CA2301309A1 - Microstructures permettant de manipuler des echantillons fluides - Google Patents

Microstructures permettant de manipuler des echantillons fluides Download PDF

Info

Publication number
CA2301309A1
CA2301309A1 CA002301309A CA2301309A CA2301309A1 CA 2301309 A1 CA2301309 A1 CA 2301309A1 CA 002301309 A CA002301309 A CA 002301309A CA 2301309 A CA2301309 A CA 2301309A CA 2301309 A1 CA2301309 A1 CA 2301309A1
Authority
CA
Canada
Prior art keywords
chamber
fluid
columns
sample
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002301309A
Other languages
English (en)
Inventor
Lee Allan Christel
Gregory T.A. Kovacs
William A. Mcmillan
M. Allen Northrup
Kurt E. Petersen
Farzad Pourahmadi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/910,434 external-priority patent/US6368871B1/en
Application filed by Individual filed Critical Individual
Publication of CA2301309A1 publication Critical patent/CA2301309A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4323—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors
    • B01F25/43231—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa using elements provided with a plurality of channels or using a plurality of tubes which can either be placed between common spaces or collectors the channels or tubes crossing each other several times
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

L'invention traite d'un procédé et d'un dispositif microfluidique permettant de séparer une matière recherchée, par exemple un acide nucléique, d'autres matières contenues dans un échantillon fluide. Selon un mode de réalisation préféré, ce dispositif comporte une microplaquette (20) dotée d'un orifice d'entrée (28), d'un orifice de sortie (30) et d'une chambre d'extraction (26) en communication par voie de fluide avec ces orifices. Cette chambre (26) possède des surfaces de fixation internes destinées à capturer la matière recherchée de l'échantillon fluide au fur et à mesure que celui-ci s'écoule de manière continue dans ladite chambre. La matière capturée peut ensuite être éluée en forçant l'écoulement d'un fluide d'élution dans la chambre (26). Ce fluide libère la matière des surfaces internes et provoque son passage dans le fluide d'élution. L'écoulement continu qui caractérise ce dispositif permet à la matière cible issue d'un volume relativement important d'échantillon fluide d'être concentrée dans un volume beaucoup plus petit de fluide d'élution. Lesdites surfaces internes sont de préférence formées d'un réseau de colonnes (32) intégrées à la paroi de la chambre (26) et s'étendant dans cette dernière. Ces colonnes (32) assurent une large surface de capture de la matière recherchée. Ce dispositif comporte de préférence un chauffage (34) destiné à augmenter l'efficacité de l'élution.
CA002301309A 1997-08-13 1998-08-13 Microstructures permettant de manipuler des echantillons fluides Abandoned CA2301309A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/910,434 US6368871B1 (en) 1997-08-13 1997-08-13 Non-planar microstructures for manipulation of fluid samples
US08/910,434 1997-08-13
US11545498A 1998-07-14 1998-07-14
US09/115,454 1998-07-14
PCT/US1998/016870 WO1999009042A2 (fr) 1997-08-13 1998-08-13 Microstructures permettant de manipuler des echantillons fluides

Publications (1)

Publication Number Publication Date
CA2301309A1 true CA2301309A1 (fr) 1999-02-25

Family

ID=26813216

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301309A Abandoned CA2301309A1 (fr) 1997-08-13 1998-08-13 Microstructures permettant de manipuler des echantillons fluides

Country Status (5)

Country Link
EP (1) EP1003759A2 (fr)
JP (1) JP2001515216A (fr)
AU (1) AU745989B2 (fr)
CA (1) CA2301309A1 (fr)
WO (1) WO1999009042A2 (fr)

Families Citing this family (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681871A (en) * 1995-05-24 1997-10-28 Johnson & Johnson Vision Products, Inc. Method for preparing ultraviolet radiation absorbing contact lenses
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DK1179585T3 (da) * 1997-12-24 2008-11-10 Cepheid Indretning og fremgangsmåde til lysis
CA2341896A1 (fr) 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Support pour un procede de determination d'analyte et procede de fabrication du support
JP3746658B2 (ja) * 1999-04-12 2006-02-15 株式会社日立製作所 微粒子を用いたプローブアレーの作製方法及び装置
US20050100943A1 (en) 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
CA2373198C (fr) * 1999-05-28 2011-10-11 Cepheid Cartouche servant a effectuer une reaction chimique
JP4078073B2 (ja) * 1999-05-28 2008-04-23 シーフィード 流体試料分析装置および方法
DE19927534B4 (de) * 1999-06-16 2008-01-31 Merck Patent Gmbh Vorrichtung zur Probenaufgabe
HK1046381A1 (zh) * 1999-07-02 2003-01-10 Clondiag Chip Technologies Gmbh 用於复制和描述核酸的芯片矩阵装置
US6930292B1 (en) * 1999-07-21 2005-08-16 Dako A/S Method of controlling the temperature of a specimen in or on a solid support member
CN1379857A (zh) * 1999-08-13 2002-11-13 美国吉诺米克斯有限公司 用于伸展聚合物的方法和装置
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
SE0001768D0 (sv) * 2000-05-12 2000-05-12 Helen Andersson Mikrofluidisk flödescell för manipulering av partiklar
DE10051396A1 (de) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
JP3538777B2 (ja) * 2001-03-26 2004-06-14 独立行政法人産業技術総合研究所 微小化学反応装置
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US6843262B2 (en) 2001-04-25 2005-01-18 President And Fellows Of Harvard College Fluidic switches and methods for controlling flow in fluidic systems
WO2002087729A1 (fr) * 2001-04-30 2002-11-07 Battelle Memorial Institute Appareil et procede de separation / de purification de fluides utilisant un changement thermique a cycle rapide
US7318912B2 (en) 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
CA2396408C (fr) 2001-08-03 2006-03-28 Nec Corporation Appareil de fractionnement dote d'un ensemble de piliers disposes par intervalles dans un passage de migration et procede de fabrication des piliers
DE10150549A1 (de) 2001-10-12 2003-04-17 Roche Diagnostics Gmbh Verfahren und Trennmodul zum Abtrennen von Partikeln aus einer Dispersion, insbesondere von Blutkörperchen aus Blut
EP1444338A4 (fr) * 2001-11-15 2007-07-04 Arryx Inc Pastille a echantillons
SE0202399D0 (sv) * 2001-12-11 2002-08-13 Thomas Laurell Device and method useable for integrated sequential separation and enrichment of proteins
US7749442B2 (en) 2001-12-14 2010-07-06 Arkray, Inc. Sample measuring device
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
DE10163476A1 (de) * 2001-12-21 2003-10-30 Siemens Ag Anordnung zur Trennung einer Komponente aus einem Fluid
JP2005164242A (ja) * 2001-12-28 2005-06-23 Cluster Technology Co Ltd 電気泳動用マイクロチップ
AU2002356341A1 (en) 2001-12-28 2003-07-30 Norchip As Fluid manipulation in a microfabricated reaction chamber system
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
FR2839660B1 (fr) * 2002-05-17 2005-01-21 Commissariat Energie Atomique Microreacteur,son procede de preparation,et procede pour realiser une reaction biochimique ou biologique
EP1380337B1 (fr) * 2002-07-12 2012-11-14 Tosoh Corporation Dispositif à canaux minces et procédé chimique permettant son utilisation du dispositif avec des fluides
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7183104B1 (en) 2002-08-23 2007-02-27 Duane Morris Llp Separator and particle detection system
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
CA2498933C (fr) 2002-09-12 2012-08-28 Cyvera Corporation Procede et appareil d'alignement de microbilles allongees de maniere a les interroger
AU2003270726A1 (en) 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
FR2846957B1 (fr) * 2002-11-13 2005-09-30 Commissariat Energie Atomique Micro-systeme a remplissage de micro-billes et procede d'obtention
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
JPWO2004051231A1 (ja) * 2002-11-29 2006-04-06 日本電気株式会社 分離装置および分離方法
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
JPWO2004051229A1 (ja) * 2002-12-02 2006-04-06 日本電気株式会社 液体スイッチおよびそれを用いたマイクロチップ、質量分析システム
GB0303524D0 (en) * 2003-02-15 2003-03-19 Sec Dep For The Home Departmen Improvements in and relating to the handling of dna
JPWO2004097393A1 (ja) * 2003-04-28 2006-07-13 松下電器産業株式会社 フィルタとそれを備えたバイオセンサ
JP4348676B2 (ja) 2003-06-03 2009-10-21 富士フイルム株式会社 マイクロ化学装置
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
DE10334238A1 (de) * 2003-07-28 2005-02-24 Robert Bosch Gmbh Sensoreinlasskanal
EP3718635A1 (fr) 2003-07-31 2020-10-07 Handylab, Inc. Traitement d'échantillons contenant des particules
FR2865806B1 (fr) * 2004-01-30 2007-02-02 Commissariat Energie Atomique Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
CA2564612A1 (fr) * 2004-02-26 2005-09-09 Thomsen Bioscience A/S Procede, puce, dispositif et systeme de collecte de particules biologiques
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2553097T3 (es) * 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
JPWO2005123242A1 (ja) * 2004-06-15 2008-07-31 日本電気株式会社 構造体ならびにこれを用いたチップ、および親／疎液性の制御方法
WO2005124332A1 (fr) * 2004-06-15 2005-12-29 Nec Corporation Puce électrophorétique; dispositf électrophorétique et procédé d'électrophorèse
WO2006020363A2 (fr) 2004-07-21 2006-02-23 Illumina, Inc. Procede et dispositif de suivi de produits medicamenteux au moyen d'elements d'identification optique codes
JP4735119B2 (ja) * 2004-08-09 2011-07-27 日本精工株式会社 反応器及びその製造方法
JP4591759B2 (ja) * 2004-11-05 2010-12-01 横河電機株式会社 マイクロ電気化学リアクタ
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
ATE459933T1 (de) 2004-11-16 2010-03-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
