CA2043108C - Methode de production d'ibuprofene - Google Patents

Methode de production d'ibuprofene Download PDF

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Publication number
CA2043108C
CA2043108C CA002043108A CA2043108A CA2043108C CA 2043108 C CA2043108 C CA 2043108C CA 002043108 A CA002043108 A CA 002043108A CA 2043108 A CA2043108 A CA 2043108A CA 2043108 C CA2043108 C CA 2043108C
Authority
CA
Canada
Prior art keywords
reaction
ibpe
ibuprofen
palladium
mole ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002043108A
Other languages
English (en)
Other versions
CA2043108A1 (fr
Inventor
Joel D. Hendricks
Graham N. Mott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Corp
Original Assignee
BASF Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF Corp filed Critical BASF Corp
Publication of CA2043108A1 publication Critical patent/CA2043108A1/fr
Application granted granted Critical
Publication of CA2043108C publication Critical patent/CA2043108C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/10—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide
    • C07C51/12—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction with carbon monoxide on an oxygen-containing group in organic compounds, e.g. alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Optical Radar Systems And Details Thereof (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA002043108A 1990-06-04 1991-05-23 Methode de production d'ibuprofene Expired - Fee Related CA2043108C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53363090A 1990-06-04 1990-06-04
US533,630 1990-06-04

Publications (2)

Publication Number Publication Date
CA2043108A1 CA2043108A1 (fr) 1991-12-05
CA2043108C true CA2043108C (fr) 2001-07-17

Family

ID=24126797

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002043108A Expired - Fee Related CA2043108C (fr) 1990-06-04 1991-05-23 Methode de production d'ibuprofene

Country Status (13)

Country Link
EP (1) EP0460905B1 (fr)
JP (1) JP2885542B2 (fr)
KR (1) KR100221484B1 (fr)
AT (1) ATE128451T1 (fr)
BR (1) BR9102236A (fr)
CA (1) CA2043108C (fr)
DE (1) DE69113321T2 (fr)
ES (1) ES2079032T3 (fr)
FI (1) FI102272B1 (fr)
HU (1) HU209123B (fr)
IL (1) IL98306A0 (fr)
SG (1) SG49020A1 (fr)
YU (1) YU97191A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360938A (en) * 1991-08-21 1994-11-01 Union Carbide Chemicals & Plastics Technology Corporation Asymmetric syntheses
US5223640A (en) * 1992-12-23 1993-06-29 Hoechst Celanese Corporation Preparation of optically active α-aryl propionic acids
US5315030A (en) * 1993-09-29 1994-05-24 Ethyl Corporation Catalytic carbonylation of ethers and thioethers
CN113004139B (zh) * 2019-12-18 2022-09-02 华东理工大学 一种低水含量下乙醇羰基合成丙酸的方法
CN111689847B (zh) * 2020-06-12 2022-05-17 浙江新和成股份有限公司 芳基丙酸类化合物的制备方法
CN115353448B (zh) * 2022-08-18 2023-07-21 浙江新和成股份有限公司 一种布洛芬的合成方法、催化体系及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85736A (en) * 1987-03-20 1992-07-15 Hoechst Celanese Corp Method for producing ibuprofen by high pressure carbonylation of 1-(4'-isobutylphenyl)ethanol
CA1338673C (fr) * 1988-04-15 1996-10-22 Graham N. Mott Recyclage de catalyseur dans la carbonylation de l'isobutylphenylethanol en ibuprofene

Also Published As

Publication number Publication date
IL98306A0 (en) 1992-06-21
HUT57697A (en) 1991-12-30
FI102272B (fi) 1998-11-13
KR920000692A (ko) 1992-01-29
FI102272B1 (fi) 1998-11-13
JP2885542B2 (ja) 1999-04-26
YU97191A (sh) 1993-11-16
DE69113321D1 (de) 1995-11-02
JPH04235943A (ja) 1992-08-25
KR100221484B1 (ko) 1999-09-15
EP0460905A2 (fr) 1991-12-11
FI912658A0 (fi) 1991-06-03
BR9102236A (pt) 1992-04-28
EP0460905A3 (en) 1992-10-07
FI912658L (fi) 1991-12-05
SG49020A1 (en) 1998-05-18
CA2043108A1 (fr) 1991-12-05
HU209123B (en) 1994-03-28
ATE128451T1 (de) 1995-10-15
ES2079032T3 (es) 1996-01-01
EP0460905B1 (fr) 1995-09-27
DE69113321T2 (de) 1996-03-07

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