CA2180748A1 - Peptides amphiphiliques formant des canaux ioniques et presentant des modifications n-terminales - Google Patents

Peptides amphiphiliques formant des canaux ioniques et presentant des modifications n-terminales

Info

Publication number
CA2180748A1
CA2180748A1 CA002180748A CA2180748A CA2180748A1 CA 2180748 A1 CA2180748 A1 CA 2180748A1 CA 002180748 A CA002180748 A CA 002180748A CA 2180748 A CA2180748 A CA 2180748A CA 2180748 A1 CA2180748 A1 CA 2180748A1
Authority
CA
Canada
Prior art keywords
peptide
amino acid
basic
lys
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002180748A
Other languages
English (en)
Inventor
U. Prasad Kari
Taffy J. Williams
Michael Mclane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Magainin Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2180748A1 publication Critical patent/CA2180748A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptide ou protéine à substitution N-terminale correspondant à la formule (1), dans laquelle X est un peptide ou protéine biologiquement actif formant un canal ionique amphiphilique, T est une fraction lipophile et, de préférence, représente (2) (où R est un hydrocarbure (alkyle ou aromatique ou alkylaromatique) comportant au moins 2 et au maximum 10 atomes de carbone. T est de préférence un groupe octanoyle. W est T ou hydrogène. Ces peptides et protéines à substitution N-terminale présentent une activité biologique améliorée contre des cellules cibles, des virus et des cellules infectées par un virus.
CA002180748A 1994-01-18 1995-01-18 Peptides amphiphiliques formant des canaux ioniques et presentant des modifications n-terminales Abandoned CA2180748A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18446294A 1994-01-18 1994-01-18
US08/184,462 1994-01-18

Publications (1)

Publication Number Publication Date
CA2180748A1 true CA2180748A1 (fr) 1995-07-20

Family

ID=22676966

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002180748A Abandoned CA2180748A1 (fr) 1994-01-18 1995-01-18 Peptides amphiphiliques formant des canaux ioniques et presentant des modifications n-terminales

Country Status (5)

Country Link
EP (1) EP0750632A1 (fr)
JP (1) JPH09507669A (fr)
AU (1) AU693518B2 (fr)
CA (1) CA2180748A1 (fr)
WO (1) WO1995019370A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2294518A1 (fr) * 1997-07-15 1999-01-28 Magainin Pharmaceuticals Inc. Peptides biologiquement actifs a toxicite reduite chez l'animal et procedes d'elaboration
KR100314721B1 (ko) * 1998-01-22 2001-11-23 김일웅 생물학적 활성이 있는 신규한 펩타이드
NL1008745C2 (nl) * 1998-03-30 1999-10-01 Stichting Tech Wetenschapp Therapeutisch werkzame verbinding voor behandeling van gist- en/of schimmelinfecties in de mondholte.
AU783021B2 (en) * 2000-02-15 2005-09-15 Ohio University Cationic, amphipathic beta-sheet peptides and uses thereof
BR0111718A (pt) 2000-06-16 2003-09-09 Hercules Inc Peptìdeos quimicamente modificados, composições e métodos de produção e uso
GB0024428D0 (en) * 2000-10-05 2000-11-22 King S College Absorption enhancers
AU2006212922B2 (en) * 2005-02-09 2011-04-21 Helix Biomedix Inc. Antimicrobial hexapeptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
CA2118939A1 (fr) * 1991-09-13 1993-04-01 W. Lee Maloy Compositions de peptides amphiphiles biologiquement actives et leur utilisation
AU674525B2 (en) * 1992-06-01 1997-01-02 Magainin Pharmaceuticals, Inc. Biologically active peptides having N-terminal substitutions
WO1994013697A1 (fr) * 1992-12-07 1994-06-23 Magainin Pharmaceuticals, Inc. Traitement de chocs septiques au moyen de peptides biologiquement actifs conjugues

Also Published As

Publication number Publication date
JPH09507669A (ja) 1997-08-05
EP0750632A1 (fr) 1997-01-02
AU693518B2 (en) 1998-07-02
AU1728895A (en) 1995-08-01
WO1995019370A1 (fr) 1995-07-20

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Legal Events

Date Code Title Description
FZDE Dead