CA2016181A1 - Arylthiazolylimidazoles comme antagonistes du 5ht3 - Google Patents

Arylthiazolylimidazoles comme antagonistes du 5ht3

Info

Publication number
CA2016181A1
CA2016181A1 CA2016181A CA2016181A CA2016181A1 CA 2016181 A1 CA2016181 A1 CA 2016181A1 CA 2016181 A CA2016181 A CA 2016181A CA 2016181 A CA2016181 A CA 2016181A CA 2016181 A1 CA2016181 A1 CA 2016181A1
Authority
CA
Canada
Prior art keywords
arylthiazolylimidazoles
het
mono
antagonists
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2016181A
Other languages
English (en)
Other versions
CA2016181C (fr
Inventor
Arthur A. Nagel
Terry J. Rosen
James P. Rizzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2016181A1 publication Critical patent/CA2016181A1/fr
Application granted granted Critical
Publication of CA2016181C publication Critical patent/CA2016181C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA002016181A 1989-05-09 1990-05-07 Arylthiazolylimidazoles comme antagonistes du 5ht3 Expired - Fee Related CA2016181C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US349,278 1989-05-09
US07/349,278 US4914207A (en) 1989-05-09 1989-05-09 Arylthiazolylimidazoles

Publications (2)

Publication Number Publication Date
CA2016181A1 true CA2016181A1 (fr) 1990-11-09
CA2016181C CA2016181C (fr) 1999-03-23

Family

ID=23371665

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002016181A Expired - Fee Related CA2016181C (fr) 1989-05-09 1990-05-07 Arylthiazolylimidazoles comme antagonistes du 5ht3

Country Status (10)

Country Link
US (1) US4914207A (fr)
EP (1) EP0397365B1 (fr)
JP (1) JPH0692404B2 (fr)
AT (1) ATE102197T1 (fr)
CA (1) CA2016181C (fr)
DE (1) DE69006907T2 (fr)
DK (1) DK0397365T3 (fr)
ES (1) ES2062354T3 (fr)
FI (1) FI94639C (fr)
IE (1) IE62936B1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140034A (en) * 1989-03-14 1992-08-18 Merck Sharp & Dohme Ltd. Five-membered ring systems with bonded imidazolyl ring substituents
JPH07121917B2 (ja) * 1989-07-31 1995-12-25 四国化成工業株式会社 ４（５）―チオカルバモイル―イミダゾール化合物及びその合成方法
WO1992016527A1 (fr) * 1991-03-22 1992-10-01 Nippon Soda Co., Ltd. Derive de pyridine substitue en position 2, sa production, et bactericide d'agrohorticulture
TW294595B (fr) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
WO1995024406A1 (fr) * 1994-03-10 1995-09-14 Yamanouchi Pharmaceutical Co., Ltd. NOUVEAU DERIVE de 2-(IMIDAZOLYLMETHYL)THIAZOLE ET COMPOSITION MEDICALE ISSUE DE CE DERIVE
US5874452A (en) * 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US6093737A (en) * 1996-12-30 2000-07-25 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU6013998A (en) * 1996-12-30 1998-07-31 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6127390A (en) * 1997-10-02 2000-10-03 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6426356B1 (en) 1998-11-18 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Imidazoethyl thiophenes
HU228783B1 (en) * 2001-07-26 2013-05-28 Greenearth Cleaning Dry cleaning apparatus and method capable of utilizing a siloxane solvent
WO2004014881A2 (fr) 2002-08-09 2004-02-19 Astra Zeneca Ab Nouveaux composes
US8106070B2 (en) * 2006-10-20 2012-01-31 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
EP2432467B1 (fr) 2009-05-20 2018-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur 5-ht3 de la sérotonine pour leur utilisation dans le traitement d'un trouble lésionnel vestibulaire
JP6105594B2 (ja) 2011-09-30 2017-03-29 エンドゥ ファーマシューティカルズ，インコーポレイティド 癌処置用ｃｙｐ１７阻害剤としてのイミダゾール誘導体
JP6130383B2 (ja) 2011-09-30 2017-05-17 エンドゥ ファーマシューティカルズ，インコーポレイティド ピリジン誘導体
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2019033201A1 (fr) 2017-08-14 2019-02-21 Gestion Claude Boivin Inc. Système de bras mécanique destiné à collecter des ordures à partir d'un contenant à ordures

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519637A (en) * 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
NL7017486A (fr) * 1969-12-15 1971-06-17
DE1964995A1 (de) * 1969-12-24 1971-07-01 Bayer Ag N-Benzyltriazole,Verfahren zu ihrer Herstellung und ihre Verwendung zur Regulierung des Pflanzenwachstums
US4468399A (en) * 1981-12-28 1984-08-28 Eli Lilly And Company 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
JPH0725754B2 (ja) * 1986-01-30 1995-03-22 富山化学工業株式会社 新規なチアゾール化合物またはその塩
DE3830240A1 (de) * 1987-10-14 1989-04-27 Bayer Ag Substituierte 1-aryl-1-(thiazol-2-yl)-2-(1,2,4-triazol-1-yl)- und -(imidazol-1-yl)-ethanole, verfahren sowie substituierte 1-aryl-1-(thiazol-2-yl)-2-bromethanole als zwischenprodukte zu ihrer herstellung, und sie enthaltende fungizide und pflanzenwuchsregulierende mittel

Also Published As

Publication number Publication date
FI902292A0 (fi) 1990-05-08
US4914207A (en) 1990-04-03
CA2016181C (fr) 1999-03-23
FI94639B (fi) 1995-06-30
DK0397365T3 (da) 1994-05-24
DE69006907D1 (de) 1994-04-07
IE901665L (en) 1990-11-09
JPH0692404B2 (ja) 1994-11-16
DE69006907T2 (de) 1994-06-09
EP0397365A1 (fr) 1990-11-14
IE62936B1 (en) 1995-03-08
JPH032180A (ja) 1991-01-08
ATE102197T1 (de) 1994-03-15
EP0397365B1 (fr) 1994-03-02
FI94639C (fi) 1995-10-10
ES2062354T3 (es) 1994-12-16

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