NO992229L - (4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor - Google Patents

(4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor

Info

Publication number: NO992229L
Authority: NO; Norway
Prior art keywords: hiv protease; aminoinazol; diazepin; phenylmethyl; hexahydro
Prior art date: 1996-11-08

Application number

NO992229A

Other languages

English (en)

Norwegian (no)

Other versions

NO992229D0 (no

Inventor

James David Rodgers

Patrick Yuk-Sun Lam

Original Assignee

Du Pont Pharm Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-08

Filing date

1999-05-07

Publication date

1999-06-07

1999-05-07 Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co

1999-05-07 Publication of NO992229D0 publication Critical patent/NO992229D0/no

1999-06-07 Publication of NO992229L publication Critical patent/NO992229L/no

Links

HHVIPGYWIHLNFW-UHFFFAOYSA-N 4-benzyl-1,3-diazepin-2-one Chemical compound O=C1N=CC=CC(CC=2C=CC=CC=2)=N1 HHVIPGYWIHLNFW-UHFFFAOYSA-N 0.000 title 1
229940122440 HIV protease inhibitor Drugs 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO992229A 1996-11-08 1999-05-07 (4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor NO992229L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US74710396A	1996-11-08	1996-11-08
US2974696P	1996-11-08	1996-11-08
PCT/US1997/020036 WO1998020009A1 (en)	1996-11-08	1997-11-04	(4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number	Publication Date
NO992229D0 NO992229D0 (no)	1999-05-07
NO992229L true NO992229L (no)	1999-06-07

Family

ID=26705295

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO992229A NO992229L (no)	1996-11-08	1999-05-07	(4R,5S,6S,7R)-heksahydro-1-[5-(3-aminoinazol)metyl]-3-butyl-5,6-dihydroksy-4,7-bis[fenylmetyl]-2H-1,3-diazepin-2-on, dens fremstilling og dens anvendelse som HIV-proteaseinhibitor

Country Status (19)

Country	Link
EP (1)	EP0937066A1 (cs)
JP (1)	JP2001503429A (cs)
KR (1)	KR20000053123A (cs)
CN (1)	CN1235601A (cs)
AU (1)	AU722489B2 (cs)
BR (1)	BR9712755A (cs)
CA (1)	CA2270963A1 (cs)
CZ (1)	CZ157499A3 (cs)
EA (1)	EA001154B1 (cs)
EE (1)	EE9900187A (cs)
HU (1)	HUP9904143A3 (cs)
IL (1)	IL129726A0 (cs)
LV (1)	LV12374B (cs)
NO (1)	NO992229L (cs)
NZ (1)	NZ335919A (cs)
PL (1)	PL333412A1 (cs)
SI (1)	SI9720071A (cs)
SK (1)	SK59599A3 (cs)
WO (1)	WO1998020009A1 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6870098A (en) *	1997-03-31	1998-10-22	Du Pont Merck Pharmaceutical Company, The	Indazoles of cyclic ureas useful as hiv protease inhibitors
CA2335617C (en) *	1998-06-24	2009-12-15	Novirio Pharmaceuticals Limited	Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
FR2810039B1 (fr)	2000-06-13	2007-05-25	Centre Nat Rech Scient	Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69221309T2 (de) *	1991-10-11	1997-12-11	The Du Pont Merck Pharmaceutical Co., Wilmington, Del.	Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5610294A (en) *	1991-10-11	1997-03-11	The Du Pont Merck Pharmaceutical Company	Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors

1997
- 1997-11-04 CA CA002270963A patent/CA2270963A1/en not_active Abandoned
- 1997-11-04 BR BR9712755-8A patent/BR9712755A/pt unknown
- 1997-11-04 KR KR1019990704049A patent/KR20000053123A/ko not_active Withdrawn
- 1997-11-04 CZ CZ991574A patent/CZ157499A3/cs unknown
- 1997-11-04 EP EP97945596A patent/EP0937066A1/en not_active Ceased
- 1997-11-04 IL IL12972697A patent/IL129726A0/xx unknown
- 1997-11-04 HU HU9904143A patent/HUP9904143A3/hu unknown
- 1997-11-04 PL PL97333412A patent/PL333412A1/xx unknown
- 1997-11-04 SI SI9720071A patent/SI9720071A/sl unknown
- 1997-11-04 EE EEP199900187A patent/EE9900187A/xx unknown
- 1997-11-04 JP JP52168298A patent/JP2001503429A/ja active Pending
- 1997-11-04 AU AU51033/98A patent/AU722489B2/en not_active Ceased
- 1997-11-04 CN CN97199418A patent/CN1235601A/zh active Pending
- 1997-11-04 WO PCT/US1997/020036 patent/WO1998020009A1/en not_active Ceased
- 1997-11-04 EA EA199900451A patent/EA001154B1/ru not_active IP Right Cessation
- 1997-11-04 NZ NZ335919A patent/NZ335919A/xx unknown
- 1997-11-04 SK SK595-99A patent/SK59599A3/sk unknown
1999
- 1999-04-29 LV LVP-99-75A patent/LV12374B/en unknown
- 1999-05-07 NO NO992229A patent/NO992229L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
LV12374A (lv)	1999-11-20
NO992229D0 (no)	1999-05-07
SK59599A3 (en)	1999-12-10
BR9712755A (pt)	1999-10-19
IL129726A0 (en)	2000-02-29
NZ335919A (en)	2000-09-29
HUP9904143A2 (hu)	2000-06-28
JP2001503429A (ja)	2001-03-13
EA001154B1 (ru)	2000-10-30
CZ157499A3 (cs)	1999-11-17
WO1998020009A1 (en)	1998-05-14
HUP9904143A3 (en)	2002-11-28
EA199900451A1 (ru)	1999-12-29
AU722489B2 (en)	2000-08-03
EE9900187A (et)	1999-12-15
CN1235601A (zh)	1999-11-17
KR20000053123A (ko)	2000-08-25
EP0937066A1 (en)	1999-08-25
LV12374B (en)	2000-04-20
SI9720071A (sl)	1999-12-31
CA2270963A1 (en)	1998-05-14
AU5103398A (en)	1998-05-29
PL333412A1 (en)	1999-12-06

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Legal Events

Date	Code	Title	Description
2003-07-14	FC2A	Withdrawal, rejection or dismissal of laid open patent application