CA2288705C - Utilisation de composes de quinazoline pour le traitement de la maladie polykystique des reins - Google Patents
Utilisation de composes de quinazoline pour le traitement de la maladie polykystique des reins Download PDFInfo
- Publication number
- CA2288705C CA2288705C CA002288705A CA2288705A CA2288705C CA 2288705 C CA2288705 C CA 2288705C CA 002288705 A CA002288705 A CA 002288705A CA 2288705 A CA2288705 A CA 2288705A CA 2288705 C CA2288705 C CA 2288705C
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- CA
- Canada
- Prior art keywords
- amino
- bromophenyl
- carbon atoms
- quinazolinyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XNERWVPQCYSMLC-UHFFFAOYSA-N phenylpropiolic acid Chemical compound OC(=O)C#CC1=CC=CC=C1 XNERWVPQCYSMLC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un procédé permettant de traiter ou de prévenir la maladie polykystique des reins chez un mammifère dont l'état justifie ce traitement, lequel procédé consiste à administrer au dit mammifère un composé de la formule (1) dans laquelle X est un phényle facultativement substitué; R et R1 sont chacun indépendamment hydrogène, halogène, alkyle, alcoxy, hydroxy ou trifluorométhyle; R2 est hydrogène, alkyle, alcoxy, hydroxy, trifluorométhyle; Y est un radical choisi dans le groupe composé de (a), (b), (c), (d), (e), (f) et (g); R3 est indépendamment hydrogène, alkyle, carboxy, carboalcoxy, phényle ou carboalkyle; n=2-4; ou un sel pharmaceutiquement acceptable de ce composé, à condition que chaque R3 de Y puisse être le même ou différent.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85226697A | 1997-05-06 | 1997-05-06 | |
| US08/852,266 | 1997-05-06 | ||
| PCT/US1998/008482 WO1998050038A1 (fr) | 1997-05-06 | 1998-04-28 | Utilisation de composes de la quinazoline dans le traitement de la maladie polykystique des reins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2288705A1 CA2288705A1 (fr) | 1998-11-12 |
| CA2288705C true CA2288705C (fr) | 2008-03-18 |
Family
ID=25312893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002288705A Expired - Fee Related CA2288705C (fr) | 1997-05-06 | 1998-04-28 | Utilisation de composes de quinazoline pour le traitement de la maladie polykystique des reins |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0980244B1 (fr) |
| JP (1) | JP4327259B2 (fr) |
| CN (1) | CN1195521C (fr) |
| AR (1) | AR012660A1 (fr) |
| AT (1) | ATE241986T1 (fr) |
| AU (1) | AU7165698A (fr) |
| CA (1) | CA2288705C (fr) |
| DE (1) | DE69815340T2 (fr) |
| DK (1) | DK0980244T3 (fr) |
| ES (1) | ES2201484T3 (fr) |
| PT (1) | PT980244E (fr) |
| WO (1) | WO1998050038A1 (fr) |
| ZA (1) | ZA983731B (fr) |
Families Citing this family (154)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| CZ301689B6 (cs) | 1999-11-05 | 2010-05-26 | Astrazeneca Ab | Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| GB0309850D0 (en) | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
| JP4724657B2 (ja) | 2003-05-30 | 2011-07-13 | アストラゼネカ ユーケー リミテッド | プロセス |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| CN1972688B (zh) | 2004-05-06 | 2012-06-27 | 沃尼尔·朗伯有限责任公司 | 4-苯胺基-喹唑啉-6-基-酰胺类化合物 |
| EP1838712B8 (fr) | 2004-12-14 | 2011-10-12 | AstraZeneca AB | Composes de pyrazolopyrimidine en tant qu`agents antitumoraux |
| WO2007034144A1 (fr) | 2005-09-20 | 2007-03-29 | Astrazeneca Ab | Composes de 4- (ih-indazol-s-yl-amino)-quinazoline utilises comme inhibiteurs des tyrosines kinases erbb associees au recepteur pour traiter le cancer |
