AT407216B - Lösung zur perfusion, konservierung und reperfusion von organen - Google Patents

Lösung zur perfusion, konservierung und reperfusion von organen Download PDF

Info

Publication number: AT407216B
Authority: AT; Austria
Prior art keywords: sep; solution; glutathione; reperfusion; reduced glutathione
Prior art date: 1992-09-18

Application number

AT0189793A

Other languages

German (de)

English (en)

Other versions

ATA189793A (de

Original Assignee

Imtix Sangstat Immeuble Le Cha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-18

Filing date

1993-09-20

Publication date

2001-01-25

1993-09-20 Application filed by Imtix Sangstat Immeuble Le Cha filed Critical Imtix Sangstat Immeuble Le Cha

2000-06-15 Publication of ATA189793A publication Critical patent/ATA189793A/de

2001-01-25 Application granted granted Critical

2001-01-25 Publication of AT407216B publication Critical patent/AT407216B/de

Links

210000000056 organ Anatomy 0.000 title description 16
230000010410 reperfusion Effects 0.000 title description 14
230000010412 perfusion Effects 0.000 title description 10
238000004321 preservation Methods 0.000 title description 6
239000000243 solution Substances 0.000 claims description 69
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 51
108010024636 Glutathione Proteins 0.000 claims description 26
229960003180 glutathione Drugs 0.000 claims description 18
239000001301 oxygen Substances 0.000 claims description 15
229910052760 oxygen Inorganic materials 0.000 claims description 15
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 13
239000000654 additive Substances 0.000 claims description 12
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 11
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
229930195725 Mannitol Natural products 0.000 claims description 7
229940099584 lactobionate Drugs 0.000 claims description 7
JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 claims description 7
235000010355 mannitol Nutrition 0.000 claims description 7
239000000594 mannitol Substances 0.000 claims description 7
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 6
229930195712 glutamate Natural products 0.000 claims description 6
230000007717 exclusion Effects 0.000 claims description 5
150000001450 anions Chemical class 0.000 claims description 3
230000015572 biosynthetic process Effects 0.000 claims description 3
238000002347 injection Methods 0.000 claims description 3
239000007924 injection Substances 0.000 claims description 3
239000004033 plastic Substances 0.000 claims description 3
229920003023 plastic Polymers 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
230000000996 additive effect Effects 0.000 claims description 2
150000001768 cations Chemical class 0.000 claims description 2
239000002738 chelating agent Substances 0.000 claims description 2
229910052751 metal Inorganic materials 0.000 claims description 2
239000002184 metal Substances 0.000 claims description 2
150000002739 metals Chemical class 0.000 claims description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims 1
229960000958 deferoxamine Drugs 0.000 claims 1
239000000126 substance Substances 0.000 description 11
239000000203 mixture Substances 0.000 description 8
150000003254 radicals Chemical class 0.000 description 8
239000011575 calcium Substances 0.000 description 7
210000004027 cell Anatomy 0.000 description 7
208000028867 ischemia Diseases 0.000 description 7
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 6
229960004308 acetylcysteine Drugs 0.000 description 6
239000002253 acid Substances 0.000 description 6
238000003860 storage Methods 0.000 description 6
230000002107 myocardial effect Effects 0.000 description 5
239000011734 sodium Substances 0.000 description 5
238000007792 addition Methods 0.000 description 4
239000003963 antioxidant agent Substances 0.000 description 4
235000006708 antioxidants Nutrition 0.000 description 4
230000001681 protective effect Effects 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
230000003078 antioxidant effect Effects 0.000 description 3
239000008280 blood Substances 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
230000002631 hypothermal effect Effects 0.000 description 3
238000002513 implantation Methods 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000002516 radical scavenger Substances 0.000 description 3
238000002054 transplantation Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
229940123457 Free radical scavenger Drugs 0.000 description 2
102000003992 Peroxidases Human genes 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
206010063837 Reperfusion injury Diseases 0.000 description 2
102000019197 Superoxide Dismutase Human genes 0.000 description 2
108010012715 Superoxide dismutase Proteins 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000000872 buffer Substances 0.000 description 2
230000001101 cardioplegic effect Effects 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
230000006378 damage Effects 0.000 description 2
230000006870 function Effects 0.000 description 2
-1 oxygen radicals Chemical class 0.000 description 2
108040007629 peroxidase activity proteins Proteins 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000011591 potassium Substances 0.000 description 2
230000002265 prevention Effects 0.000 description 2
238000010791 quenching Methods 0.000 description 2
125000003396 thiol group Chemical group [H]S* 0.000 description 2
GZFOMNDCXQBAAX-BQBZGAKWSA-N (2s)-2-amino-5-[[(2r)-1-[(2-methoxy-2-oxoethyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound COC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O GZFOMNDCXQBAAX-BQBZGAKWSA-N 0.000 description 1
PRPINYUDVPFIRX-UHFFFAOYSA-N 1-naphthaleneacetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CC=CC2=C1 PRPINYUDVPFIRX-UHFFFAOYSA-N 0.000 description 1
UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 description 1
208000010496 Heart Arrest Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical compound O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
229960003459 allopurinol Drugs 0.000 description 1
206010003119 arrhythmia Diseases 0.000 description 1
230000006793 arrhythmia Effects 0.000 description 1
230000001964 calcium overload Effects 0.000 description 1
239000008148 cardioplegic solution Substances 0.000 description 1
210000000038 chest Anatomy 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
210000003722 extracellular fluid Anatomy 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
229950006191 gluconic acid Drugs 0.000 description 1
230000004217 heart function Effects 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
229940099563 lactobionic acid Drugs 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
210000004165 myocardium Anatomy 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
230000004792 oxidative damage Effects 0.000 description 1
238000006213 oxygenation reaction Methods 0.000 description 1
230000037361 pathway Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000036313 post-ischemic recovery Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011084 recovery Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000009291 secondary effect Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000002861 ventricular Effects 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

