CA2597717C - Anticorps contre cxcr4 et leurs procedes d'utilisation - Google Patents

Anticorps contre cxcr4 et leurs procedes d'utilisation Download PDF

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Publication number
CA2597717C
CA2597717C CA2597717A CA2597717A CA2597717C CA 2597717 C CA2597717 C CA 2597717C CA 2597717 A CA2597717 A CA 2597717A CA 2597717 A CA2597717 A CA 2597717A CA 2597717 C CA2597717 C CA 2597717C
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CA
Canada
Prior art keywords
cxcr4
antibody
antibodies
scfv
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2597717A
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English (en)
Other versions
CA2597717A1 (fr
Inventor
Wayne A. Marasco
Jianhua Sui
Chen Xu
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of CA2597717A1 publication Critical patent/CA2597717A1/fr
Application granted granted Critical
Publication of CA2597717C publication Critical patent/CA2597717C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention a trait à des anticorps monoclonaux humains, des anticorps scFv, des fusions scFv-Fc, et un domaine d'anticorps, des fragments de Fab, Fab' et F(ab')2, des anticorps à chaîne unique et/ou de minicorps de liaison spécifique au CXCR4. L'invention a également trait à des procédés de traitement et/ou de prévention d'une maladie ou trouble CXCR4 tel que le cancer ou l'infection VIH-I X4-tropique ainsi qu'à des utilisations de tels anticorps et de fragments d'anticorps dans la fabrication d'un médicament pour le traitement ou la prévention d'un trouble CXCR4. L'invention a également trait à des procédés de prévention de maladies ou de troubles associés à la fonction ou l'expression de CXCR4. L'invention a également trait à l'utilisation des anticorps (ou des fragments de ceux-ci) de l'invention dans la fabrication d'un médicament pour la prévention de maladies ou de troubles associés à l'expression de CXCR4. L'invention a également trait à des procédés de traitement ou de prévention de la métastase cancéreuse chez un patient atteint de cancer impliquant des cellules tumorales qui expriment le CXCR4. L'invention a trait en outre à l'utilisation de tels anticorps et de fragments d'anticorps dans la fabrication d'un médicament pour le traitement ou la prévention de la métastase cancéreuse. L'invention a également trait à des procédés de traitement ou de prévention de la métastase cancéreuse chez un patient atteint d'une tumeur hypoxique, telle qu'un tumeur solide caractérisée par une activation de CXCR4 dépendante de HIF. Les anticorps et les fragments de l'invention peuvent être utilisés dans la fabrication d'un médicament pour la prévention de la métastase cancéreuse chez un patient atteint d'une tumeur hypoxique. L'invention a trait en outre à des procédés de mobilisation de cellules souches CD34+ dérivées de la moelle osseuse ainsi qu'à des procédés de blocage de la chimiotaxie de cellules d'expression CXCR4 en réponse au SDF-1. L'invention a également trait à des procédés de traitement ou de prévention de réaction du greffon contre l'hôte ainsi qu'à l'utilisation des anticorps et fragments de ceux-ci dans la fabrication d'un médicament pour la prévention ou le traitement de la réaction du greffon contre l'hôte. Enfin, l'invention a trait à des procédés d'inhibition de formation de nouveaux vaisseaux sanguins tumoraux et/ou d'inhibition de l'angiogenèse de cellules tumorales.
CA2597717A 2005-02-18 2006-02-15 Anticorps contre cxcr4 et leurs procedes d'utilisation Expired - Lifetime CA2597717C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65437705P 2005-02-18 2005-02-18
US60/654,377 2005-02-18
PCT/US2006/005691 WO2006089141A2 (fr) 2005-02-18 2006-02-15 Anticorps contre cxcr4 et leurs procédés d'utilisation

Publications (2)

Publication Number Publication Date
CA2597717A1 CA2597717A1 (fr) 2006-08-24
CA2597717C true CA2597717C (fr) 2014-10-21

Family

ID=36917101

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2597717A Expired - Lifetime CA2597717C (fr) 2005-02-18 2006-02-15 Anticorps contre cxcr4 et leurs procedes d'utilisation

Country Status (4)

Country Link
US (1) US8329178B2 (fr)
EP (1) EP1871807B1 (fr)
CA (1) CA2597717C (fr)
WO (1) WO2006089141A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107207590A (zh) * 2014-12-17 2017-09-26 癌症研究技术有限公司 抗cxcl12抗体分子及其用途

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EP2297206A1 (fr) * 2008-05-14 2011-03-23 Eli Lilly And Company Anticorps anti-cxcr4
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Also Published As

Publication number Publication date
WO2006089141A3 (fr) 2006-12-07
EP1871807B1 (fr) 2012-11-28
US20110250165A1 (en) 2011-10-13
WO2006089141A2 (fr) 2006-08-24
CA2597717A1 (fr) 2006-08-24
EP1871807A2 (fr) 2008-01-02
US8329178B2 (en) 2012-12-11

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