CA2224074C - System and method for producing drug-loaded microparticles - Google Patents

System and method for producing drug-loaded microparticles Download PDF

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Publication number
CA2224074C
CA2224074C CA002224074A CA2224074A CA2224074C CA 2224074 C CA2224074 C CA 2224074C CA 002224074 A CA002224074 A CA 002224074A CA 2224074 A CA2224074 A CA 2224074A CA 2224074 C CA2224074 C CA 2224074C
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CA
Canada
Prior art keywords
icam
drug
alginate
stream
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002224074A
Other languages
English (en)
French (fr)
Other versions
CA2224074A1 (en
Inventor
David C. Bomberger
Paul G. Catz
Mark I. Smedley
Paul C. Stearns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc filed Critical SRI International Inc
Publication of CA2224074A1 publication Critical patent/CA2224074A1/en
Application granted granted Critical
Publication of CA2224074C publication Critical patent/CA2224074C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002224074A 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles Expired - Lifetime CA2224074C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/480,624 1995-06-07
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
PCT/US1996/010031 WO1996040069A1 (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Publications (2)

Publication Number Publication Date
CA2224074A1 CA2224074A1 (en) 1996-12-19
CA2224074C true CA2224074C (en) 2009-09-08

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224074A Expired - Lifetime CA2224074C (en) 1995-06-07 1996-06-06 System and method for producing drug-loaded microparticles

Country Status (8)

Country Link
US (3) US5879712A (2)
EP (1) EP0833614B1 (2)
JP (1) JP4156665B2 (2)
AT (1) ATE353631T1 (2)
CA (1) CA2224074C (2)
DE (1) DE69636904T2 (2)
ES (1) ES2281084T3 (2)
WO (1) WO1996040069A1 (2)

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US6485747B1 (en) * 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
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US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
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US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
AR048220A1 (es) * 2005-01-28 2006-04-12 Lkm S A Lab Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
WO2007025244A2 (en) 2005-08-25 2007-03-01 Houle Philip R Treatment systems for delivery of sensitizer solutions
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
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WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
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US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
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Also Published As

Publication number Publication date
ES2281084T3 (es) 2007-09-16
JPH11507382A (ja) 1999-06-29
DE69636904T2 (de) 2007-11-15
US20030091649A1 (en) 2003-05-15
EP0833614A1 (en) 1998-04-08
CA2224074A1 (en) 1996-12-19
WO1996040069A1 (en) 1996-12-19
US5879712A (en) 1999-03-09
US7087245B2 (en) 2006-08-08
EP0833614B1 (en) 2007-02-14
US6375985B1 (en) 2002-04-23
JP4156665B2 (ja) 2008-09-24
ATE353631T1 (de) 2007-03-15
DE69636904D1 (de) 2007-03-29
EP0833614A4 (en) 2001-07-11

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Effective date: 20160606