CA1266769A - Particules aimantees pour emploi dans les separations - Google Patents

Particules aimantees pour emploi dans les separations

Info

Publication number: CA1266769A
Authority: CA; Canada
Prior art keywords: precipitate; particles; silane; magnetic; magnetically
Prior art date: 1983-05-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000595288A

Other languages

English (en)

Inventor

Mark S. Chagnon

Ernest V. Groman

Lee Josephson

Roy A. Whitehead

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Corp

Original Assignee

Advanced Magnetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-12

Filing date

1989-03-30

Publication date

1990-03-20

1983-05-12 Priority claimed from US06/493,991 external-priority patent/US4554088A/en

1989-03-30 Application filed by Advanced Magnetics Inc filed Critical Advanced Magnetics Inc

1989-03-30 Priority to CA000595288A priority Critical patent/CA1266769A/fr

1990-03-20 Application granted granted Critical

1990-03-20 Publication of CA1266769A publication Critical patent/CA1266769A/fr

2007-03-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000926 separation method Methods 0.000 title claims abstract description 19
239000006249 magnetic particle Substances 0.000 title abstract description 66
239000002245 particle Substances 0.000 claims abstract description 188
230000005291 magnetic effect Effects 0.000 claims abstract description 86
238000000034 method Methods 0.000 claims abstract description 68
230000008569 process Effects 0.000 claims abstract description 15
239000012736 aqueous medium Substances 0.000 claims abstract description 8
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 45
229910000077 silane Inorganic materials 0.000 claims description 44
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 36
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 35
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
239000002244 precipitate Substances 0.000 claims description 33
230000008878 coupling Effects 0.000 claims description 31
238000010168 coupling process Methods 0.000 claims description 31
238000005859 coupling reaction Methods 0.000 claims description 31
150000004706 metal oxides Chemical group 0.000 claims description 30
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 25
230000027455 binding Effects 0.000 claims description 21
-1 iron cations Chemical class 0.000 claims description 20
239000000243 solution Substances 0.000 claims description 20
239000006185 dispersion Substances 0.000 claims description 18
229910044991 metal oxide Inorganic materials 0.000 claims description 18
238000005406 washing Methods 0.000 claims description 17
239000013078 crystal Substances 0.000 claims description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
229920000642 polymer Polymers 0.000 claims description 14
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238000000576 coating method Methods 0.000 claims description 10
230000005294 ferromagnetic effect Effects 0.000 claims description 10
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
239000011248 coating agent Substances 0.000 claims description 8
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CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 7
239000003960 organic solvent Substances 0.000 claims description 7
239000011780 sodium chloride Substances 0.000 claims description 7
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VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical group [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 claims description 6
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SJECZPVISLOESU-UHFFFAOYSA-N 3-trimethoxysilylpropan-1-amine Chemical compound CO[Si](OC)(OC)CCCN SJECZPVISLOESU-UHFFFAOYSA-N 0.000 claims description 4
VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 4
229960000583 acetic acid Drugs 0.000 claims description 4
YGUFXEJWPRRAEK-UHFFFAOYSA-N dodecyl(triethoxy)silane Chemical compound CCCCCCCCCCCC[Si](OCC)(OCC)OCC YGUFXEJWPRRAEK-UHFFFAOYSA-N 0.000 claims description 4
239000003792 electrolyte Substances 0.000 claims description 4
239000012362 glacial acetic acid Substances 0.000 claims description 4
CZWLNMOIEMTDJY-UHFFFAOYSA-N hexyl(trimethoxy)silane Chemical compound CCCCCC[Si](OC)(OC)OC CZWLNMOIEMTDJY-UHFFFAOYSA-N 0.000 claims description 4
WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical group [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 claims description 4
239000000725 suspension Substances 0.000 claims description 4
CNODSORTHKVDEM-UHFFFAOYSA-N 4-trimethoxysilylaniline Chemical compound CO[Si](OC)(OC)C1=CC=C(N)C=C1 CNODSORTHKVDEM-UHFFFAOYSA-N 0.000 claims description 3
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239000003929 acidic solution Substances 0.000 claims 2
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RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims 2
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
PHQOGHDTIVQXHL-UHFFFAOYSA-N n'-(3-trimethoxysilylpropyl)ethane-1,2-diamine Chemical compound CO[Si](OC)(OC)CCCNCCN PHQOGHDTIVQXHL-UHFFFAOYSA-N 0.000 claims 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
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XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
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XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 6
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SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 5
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ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
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210000001519 tissue Anatomy 0.000 description 1
238000012546 transfer Methods 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
229910000314 transition metal oxide Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
YUYCVXFAYWRXLS-UHFFFAOYSA-N trimethoxysilane Chemical compound CO[SiH](OC)OC YUYCVXFAYWRXLS-UHFFFAOYSA-N 0.000 description 1
208000007089 vaccinia Diseases 0.000 description 1
239000011715 vitamin B12 Substances 0.000 description 1
235000019163 vitamin B12 Nutrition 0.000 description 1
238000003260 vortexing Methods 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Landscapes

Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

CA000595288A 1983-05-12 1989-03-30 Particules aimantees pour emploi dans les separations Expired - Lifetime CA1266769A (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000595288A CA1266769A (fr)	1983-05-12	1989-03-30	Particules aimantees pour emploi dans les separations

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US06/493,991 US4554088A (en)	1983-05-12	1983-05-12	Magnetic particles for use in separations
US493,991		1983-05-12
CA 453195 CA1266769C (fr)	1983-05-12	1984-04-30	Particules aimantees pour emploi dans les separations
CA000595288A CA1266769A (fr)	1983-05-12	1989-03-30	Particules aimantees pour emploi dans les separations

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 453195 Division CA1266769C (fr)	1983-05-12	1984-04-30	Particules aimantees pour emploi dans les separations

Publications (1)

Publication Number	Publication Date
CA1266769A true CA1266769A (fr)	1990-03-20

Family

ID=25670376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000595288A Expired - Lifetime CA1266769A (fr)	1983-05-12	1989-03-30	Particules aimantees pour emploi dans les separations

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CA (1)	CA1266769A (fr)

1989
- 1989-03-30 CA CA000595288A patent/CA1266769A/fr not_active Expired - Lifetime

Legal Events

Date	Code	Title	Description
2007-03-20	MKLA	Lapsed
2012-12-05	MKEC	Expiry (correction)	Effective date: 20121205

Publication	Publication Date	Title
US4695393A (en)	1987-09-22	Magnetic particles for use in separations
US4695392A (en)	1987-09-22	Magnetic particles for use in separations
US4672040A (en)	1987-06-09	Magnetic particles for use in separations
US4554088A (en)	1985-11-19	Magnetic particles for use in separations
US4698302A (en)	1987-10-06	Enzymatic reactions using magnetic particles
US4628037A (en)	1986-12-09	Binding assays employing magnetic particles
Halling et al.	1980	Magnetic supports for immobilized enzymes and bioaffinity adsorbents
US7169618B2 (en)	2007-01-30	Magnetic particles and methods of producing coated magnetic particles
CA1304006C (fr)	1992-06-23	Methode de separation des particules
US4661408A (en)	1987-04-28	Coated chromium dioxide particles
CA1304421C (fr)	1992-06-30	Separation d'affinite utilisant des floculants immobilises
JP2736467B2 (ja)	1998-04-02	磁気応答ポリマー粒子の製造法およびその応用
CN105980046B (zh)	2018-04-03	使用具有磁性性质的颗粒的新诊断测定
GB2048470A (en)	1980-12-10	Solid-phase immunoassay reagent using magnetic carrier particles
JPH06505673A (ja)	1994-06-30	磁気分離機、磁気分離方法、リガンド測定方法ならびに分離方法
JPH05502944A (ja)	1993-05-20	分離に使用するための有機金属で被覆された粒子
US20050079545A1 (en)	2005-04-14	Method for producing microparticles loaded with proteins
WO1990015666A1 (fr)	1990-12-27	Particules magnetiques enrobees utilisees dans des procedes de separation
CA1322067C (fr)	1993-09-07	Mediateurs d'agglutination reversible
AU654381B2 (en)	1994-11-03	Process for producing magnetically responsive polymer particles and application thereof
CA2131605A1 (fr)	1995-03-14	Enduit de sous-couche pour particules et methode d'enduction directe
JPH02210262A (ja)	1990-08-21	間接凝集反応測定法
JPH10505423A (ja)	1998-05-26	細胞分離
Rongsen et al.	1996	Magnetic microparticle antibodies and their application to RIAs
CA1083934A (fr)	1980-08-19	Porte-cupule pour immunoadsorbant