CA2106249A1 - Solution pour la perfusion, la conservation et la reperfusion d'organes - Google Patents
Solution pour la perfusion, la conservation et la reperfusion d'organesInfo
- Publication number
- CA2106249A1 CA2106249A1 CA002106249A CA2106249A CA2106249A1 CA 2106249 A1 CA2106249 A1 CA 2106249A1 CA 002106249 A CA002106249 A CA 002106249A CA 2106249 A CA2106249 A CA 2106249A CA 2106249 A1 CA2106249 A1 CA 2106249A1
- Authority
- CA
- Canada
- Prior art keywords
- reperfusion
- preservation
- mmol
- equivalent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000010410 reperfusion Effects 0.000 title abstract 3
- 210000000056 organ Anatomy 0.000 title abstract 2
- 230000010412 perfusion Effects 0.000 title abstract 2
- 238000004321 preservation Methods 0.000 title abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 5
- 108010024636 Glutathione Proteins 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229960003180 glutathione Drugs 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 150000003841 chloride salts Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 229940099584 lactobionate Drugs 0.000 abstract 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L magnesium chloride Substances [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Inorganic materials [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Solution de perfusion, de conservation et reperfusion d'organes. Solution unique de perfusion, stockage et reperfusion, ayant sensiblement la composition suivante : Constituant Concentration g/l mmol/litre K+ 15 ? 5 % Na+ 100 ? 10 % Mg++ 13 ? 5 % Ca++ 0.25 ? 5 % Chlorures 41.5 ? 5 % - Chlorure de calcium, 2H2O 0,037 - Chlorure de potassium 1,118 ? 5 % - Chlorure de magnésium 2,642 Histidine (base) 4,650 30 ? 10 % Mannitol 10,930 60 ? 5 % Lactobionate (acide) 28,664 80 ? 5 % Glutamate (acide) 2,942 20 ? 10 % Eau (quantité pour un litre réajusté à pH 7,30 ? 0,10 à + 20.degree.C) Osmolalité théorique 360 m Osm/kg Glutathion (réduit GSH) ou équivalent 0,5 à 10 mmol/l, (de préférence 3) le glutathion réduit, ou équivalent, étant en solution sous pression partielle d'oxygène réduite ou nulle et se maintenant sensiblement à cette valeur jusqu'à l'utilisation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94607392A | 1992-09-18 | 1992-09-18 | |
| US07/946,073 | 1992-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2106249A1 true CA2106249A1 (fr) | 1994-03-19 |
| CA2106249C CA2106249C (fr) | 2009-04-14 |
Family
ID=25483919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002106249A Expired - Lifetime CA2106249C (fr) | 1992-09-18 | 1993-09-15 | Solution pour la perfusion, la conservation et la reperfusion d'organes |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT407216B (fr) |
| BE (1) | BE1007500A3 (fr) |
| CA (1) | CA2106249C (fr) |
| CH (1) | CH686870A5 (fr) |
| DE (1) | DE4331711C2 (fr) |
| ES (1) | ES2070089B1 (fr) |
| FR (1) | FR2695827B1 (fr) |
| GB (1) | GB2270614B (fr) |
| IT (1) | IT1272638B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19527734A1 (de) * | 1995-07-28 | 1997-01-30 | Hubert Verhaag | Verfahren und Vorrichtung zur Konservierung von Geweben und Organen, insbesondere von Transplantationsgeweben und -organen |
| SE9601396D0 (sv) * | 1996-04-12 | 1996-04-12 | Dieter Haeussinger | New therapeutic treatment 2 |
| US5880098A (en) * | 1996-04-12 | 1999-03-09 | Pharmacia & Upjohn Aktiebolag | Therapeutic treatment |
| DE19706111C2 (de) * | 1997-02-17 | 1999-02-18 | Fresenius Medical Care De Gmbh | Lösung zur Aufbewahrung von Organen |
| RU2140152C1 (ru) * | 1997-03-13 | 1999-10-27 | Иван Антонович Мазур | Консервирующий раствор "б-2" для трансплантатов |
| US5834178C1 (en) * | 1997-07-09 | 2002-04-23 | Univ Wayne State | Flush-storage solution for donor organs |
| CN1057192C (zh) * | 1997-09-10 | 2000-10-11 | 上海长征医院 | 一种配制多器官保存液的方法 |
| DE19834087C1 (de) * | 1998-07-29 | 2000-03-30 | Mirzaie Sedaposhteh Massoud | Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes |
| FR2785501B1 (fr) * | 1998-11-10 | 2001-01-05 | Centre Nat Rech Scient | Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes |
| GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
| US20060078872A1 (en) * | 2004-10-12 | 2006-04-13 | Atsushi Taguchi | Cell-preservation liquid |
| WO2007128866A2 (fr) * | 2006-05-09 | 2007-11-15 | Novobion Oy | Nouvelles compositions chimiques |
| CA2910189A1 (fr) * | 2013-04-24 | 2014-10-30 | Somahlution, Llc | Solutions de conservation de tissu et d'organe ayant une teneur en oxygene augmente, stabilite et duree de conservation |
| US20160088832A1 (en) * | 2013-04-29 | 2016-03-31 | Somahlution, Llc | Formulations containing poly (0-2 hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution |
| CA2923441C (fr) | 2013-11-22 | 2023-03-28 | Somahlution, Llc | Solutions pour augmenter la stabilite et la duree de vie en stockage d'une solution de conservation d'organe et de tissu |
| CN115720893B (zh) * | 2022-08-08 | 2024-02-23 | 四川大学华西医院 | 一种甲状旁腺体外保存液和保存方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| ES2007994A6 (es) * | 1988-08-16 | 1989-07-01 | Grino Boira Jose Maria | Medio liquido para perfusion y preservacion de organos. |
| US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
| US4938961A (en) * | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5104787A (en) * | 1990-03-05 | 1992-04-14 | Lindstrom Richard L | Method for apparatus for a defined serumfree medical solution useful for corneal preservation |
| US5145771A (en) * | 1990-04-12 | 1992-09-08 | The University Of North Carolina At Chapel Hill | Rinse solution for organs and tissues |
| GB9021325D0 (en) * | 1990-10-01 | 1990-11-14 | Geistlich Soehne Ag | Chemical composition |
| CH683485A5 (fr) * | 1990-11-20 | 1994-03-31 | Pasteur Merieux Serums Vacc | Solutions de perfusion, de conservation et de reperfusion d'organes. |
-
1993
- 1993-09-14 BE BE9300965A patent/BE1007500A3/fr not_active IP Right Cessation
- 1993-09-14 FR FR9310926A patent/FR2695827B1/fr not_active Expired - Lifetime
- 1993-09-14 CH CH02760/93A patent/CH686870A5/fr not_active IP Right Cessation
- 1993-09-15 CA CA002106249A patent/CA2106249C/fr not_active Expired - Lifetime
- 1993-09-16 IT ITMI931994A patent/IT1272638B/it active IP Right Grant
- 1993-09-17 ES ES09301971A patent/ES2070089B1/es not_active Expired - Fee Related
- 1993-09-17 GB GB9319264A patent/GB2270614B/en not_active Expired - Lifetime
- 1993-09-17 DE DE4331711A patent/DE4331711C2/de not_active Expired - Lifetime
- 1993-09-20 AT AT0189793A patent/AT407216B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2270614A (en) | 1994-03-23 |
| ATA189793A (de) | 2000-06-15 |
| CH686870A5 (fr) | 1996-07-31 |
| CA2106249C (fr) | 2009-04-14 |
| GB2270614B (en) | 1996-03-20 |
| BE1007500A3 (fr) | 1995-07-18 |
| ITMI931994A0 (it) | 1993-09-16 |
| AT407216B (de) | 2001-01-25 |
| DE4331711C2 (de) | 2001-05-03 |
| ES2070089A1 (es) | 1995-05-16 |
| FR2695827B1 (fr) | 1995-07-28 |
| FR2695827A1 (fr) | 1994-03-25 |
| ITMI931994A1 (it) | 1995-03-16 |
| IT1272638B (it) | 1997-06-26 |
| ES2070089B1 (es) | 1995-12-16 |
| DE4331711A1 (de) | 1994-03-24 |
| GB9319264D0 (en) | 1993-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0606673A3 (fr) | Oxidation contrÔlée des protéines contenant la cystéine, obtenues par voie microbienne. | |
| ES2070089B1 (es) | Solucion de perfusion, conservacion y reperfusion de organos. | |
| BE904831A (fr) | Composition d'activateur tissulaire du plasminogene. | |
| FR2785501B1 (fr) | Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes | |
| DK0943326T4 (da) | Pulveragtigt præparat til nasal administration | |
| US4670261A (en) | Parenteral alimentation solution | |
| TNSN89060A1 (fr) | Methode de conservation de poisson et de fruits de mer frais | |
| EP0202936A1 (fr) | Chélates pures d'amino-acides | |
| IL105339A0 (en) | Pharmaceutical compositions containing undenatured whey protein concentrate | |
| BE1003188A4 (fr) | Composition pharmaceutique destinee a etre administree par voie orale et contenant de la n-acetyl-cysteine, et son application. | |
| JOP20240287A1 (ar) | مركبات تيرزيباتيد واستخداماتها | |
| GR3034946T3 (en) | Preparation of factor ix. | |
| ATA130496A (de) | Pharmazeutische bzw. diätetische zusammensetzungen | |
| DK0639202T3 (da) | Stabil polypeptidsammensætning | |
| DE60213990D1 (de) | Lösungen für die lagerung und perfusion von organen für transplantationen | |
| Jacangelo et al. | Oxidation of sulfhydryl groups by monochloramine | |
| SI0875248T1 (en) | Use of hyaluronic acid for the preparation of an aqueous solution useful as intra-articular lavage liquid | |
| EG19218A (en) | Stable solutions of rebeccamycin analogs and preparation thereof | |
| CA2335913A1 (fr) | Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions | |
| Damuni et al. | Specificity of the heat-stable protein inhibitor of the branched-chain α-keto acid dehydrogenase phosphatase | |
| JPS647983B2 (fr) | ||
| Iizuka et al. | Induction of glutathione leakage from Saccharomyces cerevisiae cells by selenite | |
| RU95117286A (ru) | Ирригационный раствор для офтальмологических операций | |
| Abdel-Rahman et al. | Effect of exogenous glutathione, glutathione reductase, chlorine dioxide, and chlorite on osmotic fragility of rat blood in vitro | |
| RU98111171A (ru) | Состав для обработки призабойной зоны пласта |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |