CA2504720C - Composes oligomere chimeres et leur utilisation dans la modulation genique - Google Patents

Composes oligomere chimeres et leur utilisation dans la modulation genique Download PDF

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CA2504720C
CA2504720C CA2504720A CA2504720A CA2504720C CA 2504720 C CA2504720 C CA 2504720C CA 2504720 A CA2504720 A CA 2504720A CA 2504720 A CA2504720 A CA 2504720A CA 2504720 C CA2504720 C CA 2504720C
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rna
oligomer
linkages
nucleosides
oligomers
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CA2504720A
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CA2504720A1 (fr
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Brenda F. Baker
Anne B. Eldrup
Muthiah Manoharan
Balkrishen Bhat
Richard Griffey
Eric E. Swayze
Stanley T. Crooke
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compositions oligomères comprenant un premier et un second oligomère dans lesquelles au moins une partie du premier oligomère peut s'hybrider avec au moins une partie du second oligomère, au moins une partie du premier oligomère est complémentaire d'un acide nucléique cible choisi avec lequel il peut s'hybrider, et au moins le premier ou le second oligomère comprend au moins un nucléotide renfermant une composition organique chimère. Sont également décrites des compositions oligomère/protéine comprenant un oligomère complémentaire d'un acide nucléique cible choisi avec lequel il peut s'hybrider et au moins une protéine renfermant au moins un complexe de silençage induit par ARN, avec au moins un nucléotide qui comprend une composition organique chimère.
CA2504720A 2002-11-05 2003-11-04 Composes oligomere chimeres et leur utilisation dans la modulation genique Expired - Fee Related CA2504720C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42376002P 2002-11-05 2002-11-05
US60/423,760 2002-11-05
US50327103P 2003-09-15 2003-09-15
US60/503,271 2003-09-15
PCT/US2003/035074 WO2004044138A2 (fr) 2002-11-05 2003-11-04 Composes oligomere chimeres et leur utilisation dans la modulation genique

Publications (2)

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CA2504720A1 CA2504720A1 (fr) 2004-05-27
CA2504720C true CA2504720C (fr) 2013-12-24

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CA2504720A Expired - Fee Related CA2504720C (fr) 2002-11-05 2003-11-04 Composes oligomere chimeres et leur utilisation dans la modulation genique

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EP (1) EP1560839A4 (fr)
AU (1) AU2003287505A1 (fr)
CA (1) CA2504720C (fr)
WO (1) WO2004044138A2 (fr)

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US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
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AU2003291755A1 (en) * 2002-11-05 2004-06-07 Isis Pharmaceuticals, Inc. Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
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