CA2456901C - Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity - Google Patents

Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity Download PDF

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Publication number
CA2456901C
CA2456901C CA2456901A CA2456901A CA2456901C CA 2456901 C CA2456901 C CA 2456901C CA 2456901 A CA2456901 A CA 2456901A CA 2456901 A CA2456901 A CA 2456901A CA 2456901 C CA2456901 C CA 2456901C
Authority
CA
Canada
Prior art keywords
thieno
pyrimidine
methylthio
amino
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2456901A
Other languages
English (en)
French (fr)
Other versions
CA2456901A1 (en
Inventor
Robert Gerard Jules Marie Hanssen
Cornelis Marius Timmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of CA2456901A1 publication Critical patent/CA2456901A1/en
Application granted granted Critical
Publication of CA2456901C publication Critical patent/CA2456901C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2456901A 2001-09-04 2002-08-29 Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity Expired - Fee Related CA2456901C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203327 2001-09-04
EP01203327.0 2001-09-04
PCT/EP2002/009647 WO2003020726A1 (en) 2001-09-04 2002-08-29 Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity

Publications (2)

Publication Number Publication Date
CA2456901A1 CA2456901A1 (en) 2003-03-13
CA2456901C true CA2456901C (en) 2011-01-04

Family

ID=8180876

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2456901A Expired - Fee Related CA2456901C (en) 2001-09-04 2002-08-29 Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity

Country Status (28)

Country Link
US (1) US7317006B2 (pl)
EP (1) EP1427733B1 (pl)
JP (1) JP4262092B2 (pl)
KR (1) KR100900018B1 (pl)
CN (1) CN1246324C (pl)
AR (1) AR036407A1 (pl)
AT (1) ATE345345T1 (pl)
AU (1) AU2002337035B2 (pl)
BR (1) BR0211938A (pl)
CA (1) CA2456901C (pl)
CY (1) CY1106012T1 (pl)
DE (1) DE60216128T2 (pl)
DK (1) DK1427733T3 (pl)
ES (1) ES2275005T3 (pl)
HR (1) HRP20040202A2 (pl)
HU (1) HUP0401444A3 (pl)
IL (1) IL160084A0 (pl)
IS (1) IS2424B (pl)
MX (1) MXPA04002045A (pl)
NO (1) NO20040927L (pl)
NZ (1) NZ531340A (pl)
PE (1) PE20030439A1 (pl)
PL (1) PL368502A1 (pl)
PT (1) PT1427733E (pl)
RU (1) RU2298011C2 (pl)
TW (1) TWI228508B (pl)
WO (1) WO2003020726A1 (pl)
ZA (1) ZA200401455B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
GB0315950D0 (en) * 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
CN100430403C (zh) * 2006-10-13 2008-11-05 中国科学院上海有机化学研究所 3-芳基-5,6-取代噻吩并嘧啶-4-羰基-2-巯基乙腈、合成方法和用途
US20090118276A1 (en) * 2007-11-02 2009-05-07 Wyeth Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors
TWI389913B (zh) * 2008-09-08 2013-03-21 Lg Life Sciences Ltd 并合雜環化合物
US8741259B2 (en) * 2008-10-20 2014-06-03 Marvin C. Gershengorn Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists
GB0905525D0 (en) 2009-03-31 2009-05-13 Univ Leiden Compounds and uses
EP2525658B1 (de) 2010-01-22 2017-03-01 Bayer Intellectual Property GmbH Akarizide und/oder insektizide wirkstoffkombinationen
US9206154B2 (en) 2010-04-08 2015-12-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inverse agonists and neutral antagonists for the TSH receptor
WO2016029372A1 (en) 2014-08-27 2016-03-03 The Procter & Gamble Company Wearable article having elastic belt
WO2016029375A1 (en) 2014-08-27 2016-03-03 The Procter & Gamble Company Wearable article having elastic belt
RU2619091C2 (ru) * 2015-10-13 2017-05-11 Министерство Промышленности И Торговли Рф Цилиндрический термоэмиссионный катод
CN108883011B (zh) 2016-04-08 2021-05-07 宝洁公司 具有艺术作品的可穿着制品
CA3258277A1 (en) * 2022-06-08 2023-12-14 Icahn School Of Medicine At Mount Sinai METHOD FOR OBESITY TREATMENT WITH A LUTEINIZING HORMONE RECEPTOR AGONIST

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound

Also Published As

Publication number Publication date
CY1106012T1 (el) 2011-04-06
ES2275005T3 (es) 2007-06-01
WO2003020726A1 (en) 2003-03-13
RU2004110042A (ru) 2005-08-20
CA2456901A1 (en) 2003-03-13
IS2424B (is) 2008-10-15
KR20040029134A (ko) 2004-04-03
NZ531340A (en) 2005-08-26
PE20030439A1 (es) 2003-05-17
HRP20040202A2 (en) 2004-08-31
DE60216128T2 (de) 2007-09-27
US7317006B2 (en) 2008-01-08
ATE345345T1 (de) 2006-12-15
AR036407A1 (es) 2004-09-08
CN1551884A (zh) 2004-12-01
DK1427733T3 (da) 2007-03-19
ZA200401455B (en) 2004-11-19
DE60216128D1 (de) 2006-12-28
TWI228508B (en) 2005-03-01
KR100900018B1 (ko) 2009-06-01
EP1427733A1 (en) 2004-06-16
EP1427733B1 (en) 2006-11-15
JP2005505555A (ja) 2005-02-24
IL160084A0 (en) 2004-06-20
RU2298011C2 (ru) 2007-04-27
BR0211938A (pt) 2004-09-21
AU2002337035B2 (en) 2008-04-24
JP4262092B2 (ja) 2009-05-13
NO20040927L (no) 2004-03-03
CN1246324C (zh) 2006-03-22
PT1427733E (pt) 2007-02-28
IS7130A (is) 2004-01-29
PL368502A1 (pl) 2005-04-04
HUP0401444A3 (en) 2008-05-28
HUP0401444A2 (hu) 2004-11-29
MXPA04002045A (es) 2004-07-08
US20040180873A1 (en) 2004-09-16

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CA2456901C (en) Thieno[2,3-d]pyrimidines with combined lh and fsh agonistic activity
AU2002337035A1 (en) Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity
EP1322651B1 (en) Bicyclic heteroaromatic compounds
EP1427734B1 (en) GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY
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Effective date: 20190829