ATE353631T1 - System und verfahren zur herstellung arzneistoffbeladener mikropartikel - Google Patents

System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Info

Publication number
ATE353631T1
ATE353631T1 AT96918456T AT96918456T ATE353631T1 AT E353631 T1 ATE353631 T1 AT E353631T1 AT 96918456 T AT96918456 T AT 96918456T AT 96918456 T AT96918456 T AT 96918456T AT E353631 T1 ATE353631 T1 AT E353631T1
Authority
AT
Austria
Prior art keywords
microparticles
emulsion
mixing chamber
drug
linking agent
Prior art date
Application number
AT96918456T
Other languages
English (en)
Inventor
David C Bomberger
Paul G Catz
Mark I Smedley
Paul C Stearns
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Application granted granted Critical
Publication of ATE353631T1 publication Critical patent/ATE353631T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT96918456T 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel ATE353631T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/480,624 US5879712A (en) 1995-06-07 1995-06-07 Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced

Publications (1)

Publication Number Publication Date
ATE353631T1 true ATE353631T1 (de) 2007-03-15

Family

ID=23908687

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918456T ATE353631T1 (de) 1995-06-07 1996-06-06 System und verfahren zur herstellung arzneistoffbeladener mikropartikel

Country Status (8)

Country Link
US (3) US5879712A (de)
EP (1) EP0833614B1 (de)
JP (1) JP4156665B2 (de)
AT (1) ATE353631T1 (de)
CA (1) CA2224074C (de)
DE (1) DE69636904T2 (de)
ES (1) ES2281084T3 (de)
WO (1) WO1996040069A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
EP0362531B1 (de) 1988-09-01 1999-11-10 Bayer Corporation Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US6365343B1 (en) 1996-03-06 2002-04-02 Boehringer Ingelheim Pharmaceuticals, Inc. Intercellular adhesion molecule powder formulation
US20020182258A1 (en) * 1997-01-22 2002-12-05 Zycos Inc., A Delaware Corporation Microparticles for delivery of nucleic acid
IT1291559B1 (it) * 1997-04-14 1999-01-11 Univ Degli Studi Milano Uso di microparticelle su cui sono stati adsorbiti una proteina ed un anticorpo per preparare una composizione farmaceutica somministrabile
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
WO1999022768A1 (en) * 1997-10-31 1999-05-14 Monsanto Company Controlled release compositions comprising gellan gum gels
US6326028B1 (en) * 1997-10-31 2001-12-04 Monsanto Company Alginate and gellan gum as tablet coating
DE69817009T2 (de) * 1997-11-10 2004-06-09 Quest International B.V. Verkapseltes aktives material in einer alginatmatrix
US6485747B1 (en) * 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
US6248321B1 (en) * 1999-01-14 2001-06-19 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources, Canadian Forestry Service Encapsulation of microparticles in teardrop shaped polymer capsules of cellular size
DE19904785A1 (de) * 1999-02-05 2000-08-10 Ulrich Zimmermann Verfahren zur Herstellung von stabilem Alginatmaterial
US6927223B1 (en) 2000-05-26 2005-08-09 Washington State University Research Foundation Use of serotonin agents for adjunct therapy in the treatment of cancer
US20030191291A1 (en) * 2000-09-08 2003-10-09 Kochendoerfer Gerd G. Synthetic erythropoiesis stimulating proteins
US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US7008650B2 (en) * 2001-08-09 2006-03-07 Lam Paul Y S Compositions for the treatment of acquired immunodeficiency disease
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
US20040028729A1 (en) * 2002-04-29 2004-02-12 Shojaei Amir H. Pharmaceutical formulations with improved bioavailability
US20030206957A1 (en) * 2002-05-06 2003-11-06 Scherr George H. Orally administered medicament delivery systems
GB2399084B (en) * 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
DK1551876T3 (da) 2002-10-16 2011-06-14 Purdue Pharma Lp Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmåder til anvendelse deraf
JP4463109B2 (ja) 2002-11-07 2010-05-12 アドバンスド バイオニュートリション コーポレーション 栄養補助食品および水生動物の給餌方法
US20050053655A1 (en) * 2003-09-05 2005-03-10 Pharmaceutical Industry Technology And Development Center Rapid disintegrating tablets (RDTs) for pharmaceutical use and method for preparing the same
DE602004030931D1 (de) * 2003-11-04 2011-02-17 Supernus Pharmaceuticals Inc
US8709476B2 (en) 2003-11-04 2014-04-29 Supernus Pharmaceuticals, Inc. Compositions of quaternary ammonium compounds containing bioavailability enhancers
US20050260258A1 (en) 2003-12-18 2005-11-24 The Texas A&M University System Use of vitelline protein B as a microencapsulating additive
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
WO2007001448A2 (en) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
AR048220A1 (es) * 2005-01-28 2006-04-12 Lkm S A Lab Arreglo de dispositivos utilizables en la elaboracion de microcapsulas para la liberacion controlada de peptidos y procedimiento de elaboracion de dichas opcionalmente sustituido
CA2632183A1 (en) 2005-08-25 2007-03-01 Philip R. Houle Treatment systems for delivery of sensitizer solutions
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2008105773A2 (en) 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2007137117A2 (en) * 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008031780A2 (de) * 2006-09-13 2008-03-20 Basf Se Verfahren zur herstellung feinteiliger dispersionen
US7731604B2 (en) * 2006-10-31 2010-06-08 Taylor Made Golf Company, Inc. Golf club iron head
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
US20090074828A1 (en) * 2007-04-04 2009-03-19 Massachusetts Institute Of Technology Poly(amino acid) targeting moieties
MX2010003642A (es) 2007-10-12 2010-08-09 Massachusetts Inst Technology Nanotecnologia de vacuna.
CA2730760A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
HUE030071T2 (en) * 2009-12-04 2017-04-28 Magle Ab Endogenous hydrolysed microparticles containing charged ligands
AU2014350208B2 (en) * 2013-11-13 2017-09-07 Tillotts Pharma Ag Multi-particulate drug delivery system
DE112016001911A5 (de) * 2015-05-21 2018-01-11 Arnold Lösler Matrixmembranschicht auf Alginatbasis
US12447166B2 (en) 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
EP3419629A4 (de) 2016-02-25 2019-10-30 Applied Biological Laboratories, Inc. Zusammensetzungen und verfahren zum schutz gegen luftbürtige pathogene und reizmittel

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4278206A (en) * 1979-04-13 1981-07-14 Ae Development Corporation Non-pressurized dispensing system
JPS6034925B2 (ja) * 1979-07-31 1985-08-12 帝人株式会社 持続性鼻腔用製剤およびその製造法
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4350840A (en) * 1981-03-20 1982-09-21 Ideal Industries, Inc. Cord grip
JPS6032714A (ja) * 1983-08-01 1985-02-19 Teijin Ltd 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
JPS61138529A (ja) * 1984-12-10 1986-06-26 Idemitsu Petrochem Co Ltd サイズ用乳化液の製造方法
DE3583799D1 (de) * 1985-01-11 1991-09-19 Abbott Lab Ltd Feste zubereitung mit langsamer freisetzung.
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
ATE114972T1 (de) * 1987-11-02 1994-12-15 Baylor College Medicine Verwendung von icam-1 oder ihre funktionelle derivate zur behandlung unspezifischer entzündungen.
US5079005A (en) * 1988-06-17 1992-01-07 Gupta Kashmiri L Time release protein
EP0362531B1 (de) 1988-09-01 1999-11-10 Bayer Corporation Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
WO1990013361A1 (en) * 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
FR2655732B1 (fr) 1989-12-11 1992-02-07 Snecma Procede et dispositif de controle du collage d'un nida sur un support.
ATE184049T1 (de) 1990-07-20 1999-09-15 Bayer Ag Multimere formen des menschlichen rhinovirus- rezeptorproteins
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
WO1993006842A1 (en) * 1991-10-02 1993-04-15 Boehringer Ingelheim Pharmaceuticals, Inc. Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
AU690567B2 (en) * 1993-07-12 1998-04-30 Avant Immunotherapeutics, Inc. Hydrogel microencapsulated vaccines
JP3285427B2 (ja) * 1993-08-04 2002-05-27 冷化工業株式会社 エマルション製造装置及び方法
ATE212830T1 (de) * 1993-11-19 2002-02-15 Alkermes Inc Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel
GB9414966D0 (en) * 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
US5840254A (en) * 1995-06-02 1998-11-24 Cdc Technologies, Inc. Apparatus for mixing fluids for analysis
US5879712A (en) * 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced

