CA2190983C - Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs - Google Patents

Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs Download PDF

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Publication number
CA2190983C
CA2190983C CA002190983A CA2190983A CA2190983C CA 2190983 C CA2190983 C CA 2190983C CA 002190983 A CA002190983 A CA 002190983A CA 2190983 A CA2190983 A CA 2190983A CA 2190983 C CA2190983 C CA 2190983C
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CA
Canada
Prior art keywords
halogen
alkyl
residue
hydroxy
hydrogen
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Expired - Fee Related
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CA002190983A
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English (en)
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CA2190983A1 (fr
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
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Heidelberg Pharma Holding GmbH
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Heidelberg Pharma Holding GmbH
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Publication date
Application filed by Heidelberg Pharma Holding GmbH filed Critical Heidelberg Pharma Holding GmbH
Publication of CA2190983A1 publication Critical patent/CA2190983A1/fr
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Publication of CA2190983C publication Critical patent/CA2190983C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention se rapporte à de nouveaux dérivés monophosphate de nucléosides de restes ester lipidiques de la formule générale (I), dans laquelle R?1¿ représente une chaîne alkyle éventuellement substituée et contenant de 1 à 20 atomes de carbone; R?2¿ représente hydrogène ou une chaîne alkyle éventuellement substituée et contenant de 1 à 20 atomes de carbone; R?3¿, R?4¿ et R?5¿ représentent hydrogène, hydroxy, azido, amino, cyano ou halogène; X représente une valence partielle, oxygène, soufre, un groupe sulfinyle ou sulfonyle; Y représente une valence partielle, un atome d'oxygène ou de soufre; et B représente une base purine et/ou pyrimidine, sachant qu'au moins l'un des restes R?3¿ et R?5¿ représente hydrogène; ainsi qu'à leurs tautomères et leurs sels physiologiquement acceptables de bases et/ou acides inorganiques et organiques, à leurs procédés de préparation et à des médicaments contenant lesdits composés.
CA002190983A 1994-05-28 1995-05-23 Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs Expired - Fee Related CA2190983C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DEP4418690.8 1994-05-28
PCT/EP1995/001951 WO1995032984A1 (fr) 1994-05-28 1995-05-23 Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs

Publications (2)

Publication Number Publication Date
CA2190983A1 CA2190983A1 (fr) 1995-12-07
CA2190983C true CA2190983C (fr) 2006-08-15

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002190983A Expired - Fee Related CA2190983C (fr) 1994-05-28 1995-05-23 Nouveaux esters lipidiques de monophosphates de nucleosides et leur utilisation comme medicaments immunosuppresseurs

Country Status (27)

Country Link
US (1) US6025343A (fr)
EP (2) EP0763049B1 (fr)
JP (1) JP3802057B2 (fr)
KR (1) KR100279087B1 (fr)
CN (1) CN1168735C (fr)
AT (2) ATE236189T1 (fr)
AU (1) AU688516B2 (fr)
BR (1) BR9507785A (fr)
CA (1) CA2190983C (fr)
CZ (1) CZ291846B6 (fr)
DE (3) DE4418690A1 (fr)
DK (2) DK1229040T3 (fr)
ES (2) ES2206429T3 (fr)
FI (1) FI117673B (fr)
HU (1) HU220336B (fr)
IL (1) IL113865A (fr)
MX (1) MX9605809A (fr)
NO (1) NO308998B1 (fr)
NZ (1) NZ287434A (fr)
PL (1) PL185290B1 (fr)
PT (2) PT763049E (fr)
RU (1) RU2165429C2 (fr)
SK (1) SK284207B6 (fr)
TW (1) TW420686B (fr)
UA (1) UA45339C2 (fr)
WO (1) WO1995032984A1 (fr)
ZA (1) ZA954374B (fr)

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US8101745B2 (en) 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
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Also Published As

Publication number Publication date
NO308998B1 (no) 2000-11-27
ES2206429T3 (es) 2004-05-16
EP1229040A2 (fr) 2002-08-07
SK284207B6 (en) 2004-11-03
DE69530197D1 (de) 2003-05-08
IL113865A (en) 2008-12-29
BR9507785A (pt) 1997-09-23
DE4418690A1 (de) 1996-01-11
PL317380A1 (en) 1997-04-01
NZ287434A (en) 1998-01-26
CZ291846B6 (cs) 2003-06-18
JPH10500964A (ja) 1998-01-27
DK1229040T3 (da) 2003-12-22
ATE249472T1 (de) 2003-09-15
CN1168735C (zh) 2004-09-29
SK151896A3 (en) 1997-06-04
PL185290B1 (pl) 2003-04-30
NO965054L (no) 1997-01-28
WO1995032984A1 (fr) 1995-12-07
CA2190983A1 (fr) 1995-12-07
TW420686B (en) 2001-02-01
PT763049E (pt) 2003-08-29
JP3802057B2 (ja) 2006-07-26
CZ347796A3 (en) 1997-04-16
EP1229040B8 (fr) 2003-11-05
FI964727A0 (fi) 1996-11-27
ATE236189T1 (de) 2003-04-15
DE69531749D1 (de) 2003-10-16
DE69531749T2 (de) 2004-07-29
ES2199250T3 (es) 2004-02-16
HUT75340A (en) 1997-05-28
AU2615495A (en) 1995-12-21
FI117673B (fi) 2007-01-15
HU220336B (hu) 2001-12-28
DE69530197T2 (de) 2004-01-29
DK0763049T3 (da) 2003-07-28
US6025343A (en) 2000-02-15
EP0763049A1 (fr) 1997-03-19
MX9605809A (es) 1997-12-31
NO965054D0 (no) 1996-11-27
EP1229040B1 (fr) 2003-09-10
FI964727L (fi) 1996-11-27
WO1995032984A8 (fr) 2003-01-16
EP0763049B1 (fr) 2003-04-02
ZA954374B (en) 1996-11-29
KR100279087B1 (ko) 2001-01-15
HU9603269D0 (en) 1997-01-28
EP1229040A3 (fr) 2002-08-21
CN1154111A (zh) 1997-07-09
AU688516B2 (en) 1998-03-12
KR970703354A (ko) 1997-07-03
RU2165429C2 (ru) 2001-04-20
PT1229040E (pt) 2003-12-31
UA45339C2 (uk) 2002-04-15
IL113865A0 (en) 1995-08-31

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