| US20100008910A1 (en) | 2006-09-12 | 2010-01-14 | John Chant | Methods and compositions for the diagnosis and treatment of cancer |
| EP1921070A1 (fr) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | heterocycles bicycliques, medicaments á base de ces composes, leur usage et procédé pour leur preparation |
| EP2118075A1 (fr) | 2007-02-06 | 2009-11-18 | Boehringer Ingelheim International GmbH | Hétérocycles bicycliques, agents pharmaceutiques contenant ces composés, leur utilisation et leur procédé de préparation |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物 |
| CA2711582A1 (fr) | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Heterocycles spirocycliques, formules comportant lesdits composes, leur utilisation et procedes de preparation associes |
| EP2303276B1 (fr) | 2008-05-13 | 2013-11-13 | AstraZeneca AB | Sel de fumarate de 4-(3-chloro-2-fluoroanilino)-7-méthoxy-6-{[1-(n-méthylcarbamoylméthyl)pipéridin-4-yl]oxy}quinazoline |
| CA2733153C (fr) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Heterocycles a substitution cyclohexyloxy, medicaments contenant ces composes, leur utilisation et procedes pour les preparer |
| CN104447995A (zh) | 2009-03-20 | 2015-03-25 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-her抗体 |
| KR20120103587A (ko) | 2009-11-12 | 2012-09-19 | 제넨테크, 인크. | 수상돌기 소극 밀도를 증진시키는 방법 |
| EP2523957A1 (fr) | 2010-01-12 | 2012-11-21 | F. Hoffmann-La Roche AG | Composés hétérocycliques tricycliques, leurs compositions et procédés d'utilisation |
| DK2536748T3 (da) | 2010-02-18 | 2014-10-13 | Genentech Inc | Neuregulin-antagonister og anvendelse deraf ved behandling af kræft |
| CA2793024A1 (fr) | 2010-03-17 | 2011-09-22 | F. Hoffmann-La Roche Ag | Composes d'imidazopyridine, compositions et procedes d'utilisation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| TW321649B (fr) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd |
-
1998
- 1998-04-28 AT AT98918802T patent/ATE241986T1/de not_active IP Right Cessation
- 1998-04-28 AU AU71656/98A patent/AU7165698A/en not_active Abandoned
- 1998-04-28 ES ES98918802T patent/ES2201484T3/es not_active Expired - Lifetime
- 1998-04-28 WO PCT/US1998/008482 patent/WO1998050038A1/fr not_active Ceased
- 1998-04-28 PT PT98918802T patent/PT980244E/pt unknown
- 1998-04-28 CN CNB988048388A patent/CN1195521C/zh not_active Expired - Fee Related
- 1998-04-28 CA CA002288705A patent/CA2288705C/fr not_active Expired - Fee Related
- 1998-04-28 JP JP54816098A patent/JP4327259B2/ja not_active Expired - Fee Related
- 1998-04-28 DE DE69815340T patent/DE69815340T2/de not_active Expired - Fee Related
- 1998-04-28 DK DK98918802T patent/DK0980244T3/da active
- 1998-04-28 EP EP98918802A patent/EP0980244B1/fr not_active Expired - Lifetime
- 1998-05-04 ZA ZA9803731A patent/ZA983731B/xx unknown
- 1998-05-05 AR ARP980102087A patent/AR012660A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0980244A1 (fr) | 2000-02-23 |
| JP4327259B2 (ja) | 2009-09-09 |
| AR012660A1 (es) | 2000-11-08 |
| CN1195521C (zh) | 2005-04-06 |
| AU7165698A (en) | 1998-11-27 |
| EP0980244B1 (fr) | 2003-06-04 |
| CA2288705A1 (fr) | 1998-11-12 |
| DE69815340T2 (de) | 2004-05-06 |
| DK0980244T3 (da) | 2003-09-29 |
| CN1255062A (zh) | 2000-05-31 |
| PT980244E (pt) | 2003-10-31 |
| WO1998050038A1 (fr) | 1998-11-12 |
| JP2001523267A (ja) | 2001-11-20 |
| ATE241986T1 (de) | 2003-06-15 |
| HK1025262A1 (en) | 2000-11-10 |
| ES2201484T3 (es) | 2004-03-16 |
| DE69815340D1 (de) | 2003-07-10 |
| ZA983731B (en) | 1999-11-04 |
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| EEER | Examination request | ||
| MKLA | Lapsed |