ES2070089A1 - Solucion de perfusion, conservacion y reperfusion de organos. - Google Patents

Solucion de perfusion, conservacion y reperfusion de organos.

Info

Publication number
ES2070089A1
ES2070089A1 ES09301971A ES9301971A ES2070089A1 ES 2070089 A1 ES2070089 A1 ES 2070089A1 ES 09301971 A ES09301971 A ES 09301971A ES 9301971 A ES9301971 A ES 9301971A ES 2070089 A1 ES2070089 A1 ES 2070089A1
Authority
ES
Spain
Prior art keywords
mmoles
liter
organs
solution
reperfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301971A
Other languages
English (en)
Other versions
ES2070089B1 (es
Inventor
Philippe Menasche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Pasteur Merieux Serum et Vaccines SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA
Publication of ES2070089A1 publication Critical patent/ES2070089A1/es
Application granted granted Critical
Publication of ES2070089B1 publication Critical patent/ES2070089B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

SOLUCION DE PERFUSION, CONSERVACION Y REPERFUSION DE ORGANOS. PRESENTA SENSIBLEMENTE LA COMPOSICION SIGUIENTE: KBS+SC, 15 Q 5% MMOLES/LITRO; NABS+SC, 100 Q 10% MMOLES/LITRO; MGBS++SC, 13 Q 5% MMOLES/LITRO; CABS++SC, 0,25 Q 5% MMOL ES/LITRO; CLORUROS: CLORURO DE CALCIO 2H SI2SCO, 0,037 G/L, Q 5% MMOLES/LITRO ; CLORURO DE POTASIO, 1,118 G/L, Q 5% MMOLES/LITRO; CLORURO DE MAGNESIO, 2,642 G/L, Q 5% MMOLES/LITRO; HISTIDINA (BASE), 4,650 G/L, 30 Q 10% MMOLES/LITRO; MANITOL, 10,930 G/L, 60 Q 5% MMOLES/LITRO; LACTOBIONATO (ACIDO), 28,664, 80 Q 5% MMOLES/LITRO; GLUTAMATO (ACIDO), 2,942, 20 Q 10% MMOLES/LITRO; AGUA (CANTIDAD PARA UN LITRO REAJUSTADO A PH, 7,30 Q 0,10% MMOLES/LITRO A 0''C); OSMOLALIDAD TEORICA 360 M OSM/KG.; GLUTATION REDUCIDO (GSH) O EQUIVALENTE 0,5 A 10 MMOLES/1 (PREFERENTEMENTE 3), ESTANDO EL GLUTATION REDUCIDO, O EQUIVALENTE, EN SOLUCION BAJO PRESION PARCIAL DE OXIGENO REDUCIDA O NULA Y MANTENIENDOSE SENSIBLEMENTE A ESTE VALOR HASTA LA UTILIZACION. LA INVENCION ES UTIL EN CIRUGIA Y TRASPLANTES DE CORAZON Y OTROS ORGANOS.
ES09301971A 1992-09-18 1993-09-17 Solucion de perfusion, conservacion y reperfusion de organos. Expired - Fee Related ES2070089B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94607392A 1992-09-18 1992-09-18

Publications (2)

Publication Number Publication Date
ES2070089A1 true ES2070089A1 (es) 1995-05-16
ES2070089B1 ES2070089B1 (es) 1995-12-16

Family

ID=25483919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09301971A Expired - Fee Related ES2070089B1 (es) 1992-09-18 1993-09-17 Solucion de perfusion, conservacion y reperfusion de organos.

Country Status (9)

Country Link
AT (1) AT407216B (es)
BE (1) BE1007500A3 (es)
CA (1) CA2106249C (es)
CH (1) CH686870A5 (es)
DE (1) DE4331711C2 (es)
ES (1) ES2070089B1 (es)
FR (1) FR2695827B1 (es)
GB (1) GB2270614B (es)
IT (1) IT1272638B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19527734A1 (de) * 1995-07-28 1997-01-30 Hubert Verhaag Verfahren und Vorrichtung zur Konservierung von Geweben und Organen, insbesondere von Transplantationsgeweben und -organen
SE9601396D0 (sv) * 1996-04-12 1996-04-12 Dieter Haeussinger New therapeutic treatment 2
US5880098A (en) * 1996-04-12 1999-03-09 Pharmacia & Upjohn Aktiebolag Therapeutic treatment
DE19706111C2 (de) * 1997-02-17 1999-02-18 Fresenius Medical Care De Gmbh Lösung zur Aufbewahrung von Organen
RU2140152C1 (ru) * 1997-03-13 1999-10-27 Иван Антонович Мазур Консервирующий раствор "б-2" для трансплантатов
US5834178C1 (en) * 1997-07-09 2002-04-23 Univ Wayne State Flush-storage solution for donor organs
CN1057192C (zh) * 1997-09-10 2000-10-11 上海长征医院 一种配制多器官保存液的方法
DE19834087C1 (de) * 1998-07-29 2000-03-30 Mirzaie Sedaposhteh Massoud Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
US20060078872A1 (en) * 2004-10-12 2006-04-13 Atsushi Taguchi Cell-preservation liquid
WO2007128866A2 (en) * 2006-05-09 2007-11-15 Novobion Oy Novel chemical compositions
CA2910189A1 (en) * 2013-04-24 2014-10-30 Somahlution, Llc Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life
US20160088832A1 (en) * 2013-04-29 2016-03-31 Somahlution, Llc Formulations containing poly (0-2 hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution
CA2923441C (en) 2013-11-22 2023-03-28 Somahlution, Llc Solutions for increasing the stability and shelf life of an organ and tissue preservation solution
CN115720893B (zh) * 2022-08-08 2024-02-23 四川大学华西医院 一种甲状旁腺体外保存液和保存方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001940A1 (en) * 1985-10-03 1987-04-09 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (es) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Medio liquido para perfusion y preservacion de organos.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs
ES2050580A1 (es) * 1990-11-20 1994-05-16 Pasteur Merieux Serums Vacc Soluciones de perfusion, de conservacion y/o de reperfusion de organos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4938961A (en) * 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5104787A (en) * 1990-03-05 1992-04-14 Lindstrom Richard L Method for apparatus for a defined serumfree medical solution useful for corneal preservation
US5145771A (en) * 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
GB9021325D0 (en) * 1990-10-01 1990-11-14 Geistlich Soehne Ag Chemical composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001940A1 (en) * 1985-10-03 1987-04-09 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
ES2007994A6 (es) * 1988-08-16 1989-07-01 Grino Boira Jose Maria Medio liquido para perfusion y preservacion de organos.
US4920044A (en) * 1988-11-08 1990-04-24 The Cleveland Clinic Foundation Intracellular flush solution for preserving organs
ES2050580A1 (es) * 1990-11-20 1994-05-16 Pasteur Merieux Serums Vacc Soluciones de perfusion, de conservacion y/o de reperfusion de organos.

Also Published As

Publication number Publication date
CA2106249A1 (fr) 1994-03-19
GB2270614A (en) 1994-03-23
ATA189793A (de) 2000-06-15
CH686870A5 (fr) 1996-07-31
CA2106249C (fr) 2009-04-14
GB2270614B (en) 1996-03-20
BE1007500A3 (fr) 1995-07-18
ITMI931994A0 (it) 1993-09-16
AT407216B (de) 2001-01-25
DE4331711C2 (de) 2001-05-03
FR2695827B1 (fr) 1995-07-28
FR2695827A1 (fr) 1994-03-25
ITMI931994A1 (it) 1995-03-16
IT1272638B (it) 1997-06-26
ES2070089B1 (es) 1995-12-16
DE4331711A1 (de) 1994-03-24
GB9319264D0 (en) 1993-11-03

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Effective date: 20141120