CA2104698A1 - Aptameres specifiques de biomolecules et methodes de production - Google Patents

Aptameres specifiques de biomolecules et methodes de production

Info

Publication number: CA2104698A1
Authority: CA; Canada
Prior art keywords: aptamer; target; oligonucleotides; oligonucleotide; binding
Prior art date: 1991-02-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002104698A

Other languages

English (en)

Inventor

John J. Toole

Linda C. Griffin

Louis C. Bock

John A. Latham

Daryl Dean Muenchau

Steven Krawczyk

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gilead Sciences Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-21

Filing date

1992-02-21

Publication date

1992-08-22

1992-02-21 Application filed by Individual filed Critical Individual

1992-08-22 Publication of CA2104698A1 publication Critical patent/CA2104698A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin

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Health & Medical Sciences (AREA)
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Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
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Microbiology (AREA)
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Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)

CA002104698A 1991-02-21 1992-02-21 Aptameres specifiques de biomolecules et methodes de production Abandoned CA2104698A1 (fr)

Applications Claiming Priority (20)

Application Number	Priority Date	Filing Date
US659,114		1984-10-09
US65910391A	1991-02-21	1991-02-21
US65884991A	1991-02-21	1991-02-21
US65998091A	1991-02-21	1991-02-21
US65911391A	1991-02-21	1991-02-21
US65998191A	1991-02-21	1991-02-21
US65911491A	1991-02-21	1991-02-21
US65879691A	1991-02-21	1991-02-21
US659,113		1991-02-21
US659,980		1991-02-21
US659,103		1991-02-21
US658,796		1991-02-21
US659,981		1991-02-21
US658,849		1991-02-21
US74521591A	1991-08-14	1991-08-14
US74487091A	1991-08-14	1991-08-14
US744,870		1991-08-14
US745,215		1991-08-14
US78792191A	1991-11-06	1991-11-06
US787,921		1991-11-06

Publications (1)

Publication Number	Publication Date
CA2104698A1 true CA2104698A1 (fr)	1992-08-22

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ID=27581306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002104698A Abandoned CA2104698A1 (fr)	1991-02-21	1992-02-21	Aptameres specifiques de biomolecules et methodes de production

Country Status (6)

Country	Link
EP (1)	EP0572529A4 (fr)
JP (1)	JPH06508022A (fr)
AU (1)	AU1435492A (fr)
CA (1)	CA2104698A1 (fr)
IE (1)	IE920562A1 (fr)
WO (1)	WO1992014843A1 (fr)

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1992
- 1992-02-21 CA CA002104698A patent/CA2104698A1/fr not_active Abandoned
- 1992-02-21 IE IE920562A patent/IE920562A1/en unknown
- 1992-02-21 JP JP4507073A patent/JPH06508022A/ja active Pending
- 1992-02-21 WO PCT/US1992/001383 patent/WO1992014843A1/fr not_active Ceased
- 1992-02-21 AU AU14354/92A patent/AU1435492A/en not_active Abandoned
- 1992-02-21 EP EP9292907174A patent/EP0572529A4/fr not_active Withdrawn

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Publication number	Publication date
JPH06508022A (ja)	1994-09-14
AU1435492A (en)	1992-09-15
EP0572529A4 (fr)	1994-11-02
WO1992014843A1 (fr)	1992-09-03
EP0572529A1 (fr)	1993-12-08
IE920562A1 (en)	1992-08-26

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Date	Code	Title	Description
1999-01-27	EEER	Examination request
2001-02-21	FZDE	Dead

Publication	Publication Date	Title
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Murakami et al.	1986	Role of DNA polymerase alpha and DNA primase in simian virus 40 DNA replication in vitro.
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US20040132067A1 (en)	2004-07-08	Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
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WO2000012530A1 (fr)	2000-03-09	CLIVAGE DIRIGE SUR SITE dU DE CONJUGUES COVALENTS
AU728910B2 (en)	2001-01-18	Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex