CA2092414A1 - Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase - Google Patents

Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase

Info

Publication number: CA2092414A1
Authority: CA; Canada
Prior art keywords: methyl; formula; aminocarbonyl; group; compound according
Prior art date: 1990-10-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002092414A

Other languages

English (en)

Inventor

Roger E. Markwell

Robert W. Ward

Shahzad S. Rahman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-10-11

Filing date

1991-10-09

Publication date

1992-04-12

1991-10-09 Application filed by Individual filed Critical Individual

1992-04-12 Publication of CA2092414A1 publication Critical patent/CA2092414A1/fr

Status Abandoned legal-status Critical Current

Links

239000002442 collagenase inhibitor Substances 0.000 title abstract description 5
238000000034 method Methods 0.000 claims abstract description 23
238000002360 preparation method Methods 0.000 claims abstract description 11
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229910052739 hydrogen Inorganic materials 0.000 claims description 26
239000001257 hydrogen Substances 0.000 claims description 26
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 22
-1 t-butoxycarbonyl Chemical group 0.000 claims description 21
238000011282 treatment Methods 0.000 claims description 21
125000003545 alkoxy group Chemical group 0.000 claims description 14
239000002253 acid Substances 0.000 claims description 13
229910052757 nitrogen Inorganic materials 0.000 claims description 13
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QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 7
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230000009466 transformation Effects 0.000 description 1
238000000844 transformation Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

CA002092414A 1990-10-11 1991-10-09 Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase Abandoned CA2092414A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9022117.7		1990-10-11
GB909022117A GB9022117D0 (en)	1990-10-11	1990-10-11	Novel compounds

Publications (1)

Publication Number	Publication Date
CA2092414A1 true CA2092414A1 (fr)	1992-04-12

Family

ID=10683561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002092414A Abandoned CA2092414A1 (fr)	1990-10-11	1991-10-09	Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase

Country Status (11)

Country	Link
EP (1)	EP0552264A1 (fr)
JP (1)	JPH06501944A (fr)
AU (1)	AU642046B2 (fr)
CA (1)	CA2092414A1 (fr)
GB (1)	GB9022117D0 (fr)
IE (1)	IE913572A1 (fr)
MX (1)	MX9101501A (fr)
NZ (1)	NZ240167A (fr)
PT (1)	PT99184A (fr)
WO (1)	WO1992006966A1 (fr)
ZA (1)	ZA918074B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5773428A (en) *	1993-08-05	1998-06-30	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
US6013792A (en) *	1993-08-05	2000-01-11	Syntex (U.S.A.), Inc.	Matrix metalloprotease inhibitors
CA2168791A1 (fr) *	1993-08-05	1995-02-16	Arlindo L. Castelhano	Inhibiteurs de la metalloprotease de la matrice
US6037472A (en) *	1993-11-04	2000-03-14	Syntex (U.S.A.) Inc.	Matrix metalloprotease inhibitors
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
CA2238306A1 (fr) *	1995-12-08	1997-06-12	Agouron Pharmaceuticals, Inc.	Inhibiteurs de metalloproteinases, compositions pharmaceutiques contenant ces inhibiteurs et leurs utilisations pharmaceutiques, et procedes et intermediaires servant a leur preparation
DE69624081T2 (de) *	1995-12-20	2003-06-12	Agouron Pharmaceuticals, Inc.	Matrix-metalloprotease Inhibitoren
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en)	1998-08-07	2004-09-24	Pont Pharmaceuticals Du	Succinoylamino lactams as inhibitors of Abeta protein production
AU1618000A (en) *	1998-11-12	2000-05-29	Du Pont Pharmaceuticals Company	Use of radioligands to screen inhibitors of amyloid-beta peptide production
US6737038B1 (en)	1998-11-12	2004-05-18	Bristol-Myers Squibb Company	Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1268450A1 (fr)	2000-06-01	2003-01-02	Bristol-Myers Squibb Pharma Company	Lactames substitues par des succinates cycliques en tant qu'inhibiteurs de la production de la proteine beta
AU2003233154A1 (en)	2002-06-10	2003-12-22	Pfizer Inc.	Metabolites of prinomastat and their sythesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK681287A (da) *	1986-12-24	1988-06-25	Beecham Group Plc	Hidtil ukendte forbindelser
GB9000846D0 (en) *	1990-01-15	1990-03-14	Beecham Group Plc	Novel compounds

1990
- 1990-10-11 GB GB909022117A patent/GB9022117D0/en active Pending
1991
- 1991-10-09 PT PT99184A patent/PT99184A/pt not_active Application Discontinuation
- 1991-10-09 NZ NZ240167A patent/NZ240167A/en unknown
- 1991-10-09 JP JP3516460A patent/JPH06501944A/ja active Pending
- 1991-10-09 AU AU86604/91A patent/AU642046B2/en not_active Ceased
- 1991-10-09 EP EP91919268A patent/EP0552264A1/fr not_active Withdrawn
- 1991-10-09 ZA ZA918074A patent/ZA918074B/xx unknown
- 1991-10-09 CA CA002092414A patent/CA2092414A1/fr not_active Abandoned
- 1991-10-09 WO PCT/GB1991/001749 patent/WO1992006966A1/fr not_active Ceased
- 1991-10-09 MX MX9101501A patent/MX9101501A/es unknown
- 1991-10-16 IE IE357291A patent/IE913572A1/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1992006966A1 (fr)	1992-04-30
MX9101501A (es)	1992-06-05
AU642046B2 (en)	1993-10-07
EP0552264A1 (fr)	1993-07-28
NZ240167A (en)	1993-11-25
ZA918074B (en)	1993-04-13
PT99184A (pt)	1992-09-30
AU8660491A (en)	1992-05-20
IE913572A1 (en)	1992-04-22
GB9022117D0 (en)	1990-11-21
JPH06501944A (ja)	1994-03-03

Legal Events

Date	Code	Title	Description
1995-04-09	FZDE	Dead

Publication	Publication Date	Title
JP2768554B2 (ja)	1998-06-25	金属タンパク質加水分解酵素阻害剤であるヒドロキサム酸誘導体
CA2092414A1 (fr)	1992-04-12	Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase
EP0579650A1 (fr)	1994-01-26	Nouveaux composes
EP0859784B1 (fr)	2002-12-18	Peptides thio-substitues utiles comme inhibiteurs de metalloproteases et de la liberation du tnf
JPS62230757A (ja)	1987-10-09	ヒドロキシルアミン誘導体
EP0216539A2 (fr)	1987-04-01	Dérivés d'acides aminés
JPH0859610A (ja)	1996-03-05	ファルネシル蛋白質トランスフェラーゼの抑制剤
EP0613883A1 (fr)	1994-09-07	Derive d'acide hydroxamique
CA1322073C (fr)	1993-09-07	Derives de l'acide thiolcarboxylique
EP0320118A2 (fr)	1989-06-14	Peptides à activité inhibant la collagénase
US20020107266A1 (en)	2002-08-08	Compounds, compositions and methods for treatment of parasitic infections
US5190937A (en)	1993-03-02	Lactam derivatives
JPS6323897A (ja)	1988-02-01	タフトシン類似体、その製法及び医薬組成物
RU2181123C2 (ru)	2002-04-10	Фармацевтическая композиция с фунгицидной активностью и производные дипептида из альфа-аминокислоты или ее производного и циклопентан-бета-аминокислоты или ее производного
WO1999031052A1 (fr)	1999-06-24	Nouveaux inhibiteurs de metalloproteinases
US5281717A (en)	1994-01-25	Epoxysuccinamic acid derivatives
US4587250A (en)	1986-05-06	Thiazaspirane derivatives, process for their preparation, and medicaments
WO1991015506A1 (fr)	1991-10-17	Phosphonopeptides avec activite inhibitrice de la collagenase
WO1992015319A1 (fr)	1992-09-17	Agents inhibiteurs de protease de l'hiv
IE921100A1 (en)	1992-10-21	Novel compounds
JPS63215660A (ja)	1988-09-08	新規化合物、その製法及びそれを含む医薬組成物
WO2001083433A1 (fr)	2001-11-08	Inhibiteurs bifonctionnels de proteases paludeennes et leurs applications