AT0189793A 1992-09-18 1993-09-20 Lösung zur perfusion, konservierung und reperfusion von organen AT407216B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US94607392A	1992-09-18	1992-09-18

Publications (2)

Publication Number	Publication Date
ATA189793A ATA189793A (de)	2000-06-15
AT407216B true AT407216B (de)	2001-01-25

Family

ID=25483919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0189793A AT407216B (de)	1992-09-18	1993-09-20	Lösung zur perfusion, konservierung und reperfusion von organen

Country Status (9)

Country	Link
AT (1)	AT407216B (fr)
BE (1)	BE1007500A3 (fr)
CA (1)	CA2106249C (fr)
CH (1)	CH686870A5 (fr)
DE (1)	DE4331711C2 (fr)
ES (1)	ES2070089B1 (fr)
FR (1)	FR2695827B1 (fr)
GB (1)	GB2270614B (fr)
IT (1)	IT1272638B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19527734A1 (de) *	1995-07-28	1997-01-30	Hubert Verhaag	Verfahren und Vorrichtung zur Konservierung von Geweben und Organen, insbesondere von Transplantationsgeweben und -organen
SE9601396D0 (sv) *	1996-04-12	1996-04-12	Dieter Haeussinger	New therapeutic treatment 2
US5880098A (en) *	1996-04-12	1999-03-09	Pharmacia & Upjohn Aktiebolag	Therapeutic treatment
DE19706111C2 (de) *	1997-02-17	1999-02-18	Fresenius Medical Care De Gmbh	Lösung zur Aufbewahrung von Organen
RU2140152C1 (ru) *	1997-03-13	1999-10-27	Иван Антонович Мазур	Консервирующий раствор "б-2" для трансплантатов
US5834178C1 (en) *	1997-07-09	2002-04-23	Univ Wayne State	Flush-storage solution for donor organs
CN1057192C (zh) *	1997-09-10	2000-10-11	上海长征医院	一种配制多器官保存液的方法
DE19834087C1 (de) *	1998-07-29	2000-03-30	Mirzaie Sedaposhteh Massoud	Wäßrige Konservierungslösung und Verfahren zur Aufbewahrung tierischen Gewebes
FR2785501B1 (fr) *	1998-11-10	2001-01-05	Centre Nat Rech Scient	Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
GB0028414D0 (en)	2000-11-22	2001-01-03	Univ Leeds	Flush preservation solution
US20060078872A1 (en) *	2004-10-12	2006-04-13	Atsushi Taguchi	Cell-preservation liquid
WO2007128866A2 (fr) *	2006-05-09	2007-11-15	Novobion Oy	Nouvelles compositions chimiques
CA2910189A1 (fr) *	2013-04-24	2014-10-30	Somahlution, Llc	Solutions de conservation de tissu et d'organe ayant une teneur en oxygene augmente, stabilite et duree de conservation
US20160088832A1 (en) *	2013-04-29	2016-03-31	Somahlution, Llc	Formulations containing poly (0-2 hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution
CA2923441C (fr)	2013-11-22	2023-03-28	Somahlution, Llc	Solutions pour augmenter la stabilite et la duree de vie en stockage d'une solution de conservation d'organe et de tissu
CN115720893B (zh) *	2022-08-08	2024-02-23	四川大学华西医院	一种甲状旁腺体外保存液和保存方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4798824A (en) *	1985-10-03	1989-01-17	Wisconsin Alumni Research Foundation	Perfusate for the preservation of organs
US4879283A (en) *	1985-10-03	1989-11-07	Wisconsin Alumni Research Foundation	Solution for the preservation of organs
ES2007994A6 (es) *	1988-08-16	1989-07-01	Grino Boira Jose Maria	Medio liquido para perfusion y preservacion de organos.
US4920044A (en) *	1988-11-08	1990-04-24	The Cleveland Clinic Foundation	Intracellular flush solution for preserving organs
US4938961A (en) *	1989-04-28	1990-07-03	Geoffrey Collins	Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5104787A (en) *	1990-03-05	1992-04-14	Lindstrom Richard L	Method for apparatus for a defined serumfree medical solution useful for corneal preservation
US5145771A (en) *	1990-04-12	1992-09-08	The University Of North Carolina At Chapel Hill	Rinse solution for organs and tissues
GB9021325D0 (en) *	1990-10-01	1990-11-14	Geistlich Soehne Ag	Chemical composition
CH683485A5 (fr) *	1990-11-20	1994-03-31	Pasteur Merieux Serums Vacc	Solutions de perfusion, de conservation et de reperfusion d'organes.

