CA2014318A1 - Reactifs, methodes et trousses pour un dosage immunologique par polarisation de la fluorescence de substances du genre amphetamine - Google Patents
Reactifs, methodes et trousses pour un dosage immunologique par polarisation de la fluorescence de substances du genre amphetamineInfo
- Publication number
- CA2014318A1 CA2014318A1 CA2014318A CA2014318A CA2014318A1 CA 2014318 A1 CA2014318 A1 CA 2014318A1 CA 2014318 A CA2014318 A CA 2014318A CA 2014318 A CA2014318 A CA 2014318A CA 2014318 A1 CA2014318 A1 CA 2014318A1
- Authority
- CA
- Canada
- Prior art keywords
- heteroatoms
- amphetamine
- tracers
- analyte
- tracer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 238000003018 immunoassay Methods 0.000 title abstract 3
- 238000002875 fluorescence polarization Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 3
- 239000000700 radioactive tracer Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 abstract 2
- CKRJGDYKYQUNIM-UHFFFAOYSA-N 3-fluoro-2,2-dimethylpropanoic acid Chemical compound FCC(C)(C)C(O)=O CKRJGDYKYQUNIM-UHFFFAOYSA-N 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 238000003149 assay kit Methods 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000010287 polarization Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/946—CNS-stimulants, e.g. cocaine, amphetamines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/816—Alkaloids, amphetamines, and barbiturates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/901—Drugs of abuse, e.g. narcotics, amphetamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/335,627 US5101015A (en) | 1989-04-10 | 1989-04-10 | Reagents for an amphetamine-class fluorescence polarization immunoassay |
| US335,627 | 1989-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2014318A1 true CA2014318A1 (fr) | 1990-10-10 |
| CA2014318C CA2014318C (fr) | 2000-08-08 |
Family
ID=23312578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002014318A Expired - Fee Related CA2014318C (fr) | 1989-04-10 | 1990-04-10 | Reactifs, methodes et trousses pour un dosage immunologique par polarisation de la fluorescence de substances du genre amphetamine |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5101015A (fr) |
| EP (1) | EP0399184B1 (fr) |
| JP (1) | JP2894782B2 (fr) |
| CA (1) | CA2014318C (fr) |
| DE (1) | DE69022286T2 (fr) |
| ES (1) | ES2079390T3 (fr) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326708A (en) * | 1992-02-28 | 1994-07-05 | Lewis Douglas E | Forensically acceptable determinations of gestational fetal exposure to drugs and other chemical agents |
| CA2096495C (fr) * | 1992-06-16 | 2002-07-09 | Kathy Palmer Ordonez | Dosage immunologique pour deux analytes |
| US5573955A (en) * | 1995-06-05 | 1996-11-12 | Microgenics Corp. | Reducing tyramine interference in immunoassays for amphetamine and methamphetamine |
| US6110750A (en) * | 1996-06-28 | 2000-08-29 | Sugden; Edward A. | Rapid detection method of Mycobacterium bovis by fluorescence polarization |
| US20030036106A1 (en) * | 1996-10-28 | 2003-02-20 | Burke Thomas J. | Kinase and phosphatase activity measurement using fluorescence polarization |
| US5968746A (en) | 1997-11-26 | 1999-10-19 | Schneider; David R. | Method and apparatus for preserving human saliva for testing |
| US6306616B1 (en) | 1998-03-27 | 2001-10-23 | Microgenics Corporation | Adsorption type confirmatory assays |
| WO1998026644A2 (fr) * | 1998-03-27 | 1998-06-25 | Microgenics Corporation | Dosages de confirmation pour medicaments a petites molecules |
| US7411068B2 (en) * | 1998-04-08 | 2008-08-12 | Terpetschnig Ewald A | Luminescent compounds |
| EP1078023B1 (fr) * | 1998-04-08 | 2011-01-05 | Corporation Luminex | Composes luminescents |
| US7250517B2 (en) * | 1998-04-08 | 2007-07-31 | Ewald A. Terpetschnig | Luminescent compounds |
| US6538129B1 (en) | 1999-04-07 | 2003-03-25 | Ewald A. Terpetschnig | Luminescent compounds |
