CA2413251C - Compositions and methods to improve the oral absorption of antimicrobial agents - Google Patents

Compositions and methods to improve the oral absorption of antimicrobial agents Download PDF

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Publication number
CA2413251C
CA2413251C CA2413251A CA2413251A CA2413251C CA 2413251 C CA2413251 C CA 2413251C CA 2413251 A CA2413251 A CA 2413251A CA 2413251 A CA2413251 A CA 2413251A CA 2413251 C CA2413251 C CA 2413251C
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
cephalosporin
biopolymer
metal cation
carrageenan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2413251A
Other languages
English (en)
French (fr)
Other versions
CA2413251A1 (en
Inventor
Seung-Ho Choi
Jeoung-Soo Lee
Dennis Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
International Health Management Associates Inc
University of Utah Research Foundation Inc
Original Assignee
Cubist Pharmaceuticals LLC
International Health Management Associates Inc
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/598,089 external-priority patent/US6248360B1/en
Application filed by Cubist Pharmaceuticals LLC, International Health Management Associates Inc, University of Utah Research Foundation Inc filed Critical Cubist Pharmaceuticals LLC
Publication of CA2413251A1 publication Critical patent/CA2413251A1/en
Application granted granted Critical
Publication of CA2413251C publication Critical patent/CA2413251C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2413251A 2000-06-21 2001-06-18 Compositions and methods to improve the oral absorption of antimicrobial agents Expired - Fee Related CA2413251C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09/598,089 2000-06-21
US09/598,089 US6248360B1 (en) 2000-06-21 2000-06-21 Complexes to improve oral absorption of poorly absorbable antibiotics
US82940501A 2001-04-09 2001-04-09
US09/829,405 2001-04-09
US28397601P 2001-04-16 2001-04-16
US60/283,976 2001-04-16
PCT/US2001/019625 WO2001097851A2 (en) 2000-06-21 2001-06-18 Compositions and methods to improve the oral absorption of antimicrobial agents

Publications (2)

Publication Number Publication Date
CA2413251A1 CA2413251A1 (en) 2001-12-27
CA2413251C true CA2413251C (en) 2012-06-12

Family

ID=27403433

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2413251A Expired - Fee Related CA2413251C (en) 2000-06-21 2001-06-18 Compositions and methods to improve the oral absorption of antimicrobial agents

Country Status (16)

Country Link
EP (2) EP2263654B1 (pl)
JP (1) JP4969013B2 (pl)
KR (2) KR20080056308A (pl)
CN (1) CN100358579C (pl)
AT (1) ATE510533T1 (pl)
AU (2) AU2001267011B2 (pl)
BR (1) BR0112393A (pl)
CA (1) CA2413251C (pl)
ES (1) ES2394926T3 (pl)
IL (2) IL153514A0 (pl)
MX (1) MXPA02012670A (pl)
NZ (1) NZ523276A (pl)
PL (2) PL218223B1 (pl)
PT (1) PT1294361E (pl)
UA (1) UA82824C2 (pl)
WO (1) WO2001097851A2 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2726789A1 (en) 2000-02-05 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
US7527807B2 (en) 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
AU2002215180A1 (en) * 2000-10-12 2002-04-22 Orchid Chemicals And Pharmaceuticals Limited Beta-lactam antibiotic-polysaccharide complex
ATE303149T1 (de) * 2001-02-27 2005-09-15 Ranbaxy Lab Ltd Orale pharmazeutische zusammensetzung aus cefpodoxim-proxetil
US7317001B2 (en) 2002-06-06 2008-01-08 Oscient Pharmaceuticals Corporation Use of ramoplanin to treat diseases associated with the use of antibiotics
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
RU2333766C2 (ru) * 2002-11-18 2008-09-20 Вайкьюрон Фармасьютикалз Инк. Способы введения далбаванцина для лечения бактериальных инфекций
CN101130060B (zh) * 2002-11-18 2012-09-05 维克伦制药股份有限公司 含有达巴霉素的医药组合物
RU2275916C1 (ru) * 2004-10-11 2006-05-10 Меграбян Казарос Аршалуйсович Энтеросорбент для выведения тяжелых металлов
CA2597812C (en) * 2005-02-14 2012-01-24 Venus Remedies Limited Parenteral combination therapy for infective conditions with drug resistant bacterium
EP2974718A1 (en) * 2005-04-29 2016-01-20 Cubist Pharmaceuticals, Inc. Therapeutic compositions
US7795207B2 (en) 2005-11-21 2010-09-14 Harald Labischinski Lipopeptide compositions
DE102005056194A1 (de) * 2005-11-21 2007-07-12 Combinature Biopharm Ag Neue Lipopeptid Zusammensetzungen
US9023891B2 (en) 2008-05-29 2015-05-05 Nevada Naturals, Inc. Synergistic antimicrobial agents
RU2607526C2 (ru) * 2009-11-23 2017-01-10 Кьюбист Фармасьютикалз ЭлЭлСи Липопептидные композиции и родственные способы
NZ610638A (en) * 2010-11-24 2015-05-29 Melinta Therapeutics Inc Pharmaceutical compositions comprising radezolid
RU2013157188A (ru) * 2011-05-26 2015-07-10 Кьюбист Фармасьютикалз, Инк. Композиции св-183,315 и относящиеся к ним способы
WO2013025783A2 (en) * 2011-08-15 2013-02-21 Gentle Thomas M Water soluble antimicrobial composition
WO2013169231A1 (en) * 2012-05-07 2013-11-14 Nevada Naturals, Inc. Synergistic antimicrobial agents
CN102871996B (zh) * 2012-09-10 2014-12-24 中国医学科学院医药生物技术研究所 一种抗菌药物组合物及其应用
TWI504347B (zh) * 2012-11-23 2015-10-21 Pi Yen Company Ltd Anti-mosquito microcapsule composition, anti-mosquito microcapsule, anti-mosquito spray and anti-mosquito emulsion
CN103230364B (zh) * 2013-05-13 2014-06-11 青岛农业大学 一种头孢噻呋酸长效注射液的制备方法
DE102015100613A1 (de) 2015-01-16 2016-07-21 Andreas Hettich Gmbh & Co. Kg Rotor einer Dualen Zentrifuge
BR112017026245A2 (pt) 2015-06-05 2018-09-11 Firmenich & Cie microcápsulas com alta deposição em superfícies
KR20190005940A (ko) * 2016-05-09 2019-01-16 셀리아 파마슈티칼즈 에이피에스 안정화된 글리코펩티드 항생제 제형
CN106420616A (zh) * 2016-09-21 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢曲松钠干混悬剂
CN106420658A (zh) * 2016-09-23 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶胶囊
KR102044934B1 (ko) * 2017-08-11 2019-11-15 서울대학교 산학협력단 카르노스산 내포 환형 아밀로오스 복합체 및 그 제조방법
RU2770366C2 (ru) 2017-08-31 2022-04-15 Кселлия Фармасьютикалз Апс Препараты даптомицина
JP7217021B2 (ja) * 2017-09-25 2023-02-02 京都府公立大学法人 ２剤型粘膜下注入用局注液
AU2019278927A1 (en) * 2018-06-01 2020-12-24 Bt Bidco, Inc. Devices and systems for gastrointestinal microbiome detection and manipulation
WO2020229369A1 (en) * 2019-05-10 2020-11-19 Xellia Pharmaceuticals Aps Daptomycin aqueous formulations
WO2023211501A1 (en) * 2022-04-26 2023-11-02 Hikma Pharmaceuticals Usa Inc. Stable, ready-to-administer aqueous formulations of dalbavancin

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4722941A (en) 1978-06-07 1988-02-02 Kali-Chemie Pharma Gmbh Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof
US4297621A (en) 1980-10-02 1981-10-27 Sperry Corporation Cathode ray tube beam deflection amplifier system
ZA825384B (en) 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form
JPS6067413A (ja) * 1983-09-24 1985-04-17 Kyoto Yakuhin Kogyo Kk 直腸投与用組成物
US4612337A (en) * 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
ZA883887B (en) 1987-06-10 1990-02-28 Lilly Co Eli Chromatographic purification process
US5190748A (en) 1988-11-22 1993-03-02 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
IT1251153B (it) * 1991-08-06 1995-05-04 Vectorpharma Int Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5318781A (en) 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
NZ260933A (en) * 1993-07-16 1996-07-26 Hercules Inc Cation-complexed polysaccharides; use in foods and pharmaceuticals
US5856474A (en) 1994-04-25 1999-01-05 Biochemie Gesellschaft, M.B.H. Cephalosporin synthesis
GB9700624D0 (en) * 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
JP3783993B2 (ja) * 1997-07-24 2006-06-07 エーザイ株式会社 製剤組成物及びその製造方法
US6025352A (en) 1997-09-29 2000-02-15 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
EP1048669A1 (en) 1997-12-16 2000-11-02 Banyu Pharmaceutical Co., Ltd. Carbapenem derivatives
CA2322658C (en) 1998-03-02 2005-04-12 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
KR100296413B1 (ko) * 1998-04-01 2001-11-14 김선진 세파클러함유서방성정제
US6232306B1 (en) 1998-06-15 2001-05-15 Hoffmann-La Roche Inc. Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US6248360B1 (en) 2000-06-21 2001-06-19 International Health Management Associates, Inc. Complexes to improve oral absorption of poorly absorbable antibiotics

Also Published As

Publication number Publication date
MXPA02012670A (es) 2003-10-06
PL218223B1 (pl) 2014-10-31
BR0112393A (pt) 2003-07-08
KR100858945B1 (ko) 2008-09-17
EP2263654B1 (en) 2012-10-10
KR20080056308A (ko) 2008-06-20
PT1294361E (pt) 2011-07-26
HK1058763A1 (zh) 2004-06-04
CN1441668A (zh) 2003-09-10
IL153514A0 (en) 2003-07-06
WO2001097851A3 (en) 2002-05-16
ATE510533T1 (de) 2011-06-15
AU6701101A (en) 2002-01-02
ES2394926T3 (es) 2013-02-06
AU2001267011B2 (en) 2006-02-02
EP2263654A1 (en) 2010-12-22
UA82824C2 (uk) 2008-05-26
NZ523276A (en) 2005-02-25
CN100358579C (zh) 2008-01-02
WO2001097851A2 (en) 2001-12-27
EP1294361B1 (en) 2011-05-25
JP4969013B2 (ja) 2012-07-04
CA2413251A1 (en) 2001-12-27
PL206492B1 (pl) 2010-08-31
JP2003535911A (ja) 2003-12-02
HK1152232A1 (en) 2012-02-24
PL360288A1 (pl) 2004-09-06
KR20030023877A (ko) 2003-03-20
IL153514A (en) 2008-08-07
EP1294361A2 (en) 2003-03-26

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Effective date: 20170619