CA1243682A - Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique - Google Patents

Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique

Info

Publication number: CA1243682A
Authority: CA; Canada
Prior art keywords: compound; econazole; acexamic acid; solvent; acid
Prior art date: 1985-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000487284A

Other languages

English (en)

Inventor

Michele G. Di Schiena

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Meda Pharma SpA

Original Assignee

Chinoin SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-23

Filing date

1985-07-23

Publication date

1988-10-25

1985-07-23 Application filed by Chinoin SpA filed Critical Chinoin SpA

1985-07-23 Priority to CA000487284A priority Critical patent/CA1243682A/fr

1988-10-25 Application granted granted Critical

1988-10-25 Publication of CA1243682A publication Critical patent/CA1243682A/fr

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 32
WDSCBUNMANHPFH-UHFFFAOYSA-N acexamic acid Chemical compound CC(=O)NCCCCCC(O)=O WDSCBUNMANHPFH-UHFFFAOYSA-N 0.000 title claims abstract description 15
229960004582 acexamic acid Drugs 0.000 title claims abstract description 14
LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 title claims abstract description 12
229960003913 econazole Drugs 0.000 title claims abstract description 11
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 17
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
239000002904 solvent Substances 0.000 claims description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
238000001704 evaporation Methods 0.000 claims description 3
230000008020 evaporation Effects 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
230000003110 anti-inflammatory effect Effects 0.000 claims description 2
238000000034 method Methods 0.000 claims 2
230000001857 anti-mycotic effect Effects 0.000 claims 1
239000002543 antimycotic Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
238000011200 topical administration Methods 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 6
230000000699 topical effect Effects 0.000 abstract description 5
238000002360 preparation method Methods 0.000 abstract description 4
238000009472 formulation Methods 0.000 abstract description 2
239000000243 solution Substances 0.000 description 7
239000006071 cream Substances 0.000 description 5
229940099259 vaseline Drugs 0.000 description 5
239000004615 ingredient Substances 0.000 description 4
201000010099 disease Diseases 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
239000003921 oil Substances 0.000 description 3
206010017533 Fungal infection Diseases 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
208000024386 fungal infectious disease Diseases 0.000 description 2
239000000499 gel Substances 0.000 description 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
229910017604 nitric acid Inorganic materials 0.000 description 2
XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000000829 suppository Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
239000011701 zinc Substances 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
231100000315 carcinogenic Toxicity 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000006196 drop Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
230000035876 healing Effects 0.000 description 1
230000000622 irritating effect Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
230000009854 mucosal lesion Effects 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
150000002828 nitro derivatives Chemical class 0.000 description 1
150000004005 nitrosamines Chemical class 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
-1 preservers Substances 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
239000000344 soap Substances 0.000 description 1
239000011493 spray foam Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000006217 urethral suppository Substances 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000487284A 1985-07-23 1985-07-23 Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique Expired CA1243682A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000487284A CA1243682A (fr)	1985-07-23	1985-07-23	Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000487284A CA1243682A (fr)	1985-07-23	1985-07-23	Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique

Publications (1)

Publication Number	Publication Date
CA1243682A true CA1243682A (fr)	1988-10-25

Family

ID=4131028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000487284A Expired CA1243682A (fr)	1985-07-23	1985-07-23	Compose pharmaceutique d'addition entre l'econazole et l'acide acexamique

Country Status (1)

Country	Link
CA (1)	CA1243682A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN117924182A (zh) *	2024-03-25	2024-04-26	华东理工常熟研究院有限公司	益康唑的盐型及其制备方法与应用

1985
- 1985-07-23 CA CA000487284A patent/CA1243682A/fr not_active Expired

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN117924182A (zh) *	2024-03-25	2024-04-26	华东理工常熟研究院有限公司	益康唑的盐型及其制备方法与应用
CN117924182B (zh) *	2024-03-25	2024-05-24	华东理工常熟研究院有限公司	益康唑的盐型及其制备方法与应用

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Legal Events

Date	Code	Title	Description
2005-10-25	MKEX	Expiry