Also Published As

Publication number Publication date
DE69636904T2 (de) 2007-11-15
WO1996040069A1 (en) 1996-12-19
CA2224074C (en) 2009-09-08
EP0833614B1 (de) 2007-02-14
EP0833614A1 (de) 1998-04-08
JP4156665B2 (ja) 2008-09-24
US5879712A (en) 1999-03-09
CA2224074A1 (en) 1996-12-19
ES2281084T3 (es) 2007-09-16
EP0833614A4 (de) 2001-07-11
US20030091649A1 (en) 2003-05-15
US6375985B1 (en) 2002-04-23
JPH11507382A (ja) 1999-06-29
US7087245B2 (en) 2006-08-08
DE69636904D1 (de) 2007-03-29

Similar Documents

Publication Publication Date Title
DE69636904D1 (de) System und verfahren zur herstellung arzneistoffbeladener mikropartikel
ATE198982T1 (de) Verfahren zur herstellung von festen pharmazeutischen dosierungsformen hydrophobischen substanzen
ATE204468T1 (de) Mittel zur verzögerten freisetzung von menschlichem wachstumshormon
DE3864543D1 (de) Vorrichtung zur arzneistoffabgabe und verfahren zu ihrer herstellung.
DE69840495D1 (de) Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
EA200000375A1 (ru) Перфорированные микрочастицы и способ их использования
DE3850823D1 (de) System zur Freisetzung von Medikamenten und dessen Herstellungsmethode.
ATE199638T1 (de) Vorrichtung zur oralen verabreichung von diskreten einheiten
DE69433723D1 (de) Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
PT99892A (pt) Processo para a producao de microparticulas carregadas de substancia activa a partir de polimeros que se decompoem hidroliticamente
DK0591432T3 (da) System til indgivelse af lægemidler, der er baseret på opløselighedsparametre, samt fremgangsmåde til ændring af mætningskoncentration af et lægemiddel
ATE143257T1 (de) Arzneiabgabesystem, verfahren zu dessen herstellung sowie dessen verwendung
DE59609564D1 (de) Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung
DE69922017D1 (de) Arzneimittel und verfahren zur behandlung von intrazellulären infektionen
ATE204744T1 (de) Pharmazeutische zubereitung mit einem hydrophoben wirkstoff und einem brausesystem, sowie verfahren zur herstellung der zubereitung
ATE366119T1 (de) Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung
DE69901062D1 (de) Multipartikuläre pharmazeutische form mit gesteuerter und gepulster wirkstoffabgabe und verfahren zu deren herstellung
ATE93384T1 (de) Poroese mikrokugeln zur arzneistoffabgabe sowie verfahren zu deren herstellung.
ATE295157T1 (de) Mittel zur transdermalen verabreichung von arzneistoffen
DE60022507D1 (de) Einzeldosisform zur verzögerten freisetzung mit einem latexüberzug sowie verfahren zu deren herstellung
ATE176865T1 (de) Liposomen enthaltend darin verkapselte proteine, verfahren zu ihrer herstellung sowie diese liposomen enthaltende pharmazeutische und kosmetische zubereitungen
DK287982A (da) Fremgangsmaade til tidsstyring af frigoerelsen af aktive stoffer fra midler med indhold deraf navnlig fra farmaceutiske praeparater
ATE235259T1 (de) Verfahren zur herstellung von kontrastmitteln

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties