CA2656622C - Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors - Google Patents

Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors Download PDF

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Publication number
CA2656622C
CA2656622C CA2656622A CA2656622A CA2656622C CA 2656622 C CA2656622 C CA 2656622C CA 2656622 A CA2656622 A CA 2656622A CA 2656622 A CA2656622 A CA 2656622A CA 2656622 C CA2656622 C CA 2656622C
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Canada
Prior art keywords
dihydro
cyclopenta
methyl
hydroxy
pyrimidin
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Active
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CA2656622A
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English (en)
French (fr)
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CA2656622A1 (en
Inventor
Ian S. Mitchell
James F. Blake
Rui Xu
Nicholas C. Kallan
Dengming Xiao
Keith Lee Spencer
Josef R. Bencsik
Jun Liang
Brian Safina
Birong Zhang
Christine Chabot
Steven Do
Eli M. Wallace
Anna L. Banka
Stephen T. Schlachter
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Genentech Inc
Array Biopharma Inc
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Genentech Inc
Array Biopharma Inc
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Application filed by Genentech Inc, Array Biopharma Inc filed Critical Genentech Inc
Priority to CA2836316A priority Critical patent/CA2836316A1/en
Publication of CA2656622A1 publication Critical patent/CA2656622A1/en
Application granted granted Critical
Publication of CA2656622C publication Critical patent/CA2656622C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
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CA2656622A 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors Active CA2656622C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2836316A CA2836316A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81871806P 2006-07-06 2006-07-06
US60/818,718 2006-07-06
PCT/US2007/072885 WO2008006040A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2836316A Division CA2836316A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2656622A1 CA2656622A1 (en) 2008-01-10
CA2656622C true CA2656622C (en) 2017-09-12

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ID=38686743

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2656622A Active CA2656622C (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
CA2836316A Abandoned CA2836316A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

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Application Number Title Priority Date Filing Date
CA2836316A Abandoned CA2836316A1 (en) 2006-07-06 2007-07-05 Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors

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EP (4) EP2402325B1 (2)
JP (4) JP5266216B2 (2)
KR (5) KR20140093291A (2)
CN (2) CN101578273B (2)
AR (3) AR061842A1 (2)
AT (1) ATE524447T1 (2)
AU (1) AU2007269060B2 (2)
BR (3) BR122013028005B8 (2)
CA (2) CA2656622C (2)
CL (1) CL2007001993A1 (2)
CO (1) CO6150161A2 (2)
CR (1) CR10600A (2)
CY (1) CY1112117T1 (2)
DK (2) DK2049501T3 (2)
ES (3) ES2372774T3 (2)
HR (1) HRP20110908T1 (2)
HU (1) HUE026237T2 (2)
IL (2) IL196028A (2)
IN (1) IN2014KN02886A (2)
MA (1) MA31655B1 (2)
MX (4) MX366319B (2)
MY (1) MY147364A (2)
NO (1) NO342346B1 (2)
NZ (3) NZ610633A (2)
PL (2) PL2402325T3 (2)
PT (1) PT2049501E (2)
RS (1) RS52212B (2)
RU (2) RU2478632C2 (2)
SG (4) SG188905A1 (2)
SI (2) SI2049501T1 (2)
TW (2) TWI402266B (2)
UA (1) UA95641C2 (2)
WO (1) WO2008006040A1 (2)
ZA (1) ZA200900070B (2)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
CA2656566C (en) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
ATE523499T1 (de) 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
US20110135569A1 (en) 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
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