CA2270963A1 - (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor - Google Patents

(4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor Download PDF

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Publication number
CA2270963A1
CA2270963A1 CA002270963A CA2270963A CA2270963A1 CA 2270963 A1 CA2270963 A1 CA 2270963A1 CA 002270963 A CA002270963 A CA 002270963A CA 2270963 A CA2270963 A CA 2270963A CA 2270963 A1 CA2270963 A1 CA 2270963A1
Authority
CA
Canada
Prior art keywords
compound
hiv
formula
reverse transcriptase
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002270963A
Other languages
English (en)
French (fr)
Inventor
James David Rodgers
Patrick Yuk-Sun Lam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2270963A1 publication Critical patent/CA2270963A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002270963A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor Abandoned CA2270963A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74710396A 1996-11-08 1996-11-08
US2974696P 1996-11-08 1996-11-08
US08/747,103 1996-11-08
US60/029,746 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (1)

Publication Number Publication Date
CA2270963A1 true CA2270963A1 (en) 1998-05-14

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002270963A Abandoned CA2270963A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Country Status (19)

Country Link
EP (1) EP0937066A1 (cs)
JP (1) JP2001503429A (cs)
KR (1) KR20000053123A (cs)
CN (1) CN1235601A (cs)
AU (1) AU722489B2 (cs)
BR (1) BR9712755A (cs)
CA (1) CA2270963A1 (cs)
CZ (1) CZ157499A3 (cs)
EA (1) EA001154B1 (cs)
EE (1) EE9900187A (cs)
HU (1) HUP9904143A3 (cs)
IL (1) IL129726A0 (cs)
LV (1) LV12374B (cs)
NO (1) NO992229L (cs)
NZ (1) NZ335919A (cs)
PL (1) PL333412A1 (cs)
SI (1) SI9720071A (cs)
SK (1) SK59599A3 (cs)
WO (1) WO1998020009A1 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6870098A (en) * 1997-03-31 1998-10-22 Du Pont Merck Pharmaceutical Company, The Indazoles of cyclic ureas useful as hiv protease inhibitors
CA2335617C (en) * 1998-06-24 2009-12-15 Novirio Pharmaceuticals Limited Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69221309T2 (de) * 1991-10-11 1997-12-11 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors

Also Published As

Publication number Publication date
LV12374A (lv) 1999-11-20
NO992229D0 (no) 1999-05-07
SK59599A3 (en) 1999-12-10
BR9712755A (pt) 1999-10-19
IL129726A0 (en) 2000-02-29
NZ335919A (en) 2000-09-29
HUP9904143A2 (hu) 2000-06-28
JP2001503429A (ja) 2001-03-13
EA001154B1 (ru) 2000-10-30
CZ157499A3 (cs) 1999-11-17
WO1998020009A1 (en) 1998-05-14
HUP9904143A3 (en) 2002-11-28
EA199900451A1 (ru) 1999-12-29
AU722489B2 (en) 2000-08-03
EE9900187A (et) 1999-12-15
CN1235601A (zh) 1999-11-17
KR20000053123A (ko) 2000-08-25
EP0937066A1 (en) 1999-08-25
LV12374B (en) 2000-04-20
NO992229L (no) 1999-06-07
SI9720071A (sl) 1999-12-31
AU5103398A (en) 1998-05-29
PL333412A1 (en) 1999-12-06

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Legal Events

Date Code Title Description
FZDE Discontinued