CA2521202A1 - Pyrazoles substitues en position 1,3 et 4 utilises en tant qu'antagonistes des recepteurs 5-ht pour le traitement de psychoses et de troubles neurologiques - Google Patents

Pyrazoles substitues en position 1,3 et 4 utilises en tant qu'antagonistes des recepteurs 5-ht pour le traitement de psychoses et de troubles neurologiques Download PDF

Info

Publication number: CA2521202A1
Authority: CA; Canada
Prior art keywords: formula; compounds; denotes; solvates; salts
Prior art date: 2003-04-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002521202A

Other languages

English (en)

Inventor

Kai Schiemann

Oliver Schadt

Christoph Van Amsterdam

Gerd Bartoszyk

Christoph Seyfried

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-05

Filing date

2004-03-08

Publication date

2004-10-21

2004-03-08 Application filed by Individual filed Critical Individual

2004-10-21 Publication of CA2521202A1 publication Critical patent/CA2521202A1/fr

Status Abandoned legal-status Critical Current

Links

238000011282 treatment Methods 0.000 title claims description 22
208000028017 Psychotic disease Diseases 0.000 title claims description 4
208000012902 Nervous system disease Diseases 0.000 title claims description 3
208000025966 Neurological disease Diseases 0.000 title claims description 3
229940127239 5 Hydroxytryptamine receptor antagonist Drugs 0.000 title 1
150000003217 pyrazoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 81
150000003839 salts Chemical class 0.000 claims abstract description 36
239000012453 solvate Substances 0.000 claims abstract description 26
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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Landscapes

Health & Medical Sciences (AREA)
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Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Psychology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
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Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Child & Adolescent Psychology (AREA)

CA002521202A 2003-04-05 2004-03-08 Pyrazoles substitues en position 1,3 et 4 utilises en tant qu'antagonistes des recepteurs 5-ht pour le traitement de psychoses et de troubles neurologiques Abandoned CA2521202A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10315573.2		2003-04-05
DE2003115573 DE10315573A1 (de)	2003-04-05	2003-04-05	Substituierte Pyrazole
PCT/EP2004/002354 WO2004089910A1 (fr)	2003-04-05	2004-03-08	Pyrazoles substitues en position 1,3 et 4 utilises en tant qu'antagonistes des recepteurs 5-ht pour le traitement de psychoses et de troubles neurologiques

Publications (1)

Publication Number	Publication Date
CA2521202A1 true CA2521202A1 (fr)	2004-10-21

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ID=32981074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002521202A Abandoned CA2521202A1 (fr)	2003-04-05	2004-03-08	Pyrazoles substitues en position 1,3 et 4 utilises en tant qu'antagonistes des recepteurs 5-ht pour le traitement de psychoses et de troubles neurologiques

Country Status (16)

Country	Link
US (1)	US7566709B2 (fr)
EP (1)	EP1611107B1 (fr)
JP (1)	JP4740116B2 (fr)
KR (1)	KR20050119194A (fr)
CN (1)	CN1768043A (fr)
AR (1)	AR043838A1 (fr)
AT (1)	ATE478052T1 (fr)
AU (1)	AU2004228121B2 (fr)
BR (1)	BRPI0409002A (fr)
CA (1)	CA2521202A1 (fr)
DE (2)	DE10315573A1 (fr)
ES (1)	ES2349922T3 (fr)
MX (1)	MXPA05010646A (fr)
RU (1)	RU2005133990A (fr)
WO (1)	WO2004089910A1 (fr)
ZA (1)	ZA200508951B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10315572A1 (de) *	2003-04-05	2004-10-14	Merck Patent Gmbh	Substituierte Pyrazole
DE10315571A1 (de) *	2003-04-05	2004-10-14	Merck Patent Gmbh	Pyrazolverbindungen
DE10315569A1 (de) *	2003-04-05	2004-10-14	Merck Patent Gmbh	Substituierte Pyrazolverbindungen
CA2581454A1 (fr)	2004-09-23	2006-03-30	Reddy Us Therapeutics, Inc.	Nouveaux composes de pyrimidine, leur procede de preparation, et compositions les contenant
WO2006089076A2 (fr) *	2005-02-18	2006-08-24	Neurogen Corporation	Thiazole amides, imidazole amides et analogues associes
BRPI0612287A8 (pt) *	2005-06-27	2019-01-22	Exelixis Inc	composição para uso farmacêutico no tratamento de doenças através da medicina nuclear e métodos de uso e para modulação de atividade de receptor nuclear
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2004
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- 2004-03-08 JP JP2006504585A patent/JP4740116B2/ja not_active Expired - Fee Related
- 2004-03-08 WO PCT/EP2004/002354 patent/WO2004089910A1/fr not_active Ceased
- 2004-03-08 AT AT04718264T patent/ATE478052T1/de active
- 2004-03-08 CN CNA2004800086295A patent/CN1768043A/zh active Pending
- 2004-03-08 KR KR1020057018898A patent/KR20050119194A/ko not_active Withdrawn
- 2004-03-08 DE DE502004011551T patent/DE502004011551D1/de not_active Expired - Lifetime
- 2004-03-08 CA CA002521202A patent/CA2521202A1/fr not_active Abandoned
- 2004-03-08 BR BRPI0409002-0A patent/BRPI0409002A/pt not_active Application Discontinuation
- 2004-03-08 EP EP04718264A patent/EP1611107B1/fr not_active Expired - Lifetime
- 2004-03-08 RU RU2005133990/04A patent/RU2005133990A/ru not_active Application Discontinuation
- 2004-03-08 MX MXPA05010646A patent/MXPA05010646A/es unknown
- 2004-03-08 AU AU2004228121A patent/AU2004228121B2/en not_active Ceased
- 2004-03-08 US US10/551,998 patent/US7566709B2/en not_active Expired - Fee Related
- 2004-04-02 AR ARP040101120A patent/AR043838A1/es unknown
2005
- 2005-11-04 ZA ZA200508951A patent/ZA200508951B/en unknown

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Publication number	Publication date
BRPI0409002A (pt)	2006-03-28
EP1611107B1 (fr)	2010-08-18
ATE478052T1 (de)	2010-09-15
AR043838A1 (es)	2005-08-17
RU2005133990A (ru)	2006-03-20
DE502004011551D1 (de)	2010-09-30
US7566709B2 (en)	2009-07-28
EP1611107A1 (fr)	2006-01-04
DE10315573A1 (de)	2004-10-14
AU2004228121A1 (en)	2004-10-21
WO2004089910A1 (fr)	2004-10-21
JP4740116B2 (ja)	2011-08-03
US20070105871A1 (en)	2007-05-10
ZA200508951B (en)	2007-03-28
AU2004228121B2 (en)	2010-11-04
MXPA05010646A (es)	2005-12-12
CN1768043A (zh)	2006-05-03
KR20050119194A (ko)	2005-12-20
ES2349922T3 (es)	2011-01-13
JP2006522036A (ja)	2006-09-28

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2013-05-01	FZDE	Discontinued	Effective date: 20130306

Publication	Publication Date	Title
JP4740115B2 (ja)	2011-08-03	置換ピラゾール
AU2004228121B2 (en)	2010-11-04	1,3,4-substituted pyrazoles for use as 5-HT receptor antagonists in the treatment of psychoses and neurological disorders
JP4795889B2 (ja)	2011-10-19	ベンゾフラン化合物
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JP2004502760A (ja)	2004-01-29	ピラゾール誘導体
WO1998041519A1 (fr)	1998-09-24	Nouveaux agonistes de recepteurs de cannabinoides
JP2011153144A (ja)	2011-08-11	置換ピラゾール化合物
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CA2521199A1 (fr)	2004-10-21	Composes pyrazole
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JP2002521377A (ja)	2002-07-16	ビフェニル誘導体