CA2430527C - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2430527C CA2430527C CA2430527A CA2430527A CA2430527C CA 2430527 C CA2430527 C CA 2430527C CA 2430527 A CA2430527 A CA 2430527A CA 2430527 A CA2430527 A CA 2430527A CA 2430527 C CA2430527 C CA 2430527C
- Authority
- CA
- Canada
- Prior art keywords
- mass spectrometer
- transient
- ions
- electrodes
- fragmentation device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 321
- 238000006243 chemical reaction Methods 0.000 claims abstract description 87
- 238000001816 cooling Methods 0.000 claims abstract description 69
- 230000001052 transient effect Effects 0.000 claims description 129
- 238000013467 fragmentation Methods 0.000 claims description 122
- 238000006062 fragmentation reaction Methods 0.000 claims description 122
- 239000007789 gas Substances 0.000 claims description 44
- 230000007423 decrease Effects 0.000 claims description 32
- 239000012634 fragment Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 12
- 230000004888 barrier function Effects 0.000 claims description 11
- 238000005036 potential barrier Methods 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 11
- 238000005040 ion trap Methods 0.000 claims description 9
- 230000001360 synchronised effect Effects 0.000 claims description 9
- 238000001698 laser desorption ionisation Methods 0.000 claims description 6
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 6
- 238000013016 damping Methods 0.000 claims description 5
- 238000004949 mass spectrometry Methods 0.000 claims description 5
- 238000010265 fast atom bombardment Methods 0.000 claims description 4
- 238000009616 inductively coupled plasma Methods 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 4
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 3
- 238000003795 desorption Methods 0.000 claims description 3
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 2
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 2
- 230000004323 axial length Effects 0.000 claims description 2
- 230000005684 electric field Effects 0.000 claims description 2
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 1
- 238000001819 mass spectrum Methods 0.000 description 90
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 12
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 12
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 12
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 12
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 12
- 229960003147 reserpine Drugs 0.000 description 12
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 12
- 229960001722 verapamil Drugs 0.000 description 12
- 238000004804 winding Methods 0.000 description 12
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 9
- 229960000520 diphenhydramine Drugs 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 230000035945 sensitivity Effects 0.000 description 8
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 description 8
- 229960000973 sulfadimethoxine Drugs 0.000 description 8
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229960000351 terfenadine Drugs 0.000 description 7
- 238000002552 multiple reaction monitoring Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000010884 ion-beam technique Methods 0.000 description 4
- 238000002542 parent ion scan Methods 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000003446 memory effect Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001977 collision-induced dissociation tandem mass spectrometry Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/065—Ion guides having stacked electrodes, e.g. ring stack, plate stack
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
- H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
On présente un spectromètre de masse comportant une cellule de collision en phase gazeuse, une cellule de réaction ou une cellule de refroidissement collisionnel (1) comptant une série d'électrodes (2). On applique de manière progressive des différences de potentiel en courant continu à la cellule (1), de manière à ce que les ions sont précipités dans celle-ci.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212511.0 | 2002-05-30 | ||
| GB0212511A GB0212511D0 (en) | 2002-05-30 | 2002-05-30 | Mass spectrometer |
| GB0308346.6 | 2003-04-11 | ||
| GB0308346A GB0308346D0 (en) | 2002-05-30 | 2003-04-11 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2430527A1 CA2430527A1 (fr) | 2003-11-30 |
| CA2430527C true CA2430527C (fr) | 2012-03-27 |
Family
ID=26247076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2430527A Expired - Lifetime CA2430527C (fr) | 2002-05-30 | 2003-05-30 | Spectrometre de masse |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1367632B1 (fr) |
| AT (1) | ATE372587T1 (fr) |
| CA (1) | CA2430527C (fr) |
| DE (1) | DE60316070T2 (fr) |
| GB (1) | GB2391698B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050242281A1 (en) * | 2004-04-30 | 2005-11-03 | Gangqiang Li | Unevenly segmented multipole |
| GB0426900D0 (en) | 2004-12-08 | 2005-01-12 | Micromass Ltd | Mass spectrometer |
| US7312442B2 (en) * | 2005-09-13 | 2007-12-25 | Agilent Technologies, Inc | Enhanced gradient multipole collision cell for higher duty cycle |
| DE102005044307B4 (de) * | 2005-09-16 | 2008-04-17 | Bruker Daltonik Gmbh | Ionisierung desorbierter Moleküle |
| GB0723183D0 (en) | 2007-11-23 | 2008-01-09 | Micromass Ltd | Mass spectrometer |
| WO2010089798A1 (fr) * | 2009-02-05 | 2010-08-12 | 株式会社島津製作所 | Spectromètre de masse en tandem |
| GB201104665D0 (en) | 2011-03-18 | 2011-05-04 | Shimadzu Res Lab Europe Ltd | Ion analysis apparatus and methods |
| GB201111568D0 (en) * | 2011-07-06 | 2011-08-24 | Micromass Ltd | Apparatus and method of mass spectrometry |
| GB201504817D0 (en) | 2015-03-23 | 2015-05-06 | Micromass Ltd | Pre-filter fragmentation |
| US11600480B2 (en) | 2020-09-22 | 2023-03-07 | Thermo Finnigan Llc | Methods and apparatus for ion transfer by ion bunching |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206506A (en) * | 1991-02-12 | 1993-04-27 | Kirchner Nicholas J | Ion processing: control and analysis |
| WO1994001883A1 (fr) * | 1992-07-01 | 1994-01-20 | United States Department Of Energy | Procede de selection de particules par discrimination |
| AU6653296A (en) * | 1995-08-11 | 1997-03-12 | Mds Health Group Limited | Spectrometer with axial field |
| GB2341270A (en) * | 1998-09-02 | 2000-03-08 | Shimadzu Corp | Mass spectrometer having ion lens composed of plurality of virtual rods comprising plurality of electrodes |
| CA2391140C (fr) * | 2001-06-25 | 2008-10-07 | Micromass Limited | Spectrometre de masse |
| CA2391148C (fr) * | 2001-06-25 | 2008-02-19 | Micromass Limited | Spectrometre de masse |
-
2003
- 2003-05-30 CA CA2430527A patent/CA2430527C/fr not_active Expired - Lifetime
- 2003-05-30 GB GB0312482A patent/GB2391698B/en not_active Expired - Lifetime
- 2003-05-30 AT AT03253411T patent/ATE372587T1/de not_active IP Right Cessation
- 2003-05-30 EP EP03253411A patent/EP1367632B1/fr not_active Expired - Lifetime
- 2003-05-30 DE DE60316070T patent/DE60316070T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1367632A3 (fr) | 2004-09-29 |
| GB2391698A (en) | 2004-02-11 |
| EP1367632A2 (fr) | 2003-12-03 |
| DE60316070D1 (de) | 2007-10-18 |
| GB0312482D0 (en) | 2003-07-09 |
| EP1367632B1 (fr) | 2007-09-05 |
| DE60316070T2 (de) | 2008-06-05 |
| ATE372587T1 (de) | 2007-09-15 |
| CA2430527A1 (fr) | 2003-11-30 |
| GB2391698B (en) | 2004-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230530 |