JPH09507669A - Ｎ末端修飾を有する両親媒性のイオンチャンネル形成ペプチド - Google Patents
Ｎ末端修飾を有する両親媒性のイオンチャンネル形成ペプチドInfo
- Publication number
- JPH09507669A JPH09507669A JP7519212A JP51921295A JPH09507669A JP H09507669 A JPH09507669 A JP H09507669A JP 7519212 A JP7519212 A JP 7519212A JP 51921295 A JP51921295 A JP 51921295A JP H09507669 A JPH09507669 A JP H09507669A
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- peptide
- basic
- composition
- hydrophilic amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229940041009 monobactams Drugs 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
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- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
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- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 description 1
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- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
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- 229940081192 rifamycins Drugs 0.000 description 1
- WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 description 1
- 229940116736 romycin Drugs 0.000 description 1
- 229960005224 roxithromycin Drugs 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
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- 239000004332 silver Substances 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical group CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
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- 229960004576 temafloxacin Drugs 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18446294A | 1994-01-18 | 1994-01-18 | |
| US08/184,462 | 1994-01-18 | ||
| PCT/US1995/000714 WO1995019370A1 (fr) | 1994-01-18 | 1995-01-18 | Peptides amphiphiliques formant des canaux ioniques et presentant des modifications n-terminales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09507669A true JPH09507669A (ja) | 1997-08-05 |
Family
ID=22676966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7519212A Pending JPH09507669A (ja) | 1994-01-18 | 1995-01-18 | Ｎ末端修飾を有する両親媒性のイオンチャンネル形成ペプチド |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0750632A1 (fr) |
| JP (1) | JPH09507669A (fr) |
| AU (1) | AU693518B2 (fr) |
| CA (1) | CA2180748A1 (fr) |
| WO (1) | WO1995019370A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008537537A (ja) * | 2005-02-09 | 2008-09-18 | ヘリックス バイオメディックス インコーポレイテッド | 抗微生物ヘキサペプチド |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2294518A1 (fr) * | 1997-07-15 | 1999-01-28 | Magainin Pharmaceuticals Inc. | Peptides biologiquement actifs a toxicite reduite chez l'animal et procedes d'elaboration |
| KR100314721B1 (ko) * | 1998-01-22 | 2001-11-23 | 김일웅 | 생물학적 활성이 있는 신규한 펩타이드 |
| NL1008745C2 (nl) * | 1998-03-30 | 1999-10-01 | Stichting Tech Wetenschapp | Therapeutisch werkzame verbinding voor behandeling van gist- en/of schimmelinfecties in de mondholte. |
| AU783021B2 (en) * | 2000-02-15 | 2005-09-15 | Ohio University | Cationic, amphipathic beta-sheet peptides and uses thereof |
| BR0111718A (pt) | 2000-06-16 | 2003-09-09 | Hercules Inc | Peptìdeos quimicamente modificados, composições e métodos de produção e uso |
| GB0024428D0 (en) * | 2000-10-05 | 2000-11-22 | King S College | Absorption enhancers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07504152A (ja) * | 1990-02-08 | 1995-05-11 | マゲイニン ファーマスーティカルズ， インコーポレーテッド | 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法 |
| CA2118939A1 (fr) * | 1991-09-13 | 1993-04-01 | W. Lee Maloy | Compositions de peptides amphiphiles biologiquement actives et leur utilisation |
| AU674525B2 (en) * | 1992-06-01 | 1997-01-02 | Magainin Pharmaceuticals, Inc. | Biologically active peptides having N-terminal substitutions |
| WO1994013697A1 (fr) * | 1992-12-07 | 1994-06-23 | Magainin Pharmaceuticals, Inc. | Traitement de chocs septiques au moyen de peptides biologiquement actifs conjugues |
-
1995
- 1995-01-18 AU AU17288/95A patent/AU693518B2/en not_active Ceased
- 1995-01-18 EP EP95909267A patent/EP0750632A1/fr not_active Withdrawn
- 1995-01-18 CA CA002180748A patent/CA2180748A1/fr not_active Abandoned
- 1995-01-18 WO PCT/US1995/000714 patent/WO1995019370A1/fr not_active Ceased
- 1995-01-18 JP JP7519212A patent/JPH09507669A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008537537A (ja) * | 2005-02-09 | 2008-09-18 | ヘリックス バイオメディックス インコーポレイテッド | 抗微生物ヘキサペプチド |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2180748A1 (fr) | 1995-07-20 |
| EP0750632A1 (fr) | 1997-01-02 |
| AU693518B2 (en) | 1998-07-02 |
| AU1728895A (en) | 1995-08-01 |
| WO1995019370A1 (fr) | 1995-07-20 |
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