CA1268770C - Preparation de derives genre d'imidazole - Google Patents

Preparation de derives genre d'imidazole

Info

Publication number: CA1268770C
Authority: CA; Canada
Prior art keywords: preparation; och3; hal; compounds; imidazole derivatives
Prior art date: 1984-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA 495608

Other languages

English (en)

Other versions

CA1266669A1 (fr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-23

Filing date

1985-11-18

Publication date

1990-05-08

1985-11-18 Application filed filed Critical

1989-08-08 Priority to CA000607789A priority Critical patent/CA1268770A/fr

1990-03-13 Publication of CA1266669A1 publication Critical patent/CA1266669A1/fr

1990-05-08 Application granted granted Critical

1990-05-08 Publication of CA1268770C publication Critical patent/CA1268770C/fr

2007-05-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000002460 imidazoles Chemical class 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Lubricants (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Golf Clubs (AREA)
Dental Preparations (AREA)
Epoxy Resins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA 495608 1984-11-23 1985-11-18 Preparation de derives genre d'imidazole Expired - Lifetime CA1268770C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA000607789A CA1268770A (fr)	1984-11-23	1989-08-08	Preparation de derives genre d'imidazole

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB08429578A GB2167408B (en)	1984-11-23	1984-11-23	Substituted imidazole derivatives and their preparation and use
GB8429578		1984-11-23

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000607789A Division CA1268770A (fr)	1984-11-23	1989-08-08	Preparation de derives genre d'imidazole

Publications (2)

Publication Number	Publication Date
CA1266669A1 CA1266669A1 (fr)	1990-03-13
CA1268770C true CA1268770C (fr)	1990-05-08

Family

ID=10570140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 495608 Expired - Lifetime CA1268770C (fr)	1984-11-23	1985-11-18	Preparation de derives genre d'imidazole

Country Status (26)