1993
- 1993-09-14 BE BE9300965A patent/BE1007500A3/fr not_active IP Right Cessation
- 1993-09-14 FR FR9310926A patent/FR2695827B1/fr not_active Expired - Lifetime
- 1993-09-14 CH CH02760/93A patent/CH686870A5/fr not_active IP Right Cessation
- 1993-09-15 CA CA002106249A patent/CA2106249C/fr not_active Expired - Lifetime
- 1993-09-16 IT ITMI931994A patent/IT1272638B/it active IP Right Grant
- 1993-09-17 ES ES09301971A patent/ES2070089B1/es not_active Expired - Fee Related
- 1993-09-17 GB GB9319264A patent/GB2270614B/en not_active Expired - Lifetime
- 1993-09-17 DE DE4331711A patent/DE4331711C2/de not_active Expired - Lifetime
- 1993-09-20 AT AT0189793A patent/AT407216B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2106249A1 (fr)	1994-03-19
GB2270614A (en)	1994-03-23
ATA189793A (de)	2000-06-15
CH686870A5 (fr)	1996-07-31
CA2106249C (fr)	2009-04-14
GB2270614B (en)	1996-03-20
BE1007500A3 (fr)	1995-07-18
ITMI931994A0 (it)	1993-09-16
DE4331711C2 (de)	2001-05-03
ES2070089A1 (es)	1995-05-16
FR2695827B1 (fr)	1995-07-28
FR2695827A1 (fr)	1994-03-25
ITMI931994A1 (it)	1995-03-16
IT1272638B (it)	1997-06-26
ES2070089B1 (es)	1995-12-16
DE4331711A1 (de)	1994-03-24
GB9319264D0 (en)	1993-11-03

Legal Events

Date	Code	Title	Description
2000-08-15	UEP	Publication of translation of european patent specification
2008-02-15	ELJ	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE4331711C2 (de)	2001-05-03	Lösung zur Perfusion, Konservierung und Re-Perfusion von Organen
DE3843958C2 (de)	1994-03-10	Zusammensetzung für die Konservierung und Lagerung eines Organtransplantats und Verfahren zu dessen Konservierung
EP1859679B1 (fr)	2009-10-28	Solution protectrice destinée à éviter les lésions ischémiques
DE69410634T2 (de)	1998-12-24	Anatomisches und biologisches konservierungsmittel und verbesserte einbalsamierungszusammensetzung und -verfahren
DE60131189T2 (de)	2008-08-14	Spül- und konservierungslösung
DE69226184T2 (de)	1999-04-08	Hypertone isochlorämische formulierung zur behandlung des kreislaufschocks
DE19951328C2 (de)	2002-03-14	Kältestabile Konservierungsmittel
DE4138040A1 (de)	1992-05-21	Loesungen fuer die perfusion, konservierung und reperfusion von organgen
EP2154956A2 (fr)	2010-02-24	Solutions pour la transfusion et la conservation d'organes et de tissus
DE69103427T2 (de)	1995-04-20	Chemische zusammensetzungen.
DE2720816C2 (de)	1985-11-21	Komplex aus 2-(4'Thiazolyl)-benzimidazol mit Glykolsäure und anthelminthische und fungizide Zusammensetzungen
EP0012272B1 (fr)	1981-12-30	Solution protégeant le coeur et les reins et procédé pour sa préparation
DE3344433C2 (de)	1995-05-11	Fungicide Zusammensetzungen auf Phosphitbasis und ihre Verwendung
DE1667900B2 (de)	1974-03-07	Schnell wirkende, beständige Rinderinsulinlösung
EP2187735A2 (fr)	2010-05-26	Substances pour la protection de cellules et/ou de tissus
DE932146C (de)	1955-08-25	Verfahren zur Herstellung von stabilisierten, waessrigen Hyaluronidase-Loesungen
DE69414859T2 (de)	1999-04-15	Sulfonylsemicarbazid-derivat und zubereitung zur frischhaltung von schnittblumen
DE672300C (de)	1939-03-01	Verfahren zur Konservierung von Stallduenger und Jauche
AT234279B (de)	1964-06-25	Verfahren zur Stabilisierung therapeutisch anwendbarer Plasminlösungen
Martini	1924	Culiciden-Beobachtungen
DE2551282C3 (de)	1978-05-18	Fungizide mit systemischer Wirkung
WO2026041529A1 (fr)	2026-02-26	Compositions aqueuses de produits agrochimiques stabilisées contre des attaques microbiennes
AT393438B (de)	1991-10-25	Mittel zur verminderung von immissionsschaeden im forst
Kierfeld et al.	1971	Erfolgreiche Nierenkonservierung bis zu 48 Stunden im Experiment am Miniaturschwein
DE1175937B (de)	1964-08-13	Nematodizid auf der Basis von N, N'-Dimethylthiuramdisulfid