| US20030235846A1 (en) * | 1998-04-08 | 2003-12-25 | Terpetschnig Ewald A. | Luminescent compounds |
| US6495529B1 (en) * | 1998-07-01 | 2002-12-17 | Warner-Lambert Company | (−)-Pseudoephedrine as a sympathomimetic drug |
| GB2361473C (en) * | 2000-03-08 | 2005-06-28 | Microgenics Corp | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds |
| US6472228B2 (en) * | 2000-12-04 | 2002-10-29 | Lifepoint, Inc. | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples |
| US6663831B2 (en) | 2001-04-04 | 2003-12-16 | Forefront Diagnostics, Inc. | “One-device” system for testing constituents in fluids |
| DE60228927D1 (de) * | 2001-12-20 | 2008-10-30 | Randox Lab Ltd | Verfahren und Kit zum Nachweis oder zur Bestimmung von 3,4-Methylendioxymethamphetamin |
| US20030171435A1 (en) * | 2002-01-23 | 2003-09-11 | Drug Abuse Sciences, Inc. | New amphetamine derivatives, antibodies against them and pharmaceutical compositions containing them |
| US7101980B2 (en) * | 2002-03-01 | 2006-09-05 | Roche Diagnostics Operations, Inc. | Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes |
| US20030170917A1 (en) * | 2002-03-01 | 2003-09-11 | Roche Diagnostics Corporation | Compounds, antibodies, reagent kits, methods of producing antibodies, and methods of detecting analytes |
| US7169907B2 (en) * | 2002-03-01 | 2007-01-30 | Roche Diagnostics Operations, Inc. | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs |
| US20040087874A1 (en) * | 2002-10-28 | 2004-05-06 | David Schneider | Saliva collection system |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| JP3615752B1 (ja) | 2003-11-18 | 2005-02-02 | 淳 高橋 | 細径樹脂捩じりブラシ |
| US20050130243A1 (en) * | 2003-12-15 | 2005-06-16 | Zheng Yi F. | Assay for entactogens |
| US6991911B2 (en) | 2003-12-15 | 2006-01-31 | Dade Behring Inc. | Assay for entactogens |
| US7022492B2 (en) | 2003-12-15 | 2006-04-04 | Dade Behring Inc. | Ecstasy haptens and immunogens |
| US7037669B2 (en) * | 2004-03-22 | 2006-05-02 | Dade Behring Inc. | Assays for amphetamine and methamphetamine using stereospecific reagents |
| US7115383B2 (en) * | 2004-03-22 | 2006-10-03 | Dade Behring Inc. | Assays for amphetamine and methamphetamine |
| GB2404022B (en) * | 2004-06-14 | 2005-08-10 | Cozart Bioscience Ltd | Competitive assays for the detection of methamphetamine group drugs |
| US20060024769A1 (en) * | 2004-07-29 | 2006-02-02 | Saladax Biomedical Inc. | Taxol immunoassay |
| US20060024768A1 (en) | 2004-07-29 | 2006-02-02 | Saladax Biomedical, Inc. | Taxol immunoassay |
| US20060177883A1 (en) | 2005-02-08 | 2006-08-10 | Saladax Biomedical Inc. | 5-Fluoro-uracil immunoassay |
| US20060216767A1 (en) | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
| JP4896959B2 (ja) | 2005-03-30 | 2012-03-14 | サラダックス バイオメディカル インク. | ドキソルビシン免疫測定法 |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US7695975B2 (en) | 2005-06-23 | 2010-04-13 | Siemens Healthcare Diagnostics Inc. | Detection of adulterated samples |
| US20070281363A1 (en) * | 2006-04-13 | 2007-12-06 | Ewald Terpetschnig | Luminescent compounds |
| US20080076188A1 (en) * | 2006-06-19 | 2008-03-27 | Patsenker Leonid D | Luminescent compounds |
| EP2129788B1 (fr) | 2007-01-30 | 2014-09-03 | SETA BioMedicals, LLC | Composes luminescents |
| US7790401B2 (en) | 2007-08-06 | 2010-09-07 | Siemens Healthcare Diagnostics | Methods for detection of immunosuppressant drugs |
| US7910378B2 (en) | 2007-12-14 | 2011-03-22 | Siemens Healthcare Diagnostics Inc. | Methods for detection of hydrophobic drugs |
| US8329424B2 (en) | 2010-06-25 | 2012-12-11 | Siemens Healthcare Diagnostics | Reduction in false results in assay measurements |
| US10088490B2 (en) | 2010-08-20 | 2018-10-02 | Siemens Healthcare Diagnostics Inc. | Assay for analytes using multiple receptors |
| US8771972B2 (en) * | 2011-05-24 | 2014-07-08 | Saladax Biomedical Inc. | Clozapine immunoassay |
| US8426143B2 (en) | 2011-05-24 | 2013-04-23 | Saladax Biomedical Inc. | Gemcitabine immunoassay |
| ES2671238T3 (es) | 2011-08-12 | 2018-06-05 | Siemens Healthcare Diagnostics Inc. | Detección de esteroides sexuales |
| US8771964B2 (en) | 2012-02-02 | 2014-07-08 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detection of methadone metabolite |
| ES2704857T3 (es) | 2012-06-27 | 2019-03-20 | Siemens Healthcare Diagnostics Inc | Composiciones y métodos para la evaluación de la mezcla de líquidos |
| US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
| US9121859B2 (en) | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
| US20140308751A1 (en) | 2013-04-12 | 2014-10-16 | Siemens Healthcare Diagnostics Inc. | Assays for Analyte Homologs |
| GB201313938D0 (en) | 2013-08-05 | 2013-09-18 | Randox Lab Ltd | Immunoassay for phenethylamines of the 2C and DO sub-families |
| EP3060917B1 (fr) | 2013-10-24 | 2019-05-15 | Siemens Healthcare Diagnostics Inc. | Dosages pour analytes macromoléculaires |
| ES2740851T3 (es) | 2013-12-13 | 2020-02-06 | Siemens Healthcare Diagnostics Inc | Agente de tratamiento previo en ensayos sin aglutinación |
| ES2670991T3 (es) | 2013-12-18 | 2018-06-04 | Siemens Healthcare Diagnostics Inc. | Detección de enfermedad endotelial |
| GB201409516D0 (en) | 2014-05-29 | 2014-07-16 | Randox Lab Ltd | Immunoassay for compounds of the NBOMe family |
| CN106661115A (zh) | 2014-06-27 | 2017-05-10 | 西门子医疗保健诊断公司 | 对维生素d差向异构体特异性的结合配偶体 |
| ES2853525T3 (es) | 2014-06-27 | 2021-09-16 | Siemens Healthcare Diagnostics Inc | Parejas de unión específicas para epímeros de vitamina D en ensayos de vitamina D |
| CA3097360A1 (fr) * | 2018-04-19 | 2019-10-24 | Ellie LLC | Clarification d'echantillon et reduction de fluorescence de fond pour la detection par fluorescence d'analytes |
| CN112202628B (zh) * | 2020-09-08 | 2022-09-02 | 杭州涂鸦信息技术有限公司 | 一种WiFi模块串口协议自动化测试系统及方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1553291A (fr) * | 1967-01-27 | 1969-01-10 | ||
| HU162378B (fr) * | 1970-06-10 | 1973-02-28 | ||
| US4097586A (en) * | 1970-06-11 | 1978-06-27 | Biological Developments, Inc. | Immunochemical assay method |
| US3940475A (en) * | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US3825561A (en) * | 1970-10-12 | 1974-07-23 | Sumitomo Chemical Co | Fluoran compounds |
| US3690834A (en) * | 1971-01-11 | 1972-09-12 | Syva Co | Ligand determination with spin labeled compounds by receptor displacement |
| US3704282A (en) * | 1971-04-09 | 1972-11-28 | Sidney Spector | Catecholamine antigens and antibodies specific therefor |
| US4067774A (en) * | 1971-05-14 | 1978-01-10 | Syva Company | Compounds for enzyme amplification assay |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3996344A (en) * | 1972-05-15 | 1976-12-07 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies and use |
| US4022878A (en) * | 1972-05-15 | 1977-05-10 | Biological Developments, Inc. | Methods and compounds for producing specific antibodies |
| US3966764A (en) * | 1972-07-10 | 1976-06-29 | Syva Company | Ligand determination of spin labeled compounds by receptor displacement-amphetamine analogs |
| US3878187A (en) * | 1972-09-11 | 1975-04-15 | Syva Co | Polypeptide derivatives of amphetamine and analogs for immunoassays |
| US3856469A (en) * | 1973-01-02 | 1974-12-24 | Syva Corp | Interferant removal from amphetamine immunoassay |
| US4255329A (en) * | 1973-10-02 | 1981-03-10 | Syva Company | Double receptor fluorescent immunoassay |
| US4041076A (en) * | 1974-10-23 | 1977-08-09 | Hoffmann-La Roche Inc. | Immunoassay for pharmacologically active phenethylamines |
| US4016146A (en) * | 1974-12-10 | 1977-04-05 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies, and use |
| JPS51101120A (en) * | 1975-02-28 | 1976-09-07 | Dai Ichi Kogyo Seiyaku Co Ltd | Kogen oyobi kotainoseiho |
| US4329281A (en) * | 1978-06-05 | 1982-05-11 | Hoffmann-La Roche Inc. | Hapten compositions |
| US4588697A (en) * | 1979-09-07 | 1986-05-13 | Syntex (U.S.A.) Inc. | Method for performing fluorescent protein binding assay employing novel alkyl substituted fluorescent compounds and conjugates |