Country	Link
US (1)	US4689339A (fr)
EP (2)	EP0183492B1 (fr)
JP (1)	JPH064597B2 (fr)
KR (1)	KR930004673B1 (fr)
AT (2)	ATE85050T1 (fr)
AU (2)	AU586839B2 (fr)
BG (1)	BG60762B2 (fr)
CA (1)	CA1268770C (fr)
DD (1)	DD258230A1 (fr)
DE (2)	DE3574252D1 (fr)
DK (2)	DK164903C (fr)
ES (2)	ES8704462A1 (fr)
FI (1)	FI80264C (fr)
GB (1)	GB2167408B (fr)
GR (1)	GR852817B (fr)
HK (1)	HK3592A (fr)
HU (1)	HU195189B (fr)
IE (1)	IE58165B1 (fr)
IL (1)	IL77111A (fr)
NO (1)	NO166585C (fr)
NZ (1)	NZ214258A (fr)
PH (1)	PH22016A (fr)
PT (1)	PT81542B (fr)
SG (1)	SG106891G (fr)
SU (1)	SU1424736A3 (fr)
ZA (1)	ZA858942B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0252162A4 (fr) *	1986-01-28	1988-07-29	Mitsui Petrochemical Ind	Procede de preparation de 2-imidazoles non substitues.
FI862039A0 (fi) *	1986-05-15	1986-05-15	Farmos Oy	Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) *	1986-05-15	1990-09-10	Farmos Oy	Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) *	1987-03-20	1997-01-29	アイシン精機株式会社	原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) *	1987-10-06	1990-01-05	Commissariat Energie Atomique	Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) *	1988-12-09	1990-06-13	Farmos Group Limited	Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) *	1989-02-15	1989-04-05	Erba Carlo Spa	Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (fr) *	1989-02-21	1993-08-31	Eugene C. Crichlow	Mecanisme mediatisant la stase ruminale dans l'acidose lactique ruminale
DK344489D0 (da) *	1989-07-12	1989-07-12	Novo Nordisk As	Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) *	1990-05-31	1991-12-04	Farmos Oy	Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en)	1991-05-31	1995-01-18	Orion Yhtymae Oy	Transdermal administration of 4-substituted imidazoles
US5541211A (en) *	1991-06-18	1996-07-30	Orion-Yhtyma Oy	Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
PL176250B1 (pl) *	1991-11-05	1999-05-31	Smithkline Beecham Corp	Sposób wytwarzania pochodnych indanu
GB9127050D0 (en) *	1991-12-20	1992-02-19	Orion Yhtymae Oy	Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) *	1991-12-27	1992-02-19	Scras	Benzofuranylimidazole derivatives
GB9312669D0 (en) *	1993-06-18	1993-08-04	Orion Yhtymae Oy	New opticla isomers
GB9425211D0 (en) *	1994-12-14	1995-02-15	Ucb Sa	Substituted 1H-imidazoles
FR2733983B1 (fr) *	1995-05-10	1997-08-01	Pf Medicament	Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) *	1995-10-03	1995-12-06	Orion Yhtymae Oy	New imidazole derivatives
FR2754709B1 (fr)	1996-10-23	1999-03-05	Sanofi Sa	Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
EP0986530A1 (fr)	1997-06-05	2000-03-22	Venantius Limited	Composes d'indane et leur utilisation pharmaceutique
WO1999051593A1 (fr) *	1998-04-02	1999-10-14	Ortho-Mcneil Pharmaceutical, Inc.	4-thionaphtyl-1h-imidazoles ayant une activite recepteur alpha-2-adrenergique
FR2784989B1 (fr) *	1998-09-10	2002-09-27	Fabre Pierre Sante	Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
JP2002534511A (ja) *	1999-01-18	2002-10-15	ノボノルディスクアクティーゼルスカブ	置換型イミダゾール、それらの調製及び使用
US6388090B2 (en) *	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
US6593324B2 (en)	2000-03-01	2003-07-15	Orion Corporation	Dervatives of quinoline as alpha-2 antagonists
JP2003532712A (ja)	2000-05-08	2003-11-05	オリオンコーポレーション	α２アドレナリン作用活性を有する新規な多環式インダニルイミダゾール
US6503894B1 (en)	2000-08-30	2003-01-07	Unimed Pharmaceuticals, Inc.	Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en)	2001-06-26	2003-04-08	Pfizer Inc.	Insecticidal pet collar
DE60316672T2 (de)	2002-04-03	2008-07-17	Orion Corp.	Polycyclische verbindungen als potente alpha2-adrenoceptor antagonisten
US8188126B2 (en)	2002-05-16	2012-05-29	Pierre Fabre Medicament	Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) *	2003-01-08	2005-10-31	Juvantia Pharma Ltd Oy	Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
ES2315740T3 (es) *	2003-11-04	2009-04-01	Intervet International Bv	Formulaciones ectoparasiticidas de espinosinas y pesticidas de azol.
FI20050657A0 (fi) *	2005-06-17	2005-06-17	Orion Corp	Atipametsolin kiteytysmenetelmä
SI1937276T1 (sl)	2005-10-12	2013-04-30	Unimed Pharmaceuticals, Llc C/O Abbott Laboratoires 100 Abbott Park Road	IzboljĹˇani testosteronski gel in postopek uporabe
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CA2659379A1 (fr) *	2006-08-08	2008-02-14	Intervet International B.V.	Composition a activite antiparasitaire amelioree
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) *	2007-12-05	2009-11-27	Grindeks Jsc	Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP3065741B1 (fr)	2013-11-05	2021-09-22	3M Innovative Properties Company	Formulations d'injection a base d'huile de sesame
AR104882A1 (es)	2015-06-05	2017-08-23	Orion Corp	DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
WO2017079734A1 (fr) *	2015-11-05	2017-05-11	University Of Louisville Research Foundation, Inc.	Anesthésie et analgésie locales et régionales
EP3478676A1 (fr)	2016-06-29	2019-05-08	Orion Corporation	Dérivés de benzodioxane et leur utilisation pharmaceutique
EP3897214A1 (fr)	2018-12-21	2021-10-27	Société des Produits Nestlé S.A.	Composition nutritionnelle pour induire une sensation de satiété, un meilleur sommeil et/ou limiter le réveil nocturne chez les nourrissons ou les jeunes enfants
CN111978254A (zh) *	2019-05-22	2020-11-24	南京康德祥医药科技有限公司	一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) *	2020-09-07	2020-11-13	上海阿达玛斯试剂有限公司	一种阿替美唑的制备方法
LU103072B1 (en)	2023-02-15	2024-08-19	Univ Ljubljani	N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
EP4658639A1 (fr)	2023-02-01	2025-12-10	Univerza V Ljubljani	N, n-dialkyl-4-(2-éthylindan-2-yl)-1h-imidazole-1-carboxamides et composés apparentés pour le traitement de maladies neurodégénératives
CN117186010B (zh) *	2023-08-15	2026-04-14	厦门欧瑞捷生物科技有限公司	一种盐酸阿替美唑的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2933962A1 (de) *	1979-08-22	1981-03-26	Hoechst Ag, 65929 Frankfurt	Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) *	1980-03-04	1982-08-03	Farmitalia Carlo Erba S.P.A.	3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) *	1980-09-10	1981-11-24	Syntex (U.S.A.) Inc.	2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ZW13782A1 (en) *	1981-07-28	1982-10-06	Reckitt & Colmann Prod Ltd	Imidazoline derivatives
ES8503669A1 (es) *	1982-07-05	1985-03-01	Erba Farmitalia	Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) *	1983-01-14	1985-09-13	Adir	Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) *	1983-03-18	1984-09-21	Synthelabo	Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

1984
- 1984-11-23 GB GB08429578A patent/GB2167408B/en not_active Expired
1985
- 1985-11-05 FI FI854335A patent/FI80264C/fi not_active IP Right Cessation
- 1985-11-18 CA CA 495608 patent/CA1268770C/fr not_active Expired - Lifetime
- 1985-11-20 DD DD85283044A patent/DD258230A1/de not_active IP Right Cessation
- 1985-11-20 IL IL77111A patent/IL77111A/xx not_active IP Right Cessation
- 1985-11-20 AU AU50083/85A patent/AU586839B2/en not_active Expired
- 1985-11-20 NZ NZ214258A patent/NZ214258A/xx unknown
- 1985-11-21 EP EP85308491A patent/EP0183492B1/fr not_active Expired
- 1985-11-21 DE DE8585308491T patent/DE3574252D1/de not_active Expired
- 1985-11-21 GR GR852817A patent/GR852817B/el unknown
- 1985-11-21 IE IE292985A patent/IE58165B1/en not_active IP Right Cessation
- 1985-11-21 ZA ZA858942A patent/ZA858942B/xx unknown
- 1985-11-21 DE DE8888106210T patent/DE3587045T2/de not_active Expired - Fee Related
- 1985-11-21 AT AT88106210T patent/ATE85050T1/de not_active IP Right Cessation
- 1985-11-21 US US06/800,192 patent/US4689339A/en not_active Expired - Lifetime
- 1985-11-21 EP EP88106210A patent/EP0310745B1/fr not_active Expired - Lifetime
- 1985-11-21 AT AT85308491T patent/ATE47997T1/de not_active IP Right Cessation
- 1985-11-21 KR KR1019850008704A patent/KR930004673B1/ko not_active Expired - Fee Related
- 1985-11-21 PH PH33077A patent/PH22016A/en unknown
- 1985-11-22 PT PT81542A patent/PT81542B/pt unknown
- 1985-11-22 HU HU854471A patent/HU195189B/hu unknown
- 1985-11-22 NO NO854671A patent/NO166585C/no unknown
- 1985-11-22 JP JP60263586A patent/JPH064597B2/ja not_active Expired - Lifetime
- 1985-11-22 DK DK540485A patent/DK164903C/da not_active IP Right Cessation
- 1985-11-22 SU SU853979907A patent/SU1424736A3/ru active
- 1985-11-22 ES ES549178A patent/ES8704462A1/es not_active Expired
1986
- 1986-12-29 ES ES557268A patent/ES8801248A1/es not_active Expired
1989
- 1989-04-21 AU AU33329/89A patent/AU3332989A/en not_active Abandoned
1991
- 1991-12-17 SG SG1068/91A patent/SG106891G/en unknown
1992
- 1992-01-09 HK HK35/92A patent/HK3592A/en not_active IP Right Cessation
- 1992-05-04 DK DK058292A patent/DK58292A/da not_active Application Discontinuation
1994
- 1994-01-18 BG BG098378A patent/BG60762B2/bg unknown