AU2005311631B2 (en) 2004-12-03 2012-06-07 Cytonome/St, Llc Unitary cartridge for particle processing
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
WO2006098370A1 (fr) * 2005-03-16 2006-09-21 Nec Corporation Circuit a retard avec mecanisme pour regler la duree effective de traversee d'un canal, micropuce et son procede de fabrication
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
EP1712284B1 (fr) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Méthode de séparation de cellules comprenant l'utilisation de supports solides hydrophobes
JP2006300860A (ja) * 2005-04-25 2006-11-02 Kyocera Corp マイクロ化学チップ
CN101291729B (zh) * 2005-10-24 2011-08-17 横河电机株式会社 微型芯片装置
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
EP2016415B1 (fr) 2006-04-21 2013-08-14 Nanobiosym, Inc. Plate-forme à molécules simples pour la découverte de médicaments: procédés pour la découverte de médicaments, comprenant des agents anticancéreux et antiviraux
JP4759451B2 (ja) * 2006-06-16 2011-08-31 株式会社日立ソリューションズ 生体物質の前処理チップ及び前処理チップシステム
US8163535B2 (en) 2006-06-26 2012-04-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
EP2041318A2 (fr) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Dispositif et procédé d'extraction et d'analyse d'acides nucléiques à partir d'échantillons biologiques
US20100005867A1 (en) * 2006-07-17 2010-01-14 Agilent Technologies, Inc. Temperature adjustment of a fluidic sample within a fluidic device
JP5173165B2 (ja) * 2006-08-14 2013-03-27 東京エレクトロン株式会社 クロマトグラフィ用のカラム及びその製造方法
US7919278B2 (en) * 2006-08-21 2011-04-05 Samsung Electronics Co., Ltd. Method of amplifying nucleic acid from a cell using a nonplanar solid substrate
US8158411B2 (en) 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
JP5190571B2 (ja) * 2006-08-31 2013-04-24 独立行政法人物質・材料研究機構 マイクロピラーアレイ素子の製造方法と製造装置
WO2008060604A2 (fr) 2006-11-14 2008-05-22 Handylab, Inc. Système microfluidique utilisé pour amplifier et détecter des polynucléotides en parallèle
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008085991A2 (fr) 2007-01-08 2008-07-17 U.S. Genomics, Inc. Chambre de réaction
EP2156494A2 (fr) * 2007-05-23 2010-02-24 Entegris, Inc. Articles comprenant des surfaces structurees mouillables
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
EP2072101A1 (fr) * 2007-12-21 2009-06-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Micro-évaporateur de canaux à connexions multiples
WO2009128294A1 (fr) * 2008-04-19 2009-10-22 ブラザー工業株式会社 Récepteur d'objet de test et appareil de test équipé dudit récepteur d'objet de test
KR101102532B1 (ko) * 2008-07-10 2012-01-03 삼성전자주식회사 시약 카트리지, 시약 카트리지를 구비하는 미세유동장치, 그 제조방법, 및 이를 이용한 시료분석방법
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
RU2009120627A (ru) 2009-05-29 2010-12-10 Корнинг Инкорпорейтед (US) Микрожидкостные устройства с регулированием потока
WO2010141131A1 (fr) 2009-06-04 2010-12-09 Lockheed Martin Corporation Puce microfluidique a echantillons multiples pour l'analyse d'adn
JP5585204B2 (ja) * 2010-05-18 2014-09-10 大日本印刷株式会社 マイクロチップ及びその製造方法
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
WO2012159063A2 (fr) 2011-05-19 2012-11-22 Blood Cell Strorage, Inc. Dispositif fluidique d'écoulement par gravité pour extraction d'acide nucléique
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
WO2013067202A1 (fr) 2011-11-04 2013-05-10 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
HU230238B1 (hu) * 2013-02-05 2015-10-28 NORMA Instruments Zártkörűen Működő Részvénytársaság Mérőegység folyadékot tartalmazó minták fizikai jellemzőinek meghatározásához
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
SG11201703057TA (en) * 2014-10-17 2017-05-30 Water Optics Technology Pte Ltd A method and device for concentrating particles in a fluid sample
ES2927062T3 (es) 2016-03-14 2022-11-02 Lucira Health Inc Dispositivos y procedimientos para modificar propiedades ópticas
EP3429543B1 (fr) 2016-03-14 2024-11-20 Pfizer Inc. Dispositifs d'analyse biologique à ventilation sélective et procédés associés
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
CN107779387A (zh) * 2016-08-30 2018-03-09 广州康昕瑞基因健康科技有限公司 基因测序反应小室
WO2018085453A1 (fr) * 2016-11-01 2018-05-11 California Institute Of Technology Dispositifs microfluidiques et procédés de purification de populations de lymphocytes t spécifiques d'un antigène rare
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
CN113777011B (zh) 2017-09-14 2024-11-19 辉瑞公司 具有电子读出的复用生物测定装置
EP3775834A4 (fr) * 2018-07-09 2021-03-17 Hewlett-Packard Development Company, L.P. Dispositifs de capture d'analytes à l'aide de dispositifs d'éjection fluidique
CN109100525B (zh) * 2018-09-08 2023-07-28 重庆科技学院 一种多通道检测用纸基微流控芯片的使用方法
CA3130782A1 (fr) * 2019-03-05 2020-09-10 Lucira Health, Inc. Remplissage de liquide sans bulles de chambres fluidiques
FR3097626B1 (fr) * 2019-06-20 2021-07-09 Exoes Système de thermorégulation d’une source rechargeable d’électricité
CN114829925B (zh) * 2019-12-12 2024-05-28 株式会社岛津制作所 色谱系统
CN111569962A (zh) * 2020-05-21 2020-08-25 浙江大学 一种基于介电泳的蛋白质富集方法及多生物探针快速检测系统
CN114590475B (zh) * 2020-12-07 2023-11-17 京东方科技集团股份有限公司 一种储液释放装置
CN112452367B (zh) * 2020-12-10 2022-02-22 深圳先进技术研究院 一种双层微孔芯片、双层微孔芯片制备方法及生物装置
BE1029473B1 (nl) * 2021-06-08 2023-01-16 Pharmafluidics Generiek ontwerp voor microfluïdisch apparaat
US12491513B2 (en) * 2022-04-15 2025-12-09 Hewlett-Packard Development Company, L.P. Microfluidic structures with interior pillars
US12427520B2 (en) 2022-04-15 2025-09-30 Hewlett-Packard Development Company, L.P. Microfluidic structures with angled exterior wall segments
JP7683050B2 (ja) * 2022-07-05 2025-05-26 中科合肥智慧農業協同創新研究院 土壌有機質を現場で迅速に検出する装置及びその検出方法
EP4559568A1 (fr) * 2023-11-24 2025-05-28 Sartorius BIA Separations d.o.o. Unité de mélange, système de mélange comprenant deux ou plusieurs unités de mélange, procédé de mélange de deux ou plusieurs fluides et système de lyse