| US4481136A (en) * | 1979-09-07 | 1984-11-06 | Syva Company | Alkyl substituted fluorescent compounds and conjugates |
| US4351760A (en) * | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| JPS56125666A (en) * | 1980-03-07 | 1981-10-02 | Fujisawa Pharmaceut Co Ltd | Immuno-analytical method for amphetamines and reagent thereof |
| US4593089A (en) * | 1980-07-30 | 1986-06-03 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluorescein aminoglycosides |
| US4420568A (en) * | 1980-07-30 | 1983-12-13 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins |
| AU555213B2 (en) * | 1981-02-17 | 1986-09-18 | Abbott Laboratories | N-substituted-amido-fluoresein derivatives |
| US4785080A (en) * | 1981-03-30 | 1988-11-15 | Baker Instruments Corporation | Labeled analytes |
| US4585862A (en) * | 1981-12-11 | 1986-04-29 | Abbott Laboratories | Fluorescence polarization immunoassay |
| US4492762A (en) * | 1981-12-11 | 1985-01-08 | Abbott Laboratories | Fluorescent polarization immunoassays |
| US4476228A (en) * | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques |
| US4476229A (en) * | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Substituted carboxyfluoresceins |
| US4510251A (en) * | 1982-11-08 | 1985-04-09 | Abbott Laboratories | Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers |
| US4681859A (en) * | 1984-09-21 | 1987-07-21 | Ortho Diagnostic Systems Inc. | Fluorescence polarization immunoassay for heavy antigens |
| EP0199042A1 (fr) * | 1985-03-26 | 1986-10-29 | Abbott Laboratories | Dosage, traceurs, immunogènes et anticorps du procainamide |
| EP0201761B1 (fr) * | 1985-04-30 | 1989-05-31 | Bayer Ag | Utilisation d'amides basiques pour augmenter la porosité de papier ou de matériaux semblable au papier |
| EP0201751A2 (fr) * | 1985-05-08 | 1986-11-20 | Abbott Laboratories | Dérivés de 4-aminométhylfluorescéine pour l'utilisation dans les immuno-essais de fluorescence polarisée |
| EP0218010A3 (fr) * | 1985-07-10 | 1988-01-07 | Abbott Laboratories | Méthode de détection de ligands et carboxyfluorescéines substituées comme traceurs pour sa mise en oeuvre |
| US4751190A (en) * | 1985-07-22 | 1988-06-14 | Abbott Laboratories | Fluorescence polarization immunoassay and reagents for use therein |
| US4939264A (en) * | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US4868132A (en) * | 1987-02-03 | 1989-09-19 | Abbott Laboratories | Fluorescence polarization immunoassay for amphetamine/methamphetamine |
| NL8700430A (nl) * | 1987-02-20 | 1988-09-16 | Texas Instruments Holland | Verwarmingsinrichting voor brandstof, in het bijzonder dieselolie. |
| JPH0737986B2 (ja) * | 1988-03-29 | 1995-04-26 | 松下電器産業株式会社 | 免疫的検出方法 |
| US5026827A (en) * | 1988-09-02 | 1991-06-25 | Matsushita Electric Industrial Co., Ltd. | Amphetamine-protein complex as immunogen for obtaining antibodies specific to methamphetamine |
-
1989
- 1989-04-10 US US07/335,627 patent/US5101015A/en not_active Expired - Lifetime
-
1990
- 1990-04-03 DE DE69022286T patent/DE69022286T2/de not_active Expired - Fee Related
- 1990-04-03 EP EP90106319A patent/EP0399184B1/fr not_active Expired - Lifetime
- 1990-04-03 ES ES90106319T patent/ES2079390T3/es not_active Expired - Lifetime
- 1990-04-09 JP JP2093823A patent/JP2894782B2/ja not_active Expired - Fee Related
- 1990-04-10 CA CA002014318A patent/CA2014318C/fr not_active Expired - Fee Related
-
1993
- 1993-06-29 US US08/083,928 patent/US5354693A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0399184A2 (fr) | 1990-11-28 |
| EP0399184A3 (fr) | 1991-12-27 |
| JPH02300663A (ja) | 1990-12-12 |
| US5354693A (en) | 1994-10-11 |
| US5101015A (en) | 1992-03-31 |
| CA2014318C (fr) | 2000-08-08 |
| EP0399184B1 (fr) | 1995-09-13 |
| DE69022286D1 (de) | 1995-10-19 |
| JP2894782B2 (ja) | 1999-05-24 |
| DE69022286T2 (de) | 1996-04-18 |
| ES2079390T3 (es) | 1996-01-16 |
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