Also Published As

Publication number	Publication date
GB8429578D0 (en)	1985-01-03
GR852817B (fr)	1986-03-21
HU195189B (en)	1988-04-28
HK3592A (en)	1992-01-17
IL77111A0 (en)	1986-04-29
FI80264C (fi)	1990-05-10
EP0183492B1 (fr)	1989-11-15
GB2167408B (en)	1988-05-25
EP0183492A1 (fr)	1986-06-04
GB2167408A (en)	1986-05-29
DE3587045T2 (de)	1993-06-03
DE3587045D1 (de)	1993-03-11
DD258230A1 (de)	1988-07-13
KR860004028A (ko)	1986-06-16
ZA858942B (en)	1986-08-27
FI854335A7 (fi)	1986-05-24
EP0310745B1 (fr)	1993-01-27
EP0310745A2 (fr)	1989-04-12
DK540485D0 (da)	1985-11-22
ES557268A0 (es)	1987-12-16
AU3332989A (en)	1989-08-10
DK164903C (da)	1993-01-25
JPH064597B2 (ja)	1994-01-19
EP0310745A3 (en)	1989-10-11
SG106891G (en)	1992-02-14
NO166585C (no)	1991-08-21
NO854671L (no)	1986-05-26
PH22016A (en)	1988-05-13
AU5008385A (en)	1986-05-29
US4689339A (en)	1987-08-25
PT81542A (en)	1985-12-01
CA1266669A1 (fr)	1990-03-13
NO166585B (no)	1991-05-06
IE852929L (en)	1986-05-23
IL77111A (en)	1989-09-28
ES8801248A1 (es)	1987-12-16
AU586839B2 (en)	1989-07-27
DK58292D0 (da)	1992-05-04
BG60762B2 (bg)	1996-02-29
ES8704462A1 (es)	1987-04-01
DE3574252D1 (en)	1989-12-21
ES549178A0 (es)	1987-04-01
ATE85050T1 (de)	1993-02-15
JPS61143366A (ja)	1986-07-01
ATE47997T1 (de)	1989-12-15
DK58292A (da)	1992-05-04
HUT38913A (en)	1986-07-28
SU1424736A3 (ru)	1988-09-15
FI854335A0 (fi)	1985-11-05
FI80264B (fi)	1990-01-31
DK164903B (da)	1992-09-07
KR930004673B1 (ko)	1993-06-03
PT81542B (pt)	1988-03-03
NZ214258A (en)	1989-02-24
IE58165B1 (en)	1993-07-28
DK540485A (da)	1986-05-24

Legal Events

Date	Code	Title	Description
2007-03-13	MKEX	Expiry

Publication	Publication Date	Title
ES8704462A1 (es)	1987-04-01	Un procedimiento para preparar imidazoles substituidos
PT81910B (en)	1987-05-13	Process for preparing derivatives of imidazole and pharmaceutical compositions containing these derivatives
FI871655A7 (fi)	1987-11-16	Foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
EP0106281A3 (en)	1985-01-09	Analgesia-effecting 5-hydroxytryptophan derivatives
ES8700253A1 (es)	1986-10-01	Procedimiento para preparar compuestos de 5-alquil-1-fenil- -2-piperazinoalquilpirazolin-3-ona
NZ224221A (en)	1990-07-26	Isoquino(2,1-g)(1,6)naphthyridine derivatives, and pharmaceutical compositions codntaining such
DE3569376D1 (en)	1989-05-18	1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
ES8603861A1 (es)	1986-01-01	Un procedimiento para preparar derivados sustituidos de 1,3 -dioxano
JPS6463569A (en)	1989-03-09	Heteroaryl derivative
PL244355A1 (en)	1985-02-13	Process for preparing novel semicarbazides
MY101746A (en)	1992-01-17	1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.