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2613988A (en) * 1988-01-04 1989-08-01 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
ATE235292T1 (de) * 1994-10-22 2003-04-15 Central Research Lab Ltd Verfahren und vorichtung fur diffusionsaustausch zwischen nicht mischbare flüssigkeiten

Also Published As

Publication number Publication date
WO1999009042A3 (fr) 1999-05-06
EP1003759A2 (fr) 2000-05-31
AU8906698A (en) 1999-03-08
WO1999009042A2 (fr) 1999-02-25
JP2001515216A (ja) 2001-09-18
AU745989B2 (en) 2002-04-11

Similar Documents

Publication Publication Date Title
AU745989B2 (en) Microstructures for the manipulation of fluid samples
US6368871B1 (en) Non-planar microstructures for manipulation of fluid samples
US6440725B1 (en) Integrated fluid manipulation cartridge
US6887693B2 (en) Device and method for lysing cells, spores, or microorganisms
US7914994B2 (en) Method for separating an analyte from a sample
CN100503838C (zh) 用于分析核酸的微流系统
US20040086427A1 (en) Microfluidic system utilizing thin-film layers to route fluid
AU4437702A (en) Microstructures for the manipulation of fluid samples
AU4437602A (en) Microstructures for the manipulation of fluid samples
EP1567267A1 (fr) Systeme microfluidique pour l'analyse d'acides nucleiques
AU2003200701B2 (en) Integrated fluid manipulation cartridge
AU764060B2 (en) Integrated fluid manipulation cartridge
HK1061258A (en) Microfluidic system for analyzing nucleic acids

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued