7932591 1979-09-20

Publications (1)

Publication Number Publication Date
CA1212665B true CA1212665B (fr) 1986-10-14

Family

ID=26270697

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000346011A Expired CA1154010A (fr) 1979-02-24 1980-02-20 PREPARATION D'AGENTS ANTIBACTERIENS CONTENANT DU .beta.-LACTANE ET D'INHIBITEURS DE LA .beta.-LACTAMASE
CA000499579A Expired CA1212665B (fr) 1979-02-24 1986-01-14 PREPARATION DE .beta.-LACTAM CONTENANT DES AGENTS ANTIBACTERIENS ET DES INHIBITEURS DE LA .beta.- LACTAMASE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA000346011A Expired CA1154010A (fr) 1979-02-24 1980-02-20 PREPARATION D'AGENTS ANTIBACTERIENS CONTENANT DU .beta.-LACTANE ET D'INHIBITEURS DE LA .beta.-LACTAMASE

Country Status (24)

Country Link
AT (1) AT368506B (fr)
AU (1) AU535080B2 (fr)
CA (2) CA1154010A (fr)
CH (2) CH654831A5 (fr)
CS (1) CS226010B2 (fr)
DE (1) DE3006273A1 (fr)
DK (1) DK159448C (fr)
ES (2) ES8200685A1 (fr)
FI (1) FI75163C (fr)
FR (1) FR2449690B1 (fr)
GB (1) GB2043639B (fr)
GR (1) GR73623B (fr)
HK (1) HK74487A (fr)
HU (1) HU182664B (fr)
IE (1) IE49407B1 (fr)
IT (1) IT1193922B (fr)
LU (1) LU82192A1 (fr)
NL (1) NL192265C (fr)
NO (1) NO161000C (fr)
NZ (1) NZ192949A (fr)
PT (1) PT70849A (fr)
SE (1) SE449489B (fr)
UA (1) UA6041A1 (fr)
YU (1) YU42964B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
DE3121510A1 (de) * 1980-07-04 1982-06-16 Farmitalia Carlo Erba S.p.A., 20159 Milano 6-alkyl-2-subst.-peneme und verfahren zu ihrer herstellung
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
DE3277696D1 (en) * 1981-07-15 1987-12-23 Sumitomo Pharma Carboxylic beta-lactam compounds and the preparation thereof
US4508649A (en) * 1981-12-11 1985-04-02 Farmitalia Carlo Erba Process for preparing optically active penems
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
PH21930A (en) * 1982-11-16 1988-04-08 Ciba Geigy Ag 6-hydroxy-lower alkylpenem compounds,pharmaceutical composition containing same and method of use thereof
EP0112283B1 (fr) * 1982-11-16 1987-08-12 Ciba-Geigy Ag Dérivés hétérocyclylthio, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur application
GB8300295D0 (en) * 1983-01-06 1983-02-09 Erba Farmitalia Penem esters
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物
GB8321677D0 (en) * 1983-08-11 1983-09-14 Erba Farmitalia Preparation of penems
US4656165A (en) * 1983-09-02 1987-04-07 Ciba-Geigy Corporation Aminomethyl penem compounds
US4711886A (en) * 1984-07-02 1987-12-08 Merck & Co., Inc. β-lactam derivatives as anti-inflammatory and antidegenerative agents
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
EP0278911B1 (fr) * 1987-02-11 1993-08-04 Ciba-Geigy Ag Acides bêta-lactame carboxyliques bicycliques
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
US5364768A (en) * 1987-07-07 1994-11-15 Farmitalia Carlo Erba S.R.L. Process for the preparation of penems
IT1286558B1 (it) * 1996-02-27 1998-07-15 Menarini Farma Ind Processo per la preparazione di 2-alogenometil-penems e loro uso per la preparazione di penems antibatterici
US6156745A (en) 1997-12-29 2000-12-05 Research Corporation Technologies, Inc. 2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6720445B2 (en) * 2000-12-21 2004-04-13 Beacon Laboratories, Inc. Acetyloxymethyl esters and methods for using the same
ATE339424T1 (de) 2001-07-24 2006-10-15 Univ Southern Methodist 3-substituierte 7-alkylidene-3-cephem-4- carbonsäuren als beta-lactamase inhibitoren
AU2003224874A1 (en) 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77306A1 (fr) * 1977-05-09 1979-01-18
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0003960B1 (fr) * 1978-02-02 1983-06-29 Ciba-Geigy Ag Composés thia-aza substitués en position 6, leur préparation et compositions pharmaceutiques les contenant
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (fr) * 1978-12-22 1980-07-09 Beecham Group Plc Agents antibactériens à cycle bêta-lactame bicyclique, leur utilisation dans des compositions pharmaceutiques, procédés pour leur préparation et intermédiaires à utiliser dans de tels procédés

Also Published As

Publication number Publication date
FI800493A7 (fi) 1980-08-25
NL192265B (nl) 1996-12-02
FI75163B (fi) 1988-01-29
IT1193922B (it) 1988-08-31
DE3006273A1 (de) 1980-09-04
NO161000B (no) 1989-03-13
IE800338L (en) 1980-08-24
GB2043639A (en) 1980-10-08
NL8001012A (nl) 1980-08-26
UA6041A1 (uk) 1994-12-29
DK159448B (da) 1990-10-15
HK74487A (en) 1987-10-23
GB2043639B (en) 1983-07-20
SE449489B (sv) 1987-05-04
FR2449690B1 (fr) 1986-06-13
CH654831A5 (de) 1986-03-14
LU82192A1 (fr) 1980-06-06
NZ192949A (en) 1984-03-16
FR2449690A1 (fr) 1980-09-19
AT368506B (de) 1982-10-25
NL192265C (nl) 1997-04-03
NO161000C (no) 1989-06-21
SE8001424L (sv) 1980-08-25
HU182664B (en) 1984-02-28
ES488886A0 (es) 1981-11-16
CH651570A5 (de) 1985-09-30
NO800501L (no) 1980-08-25
YU42964B (en) 1989-02-28
AU535080B2 (en) 1984-03-01
CA1154010A (fr) 1983-09-20
AU5567080A (en) 1980-09-11
PT70849A (en) 1980-03-01
DK159448C (da) 1991-03-04
FI75163C (fi) 1988-05-09
ES8107224A1 (es) 1981-10-01
DK77580A (da) 1980-08-25
GR73623B (fr) 1984-03-26
ES495977A0 (es) 1981-10-01
IE49407B1 (en) 1985-10-02
ES8200685A1 (es) 1981-11-16
CS226010B2 (en) 1984-03-19
YU46180A (en) 1983-02-28
IT8020021A0 (it) 1980-02-19
ATA91980A (de) 1982-02-15
IT8020021A1 (it) 1981-08-19

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