CA1340748C - Gene synthetique de protease de vih et methode pour son expression - Google Patents

Gene synthetique de protease de vih et methode pour son expression

Info

Publication number
CA1340748C
CA1340748C CA000604978A CA604978A CA1340748C CA 1340748 C CA1340748 C CA 1340748C CA 000604978 A CA000604978 A CA 000604978A CA 604978 A CA604978 A CA 604978A CA 1340748 C CA1340748 C CA 1340748C
Authority
CA
Canada
Prior art keywords
protease
sequence
protein
gene
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000604978A
Other languages
English (en)
Inventor
Stephen Oroszlan
Peter T. Mora
John Medabalimi Louis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Commerce
Original Assignee
United States Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Commerce filed Critical United States Department of Commerce
Application granted granted Critical
Publication of CA1340748C publication Critical patent/CA1340748C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000604978A 1988-07-13 1989-07-06 Gene synthetique de protease de vih et methode pour son expression Expired - Lifetime CA1340748C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21830488A 1988-07-13 1988-07-13
US218,304 1988-07-13

Publications (1)

Publication Number Publication Date
CA1340748C true CA1340748C (fr) 1999-09-14

Family

ID=22814563

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000604978A Expired - Lifetime CA1340748C (fr) 1988-07-13 1989-07-06 Gene synthetique de protease de vih et methode pour son expression

Country Status (6)

Country Link
EP (1) EP0425580A4 (fr)
JP (1) JPH04500602A (fr)
AU (1) AU635216B2 (fr)
CA (1) CA1340748C (fr)
IL (1) IL90947A (fr)
WO (1) WO1990000556A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012806A1 (fr) * 1991-12-24 1993-07-08 Amrad Corporation Limited Procede de traitement de tumeurs et de sarcomes
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
CA2130754C (fr) * 1992-03-11 2005-02-08 Damian W. Grobelny Derives amines d'hydrocarbures avec substitution par un groupement oxo- et hydroxy
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6001558A (en) * 1997-06-25 1999-12-14 Ortho Clinical Diagnostics, Inc. Amplification and detection of HIV-1 and/or HIV 2
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
CA2358915C (fr) 1998-12-31 2010-06-01 Chiron Corporation Polypeptides vih env modifies
WO2000039304A2 (fr) 1998-12-31 2000-07-06 Chiron Corporation Polynucleotides codant pour des polypeptides antigeniques du type c du vih; polypeptides et leurs utilisations
EP1427806A4 (fr) 2001-08-31 2006-04-26 Chiron Corp Polynucleotides codant des polypeptides de type b du vih antigeniques, polypeptides et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252477A (en) * 1987-06-01 1993-10-12 The United States Of America As Represented By The United States Department Of Health And Human Services Human immunodeficiency virus specific proteolytic enzyme and a method for its synthesis and renaturation

Also Published As

Publication number Publication date
IL90947A0 (en) 1990-02-09
AU635216B2 (en) 1993-03-18
EP0425580A4 (en) 1992-05-06
IL90947A (en) 1997-06-10
AU4058589A (en) 1990-02-05
JPH04500602A (ja) 1992-02-06
EP0425580A1 (fr) 1991-05-08
WO1990000556A1 (fr) 1990-01-25

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Kräusslich Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.
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Louis et al. Autoprocessing of the HIV‐1 protease using purified wild‐type and mutated fusion proteins expressed at high levels in Escherichia coli
Partin et al. Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase
CA1340748C (fr) Gene synthetique de protease de vih et methode pour son expression
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Legal Events

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Effective date: 20160914